Abstract：
PURPOSE:To investigate whether use of donors predisposed by corneal collagen cross-linking (CXL) reduced myopic refractive errors for keratoconic eyes after penetrating keratoplasty (PK). DESIGN:Randomized controlled trial. METHODS:One hundred sixteen eyes of 116 patients with keratoconus from Zhongshan Ophthalmic Center were enrolled. Using stratified block randomization, we assigned eligible eyes to the CXL graft group (Group 1) or conventional graft group (Group 2). Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), spherical equivalent (SE), and topographic data were compared 12, 24, and 36 months after surgery. RESULTS:Group 1 had better UDVA and CDVA than Group 2 after 1 year follow-up. Also, Group 1 had a lesser degree of SE and lower manifest cylinder than Group 2. At 3 years follow-up, mean CDVA was 0.17 ± 0.10 logarithm of the minimum angle of resolution (logMAR) in Group 1 vs 0.23 ± 0.12 logMAR in Group 2 (P = .004). Mean SE was -3.50 ± 2.93 diopter (D) in Group 1 and -4.02 ± 2.57 D in Group 2 (P = .034). Mean manifest cylinder was -5.22 ± 2.64 D and -6.35 ± 2.80 D in Group 1 and Group 2, respectively (P = .013). At 3 years follow-up, simulated keratometry in the steepest meridian (Kmax) was 46.85 ± 2.85 D vs 49.37 ± 2.92 D (P = .036); corneal power was 44.41 ± 2.89 D vs 46.35 ± 2.87 D (P = .001); and keratometric astigmatism was 4.53 ± 1.06 D vs 5.98 ± 1.28 D (P < .001) in Group 1 and Group 2, respectively. CONCLUSIONS:Use of donors predisposed by CXL could reduce topographic readings after PK for the treatment of keratoconus, and consequently reduce myopic refractive errors and improve visual acuity.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Huang T,Ye R,Ouyang C,Hou C,Hu Y,Wu Qdoi
10.1016/j.ajo.2017.10.003subject
Has Abstractpub_date
2017-12-01 00:00:00pages
115-120eissn
0002-9394issn
1879-1891pii
S0002-9394(17)30426-9journal_volume
184pub_type
杂志文章,随机对照试验abstract：:We believe axoplasmic transport alteration is the anatomic substrate for formation of drusen of the optic disk. In familial cases the cause of axoplasmic transport alteration may be related to the presence of a genetically determined, small, crowded optic nerve head. We believe these congenitally elevated nerve heads ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76658-9
更新日期：1978-01-01 00:00:00
abstract：:We devised a new binocular indirect ophthalmoscope and a complimentary examination technique that provide enhanced fundus magnification and optimum stereopsis through a wide range of patient pupillary apertures. The lightweight, mechanically simple instrument uses a variable focus Galilean telescopic observation syste...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(78)90182-4
更新日期：1978-11-01 00:00:00
abstract：PURPOSE:To determine the repeatability of automated retinal and choroidal thickness measurements with swept-source optical coherence tomography (SS OCT) and the frequency and type of scan artifacts. DESIGN:Prospective evaluation of new diagnostic technology. METHODS:Thirty healthy subjects were recruited prospectivel...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.02.008
更新日期：2014-05-01 00:00:00
abstract：:Visual loss secondary to vitreous hemorrhage or retinal detachment can occur in proliferative sickle retinopathy. Severe complications including a high incidence of anterior segment necrosis have been reported in both vitrectomy and scleral buckling operations in patients with this disease. We examined four patients w...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(87)90004-3
更新日期：1987-08-15 00:00:00
abstract：:A retrospective study of patients who underwent keratoplasty for keratoconus was done in 100 consecutive cases, of which 50 were penetrating keratoplasty procedures, and 50 were lamellar keratoplasty procedures. Each case was done by the same surgeon in both series. Criteria for patient selection were essentially the ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(78)90126-5
更新日期：1978-12-01 00:00:00
abstract：PURPOSE:To evaluate the rate of peripapillary choroidal thinning in glaucoma patients and healthy controls using spectral domain optical coherence tomography. DESIGN:Cohort study. METHODS:Participants from the multicenter African Descent and Glaucoma Evaluation Study and Diagnostic Innovations in Glaucoma Study were ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ajo.2017.10.025
更新日期：2018-02-01 00:00:00
abstract：:In 98 patients, 112 eyes with chronic closed-angle or combined glaucoma were operated on using filtering iridocycloretraction, including preparation of two limbal-based scleral strips that were introduced through scleral incisions into the anterior chamber and the supraciliary space. The intraocular pressure was contr...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(85)90366-6
更新日期：1985-03-15 00:00:00
abstract：PURPOSE:To assess the effect of verteporfin photodynamic therapy (PDT) in juxtafoveal choroidal neovascularization (CNV) secondary to pathologic myopia (PM). DESIGN:Prospective, open-label, consecutive, interventional case series. METHODS:We prospectively followed a series of 48 consecutive patients (49 eyes) with pa...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.11.037
更新日期：2007-03-01 00:00:00
abstract：OBJECTIVE:To document the clinical presentation, treatment, and visual outcome of sarcoid uveitis and to determine the timing and potential risk factors of sarcoidosis progression to symptomatic systemic disease from the time of sarcoid uveitis diagnosis. DESIGN:Retrospective, interventional case series. METHODS:Subj...
journal_title：American journal of ophthalmology
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更新日期：2019-02-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2005-03-01 00:00:00
abstract：PURPOSE:To report the cotransmission of retinitis punctata albescens (RPA) and congenital sensorineural deafness. METHODS:Case reports of two siblings with nyctalopia and profound bilateral sensorineural deafness. RESULTS:The affected siblings, an 11-year-old female and a 7-year-old male, presented with decreased vis...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00060-4
更新日期：1999-08-01 00:00:00
abstract：PURPOSE:To use the capillary-free zone along retinal arteries, a physiologic area of superficial avascularization, as an anatomic paradigm to investigate the reliability of optical coherence tomography angiography (OCTA) for visualizing the deep retinal circulation. DESIGN:Validity analysis and laboratory investigatio...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2018.02.007
更新日期：2018-05-01 00:00:00
abstract：PURPOSE:To describe the use of anterior segment optical coherence tomography (AS-OCT) to clarify the position and patency of aqueous shunt devices in the anterior chamber of eyes where corneal edema or tube position does not permit a satisfactory view. DESIGN:Noncomparative observational case series. METHODS:Four cas...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2007.02.023
更新日期：2007-06-01 00:00:00
abstract：PURPOSE:To report central serous chorioretinopathy associated with excessive use of compounds with sympathomimetic activity. DESIGN:Observational case series. METHODS:Four patients presented with clinical and fluorescein angiographic evidence of central serous chorioretinopathy. All patients expressed a concomitant p...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00076-x
更新日期：2003-07-01 00:00:00
abstract：PURPOSE:To compare optic disk size in eyes of subjects classified as normal with the eyes of subjects with open-angle glaucoma, ocular hypertension, or pseudoexfoliation syndrome in an older population-based sample. METHODS:The Blue Mountains Eye Study examined 3,654 subjects. Vertical disk diameter was measured from ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00195-6
更新日期：1999-10-01 00:00:00
abstract：PURPOSE:To present the carbon dioxide laser as an effective tool for surgical debulking of eyelid and orbital neurofibromas. METHOD:Two patients with neurofibromatosis underwent surgical debulking of their eyelid and orbital plexiform neurofibromas by means of the carbon dioxide laser. RESULTS:Acceptable cosmetic res...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00454-2
更新日期：2000-07-01 00:00:00
abstract：:Two groups of patients, 37 with primary basal cell carcinoma of the eyelid and 16 with basal cell carcinoma of the eyelid previously treated by other physicians were reviewed. All of the tumors were excised with at least 3 to 4 mm of normal-appearing tissue at each margin of resection. All of the excised specimens wer...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90358-1
更新日期：1979-06-01 00:00:00
abstract：:A 61-year-old white woman, who had progressive arthritis over a two-year period, developed bilateral peripheral corneal degeneration. The superior cornea thinned to a thickness of approximately two thirds of normal. She died suddenly in the hospital and a primary occlusive vasculitis of the anterior ciliary arteries w...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)77721-9
更新日期：1978-03-01 00:00:00
abstract：:We examined the ability of hypothermic infusion fluid to reduce the risk of light damage to the retina from the intraocular fiberoptic probe during vitreous surgery. Following vitrectomy, we exposed the retina of rabbits to light from an intraocular fiberoptic probe during infusion of fluid at body temperature (39 C) ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1986-10-15 00:00:00
abstract：:We reviewed the histories of three patients with sebaceous carcinoma (two of the eyelid and one of the caruncle) who had had their tumors excised by surgeons experienced in the Mohs' technique. In each patient the tumor was considered totally excised. In one patient, residual intraepithelial pagetoid sebaceous carcino...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74400-9
更新日期：1987-06-15 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1986-07-15 00:00:00
abstract：PURPOSE:To investigate the risk of glaucoma development after being prescribed topiramate. DESIGN:A retrospective, population-based cohort study using an administrative database. METHODS:The study group comprised 1956 patients who received their first prescription of topiramate between 2001 and 2007. The comparison c...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2013-02-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.10.020
更新日期：2005-05-01 00:00:00
abstract：:Fifty-five patients with primary open-angle glaucoma and early glaucomatous damage who had medical therapy and laser trabeculoplasty were followed up for four to 11 years or until progressive glaucomatous damage was documented. Factors associated with the stability or progression of glaucoma were evaluated. Eyes with ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76896-5
更新日期：1991-01-15 00:00:00
abstract：PURPOSE:To report associations between prognosis, total tumor necrosis, scleritis, and episcleritis in choroidal and ciliary body melanomas. METHODS:In this retrospective observational histopathologic study, 157 totally necrotic melanomas and 177 melanomas that were not totally necrotic of choroidal and ciliary body w...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2001-02-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2008-03-01 00:00:00
abstract：PURPOSE:To evaluate and compare the recurrence rates and complications between 2 therapeutic methods for primary pterygium: subconjunctival injection of mitomycin C (MMC) 1 month before bare scleral excision and conjunctival rotational flap with intraoperative MMC use. DESIGN:Prospective, interventional, randomized cl...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,随机对照试验
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更新日期：2010-08-01 00:00:00
abstract：:We studied a new method for photographing cataractous lens opacaities by retroillumination. The slit-lamp microscope was modified with an adaptor to eliminate the specular reflection from the corneal surface. We construcated two kinds of adaptors for the Zeiss and Goldmann-type slit-lamp microscopes. The cataractous l...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74852-4
更新日期：1980-08-01 00:00:00
abstract：PURPOSE:To report the echographic appearance of a scleral fold in hypotony. METHOD:We performed ultrasonography on a patient who, after trabeculectomy with mitomycin C, had an intraocular pressure of 1 mm Hg, an opaque cataract, and suspected hypotonous maculopathy in the left eye. RESULTS:An area of dome-shaped eyew...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70801-3
更新日期：1997-08-01 00:00:00
