Abstract：
PURPOSE:To evaluate and compare the recurrence rates and complications between 2 therapeutic methods for primary pterygium: subconjunctival injection of mitomycin C (MMC) 1 month before bare scleral excision and conjunctival rotational flap with intraoperative MMC use. DESIGN:Prospective, interventional, randomized clinical trial. METHODS:setting: Institutional clinical trial in a tertiary, specialty eye hospital. study population and intervention: We included 82 eyes diagnosed with primary pterygium and randomly allocated them into 2 groups. Group A consisted of 36 eyes treated with subconjunctival injection of 0.02% MMC 1 month before bare scleral excision, and group B comprised 46 eyes that underwent conjunctival rotational flap with intraoperative 0.02% MMC for 2 minutes. Follow-up periods were at least 12 months (range, 12 to 18 months). main outcome measure: Recurrence and complication rate in each arm of study. RESULTS:During the 1-year follow-up, 2 cases of clinical recurrence in third and sixth month of follow-up occurred in group B (recurrence rate, 4.3%). In group A, there was no clinically significant recurrence, but 2 cases of hypovascularity and whitening of sclera at the site of pterygium excision was observed. There was no other serious complication. There was no statistically significant difference between groups for recurrence rate, mean age, sex, or pterygium area. CONCLUSIONS:Subconjunctival injection of MMC 0.02% (0.1 ml of 0.02% solution) 1 month before bare scleral excision is a quick, easy, and safe surgical procedure and is at least as effective as conjunctival rotational flap with intraoperative MMC for 2 minutes.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Khakshoor H,Razavi ME,Daneshvar R,Shakeri MT,Ghate MF,Ghooshkhanehi Hdoi
10.1016/j.ajo.2010.03.006subject
Has Abstractpub_date
2010-08-01 00:00:00pages
193-8issue
2eissn
0002-9394issn
1879-1891pii
S0002-9394(10)00220-5journal_volume
150pub_type
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