Abstract：
PURPOSE:To investigate the risk of glaucoma development after being prescribed topiramate. DESIGN:A retrospective, population-based cohort study using an administrative database. METHODS:The study group comprised 1956 patients who received their first prescription of topiramate between 2001 and 2007. The comparison cohort consisted of 15 648 randomly matched patients who never took topiramate. Each sampled patient was traced for a 1-year period from his or her index date to identify patients who subsequently received a diagnosis of glaucoma. RESULTS:Glaucoma was diagnosed in 0.36%, 0.05%, and 0.66% of the study cohort during the first month, second to third month, and fourth to twelfth month following the index date, respectively. For the comparison cohort, glaucoma was diagnosed in 0.04%, 0.11%, and 0.46% of subjects during the first month, second to third month, and fourth to twelfth month following the index date, respectively. After adjusting for potential confounding factors, patients prescribed topiramate were found to have a 7.41-fold (95% confidence interval [CI] = 2.45-22.46) greater risk of subsequently being diagnosed with glaucoma than the comparison cohort during the first month after the index date. However, this association became statistically nonsignificant during the second-to-third-month and fourth-to-twelfth-month periods following the index date between the 2 cohorts (adjusted hazard ratio, 0.56, 95% CI = 0.07-4.29; and 1.35, 95% CI = 0.74-2.47, respectively). CONCLUSIONS:Topiramate use in Taiwan was associated with a significantly increased risk of being diagnosed with glaucoma within the first month after receiving a prescription for the drug.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Ho JD,Keller JJ,Tsai CY,Liou SW,Chang CJ,Lin HCdoi
10.1016/j.ajo.2012.07.016subject
Has Abstractpub_date
2013-02-01 00:00:00pages
336-341.e1issue
2eissn
0002-9394issn
1879-1891pii
S0002-9394(12)00513-2journal_volume
155pub_type
杂志文章abstract：PURPOSE:To determine the frequencies of medical and surgical treatments in an incidence cohort of 120 patients with Graves' ophthalmopathy. METHODS:We reviewed the community medical records and administered a follow-up questionnaire. RESULTS:Of the 120 patients, 89 (74.2%) required either no therapy or only supportiv...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70585-9
更新日期：1996-02-01 00:00:00
abstract：PURPOSE:To compare polymerase chain reaction (PCR) to microbial culture for the detection and identification of bacterial and fungal pathogens in microbial keratitis. DESIGN:Prospective cohort study. METHODS:A total of 108 consecutive corneal ulcers were cultured and analyzed by PCR using pan-bacterial and pan-fungal...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2008.06.009
更新日期：2008-11-01 00:00:00
abstract：PURPOSE:To determine whether clinically isolated anterior segment recurrence is associated with concomitant subclinical choroidal inflammation in Vogt-Koyanagi-Harada (VKH) disease. DESIGN:Interventional, retrospective case series. METHODS:Nine patients with recurrent VKH disease who satisfied the following criteria:...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2007.10.012
更新日期：2008-03-01 00:00:00
abstract：:Forty-three patients who initially presented with Krikenberg's spindles but with no glaucomatous field defects were observed for an average of 5.8 years in an attempt to evaluate the prognostic implication of spindle presence. Twenty-two of the patients had been followed for a minimum of five years. Analysis of the st...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90075-6
更新日期：1975-02-01 00:00:00
abstract：:We have developed a new model of retinal neovascularization in the rabbit. After intravitreal autotransplantation of 250,000 tissue-cultured skin fibroblasts, we observed strand formation in the midvitreous cavity. These strands grew toward the vascularized part of the retina and attached to it. Once the attachment wa...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75913-6
更新日期：1981-07-01 00:00:00
abstract：PURPOSE:To present a quantitative analysis of pterygium and ocular sun exposure, a dose-response curve, and a discussion of the health-promotion implications of the findings. METHODS:A hospital-based, case-control study was conducted in Perth, Western Australia. Case subjects had surgical removal of a pterygium; contr...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00161-0
更新日期：1999-09-01 00:00:00
abstract：PURPOSE:To report a patient with persistent subepithelial corneal opacities 18 months after adenoviral keratoconjunctivitis who underwent photorefractive keratectomy for the correction of myopia. METHODS:Case report, review of medical literature, and slit-lamp photography. RESULTS:The patient underwent photorefractiv...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00224-4
更新日期：1998-12-01 00:00:00
abstract：PURPOSE:To determine the relationship between delayed patchy choroidal filling and morphologic and functional outcomes among eyes treated with ranibizumab or bevacizumab. DESIGN:Cohort study. METHODS:Comparison of Age-related Macular Degeneration Treatment Trials participants were assigned randomly to ranibizumab or ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ajo.2014.06.004
更新日期：2014-09-01 00:00:00
abstract：:Nine patients with polyradiculomyeloneuropathy after acute hemorrhagic conjunctivitis (AHC) infection were studied serologically. All except one patient had neutralization titers larger than or equal to 1:16 against the prototype J670/71 strain of AHC virus in at least one of their serum samples. The development of a ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90279-2
更新日期：1975-11-01 00:00:00
abstract：PURPOSE:To document the variations in normal anatomy that occur at the insertion of the inferior oblique muscle and in the vicinity of its surgical capture site (10 to 12 mm from the insertion). METHODS:One hundred intact cadaver orbits with no history of eye muscle or orbital disorders during life were carefully diss...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00225-1
更新日期：1999-10-01 00:00:00
abstract：:During the last four years we treated 82 consecutive patients (83 eyes) with retinal detachments complicated by proliferative vitreoretinopathy. We used pars plana vitrectomy combined with a broad scleral buckle, cryotherapy to the retinal breaks, and a temporary intraocular gas bubble. The retina was successfully rea...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(84)90683-4
更新日期：1984-12-15 00:00:00
abstract：PURPOSE:To evaluate the safety and potential efficacy of gevokizumab, an anti-interleukin 1β (IL-1β) monoclonal antibody, in the treatment of active, noninfectious, non-necrotizing anterior scleritis. DESIGN:Phase 1/2, open label, nonrandomized, prospective, single-arm pilot trial. METHODS:Eight patients with active,...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/j.ajo.2016.09.017
更新日期：2016-12-01 00:00:00
abstract：:We conducted a histopathologic study of he meibomian glands of seven patients (all men, ranging in age from 58 to 83 years) who had severe or moderately severe meibomian dysfunction and who were undergoing ectropion or entropion repair. Abnormal features included signs of obstruction and dilatation of ducts, enlargeme...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(82)90365-8
更新日期：1982-09-01 00:00:00
abstract：:In human and primate eyes treated with cyclocryotherapy, the epithelial and capillary elements of the ciliary processes were destroyed and replaced by fibroblast-like cells. The trabecular mesh-work and Schlemm's canal were histologically affected by cyclocryotherapy. Damage to the angle structures impaired aqueous ou...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90009-x
更新日期：1976-11-01 00:00:00
abstract：PURPOSE:To determine iridocorneal angle changes produced after 2 years of implantable collamer lens (ICL) V4c (STAAR Surgical AG, Nidau, Switzerland) placement by Fourier-domain optical coherence tomography (FD-OCT). DESIGN:Prospective interventional case series. METHODS:In 54 eyes of 27 myopic subjects FD-OCT iridoc...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2017.06.018
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:To describe the clinical manifestation and course of disseminated acute lymphoblastic leukemia in an adult. METHODS:Case report. Recurrence of disseminated disease was heralded by "salmon patch" involvement of the conjunctiva. The ocular tumor was treated successfully with external beam radiotherapy. RESULTS:...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71651-4
更新日期：1997-07-01 00:00:00
abstract：PURPOSE:To assess between- and within-individual variability of macular cone topography in the eyes of young adults. DESIGN:Observational case series. METHODS:Cone photoreceptors in 40 eyes of 20 subjects aged 19-29 years with normal maculae were imaged using a research adaptive optics scanning laser ophthalmoscope. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2015.04.034
更新日期：2015-08-01 00:00:00
abstract：PURPOSE:To evaluate the effect of the blue light-filter intraocular lenses (IOLs) in vitrectomy combined with cataract surgery, focusing on the surgeon's ability to perform specific vitreoretinal procedures and on the patients' outcome. DESIGN:Randomized clinical trial. METHODS:Sixty patients, recruited from our outp...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ajo.2007.10.021
更新日期：2008-03-01 00:00:00
abstract：PURPOSE:To assess baseline and follow-up characteristics of choroidal neovascularization (CNV) lesions in age-related macular degeneration in relation to the development of subfoveal subretinal fibrosis. DESIGN:Retrospective, observational case series. METHODS:settings and study population: One hundred ninety-seven t...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2013.02.012
更新日期：2013-07-01 00:00:00
abstract：PURPOSE:To report an unusual case of hypovitaminosis A with bilateral papilledema and flecked retina that regressed after restoration of vitamin A deficiency. METHOD:Case report. A 27-year-old woman had undergone a biliopancreatic bypass for obesity in 1990. In 1995, she presented with bilateral xerophthalmia, bilater...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00011-7
更新日期：1998-05-01 00:00:00
abstract：:We treated seven patients (all male, ranging in age from 11 to 31 years) with Schwartz syndrome, a combination of uveitis, high intraocular pressure, and retinal detachment with peripheral tears. The condition was resistant to corticosteroids but responded well to surgery. Puncture of the anterior chamber disclosed ma...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(86)90767-1
更新日期：1986-06-15 00:00:00
abstract：PURPOSE:To report the clinical and histopathologic features of orbital hemangiopericytoma. METHOD:We review the clinical and histopathologic features in seven patients. RESULTS:Ultrasonography, computed tomography, and magnetic resonance imaging defined the location and extent of the tumor in each patient but did not...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70904-3
更新日期：1997-11-01 00:00:00
abstract：PURPOSE AND METHODS:To describe the clinical and histopathologic features of a patient with viral retinitis secondary to subacute sclerosing panencephalitis. RESULTS:The patient was a human immunodeficiency virus-negative intravenous drug abuser with an acute retinitis that later progressed to encephalitis despite agg...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70179-5
更新日期：1997-04-01 00:00:00
abstract：:Posterior scleritis was diagnosed in four adolescent boys. These patients represented a distinct subgroup of patients with posterior scleritis that differed from the adult variant by gender, lack of systemic disease, and absence of the associated ocular findings often seen in the adult variant of the disorder. The fou...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71579-x
更新日期：1992-03-15 00:00:00
abstract：:We used 21 cadaver eyes to study transsclerally sutured, ciliary sulcus-fixated intraocular lens implantation. Results showed that transscleral sutures should exit the sclera less than 1 mm posterior to the corneoscleral limbus for true ciliary sulcus fixation. The relationship of the ciliary sulcus to the overlying p...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(89)90121-9
更新日期：1989-09-15 00:00:00
abstract：PURPOSE:To study the prevalence of ciliochoroidal effusion (CE) after prophylactic laser iridotomy (LI). METHODS:An ultrasound biomicroscope (UBM) examination was performed before, 2, and 24 hours after LI to investigate the changes in supraciliary-choroidal space after LI in circumference of 38 eyes in 23 chronic pri...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0002-9394(03)00238-1
更新日期：2003-09-01 00:00:00
abstract：PURPOSE:To compare wound characteristics and integrity of the 2.2-mm and 2.65-mm clear corneal incisions. DESIGN:Prospective, randomized clinical trial. METHODS:Patients undergoing phacoemulsification with lens implant were randomized to receive a 2.2-mm or 2.65-mm temporal clear corneal incision. The incisions were ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ajo.2009.12.008
更新日期：2010-05-01 00:00:00
abstract：PURPOSE:Autosomal recessive congenital fibrosis of the extraocular muscles (CFEOM2) has been described in families from Saudi Arabia. Affected individuals have ptosis and exotropic ophthalmoplegia, and their disease has been mapped to chromosome 11q13. Here, we describe the phenotypic findings in a similarly affected Y...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00467-5
更新日期：2000-05-01 00:00:00
abstract：PURPOSE:To compare three different methods of measuring corneal thickness (CT) and anterior chamber depth (ACD). DESIGN:Prospective clinical trial (Medical University of Vienna, Austria). METHODS:Central CT (CCT), CT at four peripheral points, and central ACD were measured in 88 eyes of 44 healthy subjects with the P...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/j.ajo.2005.08.048
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:The aim of this study was to evaluate the baseline features associated with blindness in a cohort of children with primary congenital glaucoma (PCG) from a hospital registry. METHODS:Setting: Observational cohort study DESIGN: Retrospective clinical cohort study STUDY POPULATION: The registry included all chil...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.12.014
更新日期：2020-12-21 00:00:00
