Abstract：
PURPOSE:To train a deep learning (DL) algorithm that quantifies glaucomatous neuroretinal damage on fundus photographs using the minimum rim width relative to Bruch membrane opening (BMO-MRW) from spectral-domain optical coherence tomography (SDOCT). DESIGN:Cross-sectional study. METHODS:A total of 9282 pairs of optic disc photographs and SDOCT optic nerve head scans from 927 eyes of 490 subjects were randomly divided into the validation plus training (80%) and test sets (20%). A DL convolutional neural network was trained to predict the SDOCT BMO-MRW global and sector values when evaluating optic disc photographs. The predictions of the DL network were compared to the actual SDOCT measurements. The area under the receiver operating curve (AUC) was used to evaluate the ability of the network to discriminate glaucomatous visual field loss from normal eyes. RESULTS:The DL predictions of global BMO-MRW from all optic disc photographs in the test set (mean ± standard deviation [SD]: 228.8 ± 63.1 μm) were highly correlated with the observed values from SDOCT (mean ± SD: 226.0 ± 73.8 μm) (Pearson's r = 0.88; R2 = 77%; P < .001), with mean absolute error of the predictions of 27.8 μm. The AUCs for discriminating glaucomatous from healthy eyes with the DL predictions and actual SDOCT global BMO-MRW measurements were 0.945 (95% confidence interval [CI]: 0.874-0.980) and 0.933 (95% CI: 0.856-0.975), respectively (P = .587). CONCLUSIONS:A DL network can be trained to quantify the amount of neuroretinal damage on optic disc photographs using SDOCT BMO-MRW as a reference. This algorithm showed high accuracy for glaucoma detection, and may potentially eliminate the need for human gradings of disc photographs.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Thompson AC,Jammal AA,Medeiros FAdoi
10.1016/j.ajo.2019.01.011subject
Has Abstractpub_date
2019-05-01 00:00:00pages
9-18eissn
0002-9394issn
1879-1891pii
S0002-9394(19)30024-8journal_volume
201pub_type
杂志文章abstract：:We reviewed the charts of 29 patients with large subretinal hemorrhages involving the center of the fovea to evaluate factors that might be prognostic of visual outcome. The average final visual acuity was 20/480 with a mean follow-up of three years. Patients with thick hemorrhages (causing an obvious elevation of the...
journal_title：American journal of ophthalmology
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更新日期：2020-12-29 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章,随机对照试验
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2000-12-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：2020-10-01 00:00:00
