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The relationship of optic disk cupping to retinal vein occlusion: the Beaver Dam Eye Study.

Abstract：

PURPOSE:To examine the association between optic disk cupping and retinal vein occlusion (RVO). DESIGN:Prospective epidemiologic study. METHODS:setting: Population-based prospective study in Beaver Dam, Wisconsin. study population: Adults aged 43 to 86 years at baseline (n = 4926). observation procedures: Optic disk cupping and RVO were determined from retinal photographs. A standardized medical examination and questionnaire were administered. main outcome measure: Ten-year cumulative incidence of RVO. RESULTS:There were 58 persons who developed incident RVO at 5 (n = 31) or 10 (n = 27) years after the baseline examination. Those sustaining RVO were older, had higher intraocular pressure (IOP), and were more likely to have definite or probable glaucoma at the baseline examination. The odds of having an incident RVO increased with increasing cup-to-disk ratio at baseline (odds ratio [OR] = 1.29/0.1 increase in cup-to-disk ratio, 95% confidence interval 1.07, 1.56), while controlling for age, systolic blood pressure, current smoking, diabetes status, and IOP. A similar OR was found after excluding those with glaucoma. Excluding persons with central (as opposed to branch) vein occlusion did not have a significant effect on the OR. CONCLUSION:Cup-to-disk ratio is a significant predictor of risk of incident RVO.

journal_name

Am J Ophthalmol

journal_title

American journal of ophthalmology

authors

Klein BE,Meuer SM,Knudtson MD,Klein R

doi

10.1016/j.ajo.2005.12.015

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

859-62

issue

5

eissn

0002-9394

issn

1879-1891

pii

S0002-9394(05)01300-0

journal_volume

141

pub_type

杂志文章

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