Demonstration of herpes group virus in acute retinal necrosis syndrome.

Abstract:

:Tissue for pathologic examination was obtained from three cases of acute retinal necrosis syndrome. Virus particles belonging to the herpesvirus family were demonstrated in retinal biopsies from two patients, one of whom was immunosuppressed. Despite removal of large biopsy specimens, the retina has remained attached for 20 months postoperatively in one case and for three months in the other. In a third patient with acquired immune deficiency syndrome, the clinical course and postmortem immunopathology were suggestive of a herpes simplex virus infection, initially affecting the retina and subsequently the optic nerves, chiasm, tracts, and central nervous system. These cases illustrate that the virus associated with the acute retinal necrosis syndrome is easily demonstrable using vitrectomy and endoretinal biopsy in the acute phase of the disease, but may be difficult to demonstrate in chronically detached atrophic retinas.

journal_name

Am J Ophthalmol

authors

Freeman WR,Thomas EL,Rao NA,Pepose JS,Trousdale MD,Howes EL,Nadel AJ,Mines JA,Bowe B

doi

10.1016/0002-9394(86)90396-x

subject

Has Abstract

pub_date

1986-12-15 00:00:00

pages

701-9

issue

6

eissn

0002-9394

issn

1879-1891

pii

0002-9394(86)90396-X

journal_volume

102

pub_type

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