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Phase-Resolved Doppler Optical Coherence Tomographic Features in Retinal Angiomatous Proliferation.

Abstract：

PURPOSE:To study patients diagnosed with retinal angiomatous proliferation (RAP) based on conventional imaging techniques with phase-resolved Doppler optical coherence tomography (OCT) to detect and localize blood flow in RAP lesions; and to compare these findings to conventional imaging, which are mostly invasive and give limited information concerning intra- and transretinal blood flow. DESIGN:Single-center, consecutive observational case series. METHODS:Twelve treatment-naïve patients diagnosed with RAP based on fundus examination, fluorescein angiography, and indocyanine green angiography were included. Median age was 79 years (range 65-90). Patients were imaged with an experimental 1040 nm swept-source phase-resolved Doppler OCT instrument. Abnormal flow was defined as intraretinal neovascularization or retinal choroidal anastomosis. RESULTS:In 11 patients adequate phase-resolved Doppler OCT images were obtained showing abnormal blood flow in the RAP lesion. In 4 patients a retinal choroidal anastomosis was found, 3 patients showed intraretinal neovascularization connected with a pigment epithelial detachment, 2 patients showed only intraretinal neovascularization, and in 2 patients flow was limited to the subretinal or sub-retinal pigment epithelial space. CONCLUSIONS:Phase-resolved Doppler OCT is able to detect and localize abnormal blood flow within RAP lesions. Blood flow was mostly confined to the intraretinal structures with or without a connecting pigment epithelial detachment; in one-third of patients a retinal choroidal anastomosis was detected. The potential of angiography with phase-resolved Doppler OCT to accurately distinguish between normal and pathologic blood flow in addition to structural OCT data without invasive procedures will help to further elucidate both retinal and choroidal vascular pathologies like RAP.

journal_name

Am J Ophthalmol

journal_title

American journal of ophthalmology

authors

Amarakoon S,de Jong JH,Braaf B,Yzer S,Missotten T,van Velthoven ME,de Boer JF

doi

10.1016/j.ajo.2015.07.026

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

1044-1054.e1

issue

eissn

0002-9394

issn

1879-1891

pii

S0002-9394(15)00450-X

journal_volume

160

pub_type

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Phase-Resolved Doppler Optical Coherence Tomographic Features in Retinal Angiomatous Proliferation.