Abstract：
PURPOSE:Low docosahexaenoic acid (DHA) in X-linked retinitis pigmentosa (XLRP) may influence retinal function. The goals of this study were to elevate blood DHA levels and determine the effect on the rate of disease progression. DESIGN:In a 4-year prospective randomized clinical trial, male patients with XLRP (mean age = 16 years; range = 4-38 years) received DHA (400 mg/d; n = 23; +DHA group) or placebo (n = 21) capsules. METHODS:Red blood cell (RBC)-DHA concentrations were assessed every 6 months. Full-field cone electroretinograms (ERGs; the primary outcome measure), visual acuity, dark-adaptation, visual fields, rod ERGs, and fundus photos were recorded annually. RESULTS:In the +DHA group, RBC-DHA increased 2.5-fold over placebo levels (70 vs 28 mg DHA/l). Repeated measures analysis of variance for cone ERG showed a significant main effect of year (P <.0001) but not of group (P =.16). Preservation of cone ERG function correlated with RBC-DHA (P =.018), and there was less change in fundus appearance in the +DHA group (P =.04). Neither visual acuity nor visual fields were changed. In subset analysis, DHA supplementation was beneficial in reducing rod ERG functional loss in patients aged <12 years (P =.040) and preserving cone ERG function in patients > or =12 years (P =.038). CONCLUSIONS:Although DHA-supplemented patients had significantly elevated mean RBC-DHA levels, the rate of cone ERG functional loss was not significantly different between groups. Supplemental analyses provided evidence for a DHA benefit and a direction for subsequent investigations.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Hoffman DR,Locke KG,Wheaton DH,Fish GE,Spencer R,Birch DGdoi
10.1016/j.ajo.2003.10.045subject
Has Abstractpub_date
2004-04-01 00:00:00pages
704-18issue
4eissn
0002-9394issn
1879-1891pii
S0002939403014089journal_volume
137pub_type
临床试验,杂志文章,随机对照试验abstract：PURPOSE:To compare the prevalence of keratoconjunctivitis sicca (KCS) in a prospective cohort of 22,382 diabetic patients with that in the general population. DESIGN:Prospective, observational, cohort study. METHODS: SETTING:A district of israel's largest health maintenance organization. STUDY POPULATION:We followe...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.10.022
更新日期：2005-03-01 00:00:00
abstract：PURPOSE:To report central serous chorioretinopathy associated with excessive use of compounds with sympathomimetic activity. DESIGN:Observational case series. METHODS:Four patients presented with clinical and fluorescein angiographic evidence of central serous chorioretinopathy. All patients expressed a concomitant p...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00076-x
更新日期：2003-07-01 00:00:00
abstract：:We observed a 41-year-old man with congenital unilateral iris pigment epithelial hyperplasia associated with unilateral glaucoma, and considered the possible pathogenesis of this unique lesion and its relationship to the patient's glaucoma. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76809-6
更新日期：1978-08-01 00:00:00
abstract：PURPOSE:To evaluate persistency of pharmacotherapy in primary open-angle glaucoma suspects (glaucoma suspects) treated with latanoprost and timolol. DESIGN:Retrospective, cohort study using the Protocare Sciences managed care database; approximately 3 million members in commercial health maintenance organizations and ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2003.10.034
更新日期：2004-01-01 00:00:00
abstract：:The Prospective Evaluation of Radial Keratotomy Study is a nine-center clinical trial of a standardized technique of radial keratotomy in 435 patients who had simple myopia with a preoperative refraction between -2.00 and -8.00 diopters. We studied the stability of the refractive error during four years after surgery ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72250-0
更新日期：1991-02-15 00:00:00
abstract：PURPOSE:To compare the intraocular pressure (IOP) values during a 3-month period after implantation of the new Visian Implantable Collamer Lens (ICL; STAAR Surgical Company, Nidau, Switzerland) V4c design with CentraFLOW technology without iridotomy using a standard procedure followed by implantation of the conventiona...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2013.05.018
更新日期：2013-10-01 00:00:00
abstract：PURPOSE:compare the results of vitrectomy with or without arteriovenous (AV) crossing sheathotomy for macular edema associated with branch retinal vein occlusion (BRVO). DESIGN:Interventional case series. METHODS:A retrospective study of 36 eyes with BRVO-associated macular edema. Twenty eyes underwent AV sheathotomy...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.06.061
更新日期：2004-12-01 00:00:00
abstract：PURPOSE:To determine whether a three-year fluocinolone acetonide sustained drug delivery system can be implanted safely at the same time that phacoemulsification and intraocular lens (IOL) implantation are performed for a visually significant cataract in eyes with uveitis. DESIGN:Retrospective, single-center case seri...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/j.ajo.2008.05.035
更新日期：2008-10-01 00:00:00
abstract：:Communication between the retinal and the choroidal circulation occurred in one case of proliferative diabetic retinopathy and one case of Leber's disease (multiple miliary aneurysms) after argon laser photocoagulation treatment to eliminate abnormal retinal vasculature. In both instances rapid-sequence fluorescein an...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90426-8
更新日期：1976-08-01 00:00:00
abstract：PURPOSE:To evaluate changes in anterior chamber depth (ACD) and angle width after neodymium-yttrium-aluminum-garnet (Nd:YAG) laser capsulotomy. DESIGN:Prospective interventional case series. METHODS:In a single institution, 43 eyes of 43 consecutive pseudophakic patients with symptomatic posterior capsule opacificati...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.08.008
更新日期：2014-11-01 00:00:00
abstract：:Intralenticular hemorrhage is a rare complication of glaucoma surgery. In a 45-year-old man, the intralenticular blood caused loss of the red reflex from the fundus postoperatively. Clinically, hemorrhage into the lens has usually been misdiagnosed initially as a hyphema. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90253-1
更新日期：1976-03-01 00:00:00
abstract：PURPOSE:To report a possible association of glaucoma with Parkinson's disease and Alzheimer's disease. METHODS:Retrospective chart review (observational case series). The ophthalmologic charts of 49 patients with Alzheimer's disease and of 38 patients with Parkinson's disease were reviewed to determine the occurrence ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(01)01196-5
更新日期：2002-01-01 00:00:00
abstract：PURPOSE:To report the clinical settings, microbiological isolates, and best-corrected visual acuities (BCVA) of patients with persistently culture-positive exogenous fungal endophthlamitis. DESIGN:Retrospective consecutive case series. METHODS:Setting: Tertiary referral center. PATIENT POPULATION:Sixteen eyes of 16 ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2016.09.014
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:To report a case of unilateral blindness after ipsilateral prophylactic transcranial optic canal decompression for fibrous dysplasia. METHODS:Case report. A 37-year-old woman with fibrous dysplasia underwent a prophylactic left optic canal decompression. Preoperatively, the left eye had a visual acuity of 20/2...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00118-4
更新日期：1998-09-01 00:00:00
abstract：:We conducted a two-part study to determine whether any positive association between the use of allopurinol and the development of cataracts could be demonstrated. Study 1 included 251 Boston-area patients hospitalized for cataract and 753 matched controls. Two cataract patients were regular allopurinol users as compar...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(84)90328-3
更新日期：1984-09-15 00:00:00
abstract：PURPOSE:To determine whether the healing response of the human cornea after photoablation with a midinfrared solid-state laser was more pronounced than after excimer laser keratectomies because of the increased thermal damage in adjacent tissue. METHODS:We treated five blind human eyes with an erbium:YAG (Er:YAG) lase...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72215-9
更新日期：1995-11-01 00:00:00
abstract：PURPOSE:To report a young girl with spontaneous separation of an idiopathic epiretinal membrane and notable visual recovery. METHOD:Case report. RESULT:A 12-year-old girl had spontaneous improvement in visual acuity of the left eye from 20/100 to 20/40 attributable to spontaneous peeling of an idiopathic epiretinal m...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00021-5
更新日期：1999-06-01 00:00:00
abstract：PURPOSE:To characterize the progression of optical gaps and expand the known etiologies of this phenotype. DESIGN:Retrospective cohort study. METHODS:Thirty-six patients were selected based on the identification of an optical gap on spectral-domain optical coherence tomography (OCT) from a large cohort of patients (N...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.05.016
更新日期：2020-10-01 00:00:00
abstract：PURPOSE:To report severe ocular and orbital toxicity after administration of intracarotid etoposide phosphate and carboplatin. METHOD:Case report. RESULTS:A 52-year-old man with glioblastoma multiforme underwent left intracarotid administration of eto poside phosphate and carboplatin inferior to the ophthalmic artery...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00346-8
更新日期：1999-02-01 00:00:00
abstract：PURPOSE:To compare the long-term efficacy and safety of 2 operation methods for late in-the-bag intraocular lens (IOL) dislocation. DESIGN:Prospective, randomized, parallel group surgical clinical trial. METHODS:During a 3-year period, 104 patients (104 eyes) were assigned one group for IOL repositioning by scleral s...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ajo.2019.05.030
更新日期：2019-11-01 00:00:00
abstract：:Although asymmetric or unilateral optic disk swelling is unusual in patients with increased intracranial pressure, we treated three such patients. Two (a 31-year-old man and a 31-year-old woman, both of whom were overweight) had benign intracranial hypertension. The third patient (a 64-year-old man) had a posterior fo...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)77912-7
更新日期：1983-10-01 00:00:00
abstract：PURPOSE:To describe the clinical manifestation and course of disseminated acute lymphoblastic leukemia in an adult. METHODS:Case report. Recurrence of disseminated disease was heralded by "salmon patch" involvement of the conjunctiva. The ocular tumor was treated successfully with external beam radiotherapy. RESULTS:...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71651-4
更新日期：1997-07-01 00:00:00
abstract：:We studied four patients who, having received postoperative 5-fluorouracil after glaucoma filtering operations, developed serious corneal complications. All four patients had preexisting corneal abnormalities including keratoconjunctivitis sicca, exposure keratopathy, and bullous keratopathy. All of the patients devel...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74224-2
更新日期：1987-02-15 00:00:00
abstract：PURPOSE:To examine the visual outcomes of early intervention in the setting of fundus-obscuring vitreous hemorrhage (VH) presumed to be due to posterior vitreous detachment. DESIGN:Retrospective comparative case series. METHODS:All eyes that presented with a fundus-obscuring VH, defined as vision of 20/400 or worse a...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2015.07.025
更新日期：2015-11-01 00:00:00
abstract：:A 32-year-old woman developed bilateral blindness along with severe preeclampsia of pregnancy. Ophthalmoscopic examination disclosed chalky-white optic disks with only minimal changes in the retinal vasculature. After caesarean section, the preeclampsia improved, and complete return of visual acuity occurred during a ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74914-1
更新日期：1980-09-01 00:00:00
abstract：PURPOSE:A defect in the visual field is one of the serious complications of macular hole surgery. We investigated the relationship between the occurrence of visual field defect and the location of infusion cannula and air pressure during fluid-air exchange. METHODS:We studied 100 eyes from 90 patients with macular hol...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00597-3
更新日期：2000-11-01 00:00:00
abstract：PURPOSE:To report a case of progressive necrotizing fasciitis of the face following acute dacryocystitis. DESIGN:Interventional case report. METHODS:A 60-year-old woman presented with left acute dacryocystitis with abscess formation that had ruptured; a small wound remained. Erythematous swelling of the left eyelid a...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00089-8
更新日期：2003-07-01 00:00:00
abstract：PURPOSE:To assess baseline and follow-up characteristics of choroidal neovascularization (CNV) lesions in age-related macular degeneration in relation to the development of subfoveal subretinal fibrosis. DESIGN:Retrospective, observational case series. METHODS:settings and study population: One hundred ninety-seven t...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2013.02.012
更新日期：2013-07-01 00:00:00
abstract：:Four patients observed for a three- to four-year period had a hole in an epiretinal membrane overlying the macula that mimicked a macular hole. In two patients the clinical appearance remained essentially constant. In one, the epiretinal membrane contracted further, reducing the apparent macular hole to a slit and cau...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90002-7
更新日期：1976-11-01 00:00:00
abstract：PURPOSE:To describe the incidence rates of visual loss and ocular complications in patients with retinal vasculitis (RV). DESIGN:Retrospective cohort study. METHODS:Clinical data were collected for 96 patients (175 eyes) diagnosed with RV from 2003 to 2013. Main outcome measures included rates of visual loss and ocul...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2017.05.007
更新日期：2017-07-01 00:00:00
