Abstract：
PURPOSE:To report the clinical settings, microbiological isolates, and best-corrected visual acuities (BCVA) of patients with persistently culture-positive exogenous fungal endophthlamitis. DESIGN:Retrospective consecutive case series. METHODS:Setting: Tertiary referral center. PATIENT POPULATION:Sixteen eyes of 16 patients with at least 2 consecutive positive vitreous cultures between 1981 and 2015. INTERVENTIONS:Intravitreal antifungal injection, pars plana vitrectomy (PPV). MAIN OUTCOME MEASURE:Clinical settings, microbiologic isolates, BCVA. RESULTS:The most common clinical settings were after cataract surgery (9/16, 56%), glaucoma surgery (4/16, 25%), and trauma (2/16, 13%). The most common single fungal isolate was Candida (4/16, 25%), but 75% of all isolates were molds. Treatment for presumed bacterial endophthalmitis was given initially in 14 patients (88%). All patients underwent a vitrectomy during the course of their treatment, and all received intravitreal or systemic antifungal therapy. The mean initial BCVA was 1.76 ± 0.9 logMAR (Snellen equivalent ≈20/1200), and the mean final BCVA was 1.84 ± 1.2 logMAR (≈20/1400, P = .83). The 9 patients (56%) who had intraocular lens (IOL) and capsular bag removals had better final BCVAs than those who did not (P = .011). The BCVAs were similar in eyes with yeast and mold (P = .37). The visual acuity at the last follow-up was ≥20/40 in 13% (2/16), ≥20/400 in 50% (8/16), and no light perception in 25% (4/16). CONCLUSIONS:Candida was the single most common isolate, but the majority of isolates were molds. Eyes managed with PPV and removal of the IOL and capsular bag had better visual outcomes. Persistently culture-positive fungal endophthalmitis was associated with poor final visual acuities.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Leung EH,Kuriyan AE,Flynn HW Jr,Relhan N,Huang LC,Miller Ddoi
10.1016/j.ajo.2016.09.014subject
Has Abstractpub_date
2016-12-01 00:00:00pages
45-50eissn
0002-9394issn
1879-1891pii
S0002-9394(16)30452-4journal_volume
172pub_type
杂志文章abstract：:In four patients, we repaired leaking blebs by using a new technique of excision of the cystic bleb and replacement with free conjunctival autograft. The leaks were repaired successfully, and bleb function was maintained in all four patients. This technique should be considered when surgical management of a leaking bl...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70060-1
更新日期：1994-05-15 00:00:00
abstract：PURPOSE:Evaluate the effect of visual acuity on color vision testing. DESIGN:University based clinical experimental study. METHODS:Right eyes of 12 healthy subjects were fogged with plus lenses to logMAR 1.88 and assessed with D-15 panel, Ishihara, and Hardy-Rand-Rittler (HRR) plates. Subjects were tested at lesser d...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.07.041
更新日期：2006-01-01 00:00:00
abstract：:Total retinal detachment and neovascular glaucoma occurred after a penetrating injury to the left globe that left the eye blind and painful. A retrobulbar injection of alcohol and enucleation modified but did not relieve the orbital discomfort. At surgery, we discovered a neuroma with cartilaginous metaplasia involvin...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75139-6
更新日期：1980-11-01 00:00:00
abstract：PURPOSE:To report the clinical and histological findings of a luxated intraocular lens (IOL) in the capsular bag. METHODS:Review of a case. RESULTS:Twenty-three months after a triple procedure of vitrectomy, phacoemulsification, and IOL implantation for diabetic vitreous hemorrhage and cataract, the encapsulated IOL ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00630-9
更新日期：2000-12-01 00:00:00
abstract：:The technique of keratoprosthesis was used in 21 cases of severe and intractable forms of keratopathy during the past 3 1/2 years. The results in terms of visual acuity were satisfactory in more than half the cases. Significant problems that occurred after this procedure included the diagnosis and management of glauc...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90465-3
更新日期：1979-08-01 00:00:00
abstract：:Lamellar keratoplasty was done in 18 eyes with keratoconus in an attempt to obtain a more satisfactory postoperative refractive error than that after penetrating keratoplasty. The refractive error after lamellar keratoplasty was better than that after 7.5-mm penetrating keratoplasties, but the vision was not as good. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(77)90563-3
更新日期：1977-04-01 00:00:00
abstract：PURPOSE:To determine the incidence of developing an idiopathic full-thickness macular hole in fellow eyes that have vitreofoveal attachments and perifoveal vitreous detachment in patients with unilateral idiopathic macular hole. DESIGN:Retrospective cross-sectional observational study. METHODS:The fellow eyes of 201 ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.03.070
更新日期：2005-09-01 00:00:00
abstract：PURPOSE:To report a rare complication, delayed suprachoroidal hemorrhage, of needle revision of a nonfunctioning trabeculectomy bleb in a patient with previously undetected hairy cell leukemia. DESIGN:Interventional case report. METHODS; An 89-year-old man presented with massive delayed suprachoroidal hemorrhage after...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00574-9
更新日期：2003-12-01 00:00:00
abstract：PURPOSE:To evaluate management options for acutely symptomatic stage I macular holes, and vitrectomy with intraocular gas tamponade for advanced stage I macular holes. METHODS:Retrospective noncomparative study. SETTING:Clinical practice. STUDY POPULATION:Acutely symptomatic stage I macular holes. MANAGEMENT OPTIONS...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(01)01266-1
更新日期：2002-02-01 00:00:00
abstract：:We examined 13 patients referred for management of dislocated lens fragments after phacoemulsification. Ocular findings included corneal decompensation, glaucoma, inflammation, and retinal tears and detachments. Eleven of the 13 patients underwent vitrectomy with removal of lens fragments. Surgical indications include...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76854-0
更新日期：1991-11-15 00:00:00
abstract：PURPOSE:To report a case of congenital superior oblique palsy with an unusually large Bielschowsky head-tilt phenomenon (BHP) and disproportional inconspicuous vertical deviation. METHODS:Case report. RESULTS:An 18-year-old woman presented with slight compensatory head tilting and a Bielschowsky head-tilt phenomenon ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00639-5
更新日期：2000-12-01 00:00:00
abstract：PURPOSE:To evaluate the effectiveness of an orbital tissue expander designed to stimulate orbital bone growth in an anophthalmic socket. DESIGN:Retrospective, noncomparative, interventional case series. METHODS: SETTINGS:Institutional. STUDY POPULATION:Nine consecutive patients with unilateral congenital anophthalm...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.09.009
更新日期：2011-03-01 00:00:00
abstract：:Vitreous surgery techniques can be used to remove epiretinal tissue associated with various ocular conditions when this tissue covers, distorts, or detaches the macula and causes visual loss. Because the postoperative visual acuity is often between 6/9 (20/30) and 6/30 (20/100), we usually operate on eyes with preoper...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74654-9
更新日期：1981-11-01 00:00:00
abstract：PURPOSE:To provide insight into the course of retinal detachment in eyes with aggressive posterior retinopathy of prematurity (APROP). DESIGN:Prospective, multicenter, masked clinical trial. METHODS:Multicenter trial based on serial digital photographic imaging detailing five infants (in the Photographic Screening fo...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ajo.2007.10.027
更新日期：2008-03-01 00:00:00
abstract：PURPOSE:To evaluate postkeratoplasty astigmatism between two suture techniques 2 to 4 years postoperatively in a group of patients previously studied 9 months postoperatively. METHODS:Thirty-two patients who underwent penetrating keratoplasty were randomly assigned to one of two groups. Group 1 (16 patients) had a 24-...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0002-9394(14)70489-1
更新日期：1996-11-01 00:00:00
abstract：:The diameter of retinal arterioles, venules, and their macular branches was measured before and after macular laser photocoagulation in one eye each of six men and eight women with diabetic macular edema. The macular arteriolar branches constricted 20.2% (P < .001) and the venular branches constricted 13.8% (P < .001)...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73526-3
更新日期：1993-01-01 00:00:00
abstract：PURPOSE:To ascertain deformation of the optic nerve head (ONH) and peripapillary tissues caused by horizontal duction. DESIGN:Prospective, experimental study. METHODS:Optical coherence tomography of the ONH region was performed in 23 eyes of 12 normal volunteers in central gaze and increasing (10, 20, and 30 degrees)...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2016.10.001
更新日期：2017-02-01 00:00:00
abstract：:Three cases of bacterial endophthalmitis following corneal transplantation resulted from suture abscesses that were initiated by loose or broken exposed sutures. Histopathologic examination clearly demonstrated that the infection gained access to the anterior chamber by following a deeply placed suture that traversed ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(85)90217-x
更新日期：1985-02-15 00:00:00
abstract：PURPOSE:To determine whether clinical features and visual outcomes of myelin oligodendrocyte glycoprotein antibody-associated optic neuritis (MOG-ON) differ between White and Asian subjects. DESIGN:Multicenter retrospective cohort. METHODS:This was a multicenter study of 153 subjects who were White or Asian with a hi...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ajo.2020.07.008
更新日期：2020-11-01 00:00:00
abstract：PURPOSE:To investigate the effect of posterior subtenon injections of corticosteroids on intraocular pressure in a variety of ocular diseases. METHODS:We retrospectively analyzed 202 consecutive posterior subtenon corticosteroid injections (148 of methylprednisolone acetate, 80 mg, and 54 of triamcinolone acetonide, 4...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)80085-3
更新日期：1998-02-01 00:00:00
abstract：PURPOSE:To investigate the presence of the fibronectin isoform containing the extradomain B (B-FN), a marker-protein of angiogenesis, in surgically excised human choroidal neovascular membranes (CNVM) to evaluate whether B-FN could be used as a therapeutic target for specific antibody-photosensitizer immunoconjugates. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)01839-1
更新日期：2003-01-01 00:00:00
abstract：PURPOSE:To determine whether the healing response of the human cornea after photoablation with a midinfrared solid-state laser was more pronounced than after excimer laser keratectomies because of the increased thermal damage in adjacent tissue. METHODS:We treated five blind human eyes with an erbium:YAG (Er:YAG) lase...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72215-9
更新日期：1995-11-01 00:00:00
abstract：:Sebaceous adenocarcinoma (meibomian gland cancer) can be localized at times to one specific area of the eyelid; at other times, it spreads diffusely by pagetoid invasion throughout the conjunctiva. The pagetoid spread is often impossible to visualize. I used a map biopsy of the conjunctiva to determine the extent of i...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(86)90214-x
更新日期：1986-07-15 00:00:00
abstract：PURPOSE:To examine the safety and efficacy of combined phacoemulsification and glaucoma drainage implant surgery in providing reduction of intraocular pressure (IOP) and visual rehabilitation in eyes with refractory glaucoma and cataract. DESIGN:Interventional case series. METHODS:A retrospective chart review was per...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2003.08.036
更新日期：2004-02-01 00:00:00
abstract：PURPOSE:To provide an overview of angiogenesis and vascular endothelial growth factor (VEGF) and discusses the development approach, safety, and efficacy results of current and emerging anti-VEGF therapies for ocular diseases. DESIGN:Analysis of literature and current clinical trials of antiangiogenic agents for age-r...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.05.061
更新日期：2006-10-01 00:00:00
abstract：PURPOSE/METHODS:I reviewed the motility of two patients who had binocular vertical diplopia after cataract operations with peribulbar anesthesia. RESULTS/CONCLUSIONS:The binocular diplopia in these patients was a result of inferior rectus muscle overaction in the absence of restriction or weakness of the antagonist mu...
journal_title：American journal of ophthalmology
pub_type： 信件
doi：10.1016/s0002-9394(14)76582-1
更新日期：1994-11-15 00:00:00
abstract：:Three patients with geographic choroiditis developed subretinal neovascular membranes associated with subretinal hemorrhage and serous elevation of the retina. Proximity of the membrane to the foveal avascular zone prevented photocoagulation of the neovascular membrane in one patient. Central visual acuity remained 6/...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90665-2
更新日期：1979-10-01 00:00:00
abstract：PURPOSE:To compare the safety and efficacy of orthokeratology as a nonsurgical treatment for myopia in children with alternate methods, such as soft contact lenses, rigid gas permeable lenses, and spectacles, throughout multiple studies. DESIGN:Perspective with literature review. METHODS:Analysis of recent studies to...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.ajo.2013.04.039
更新日期：2013-12-01 00:00:00
abstract：:The flat, circumscribed, and hyperpigmented lesion of the retinal pigment epithelium (RPE) without clinically apparent involvement of the overlying retina, designated as congenital hypertrophy, was found to be associated with corresponding scotomas in the visual field. The depth of the scotoma increased with the age o...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90069-0
更新日期：1975-02-01 00:00:00
abstract：PURPOSE/METHODS:By fundus photography and histopathologic examination, we documented a case of early endogenous Aspergillus endophthalmitis in a 29-year-old man after lung transplantation. RESULTS/CONCLUSIONS:The clinical and histopathologic features of this case are consistent with those of previous case reports of e...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73829-2
更新日期：1995-01-01 00:00:00
