Abstract:
PURPOSE:To report the clinical settings, microbiological isolates, and best-corrected visual acuities (BCVA) of patients with persistently culture-positive exogenous fungal endophthlamitis. DESIGN:Retrospective consecutive case series. METHODS:Setting: Tertiary referral center. PATIENT POPULATION:Sixteen eyes of 16 patients with at least 2 consecutive positive vitreous cultures between 1981 and 2015. INTERVENTIONS:Intravitreal antifungal injection, pars plana vitrectomy (PPV). MAIN OUTCOME MEASURE:Clinical settings, microbiologic isolates, BCVA. RESULTS:The most common clinical settings were after cataract surgery (9/16, 56%), glaucoma surgery (4/16, 25%), and trauma (2/16, 13%). The most common single fungal isolate was Candida (4/16, 25%), but 75% of all isolates were molds. Treatment for presumed bacterial endophthalmitis was given initially in 14 patients (88%). All patients underwent a vitrectomy during the course of their treatment, and all received intravitreal or systemic antifungal therapy. The mean initial BCVA was 1.76 ± 0.9 logMAR (Snellen equivalent ≈20/1200), and the mean final BCVA was 1.84 ± 1.2 logMAR (≈20/1400, P = .83). The 9 patients (56%) who had intraocular lens (IOL) and capsular bag removals had better final BCVAs than those who did not (P = .011). The BCVAs were similar in eyes with yeast and mold (P = .37). The visual acuity at the last follow-up was ≥20/40 in 13% (2/16), ≥20/400 in 50% (8/16), and no light perception in 25% (4/16). CONCLUSIONS:Candida was the single most common isolate, but the majority of isolates were molds. Eyes managed with PPV and removal of the IOL and capsular bag had better visual outcomes. Persistently culture-positive fungal endophthalmitis was associated with poor final visual acuities.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Leung EH,Kuriyan AE,Flynn HW Jr,Relhan N,Huang LC,Miller Ddoi
10.1016/j.ajo.2016.09.014subject
Has Abstractpub_date
2016-12-01 00:00:00pages
45-50eissn
0002-9394issn
1879-1891pii
S0002-9394(16)30452-4journal_volume
172pub_type
杂志文章abstract:PURPOSE:To study the clinicopathologic features of an untreated macular hole in the right eye and a macular hole in the left eye treated by vitrectomy, application of transforming growth factor-beta 2, and gas tamponade. METHODS:The patient, a 73-year-old man with bilateral macular holes, was studied clinically before...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
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journal_title:American journal of ophthalmology
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abstract::Eleven patients with intracranial malignant neoplasms underwent hyperosmotic opening of the blood-brain barrier by rapid mannitol infusion via the internal carotid or vertebral artery. Cyclophosphamide was administered intravenously preceding the mannitol infusion and methotrexate was infused after the mannitol via th...
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journal_title:American journal of ophthalmology
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更新日期:2013-12-01 00:00:00
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更新日期:2013-02-01 00:00:00
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journal_title:American journal of ophthalmology
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更新日期:2008-03-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章
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更新日期:2006-03-01 00:00:00
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更新日期:1982-04-01 00:00:00
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更新日期:2020-12-11 00:00:00
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更新日期:2019-12-01 00:00:00
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更新日期:1980-05-01 00:00:00
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更新日期:2020-12-10 00:00:00
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更新日期:2000-04-01 00:00:00
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更新日期:1975-10-01 00:00:00
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更新日期:2005-10-01 00:00:00
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更新日期:1990-09-15 00:00:00