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Maculopathy associated with combination chemotherapy and osmotic opening of the blood-brain barrier.

Abstract：

:Eleven patients with intracranial malignant neoplasms underwent hyperosmotic opening of the blood-brain barrier by rapid mannitol infusion via the internal carotid or vertebral artery. Cyclophosphamide was administered intravenously preceding the mannitol infusion and methotrexate was infused after the mannitol via the same artery. Both the mannitol and methotrexate delivered via the carotid artery have direct access to the ipsilateral choroidal and retinal circulations. In these patients, retinal pigment epithelial changes eventually developed ipsilateral to the carotid infusions. The changes probably represent the toxicity of intraarterial methotrexate possibly potentiated by mannitol-induced opening of the blood-retinal barrier. Functional visual loss was minimal and was not a limiting factor with this therapeutic modality.

journal_name

Am J Ophthalmol

journal_title

American journal of ophthalmology

authors

Millay RH,Klein ML,Shults WT,Dahlborg SA,Neuwelt EA

doi

10.1016/0002-9394(86)90536-2

subject

Has Abstract

pub_date

1986-11-15 00:00:00

pages

626-32

issue

5

eissn

0002-9394

issn

1879-1891

pii

0002-9394(86)90536-2

journal_volume

102

pub_type

杂志文章

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