Abstract：
PURPOSE:To investigate the changes in absolute neutrophil counts in patients with and without pain after verteporfin infusion. DESIGN:Experimental study. METHODS:The absolute neutrophil counts were obtained from the blood samples taken at the beginning of infusion and after the end of verteporfin infusion. RESULTS:Four patients in whom verteporfin infusion-related pain developed had a decrease in the absolute neutrophil counts from a preinfusion mean of 4,589/mm(3) to a postinfusion mean of 1,688/mm(3) while they had pain, as compared with preinfusion and postinfusion counts of 4,912/mm(3) and 4,111/mm(3), respectively, in five control patients having no pain, a difference in proportion that was significant (P =.027). CONCLUSIONS:Patients in this study with verteporfin infusion-associated pain developed neutropenia during infusion, most likely from drug-induced neutrophil margination. It is possible that medications preventing the transient neutropenia may help avert verteporfin infusion-associated pain.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Spaide RF,Maranan Ldoi
10.1016/s0002-9394(02)01983-9subject
Has Abstractpub_date
2003-04-01 00:00:00pages
549-50issue
4eissn
0002-9394issn
1879-1891pii
S0002939402019839journal_volume
135pub_type
杂志文章abstract：PURPOSE:To compare silicone-hydrogel, poly(2-hydroxyethyl methacrylate) (pHEMA), and phosphorylcholine-coated (PC-C) contact lenses in terms of their susceptibility to biofilm formation by Staphylococcus epidermidis and Pseudomonas aeruginosa. DESIGN:Laboratory investigation. METHODS:Biofilm formation on colonized te...
journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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更新日期：2014-06-01 00:00:00
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：2009-06-01 00:00:00
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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更新日期：1995-06-01 00:00:00
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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journal_title：American journal of ophthalmology
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更新日期：1994-04-15 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：2004-08-01 00:00:00
