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Influence of wavefront aberration and corneal subepithelial haze on low-contrast visual acuity after photorefractive keratectomy.

Abstract：

PURPOSE:To assess low-contrast visual acuity (LCVA) after photorefractive keratectomy in relation to ocular higher-order wavefront aberration and corneal subepithelial haze. DESIGN:Prospective, cross-sectional analysis. METHODS:Photorefractive keratectomy was performed in 51 eyes of 27 subjects with myopic refractive error of -2.0 to -10.5 diopters. Ocular higher-order wavefront aberrations for a 4-mm pupil were measured using Topcon Hartmann-Shack wavefront aberrometer, and the extent of corneal subepithelial haze was quantified with Nidek TSPC-3 hazemeter before and 1 month after photorefractive keratectomy. Low-contrast visual acuity was recorded with Vector Vision CSV-1000LanC10% chart. Total higher-order, third-order (coma-like), and fourth-order (spherical-like) aberrations of the eye were determined. The influence of wavefront aberration and corneal subepithelial haze on LCVA was analyzed. RESULTS:Total higher-order, third-order, and fourth-order aberrations significantly increased by surgery (P < .001, Wilcoxon signed rank test). Photorefractive keratectomy induced a significant increase in corneal haze (P < .01), but no case presented severe corneal haze (grade 3 or greater by Fantes grading). By surgery, LCVA was reduced significantly (P < .001). The logarithm of the minimal angle of resolution LCVA showed a significant correlation with total higher-order aberration (Spearman rank correlation coefficient, r(s) = 0.642, P < .0001). Both third-order (r(s) = 0.618, P < .0001) and fourth-order aberrations (r(s) = 0.552, P < .0001) also significantly correlated with logarithm of the minimal angle of resolution LCVA. There was no correlation between the degree of corneal haze and logarithm of the minimal angle of resolution LCVA (r(s) = 0.094, P = .523). CONCLUSIONS:In eyes with mild to moderate corneal haze after photorefractive keratectomy, deterioration of LCVA is mainly attributable to increases in wavefront aberration, and not to corneal haze.

journal_name

Am J Ophthalmol

journal_title

American journal of ophthalmology

authors

Tanabe T,Miyata K,Samejima T,Hirohara Y,Mihashi T,Oshika T

doi

10.1016/j.ajo.2004.06.015

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

620-4

issue

eissn

0002-9394

issn

1879-1891

pii

S0002-9394(04)00671-3

journal_volume

138

pub_type

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Influence of wavefront aberration and corneal subepithelial haze on low-contrast visual acuity after photorefractive keratectomy.