Abstract：
:To assess the efficacy and safety of twice-daily administration of nedocromil sodium 2% ophthalmic solution, we performed a multicenter study involving 140 patients with seasonal allergic conjunctivitis. Subjects had a history of seasonal allergic conjunctivitis and positive results of a skin test to ragweed. The trial coincided with the peak ragweed pollen season at five treatment centers. Patients treated with nedocromil sodium had improvements in symptoms with statistically significant reductions recorded for eye itching (P less than or equal to .04), conjunctival injection (P less than or equal to .001), and overall disease severity (P less than or equal to .001) as compared to the placebo-treated group. Adverse events were minor and transient. We concluded that nedocromil sodium 2% ophthalmic solution administered twice daily is effective in relieving major symptoms associated with seasonal allergic conjunctivitis.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Blumenthal M,Casale T,Dockhorn R,Jarmoszuk I,Kaiser H,Smith R,Zeitz HJdoi
10.1016/s0002-9394(14)75754-xsubject
Has Abstractpub_date
1992-01-15 00:00:00pages
56-63issue
1eissn
0002-9394issn
1879-1891pii
S0002-9394(14)75754-Xjournal_volume
113pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract：:Patients with Duane's retraction syndrome may have an associated upshoot or downshoot of the involved eye in adduction. This vertical movement has been attributed to the lateral rectus muscle slipping over or under the globe and acting as an elevator or depressor, respectively ("bridle-effect"). We used magnetic reson...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73696-7
更新日期：1991-05-15 00:00:00
abstract：:To facilitate placing pars plana infusion ports, we modified the shaft of a piece of 10-gauge tubing or of a hypodermic needle by removing the beveled tip and Luer hub, passing the tubing through the inserter sleeve, and then reattaching the tubing to the Luer hub. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(78)90251-9
更新日期：1978-09-01 00:00:00
abstract：:Although penetrating trauma is a well-recognized cause of uveitis, the role of nonpenetrating trauma in initiating uveitis is not defined. We analyzed the records of 496 patients seen at the uveitis clinic at our institution. Twenty-four of these 496 patients (4.8%) suspected that the cause of their intraocular inflam...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76245-2
更新日期：1991-10-15 00:00:00
abstract：PURPOSE:To provide evidence that corticosteroid-induced ocular hypertension has a genetic component. DESIGN:Evidence-based perspective. METHODS:We conducted a comprehensive literature search for studies exploring genetic influences on intraocular pressure responses to corticosteroid treatment. RESULTS:Studies demons...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.ajo.2019.02.001
更新日期：2019-06-01 00:00:00
abstract：PURPOSE:To report the outcome of a new keratoplasty technique aimed at treating full-thickness opacities with minimal removal of recipient endothelium. DESIGN:Interventional case report. METHODS:A deep central scar was removed using microkeratome-assisted mushroom-shaped keratoplasty, consisting of a large anterior s...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.12.024
更新日期：2005-07-01 00:00:00
abstract：PURPOSE:To determine whether patients can guess their intraocular pressure (IOP). DESIGN:Patient survey. METHODS:We asked consecutive patients to guess their IOP and then indicate the IOP and the symptoms that allowed them to guess. RESULTS:Of 132 patients, 22 (17%) believed they could guess their IOP, usually based...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/S0002-9394(03)00861-4
更新日期：2004-02-01 00:00:00
abstract：PURPOSE:To report a case of neonatal orbital ganglioglioma originating from ectopic neural tissue. METHOD:Case report. RESULTS:An African-American male presented at birth with proptosis and expansion of the left orbit. A discrete soft-tissue mass was located inferolateral to the globe, which proved to be a gangliogli...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00288-3
更新日期：2000-01-01 00:00:00
abstract：:Fluorescein angiography was safely performed in 100 consecutive cases of cataract extraction during the first postoperative week. Seventy-five percent of the 100 eyes had good quality fluorescein angiograms. Four eyes demonstrated cystoid macular edema. Therefore, the incidence of cystoid macular edema in the first we...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90126-4
更新日期：1976-05-01 00:00:00
abstract：:In several tumors of different organ sites, the amount of DNA in a cell (ploidy) is associated with malignancy. We performed DNA quantitation in 21 choroidal melanomas and compared flow cytometry with image analysis in 11 of these melanomas. We modified our preparation technique to overcome problems with pigment and c...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73592-5
更新日期：1993-03-15 00:00:00
abstract：PURPOSE:To report the sensitivity and specificity of B-scan ultrasonography to detect macular thickening. DESIGN:Observational case series. METHODS:Seventy-seven eyes of 40 consecutive patients (age range, 7-80 years) in a retinal specialty practice were examined. A single masked ultrasound operator performed B-scan ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)02273-0
更新日期：2003-07-01 00:00:00
abstract：:We applied vitreous surgical techniques in the treatment of hemorrhagic and fibrous complications of choroidal neovascular membranes by removing subretinal scars or hemorrhage, or both, in four patients. The surgical goals were achieved in all patients. Visual acuity improved in three patients. The major complication ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(88)90116-x
更新日期：1988-01-15 00:00:00
abstract：PURPOSE:To define the epidemiology of severe ocular trauma in Singapore. METHODS:A population-based incidence study involving all Singapore citizens and residents. Two government-administered databases were used to capture information on severe ocular trauma in Singapore. The national hospital discharge database provi...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00167-1
更新日期：1999-09-01 00:00:00
abstract：PURPOSE:To investigate the effect of shorter axial length on the laser spot size and laser energy during photodynamic therapy (PDT) in monkeys. DESIGN:Experimental study with four rhesus monkeys. METHODS:PDT was performed on the normal retina of monkeys whose ocular axial lengths are shorter (19.55 to 20.25 mm) than ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.08.016
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:To present the first detailed assessment of the clinical features of CL-induced subconjunctival hemorrhage and associated risk factors. DESIGN:Cross-sectional and case-control study of age-matched randomized groups. METHODS:A total of 45 CL wearers with subconjunctival hemorrhage aged 18 to 45 years (CL-Hemor...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.05.028
更新日期：2010-11-01 00:00:00
abstract：PURPOSE:To report a case of recurrent bleeding after photodynamic therapy (PDT) in an eye with polypoidal choroidal vasculopathy (PCV). DESIGN:Interventional case report. METHODS:A 73-year-old man was treated in the left eye for PCV with PDT. RESULTS:Two weeks after PDT, his left eye showed extensive subretinal hemo...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.12.002
更新日期：2006-05-01 00:00:00
abstract：PURPOSE:To report a child with the mitochondrial cytopathy of Pearson syndrome and zonular cataract. METHOD:Case report. We describe a 6-year-old boy with Pearson syndrome. RESULTS:At age 3 years, the boy developed secondary strabismus caused by bilateral zonular cataract. Subsequently, he underwent successful bilate...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)80105-6
更新日期：1998-02-01 00:00:00
abstract：PURPOSE:To report a case of unilateral proptosis and chronic pansinusitis in which the diagnosis of pneumocele was made. DESIGN:Observational case report. METHODS:A retrospective chart review was made. RESULTS:A 52-year-old man with chronic pansinusitis presented with a 5-mm proptosis and a larger palpebral fissure ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.02.054
更新日期：2004-07-01 00:00:00
abstract：PURPOSE:To determine a possible correlation specifically between hemoglobin A1C (HgbA1C) levels and the presence and severity of retinopathy during diabetic eye screening. DESIGN:Retrospective medical record review of all new patients examined in a Veteran Affairs Medical Center (VAMC) diabetic screening clinic in 200...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2007.04.008
更新日期：2007-09-01 00:00:00
abstract：PURPOSE:To estimate the cumulative probability of Nd:YAG laser posterior capsulotomy after cataract extraction in a geographically defined population. METHODS:Rochester Epidemiology Project databases were used to identify retrospectively all Nd:YAG laser posterior capsulotomies performed on Olmsted County, Minnesota, ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00795-9
更新日期：2001-02-01 00:00:00
abstract：PURPOSE:To describe a case series of neovascular glaucoma (NVG) caused by central retinal vein occlusion (CRVO) that was treated with intravitreal bevacizumab (IVB; Avastin). DESIGN:Retrospective interventional case series. METHODS:Six consecutive patients with NVG and a refractory, symptomatic elevation of intraocul...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.06.066
更新日期：2006-12-01 00:00:00
abstract：PURPOSE:To compare measurements of anterior chamber depth (ACD) and corneal curvature obtained with the Pentacam to other commonly used devices. DESIGN:Prospective, nonrandomized clinical trial. METHODS:Measurements of ACD and keratometry were prospectively obtained in 22 eyes of 11 subjects with the Pentacam compare...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/j.ajo.2006.08.031
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:To report the successful use of topical cysteamine formulated from the oral preparation in the treatment of severe photophobia from corneal crystal deposition in cystinosis. DESIGN:Interventional case report. METHODS:Retrospective chart review. RESULTS:An 8-year-old boy with nephropathic cystinosis was exper...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.05.005
更新日期：2004-10-01 00:00:00
abstract：PURPOSE:We studied patients with chronic open-angle glaucoma who had similar intraocular pressures to determine whether surgical or medical therapy is more effective in preventing progressive, long-term, glaucomatous damage. METHODS:Included in this study were patients with chronic open-angle glaucoma who were followe...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70372-1
更新日期：1996-12-01 00:00:00
abstract：PURPOSE:To report the cotransmission of retinitis punctata albescens (RPA) and congenital sensorineural deafness. METHODS:Case reports of two siblings with nyctalopia and profound bilateral sensorineural deafness. RESULTS:The affected siblings, an 11-year-old female and a 7-year-old male, presented with decreased vis...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00060-4
更新日期：1999-08-01 00:00:00
abstract：PURPOSE:To reexamine the role of the vitreous gel in ocular health and disease based on recent information in the ophthalmic literature. DESIGN:Perspective. METHODS:Review, analysis, and discussion of the implications of selected pertinent literature. RESULTS:A new understanding of the vitreous gel is emerging, plac...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.ajo.2009.07.036
更新日期：2010-01-01 00:00:00
abstract：PURPOSE:To evaluate for which range of refractive error the optic disk size depends on, or is independent of, the refractive error. DESIGN:Clinical observational study. METHODS:The study included 1999 eyes of 1011 subjects with a mean refractive error of -0.97 +/- 2.72 diopters (range, -24.25 to +9.4 diopters). Optic...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.07.047
更新日期：2005-02-01 00:00:00
abstract：PURPOSE:To report the response of acute Behçet retinitis to high-dose corticosteroids. METHOD:Case report. A 58-year-old man with Behçet disease and severe bilateral glaucoma experienced a sudden decrease of visual acuity to counting fingers in his (better-seeing) left eye. Examination disclosed hypopyon uveitis and a...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)80163-9
更新日期：1998-03-01 00:00:00
abstract：PURPOSE:To report a case of conjunctival intraepithelial neoplasia presenting as corneal ulcer. METHOD:Case report of a 28-year-old man who presented with sudden onset of pain, redness, and watering in the right eye. Examination of right cornea revealed deep stromal infiltrate inferonasally. Adjacent to the infiltrate...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00286-x
更新日期：2000-01-01 00:00:00
abstract：PURPOSE:To evaluate clinically a recently developed confocal scanning laser ophthalmoscope for simultaneous fluorescein and indocyanine green angiography. METHODS:After comprehensive ophthalmic examination, including stereoscopic biomicroscopy, and after color fundus photographs, simultaneous confocal scanning laser f...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)80095-6
更新日期：1998-02-01 00:00:00
abstract：:Six patients (all male, five homosexual and one bisexual, 23 to 48 years old) with the acquired immune deficiency syndrome (AIDS) who had cytomegalovirus retinitis were treated with a new antiviral drug as a part of a prospective open-labeled trial for serious cytomegalovirus infections. The drug, 9-[2-hydroxy-1-(hydr...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(86)90638-0
更新日期：1986-04-15 00:00:00
