Abstract:
PURPOSE:To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of ophthalmic formulations of bimatoprost 0.01% and 0.0125% compared with bimatoprost 0.03%. DESIGN:Prospective, randomized, double-masked, multicenter clinical trial. METHODS:Patients with glaucoma or ocular hypertension were randomized to receive once-daily bimatoprost 0.01% (n = 186), bimatoprost 0.0125% (n = 188), or bimatoprost 0.03% (n = 187) for 12 months. The primary efficacy measure was IOP. Safety measures included adverse events and an objective assessment of conjunctival hyperemia. RESULTS:Baseline mean IOPs were similar among treatment groups. Differences in mean IOP between the bimatoprost 0.01% or 0.0125% groups and the bimatoprost 0.03% group were less than 0.9 mm Hg throughout follow-up. Bimatoprost 0.01%, but not bimatoprost 0.0125%, was equivalent in efficacy to bimatoprost 0.03% based on predetermined criteria (limits of the 95% confidence interval of the between-group difference in mean IOP within +/- 1.5 mm Hg at all time points and within +/- 1 mm Hg at most time points). The overall incidence of treatment-related adverse events was reduced significantly in the bimatoprost 0.01% and bimatoprost 0.0125% groups compared with the bimatoprost 0.03% group (P < or = .034). The percentage of patients with a moderate to severe increase from the baseline macroscopic hyperemia score was: bimatoprost 0.01%, 3.2%; bimatoprost 0.0125%, 9.0%; bimatoprost 0.03%, 9.1% (P = .019 for bimatoprost 0.01% vs 0.03%). CONCLUSIONS:Bimatoprost 0.01% was equivalent to bimatoprost 0.03% in lowering IOP throughout 12 months of treatment and demonstrated improved tolerability, including less frequent and severe conjunctival hyperemia. Bimatoprost 0.01% demonstrated a better benefit-to-risk ratio than bimatoprost 0.0125%.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Katz LJ,Cohen JS,Batoosingh AL,Felix C,Shu V,Schiffman RMdoi
10.1016/j.ajo.2009.12.003subject
Has Abstractpub_date
2010-04-01 00:00:00pages
661-671.e1issue
4eissn
0002-9394issn
1879-1891pii
S0002-9394(09)00906-4journal_volume
149pub_type
杂志文章,多中心研究,随机对照试验abstract:PURPOSE:To report complications of cosmetic artificial iris implantation and explantation outcomes. SETTING:Stein Eye Institute DESIGN: : Retrospective case series METHODS: : Review of medical records of 12 patients (24 eyes) who presented to us after being implanted with cosmetic artificial irises elsewhere. Data col...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2021.01.005
更新日期:2021-01-22 00:00:00
abstract:PURPOSE:In previous studies of fungal keratitis (FK) from temperate countries, yeasts were the predominant isolates, with ocular surface disease (OSD) being the leading risk factor. Since the 2005-2006 outbreak of contact lens (CL)-associated Fusarium keratitis, there may have been a rise in CL-associated filamentary F...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2016.05.021
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:To evaluate the relationship between visual function and retinal nerve fiber layer (RNFL) measurements obtained with scanning laser polarimetry with variable corneal compensation (SLP-VCC) and optical coherence tomography (OCT). DESIGN:Cross-sectional analysis of normal and glaucomatous eyes in a tertiary care...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(02)02077-9
更新日期:2003-04-01 00:00:00
abstract:PURPOSE:To examine the influence of corneal allograft rejection on the survival of penetrating corneal transplantation, to review the status of conventional therapies to improve graft survival, and to consider prospects for alternative approaches to reduce the impact of rejection. DESIGN:Perspective, including prospec...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.ajo.2005.07.024
更新日期:2005-12-01 00:00:00
abstract:PURPOSE:To present a quantitative analysis of pterygium and ocular sun exposure, a dose-response curve, and a discussion of the health-promotion implications of the findings. METHODS:A hospital-based, case-control study was conducted in Perth, Western Australia. Case subjects had surgical removal of a pterygium; contr...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(99)00161-0
更新日期:1999-09-01 00:00:00
abstract::We used fluorophotometry and pachymetry to examine the longer-term (more than three months) postoperative effects in the anterior segment of extracapsular lens extraction with and without posterior chamber intraocular lens implantation. Fluorophotometry was performed after oral administration of fluorescein solution (...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)76090-8
更新日期:1984-02-01 00:00:00
abstract:PURPOSE:To describe a case of infantile neuroaxonal dystrophy with optic nerve atrophy and to discuss the diagnostic role of conjunctival biopsy. METHODS:We performed a complete ophthalmologic examination and a diagnostic conjunctival biopsy on a girl with a neurodegenerative disease. RESULTS:On the basis of "spheroi...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)71051-7
更新日期:1997-02-01 00:00:00
abstract:PURPOSE:To report a case of bilateral acute retinal necrosis caused by cytomegalovirus. METHODS:A diagnostic vitrectomy was performed on a patient with non-Hodgkin lymphoma who presented with a bilateral, rapidly progressing necrotizing retinitis and uveitis. RESULTS:Immunohistochemical studies and polymerase chain r...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(98)00250-5
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:To evaluate corneal biomechanical properties across the glaucoma spectrum and study the relationship between these measurements and intraocular pressure measured by Goldmann applanation tonometry (GAT-IOP) and central corneal thickness (CCT). DESIGN:Prospective cross-sectional study. METHODS: SETTING:Tertiar...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2011.10.032
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:To describe a technique for suturing a dislocated intraocular lens (IOL) using an intraocular cowhitch knot without IOL extraction. METHODS:Through the sideports of paracentesis, a cowhitch knot is made outside of the anterior chamber by looping 10-0 Prolene around the haptics of the IOL. The knot is then tied...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(00)00727-3
更新日期:2001-02-01 00:00:00
abstract:PURPOSE:To describe the ocular complications of smallpox vaccination and to discuss potential therapeutic options. DESIGN:Review of pertinent medical literature and recent treatment recommendations of the Centers for Disease Control and Prevention. RESULTS:After immunization against smallpox, vaccinia infection of th...
journal_title:American journal of ophthalmology
pub_type: 历史文章,杂志文章,评审
doi:10.1016/s0002-9394(03)00293-9
更新日期:2003-08-01 00:00:00
abstract::Nine patients with polyradiculomyeloneuropathy after acute hemorrhagic conjunctivitis (AHC) infection were studied serologically. All except one patient had neutralization titers larger than or equal to 1:16 against the prototype J670/71 strain of AHC virus in at least one of their serum samples. The development of a ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(75)90279-2
更新日期:1975-11-01 00:00:00
abstract:PURPOSE:To correlate fractal dimension (FD) of the retinal vasculature with the extent of retinal nonperfusion area in diabetic retinopathy (DR) on ultrawide-field fluorescein angiography (FA). DESIGN:Cross-sectional study. METHODS:Baseline Optos 200Tx ultrawide-field FA images of 80 eyes with DR from the DAVE (NCT01...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ajo.2019.08.015
更新日期:2020-01-01 00:00:00
abstract::We examined two patients who had sudden decrease in vision after intranasal cocaine or methamphetamine abuse. A 38-year-old woman with a history of systemic arterial hypertension developed a central retinal artery occlusion four hours after intranasal use of cocaine. A 26-year-old woman had blurred vision and intraret...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)73979-0
更新日期:1992-08-15 00:00:00
abstract:PURPOSE:To report the clinical settings, microbiological isolates, and best-corrected visual acuities (BCVA) of patients with persistently culture-positive exogenous fungal endophthlamitis. DESIGN:Retrospective consecutive case series. METHODS:Setting: Tertiary referral center. PATIENT POPULATION:Sixteen eyes of 16 ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2016.09.014
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:We evaluated quantitatively, with electromyography, the function of orbicularis oculi muscle flaps in modified Hughes reconstructions of the lower eyelids. METHODS:A modified Hughes procedure with a bipedicle orbicularis oculi flap was used to reconstruct large left lower eyelid defects after tumor excision in...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)73877-2
更新日期:1995-02-01 00:00:00
abstract:PURPOSE:Diseases that involve retinal or choroidal vascular endothelial cells are leading causes of vision loss: age-related macular degeneration, retinal ischemic vasculopathies, and noninfectious posterior uveitis. Proteins differentially expressed by these endothelial cell populations are potential drug targets. We ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2018.03.020
更新日期:2018-09-01 00:00:00
abstract::Fluorescein angiography was safely performed in 100 consecutive cases of cataract extraction during the first postoperative week. Seventy-five percent of the 100 eyes had good quality fluorescein angiograms. Four eyes demonstrated cystoid macular edema. Therefore, the incidence of cystoid macular edema in the first we...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(76)90126-4
更新日期:1976-05-01 00:00:00
abstract:PURPOSE:To report the successful use of topical cysteamine formulated from the oral preparation in the treatment of severe photophobia from corneal crystal deposition in cystinosis. DESIGN:Interventional case report. METHODS:Retrospective chart review. RESULTS:An 8-year-old boy with nephropathic cystinosis was exper...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2004.05.005
更新日期:2004-10-01 00:00:00
abstract:PURPOSE:We sought to assess the effects of exposure to secondhand smoke (SHS) on peripapillary retinal nerve fiber layer (p-RNFL) thickness in children. DESIGN:Cross-sectional study. METHODS:Children 6-8 years of age were consecutively recruited from the population-based Hong Kong Children Eye Study. All participants...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2020.10.016
更新日期:2020-10-29 00:00:00
abstract:PURPOSE:To describe a group of patients with dense visual field defects following macular hole surgery. METHODS:Nine (7%) of 125 patients reviewed noted onset of dense visual field defects following uncomplicated vitrectomy with gas-fluid exchange for the treatment of macular hole. Patient records were reviewed to inv...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)72064-1
更新日期:1996-09-01 00:00:00
abstract:PURPOSE:beta-Adrenergic blocking drugs lower intraocular pressure. The question of whether these drugs also alter, either directly or indirectly, orbital hemodynamics is potentially of great importance for patients with normal-tension glaucoma who may have some degree of reversible vasospasm. METHODS:We compared the e...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0002-9394(14)72604-2
更新日期:1995-08-01 00:00:00
abstract::A 46-year-old man developed symptoms of a chronic progressive uveitis in his right eye approximately one week after a dental procedure. The patient's intraocular inflammation was not diminished by massive treatment with topical and systemic corticosteroid therapy or intravenously administered adrenocorticotropic hormo...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)77101-6
更新日期:1978-05-01 00:00:00
abstract:PURPOSE:To compare the in vitro toxicity of brilliant blue G (BBG), indocyanine green (ICG), Trypan blue (TB), and Evans blue (EB) in a human retinal pigment epithelial cell line (ARPE-19) and a murine retinal ganglion/Muller glial (RGC) primary cell culture. DESIGN:In vitro cell biology experimental study. METHODS:T...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2008.08.031
更新日期:2009-02-01 00:00:00
abstract:PURPOSE:To describe the spectral-domain optical coherence tomography (SD-OCT) features of choroidal tumors imaged using enhanced depth imaging (EDI) technique. DESIGN:Prospective observational case series. METHODS:One tumor each from 23 eyes of 23 patients was included. All the patients underwent clinical fundus phot...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2010.09.028
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:To assess a response to infliximab therapy in childhood uveitis. DESIGN:Retrospective case series. METHODS:We reviewed the course of 16 children with noninfectious uveitis treated with infliximab at an academic medical center. Outcome measures included incidence of uveitis recurrences, proportion of patients ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2007.08.018
更新日期:2007-12-01 00:00:00
abstract::We reviewed the records of 78 patients who underwent 128 surgical procedures for congenital or infantile cataracts before age 30 months for the type and frequency of postoperative complications. The surgeries included 92 limbal lensectomies and anterior vitrectomies, 13 pars plicata lensectomies, 20 aspirations, and t...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/0002-9394(89)90007-x
更新日期:1989-08-15 00:00:00
abstract:PURPOSE:To develop a model for estimating the global risk of disease progression in patients with ocular hypertension and to calculate the "number-needed-to-treat" (NNT) to prevent progression to blindness as an aid to practitioners in clinical decision making. DESIGN:Development of a mathematical model for estimating...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.ajo.2004.04.054
更新日期:2004-09-01 00:00:00
abstract:PURPOSE:To report the results and complications of an aspiration cutter-assisted anterior segment tumor biopsy performed under viscoelastic. DESIGN:Retrospective, consecutive, interventional case series. METHODS:Fifty-five patients with anterior segment tumors underwent aspiration cutter-assisted biopsy at a single c...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2011.04.032
更新日期:2011-11-01 00:00:00
abstract::The flat, circumscribed, and hyperpigmented lesion of the retinal pigment epithelium (RPE) without clinically apparent involvement of the overlying retina, designated as congenital hypertrophy, was found to be associated with corresponding scotomas in the visual field. The depth of the scotoma increased with the age o...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(75)90069-0
更新日期:1975-02-01 00:00:00