Pharmacotherapy for neovascular age-related macular degeneration: an analysis of the 100% 2008 medicare fee-for-service part B claims file.


PURPOSE:To describe the usage patterns of pharmacological treatments for neovascular age-related macular degeneration (AMD) in Medicare fee-for-service beneficiaries. DESIGN:Retrospective review of all Medicare fee-for-service Part B claims for neovascular AMD during 2008. METHODS:Medicare beneficiaries having undergone treatment were identified. The data collected for each visit for a given beneficiary included age, race, gender, Medicare region, state/zip code of residence, date of visit, whether or not the beneficiary had a treatment, the type and amount of drug, and dollars paid by Medicare. The main outcome measures were the number and rate of treatments, the types of drugs used for treatment, and the payments for these drugs. RESULTS:Of the 222 886 unique beneficiaries, 146 276 (64.4%) received bevacizumab and 80 929 (35.6%) received ranibizumab. A total of 824 525 injections were performed with 480 025 injections of bevacizumab (58%) and 336 898 injections of ranibizumab (41%). National rates of injections per 100 000 fee-for-service Part B Medicare beneficiaries for bevacizumab and ranibizumab were 1506 and 1057, respectively. Total payments by Medicare were $20 290 952 for bevacizumab and $536 642 693 for ranibizumab. In 39 out of 50 states, the rate of injection was higher for bevacizumab compared with ranibizumab. CONCLUSIONS:In 2008, bevacizumab was used at a higher rate than ranibizumab for the treatment of neovascular AMD. Even though bevacizumab accounted for 58% of all injections, Medicare paid $516 million more for ranibizumab than bevacizumab. These data suggest that despite its off-label designation, intravitreal bevacizumab is currently the standard-of-care treatment for neovascular AMD in the United States.


Am J Ophthalmol


Brechner RJ,Rosenfeld PJ,Babish JD,Caplan S




Has Abstract


2011-05-01 00:00:00














  • Ocular surface squamous neoplasia after corneal graft.

    abstract:PURPOSE:To describe the clinical features and management of ocular surface squamous neoplasia (OSSN) after corneal graft. DESIGN:Retrospective case series of 4 patients. METHODS:Four eyes of 4 patients treated for OSSN after corneal graft in an institutional setting were included. All 4 patients were treated with top...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Ramasubramanian A,Shields CL,Sinha N,Shields JA

    更新日期:2010-01-01 00:00:00

  • RAND-like appropriateness methodology consensus for primary open-angle glaucoma in Latin America.

    abstract:PURPOSE:To report the results of a Latin American consensus panel regarding the diagnosis and management of primary open-angle glaucoma and to compare these results with those from a similar panel in the United States. DESIGN:A RAND-like (Research and Development) appropriateness methodology was used to assess glaucom...

    journal_title:American journal of ophthalmology

    pub_type: 共识发展会议,杂志文章


    authors: Lerner SF,Singh K,Susanna R Jr,Wilson MR,Lee BL,Maul E,Latin America Glaucoma Rand Study Group.

    更新日期:2012-09-01 00:00:00

  • Anterior segment optical coherence tomography evaluation of the integrity of clear corneal incisions: a comparison between 2.2-mm and 2.65-mm main incisions.

    abstract:PURPOSE:To compare wound characteristics and integrity of the 2.2-mm and 2.65-mm clear corneal incisions. DESIGN:Prospective, randomized clinical trial. METHODS:Patients undergoing phacoemulsification with lens implant were randomized to receive a 2.2-mm or 2.65-mm temporal clear corneal incision. The incisions were ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章,随机对照试验


    authors: Chee SP,Ti SE,Lim L,Chan AS,Jap A

    更新日期:2010-05-01 00:00:00

  • Refractive changes after pediatric intraocular lens implantation.

    abstract:PURPOSE:To report refractive changes after cataract surgery and intraocular lens implantation in infants and children. METHODS:In an ongoing prospective study, the refractive errors of all patients younger than 18 years undergoing intraocular lens implantation were determined at 6 weeks, 3 months, 6 months, and 1 year...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Enyedi LB,Peterseim MW,Freedman SF,Buckley EG

    更新日期:1998-12-01 00:00:00

  • Predictive value of a 1-day, 1-eye trial on the 1-month ocular hypotensive response of latanoprost 0.005%.

    abstract:PURPOSE:To determine if a 1-day, 1-eye trial of latanoprost 0.005% was predictive of the 1-month intraocular pressure response in patients with uncontrolled open-angle glaucoma on maximally tolerated medical therapy without latanoprost. METHODS:One eye of 39 consecutive patients was enrolled in prospective trial of la...

    journal_title:American journal of ophthalmology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Mansberger SL,Passo MS,Schalock PI,Cioffi GA

    更新日期:2001-12-01 00:00:00

  • Insights from experimental data on ciprofloxacin in the treatment of bacterial keratitis and ocular infections.

    abstract::Ciprofloxacin is a potent fluoroquinolone antibiotic with in vitro activity against many significant gram-positive and gram-negative ocular pathogens. A review of the experimental studies of this antibiotic shows bactericidal activity, a broad antimicrobial spectrum, and a low incidence of resistance. The growing body...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章,评审


    authors: Cokingtin CD,Hyndiuk RA

    更新日期:1991-10-01 00:00:00

  • Fluorophotometric study of anterior segment barrier functions after extracapsular cataract extraction and posterior chamber intraocular lens implantation.

    abstract::We used fluorophotometry and pachymetry to examine the longer-term (more than three months) postoperative effects in the anterior segment of extracapsular lens extraction with and without posterior chamber intraocular lens implantation. Fluorophotometry was performed after oral administration of fluorescein solution (...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Sawa M,Sakanishi Y,Shimizu H

    更新日期:1984-02-01 00:00:00

  • Rebubbling in Descemet Membrane Endothelial Keratoplasty: Influence of Pressure and Duration of the Intracameral Air Tamponade.

    abstract:PURPOSE:To explore the impact of intracameral air tamponade pressure and duration on graft attachment and rebubbling rates. DESIGN:A prospective, interventional, nonrandomized study. METHODS:setting: Department of Ophthalmology, Charité - Universitätsmedizin Berlin. STUDY POPULATION:One hundred seventeen patients wh...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Pilger D,Wilkemeyer I,Schroeter J,Maier AB,Torun N

    更新日期:2017-06-01 00:00:00

  • Expanded Phenotypic Spectrum of Retinopathies Associated with Autosomal Recessive and Dominant Mutations in PROM1.

    abstract:PURPOSE:To describe the genetic and phenotypic characteristics of a cohort of patients with PROM1 variants. DESIGN:Case-case study. METHODS:We screened a cohort of 2216 families with inherited retinal dystrophies using classical molecular techniques and next-generation sequencing approaches. The clinical histories of...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Del Pozo-Valero M,Martin-Merida I,Jimenez-Rolando B,Arteche A,Avila-Fernandez A,Blanco-Kelly F,Riveiro-Alvarez R,Van Cauwenbergh C,De Baere E,Rivolta C,Garcia-Sandoval B,Corton M,Ayuso C

    更新日期:2019-11-01 00:00:00

  • Peribulbar anesthesia for strabismus surgery.

    abstract::We prospectively studied 76 patients to analyze the effectiveness of peribulbar anesthesia during strabismus surgery. The patients, ranging in age from 14 to 77 years, were given anesthesia with standard preoperative medication and a peribulbar injection of a mixture of 2% mepivacaine hydrochloride and hyaluronidase. ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Sanders RJ,Nelson LB,Deutsch JA

    更新日期:1990-06-15 00:00:00

  • Enhanced circulating soluble LR11 in patients with diabetic retinopathy.

    abstract:PURPOSE:To investigate the relationship of circulating levels of soluble form of LR11 (sLR11; also called SorLA or SORL1), with the progression of proliferative diabetic retinopathy (PDR) in patients with type 2 diabetes mellitus. DESIGN:Cross-sectional study. METHODS:Fifty-four patients with type 2 diabetes mellitus...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Takahashi M,Bujo H,Shiba T,Jiang M,Maeno T,Shirai K

    更新日期:2012-07-01 00:00:00

  • Ocular and cerebral involvement in familial lymphohistiocytosis.

    abstract::A 5-month-old infant girl died of familial lymphohistiocytosis. The central nervous system showed widespread perivascular infiltration of the cerebral pia and arachnoid, the cerebral white matter and deep gray matter, the cerebellum, and brain stem by lymphocytes, benign appearing histiocytes, and macrophages with ery...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Appen RE,Weber SW,de Venecia G,Rhein GM

    更新日期:1976-11-01 00:00:00

  • Age-related Macular Degeneration: Nutrition, Genes and Deep Learning-The LXXVI Edward Jackson Memorial Lecture.

    abstract:PURPOSE:To evaluate the importance of nutritional supplements, dietary pattern, and genetic associations in age-related macular degeneration (AMD); and to discuss the technique of artificial intelligence/deep learning to potentially enhance research in detecting and classifying AMD. DESIGN:Retrospective literature rev...

    journal_title:American journal of ophthalmology



    authors: Chew EY

    更新日期:2020-09-01 00:00:00

  • Long-term Progression of Type 1 Neovascularization in Age-related Macular Degeneration Using Optical Coherence Tomography Angiography.

    abstract:PURPOSE:To analyze the long-term growth patterns of type 1 neovascularization (NV) in eyes with age-related macular degeneration (AMD) receiving anti-vascular endothelial growth factor (VEGF) therapy. DESIGN:Retrospective cohort study. METHODS:Patients were enrolled from 2 eye centers and underwent optical coherence ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章,多中心研究


    authors: Xu D,Dávila JP,Rahimi M,Rebhun CB,Alibhai AY,Waheed NK,Sarraf D

    更新日期:2018-03-01 00:00:00

  • Outcome and Prognostic Factors of Phacoemulsification Cataract Surgery in Vogt-Koyanagi-Harada Uveitis.

    abstract:PURPOSE:To investigate visual outcome and prognostic factors following cataract surgery in patients with Vogt-Koyanagi-Harada (VKH) disease. DESIGN:Retrospective, interventional case series. METHODS:The history, clinical characteristics, best-corrected visual acuity (BCVA), full-field electroretinogram (ERG), intraoc...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Ji Y,Hu K,Li C,Li P,Kijlstra A,Eghrari AO,Lei B,Du L,Wan W,Yang P

    更新日期:2018-12-01 00:00:00

  • Immune deposits in iris biopsy specimens from patients with Fuchs' heterochromic iridocyclitis.

    abstract::To investigate whether Fuchs' heterochromic iridocyclitis may be an immune complex vasculitis, we used an immunofluorescence technique to detect immunoglobulins and complement in iris biopsy specimens from nine patients with Fuchs' heterochromic iridocyclitis, 12 patients with other types of uveitis, and nine patients...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: La Hey E,Mooy CM,Baarsma GS,de Vries J,de Jong PT,Kijlstra A

    更新日期:1992-01-15 00:00:00

  • Stromal keratitis complicating anterior membrane dystrophy.

    abstract::Recurrent erosion of the cornea has been well documented in patients with nontraumatic anterior membrane dystrophies of various types. We examined five patients who, in addition to an erosion, developed stromal keratitis. Three of these patients were subjected to a complete microbiologic workup, but the lesions were a...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Shoch DE,Stock EL,Schwartz AE

    更新日期:1985-07-15 00:00:00

  • Correlation between spectral-domain optical coherence tomography and fundus autofluorescence at the margins of geographic atrophy.

    abstract:PURPOSE:To study the appearance of margins of geographic atrophy in high-resolution optical coherence tomography (OCT) images and to correlate those changes with fundus autofluorescence (FAF) imaging. DESIGN:Retrospective, observational case study. METHODS:Patients with geographic atrophy secondary to dry age-related...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Brar M,Kozak I,Cheng L,Bartsch DU,Yuson R,Nigam N,Oster SF,Mojana F,Freeman WR

    更新日期:2009-09-01 00:00:00

  • Ahmed valve implantation with adjunctive mitomycin C and 5-fluorouracil: long-term outcomes.

    abstract:PURPOSE:To evaluate long-term outcomes after Ahmed valve implantation in patients with glaucoma when using adjunctive intraoperative mitomycin C (MMC) and postoperative 5-fluorouracil (5-FU). DESIGN:Retrospective, interventional, consecutive case series. METHODS:A consecutive series of eyes undergoing Ahmed valve imp...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Alvarado JA,Hollander DA,Juster RP,Lee LC

    更新日期:2008-08-01 00:00:00

  • Angiogenic and Immunologic Proteins Identified by Deep Proteomic Profiling of Human Retinal and Choroidal Vascular Endothelial Cells: Potential Targets for New Biologic Drugs.

    abstract:PURPOSE:Diseases that involve retinal or choroidal vascular endothelial cells are leading causes of vision loss: age-related macular degeneration, retinal ischemic vasculopathies, and noninfectious posterior uveitis. Proteins differentially expressed by these endothelial cell populations are potential drug targets. We ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Smith JR,David LL,Appukuttan B,Wilmarth PA

    更新日期:2018-09-01 00:00:00

  • Blepharochalasis syndrome.

    abstract::Patients with chronic forms of blepharochalasis often develop eyelid deformities characterized by blepharoptosis and prolapse of the orbital fat and lacrimal gland. Some individuals have an acquired form of blepharophimosis, secondary to the dehiscence of the canthal tendons. In this late stage of the condition, the t...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Custer PL,Tenzel RR,Kowalczyk AP

    更新日期:1985-04-15 00:00:00

  • Correction of residual hyperopia after cataract surgery using the light adjustable intraocular lens technology.

    abstract:PURPOSE:To determine whether residual hyperopia could be corrected postoperatively using the light adjustable lens technology in patients undergoing cataract surgery and light adjustable lens implantation. DESIGN:Prospective, nonrandomized clinical trial. METHODS:Fourteen eyes of 14 patients were studied. The manifes...

    journal_title:American journal of ophthalmology

    pub_type: 临床试验,杂志文章


    authors: Chayet A,Sandstedt CA,Chang SH,Rhee P,Tsuchiyama B,Schwartz D

    更新日期:2009-03-01 00:00:00

  • Localized infection by Serratia marcescens simulating a conjunctival neoplasm.

    abstract:PURPOSE:To report a Serratia marcescens infection that clinically simulated a conjunctival neoplasm. METHOD:Case report. RESULTS:A healthy 80-year-old man without contact lenses presented with a pink-yellow conjunctival mass that resembled a solid neoplasm. Stains and cultures of material that exuded from the mass du...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Shields JA,Shields CL,Eagle RC Jr,Moster M

    更新日期:2000-02-01 00:00:00

  • Periventricular Leukomalacia in Patients With Pseudo-glaucomatous Cupping.

    abstract:PURPOSE:Periventricular leukomalacia (PVL) is a structural loss of white matter pathways that carry visual information from the lateral geniculate bodies to the visual cortex. It is observed radiologically in patients with a history of prematurity and is associated with visual field (VF) defects and optic disc cupping....

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Groth SL,Donahue SP,Reddy A,Sarma A,Wushensky C

    更新日期:2020-03-01 00:00:00

  • Congenital corneal anesthesia.

    abstract::A 6-year-old boy with a visual acuity of 6/30 (20/100) in each eye had a diffuse corneal epithelial disruption that was most severe in the interpalpebral area. Corneal anesthesia was demonstrated with the Cochet-Bonnet aesthesiometer. Artificial tears, lubricant ointments, and taping of the eyelids were unsuccessful i...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Carpel EF

    更新日期:1978-03-01 00:00:00

  • International photographic classification and grading system for myopic maculopathy.

    abstract:PURPOSE:To develop a classification and grading system for myopic maculopathy. DESIGN:Development and evaluation of a classification system for myopic maculopathy based on observational case series. METHODS:A comprehensive set of myopic macular lesions was defined via literature review and through consensus meetings ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Ohno-Matsui K,Kawasaki R,Jonas JB,Cheung CM,Saw SM,Verhoeven VJ,Klaver CC,Moriyama M,Shinohara K,Kawasaki Y,Yamazaki M,Meuer S,Ishibashi T,Yasuda M,Yamashita H,Sugano A,Wang JJ,Mitchell P,Wong TY,META-analysis for P

    更新日期:2015-05-01 00:00:00

  • Echographic localization of corticosteroids after periocular injection.

    abstract::The location of repository corticosteroid after subtenon injection was determined in 24 patients with macular edema associated with uveitis or anterior segment surgery. Standardized A-scan and B-scan echography were performed immediately before and after each injection. Localization was compared after subtenon injecti...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Freeman WR,Green RL,Smith RE

    更新日期:1987-03-15 00:00:00

  • The effect of prior trabeculectomy on refractive outcomes of cataract surgery.

    abstract:PURPOSE:To examine surgical and refractive outcomes of phacoemulsification with intraocular lens (IOL) implant in eyes with prior trabeculectomy. DESIGN:Retrospective observational case-control study. METHODS:The study compared eyes that underwent phacoemulsification with IOL implant at least 3 months post-trabeculec...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Zhang N,Tsai PL,Catoira-Boyle YP,Morgan LS,Hoop JS,Cantor LB,WuDunn D

    更新日期:2013-05-01 00:00:00

  • Combined trabeculectomy and phacoemulsification: a one-site vs a two-site approach.

    abstract:PURPOSE:To compare the results of combined trabeculectomy and phacoemulsification surgery with intraocular lens implant by means of a one-site vs a two-site approach. METHODS:Glaucomatous patients with a coexisting cataract were randomly assigned to undergo either a one-site or two-site combined procedure. One-site su...

    journal_title:American journal of ophthalmology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wyse T,Meyer M,Ruderman JM,Krupin T,Talluto D,Hernandez R,Rosenberg LF

    更新日期:1998-03-01 00:00:00

  • Retrobulbar arterial hemodynamic effects of betaxolol and timolol in normal-tension glaucoma.

    abstract:PURPOSE:beta-Adrenergic blocking drugs lower intraocular pressure. The question of whether these drugs also alter, either directly or indirectly, orbital hemodynamics is potentially of great importance for patients with normal-tension glaucoma who may have some degree of reversible vasospasm. METHODS:We compared the e...

    journal_title:American journal of ophthalmology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Harris A,Spaeth GL,Sergott RC,Katz LJ,Cantor LB,Martin BJ

    更新日期:1995-08-01 00:00:00