Abstract:
PURPOSE:To describe the usage patterns of pharmacological treatments for neovascular age-related macular degeneration (AMD) in Medicare fee-for-service beneficiaries. DESIGN:Retrospective review of all Medicare fee-for-service Part B claims for neovascular AMD during 2008. METHODS:Medicare beneficiaries having undergone treatment were identified. The data collected for each visit for a given beneficiary included age, race, gender, Medicare region, state/zip code of residence, date of visit, whether or not the beneficiary had a treatment, the type and amount of drug, and dollars paid by Medicare. The main outcome measures were the number and rate of treatments, the types of drugs used for treatment, and the payments for these drugs. RESULTS:Of the 222 886 unique beneficiaries, 146 276 (64.4%) received bevacizumab and 80 929 (35.6%) received ranibizumab. A total of 824 525 injections were performed with 480 025 injections of bevacizumab (58%) and 336 898 injections of ranibizumab (41%). National rates of injections per 100 000 fee-for-service Part B Medicare beneficiaries for bevacizumab and ranibizumab were 1506 and 1057, respectively. Total payments by Medicare were $20 290 952 for bevacizumab and $536 642 693 for ranibizumab. In 39 out of 50 states, the rate of injection was higher for bevacizumab compared with ranibizumab. CONCLUSIONS:In 2008, bevacizumab was used at a higher rate than ranibizumab for the treatment of neovascular AMD. Even though bevacizumab accounted for 58% of all injections, Medicare paid $516 million more for ranibizumab than bevacizumab. These data suggest that despite its off-label designation, intravitreal bevacizumab is currently the standard-of-care treatment for neovascular AMD in the United States.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Brechner RJ,Rosenfeld PJ,Babish JD,Caplan Sdoi
10.1016/j.ajo.2010.11.017subject
Has Abstractpub_date
2011-05-01 00:00:00pages
887-895.e1issue
5eissn
0002-9394issn
1879-1891pii
S0002-9394(10)00944-Xjournal_volume
151pub_type
杂志文章abstract:PURPOSE:To describe the ultrasound features seen in orbital hydatid disease, which may confirm the diagnosis preoperatively. DESIGN:Interventional case series. METHODS:Nine patients of orbital hydatid cyst were evaluated preoperatively with ultrasound and computed tomography scans. The diagnostic features seen on ult...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(02)02083-4
更新日期:2003-04-01 00:00:00
abstract::Fluorescein angiography was safely performed in 100 consecutive cases of cataract extraction during the first postoperative week. Seventy-five percent of the 100 eyes had good quality fluorescein angiograms. Four eyes demonstrated cystoid macular edema. Therefore, the incidence of cystoid macular edema in the first we...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(76)90126-4
更新日期:1976-05-01 00:00:00
abstract:PURPOSE:To test the hypothesis that neovascular age-related macular degeneration is related to oxidative stress involving the macular retinal pigment epithelium. This study investigated, as a function of age, levels of enzymes that defend tissues against oxidative stress in the macular retinal pigment epithelium of hum...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(99)00032-x
更新日期:1999-06-01 00:00:00
abstract:PURPOSE:To report unusual fundus findings in two cases of melanoma-associated retinopathy. METHODS:Observational case reports. The histories of two patients with melanoma-associated retinopathy were reviewed. Sera from both patients were examined for antibodies against retinal bipolar cells. Immunofluorescence was per...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(01)00915-1
更新日期:2001-08-01 00:00:00
abstract:PURPOSE:To analyze the features of retinal detachment (RD) occurring after cataract surgery performed by Kelman phacoemulsification (KPE) and to identify any potential correlations between KPE intraoperative complications and the features of RD (incidence apart) as well as the final visual outcome. DESIGN:Intervention...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(02)01347-8
更新日期:2002-05-01 00:00:00
abstract:PURPOSE:Periventricular leukomalacia (PVL) is a structural loss of white matter pathways that carry visual information from the lateral geniculate bodies to the visual cortex. It is observed radiologically in patients with a history of prematurity and is associated with visual field (VF) defects and optic disc cupping....
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2019.10.016
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:To develop patient-derived Pediatric Eye Questionnaires (PedEyeQ) to separately assess eye-related quality of life (ER-QOL) and functional vision in children with eye conditions. DESIGN:Questionnaire development study. METHODS:A total of 444 children (0 to <18 years old), across 10 diagnostic categories, were...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ajo.2019.01.001
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:To determine if a 1-day, 1-eye trial of latanoprost 0.005% was predictive of the 1-month intraocular pressure response in patients with uncontrolled open-angle glaucoma on maximally tolerated medical therapy without latanoprost. METHODS:One eye of 39 consecutive patients was enrolled in prospective trial of la...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0002-9394(01)01253-3
更新日期:2001-12-01 00:00:00
abstract::Ten patients with Stargardt's disease and 14 with fundus flavimaculatus underwent thorough ophthalmic examinations, retinal photography, and, when possible, fluorescein angiography. Retinal function was also assessed by static and kinetic perimetry, the Farnsworth-Munsell 100-hue test, electro-oculography, and electro...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(83)90455-5
更新日期:1983-07-01 00:00:00
abstract::A countrywide prevalence survey of 9,508 children was conducted in El Salvador to determine the prevalence of anterior-segment abnormalities and magnitude of clinical vitamin A deficiency. Thirty-six children had corneal opacities, 56% of them secondary to trauma. Such traumatic corneal opacities were 19 times more fr...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(75)90337-2
更新日期:1975-12-01 00:00:00
abstract::Fine-needle aspiration was used as a primary orbital diagnostic technique in 156 patients. A 20-mm syringe, a 22-gauge, 3.75-cm needle, and a plastic pistol grip were used. Local anesthetic was not necessary. When the needle is in the lesion, small to-and-fro movements with a minimum of angulation are helpful. The asp...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)77955-3
更新日期:1985-05-15 00:00:00
abstract:PURPOSE:To assess the role of hypoxia in causing the death and deconstruction of photoreceptors in detached retinas and the effectiveness of supplemental oxygen in limiting such damage. METHODS:Retinal detachment was induced surgically in the right eye of each of 10 cats. The cats were allowed to survive surgery for 3...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(99)00104-x
更新日期:1999-08-01 00:00:00
abstract:PURPOSE:To characterize spontaneous dislocation of the fluocinolone acetonide sustained release implant (Retisert; Bausch & Lomb) drug pellet from its strut. DESIGN:Retrospective, observational case series. METHODS:The medical records of 224 patients in whom 407 fluocinolone acetonide implants were placed by either o...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ajo.2015.01.031
更新日期:2015-05-01 00:00:00
abstract::A patient sustained mild bilateral alkali burns of the cornea following ocular exposure to a commercial hair straightening preparation. This compound and three other products all had an alkaline pH which was not reduced to neutrality by the neutralizer provided. Corneal alkali burns similar to those seen in our patien...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(75)90799-0
更新日期:1975-04-01 00:00:00
abstract:PURPOSE:To evaluate high-order aberrations (HOA) induced by the anterior corneal surface after deep lamellar endothelial keratoplasty (DLEK) and penetrating keratoplasty (PK). DESIGN:Prospective, randomized clinical trial. METHODS:Twenty-eight eyes of 25 patients with corneal edema resulting from Fuchs dystrophy unde...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ajo.2008.12.039
更新日期:2009-06-01 00:00:00
abstract::Retinoic acid 0.1% in arachis oil was applied to one eye and arachis oil alone to the other eye, of each of 19 patients with equivalent degrees of corneal xerophthalmia in the fellow eyes. Even with concomitant systemic vitamin A therapy, topical retinoic acid was associated with more rapid healing of corneal lesions ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)78304-7
更新日期:1983-03-01 00:00:00
abstract::We implanted nine intraocular lenses for the aphakic correction of congenital monocular cataracts in eight children (eight eyes). During follow-up periods ranging from 18 to 50 months in six children, there were no major complications connected to the surgery. Parental cooperation with treatment for amblyopia was sati...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)77820-1
更新日期:1983-09-01 00:00:00
abstract::A 56-year-old woman presented with the typical findings of cicatricial pemphigoid: vesicular lesions of the mucous membranes and skin. Ocular involvement included symblepharon and dryness. A regimen of 80 mg of oral trimcinolone per day healed the lesions of the skin and mucous membrane. The patient received three inj...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(75)90081-1
更新日期:1975-02-01 00:00:00
abstract::We examined more than 300 children as outpatients with orally administered chloral hydrate sedation during the past three years; 175 of them have been examined in the last year. Without chloral hydrate sedation, examination under anesthesia would have been necessary or the results would have been less than satisfactor...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(80)90066-5
更新日期:1980-04-01 00:00:00
abstract::A simple makeshift retinoscopy rack consists of various trial lenses placed into the slots of a nonfrosted, 35-mm slide viewing sheet. It is useful in determining the patient's refractive error at the bedside and in the operating room. ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(80)90242-1
更新日期:1980-01-01 00:00:00
abstract:PURPOSE:To describe the clinical presentation and course of Whipple disease in an adult. METHODS:A 34-year-old man with phthisis bulbi in the right eye secondary to uveitis-induced neovascular glaucoma presented with severe acute posterior uveitis in the left eye. He underwent esophagogastroduodenoscopy and jejunal bi...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(98)00084-1
更新日期:1998-07-01 00:00:00
abstract:PURPOSE:To review the progress and challenges in obtaining accurate corneal power measurements for intraocular lens (IOL) calculations. DESIGN:Personal perspective, review of literature, case presentations, and personal data. METHODS:Through literature review findings, case presentations, and data from the author's c...
journal_title:American journal of ophthalmology
pub_type:
doi:10.1016/j.ajo.2016.08.020
更新日期:2016-11-01 00:00:00
abstract:PURPOSE:To present a quantitative analysis of pterygium and ocular sun exposure, a dose-response curve, and a discussion of the health-promotion implications of the findings. METHODS:A hospital-based, case-control study was conducted in Perth, Western Australia. Case subjects had surgical removal of a pterygium; contr...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(99)00161-0
更新日期:1999-09-01 00:00:00
abstract::We reviewed the records of 78 patients who underwent 128 surgical procedures for congenital or infantile cataracts before age 30 months for the type and frequency of postoperative complications. The surgeries included 92 limbal lensectomies and anterior vitrectomies, 13 pars plicata lensectomies, 20 aspirations, and t...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/0002-9394(89)90007-x
更新日期:1989-08-15 00:00:00
abstract::Bleomycin was administered to 126 normal or human-tumor-bearing baby rats we observed for the development of cataracts. Eighty-four percent of the rats receiving this drug before the age of 10 days developed lens opacities. Bleomycin given to 10-day-old rats or older did not induce cataract formation. The cataracts in...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(75)90223-8
更新日期:1975-09-01 00:00:00
abstract::We noted two instances of forceps-induced fragmentation of the bar used for scleral plug storage during vitreous surgery. The silicone bar material was adherent to the plug in both cases. Because this represents a significant intraocular foreign body hazard, the scleral plug should be carefully inspected before insert...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(82)90542-6
更新日期:1982-03-01 00:00:00
abstract:PURPOSE:To investigate the value of whole-body positron emission tomography/computed tomography (PET/CT) as a screening tool for patients with uveal metastasis. DESIGN:Retrospective observational case series. METHODS:setting: Clinical practice. study population: Eighteen patients with uveal metastatic tumors were eva...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2011.09.028
更新日期:2012-04-01 00:00:00
abstract::Eight patients were treated for Pseudomonas endophthalmitis associated with the implantation of contaminated intraocular lenses. All patients showed clinical signs of infection (loss of red reflex, diminished visual acuity, and intraocular lens coagulum) and P. aeruginosa was isolated from vitreous aspirates and unuse...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(79)90569-5
更新日期:1979-11-01 00:00:00
abstract:PURPOSE:To evaluate the effect of vitrectomy timing on outcomes for patients with crystalline retained lens fragments receiving vitrectomy 3+ days after cataract surgery. DESIGN:Systematic review and meta-analysis of retrospective interventional cases series. METHODS:Searches of MEDLINE (English, 1/1/85 through 7/30/...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ajo.2011.02.010
更新日期:2011-09-01 00:00:00
abstract::A survey in Arkansas of 14 cases of ocular injuries caused by the explosion of Class C fireworks showed significant, and possibly permanent, visual loss in five men. The most common injuries, corneal abrasion and hyphema, occurred in nine male patients with no residual ocular damage. ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(75)90621-2
更新日期:1975-03-01 00:00:00