Pharmacotherapy for neovascular age-related macular degeneration: an analysis of the 100% 2008 medicare fee-for-service part B claims file.


PURPOSE:To describe the usage patterns of pharmacological treatments for neovascular age-related macular degeneration (AMD) in Medicare fee-for-service beneficiaries. DESIGN:Retrospective review of all Medicare fee-for-service Part B claims for neovascular AMD during 2008. METHODS:Medicare beneficiaries having undergone treatment were identified. The data collected for each visit for a given beneficiary included age, race, gender, Medicare region, state/zip code of residence, date of visit, whether or not the beneficiary had a treatment, the type and amount of drug, and dollars paid by Medicare. The main outcome measures were the number and rate of treatments, the types of drugs used for treatment, and the payments for these drugs. RESULTS:Of the 222 886 unique beneficiaries, 146 276 (64.4%) received bevacizumab and 80 929 (35.6%) received ranibizumab. A total of 824 525 injections were performed with 480 025 injections of bevacizumab (58%) and 336 898 injections of ranibizumab (41%). National rates of injections per 100 000 fee-for-service Part B Medicare beneficiaries for bevacizumab and ranibizumab were 1506 and 1057, respectively. Total payments by Medicare were $20 290 952 for bevacizumab and $536 642 693 for ranibizumab. In 39 out of 50 states, the rate of injection was higher for bevacizumab compared with ranibizumab. CONCLUSIONS:In 2008, bevacizumab was used at a higher rate than ranibizumab for the treatment of neovascular AMD. Even though bevacizumab accounted for 58% of all injections, Medicare paid $516 million more for ranibizumab than bevacizumab. These data suggest that despite its off-label designation, intravitreal bevacizumab is currently the standard-of-care treatment for neovascular AMD in the United States.


Am J Ophthalmol


Brechner RJ,Rosenfeld PJ,Babish JD,Caplan S




Has Abstract


2011-05-01 00:00:00














  • The effect of collagen shields on epithelial wound healing in rabbits.

    abstract::We evaluated the effect of a collagen shield on epithelial healing in keratectomy wounds in rabbit eyes. Superficial keratectomies 6 mm in diameter were created in 12 eyes of six rabbits. Six eyes received collagen shields every eight hours; six eyes received no treatment (control group). Epithelial healing was signif...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Frantz JM,Dupuy BM,Kaufman HE,Beuerman RW

    更新日期:1989-11-15 00:00:00

  • Testability of vision and refraction in preschoolers: the strabismus, amblyopia, and refractive error study in singaporean children.

    abstract:PURPOSE:To determine the testability of several vision and refraction tests in preschool-aged children. DESIGN:Population-based study of Chinese preschool-aged children in Singapore. METHODS:One thousand five hundred and forty-two Singaporean Chinese children aged 6 to 72 months were recruited through door-to-door sc...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Trager MJ,Dirani M,Fan Q,Gazzard G,Selvaraj P,Chia A,Wong TY,Young TL,Varma R,Saw SM

    更新日期:2009-08-01 00:00:00

  • Intraocular pressure and aqueous humor dynamics in patients with AIDS treated with intravitreal cidofovir (HPMPC) for cytomegalovirus retinitis.

    abstract:PURPOSE:To evaluate the decrease in intraocular pressure associated with cidofovir (1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine dihydrate; HPMPC) intravitreal injections. METHODS:We followed up 97 eyes of 63 patients with acquired immunodeficiency syndrome (AIDS) who had cytomegalovirus retinitis and had been...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Banker AS,Arevalo JF,Munguia D,Rahhal FM,Ishimoto B,Berry C,De Clercq E,Ochabski R,Taskintuna I,Freeman WR

    更新日期:1997-08-01 00:00:00

  • Use of dilute drug solutions for routine cycloplegia and mydriasis.

    abstract::Clinic patients and students were given several regular drops of commercial 10% phenylephrine HCl, and 1.0% cyclopentolate HCl or 1.0% tropicamide HCl. The drops were given three times at five-minute intervals. Mydriasis and cycloplegia were determined and compared with the results obtained by using one of the followi...

    journal_title:American journal of ophthalmology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Brown C,Hanna C

    更新日期:1978-12-01 00:00:00

  • Distribution of central corneal thickness and its association with intraocular pressure: The Rotterdam Study.

    abstract:PURPOSE:To perform a cross-sectional study on the distribution of central corneal thickness and its association with intraocular pressure in an elderly population. METHODS:We measured central corneal thickness and intraocular pressure in 395 subjects (352 control subjects, 13 patients with ocular hypertension, and 30 ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Wolfs RC,Klaver CC,Vingerling JR,Grobbee DE,Hofman A,de Jong PT

    更新日期:1997-06-01 00:00:00

  • Leukemic iris infiltration.

    abstract::A 7-year-old boy with acute lymphocytic leukemia developed iris infiltration, blood-streaked hypopyon, and high intraocular pressure. A diagnostic anterior chamber paracentesis was performed, which provided a cytologic diagnosis. The aspirate was studied by both the millipore filter technique with Papanicolaou stain a...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Zakka KA,Yee RD,Shorr N,Smith GS,Pettit TH,Foos RY

    更新日期:1980-02-01 00:00:00

  • Facial necrotizing fasciitis following acute dacryocystitis.

    abstract:PURPOSE:To report a case of progressive necrotizing fasciitis of the face following acute dacryocystitis. DESIGN:Interventional case report. METHODS:A 60-year-old woman presented with left acute dacryocystitis with abscess formation that had ruptured; a small wound remained. Erythematous swelling of the left eyelid a...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Lin PW,Lin HC

    更新日期:2003-07-01 00:00:00

  • Interstitial nephritis and uveitis syndrome presenting with bilateral optic disk edema.

    abstract:PURPOSE:To report a rare presentation of the tubulointerstitial nephritis and uveitis syndrome. METHOD:Case report. A 34-year-old woman underwent extensive clinical and laboratory evaluation of bilateral intermediate uveitis and optic nerve edema. RESULTS:Laboratory evaluation and nephrology consultation led to a dia...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Sherman MD,Own KH

    更新日期:1999-05-01 00:00:00

  • Improvement of retinal function in early age-related macular degeneration after lutein and zeaxanthin supplementation: a randomized, double-masked, placebo-controlled trial.

    abstract:PURPOSE:To examine the effects of lutein and zeaxanthin supplementation on retinal function using multifocal electroretinograms (mfERG) in patients with early age-related macular degeneration (AMD). DESIGN:Randomized, double-masked, placebo-controlled trial. METHODS:One hundred eight subjects with early AMD were rand...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章,随机对照试验


    authors: Ma L,Dou HL,Huang YM,Lu XR,Xu XR,Qian F,Zou ZY,Pang HL,Dong PC,Xiao X,Wang X,Sun TT,Lin XM

    更新日期:2012-10-01 00:00:00

  • Bilateral choroidal osteomas associated with fatal systemic illness.

    abstract::An 11-year-old black boy complained of intermittent occipital headaches with nausea and projectile vomiting. Previous skin and lung biopsy specimens were interpreted as histiocytosis X. Cranial computed tomographic scanning disclosed a mass lesion in the region of the choroid plexus of the left lateral ventricle. This...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Kline LB,Skalka HW,Davidson JD,Wilmes FJ

    更新日期:1982-02-01 00:00:00

  • Extent of Internal Limiting Membrane Peeling and its Impact on Macular Hole Surgery Outcomes: A Randomized Trial.

    abstract:PURPOSE:To identify whether and how outcomes of macular hole (MH) surgery are influenced by the extent of internal limiting membrane (ILM) peeling. DESIGN:Randomized clinical trial. METHODS:This study involved 65 eyes from 65 patients who underwent surgery for idiopathic MH. ILM was peeled with a radius of either 0.7...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章,随机对照试验


    authors: Bae K,Kang SW,Kim JH,Kim SJ,Kim JM,Yoon JM

    更新日期:2016-09-01 00:00:00

  • Electronic Health Records in Ophthalmology: Source and Method of Documentation.

    abstract:PURPOSE:This study analyzed and quantified the sources of electronic health record (EHR) text documentation in ophthalmology progress notes. DESIGN:EHR documentation review and analysis. METHODS:Setting: a single academic ophthalmology department. STUDY POPULATION:a cohort study conducted between November 1, 2016, a...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Henriksen BS,Goldstein IH,Rule A,Huang AE,Dusek H,Igelman A,Chiang MF,Hribar MR

    更新日期:2020-03-01 00:00:00

  • Astigmatic Vector Analysis of Posterior Corneal Surface: A Comparison Among Healthy, Forme Fruste, and Overt Keratoconic Corneas.

    abstract:PURPOSE:To determine novel diagnostic parameters for keratoconus, and to assess the correlation between anterior and posterior corneal surfaces based on vectorial astigmatism analyses. DESIGN:Retrospective case-control study. METHODS:Six hundred and ninety-eight eyes of 698 patients were enrolled in the study. Health...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Freitas Gde O,Ambrósio R Jr,Ramos I,Lopes B,Valbon Bde F,Botteon C,Alve MR

    更新日期:2016-07-01 00:00:00

  • A Randomized Controlled Trial Comparing Subconjunctival Injection to Direct Scleral Application of Mitomycin C in Trabeculectomy.

    abstract:PURPOSE:To compare the efficacy of intraoperative scleral application with subconjunctival injection of mitomycin C (MMC) in trabeculectomy. DESIGN:Prospective, randomized, interventional study. METHODS:This study took place in a single clinical practice in an academic setting. Patients had medically uncontrolled gla...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章,随机对照试验


    authors: Do JL,Xu BY,Wong B,Camp A,Ngai P,Long C,Proudfoot J,Moghimi S,Yan D,Welsbie DS,Weinreb RN

    更新日期:2020-12-01 00:00:00

  • Autosomal recessive pericentral pigmentary retinopathy.

    abstract::A brother and sister, born to consanguineous parents, had pigmentary retinopathy in a pericentral distribution. The retinopathy was noted in infancy when the siblings were examined for strabismus. The optic disks, maculae, and retinal vessels were normal. There was mild reduction in amplitude of both scotopic and phot...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Traboulsi EI,O'Neill JF,Maumenee IH

    更新日期:1988-11-15 00:00:00

  • Comparative study of two sets of criteria for the diagnosis of Vogt-Koyanagi-Harada's disease.

    abstract:PURPOSE:The Vogt-Koyanagi-Harada's (VKH) Disease Committee established the "Revised diagnostic criteria for VKH disease" in 2001. The purpose of the present study was to assess the concordance between these criteria and the traditional Sugiura's diagnosis system. DESIGN:Observational case series. METHODS:The medical ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Kitamura M,Takami K,Kitaichi N,Namba K,Kitamei H,Kotake S,Ohno S

    更新日期:2005-06-01 00:00:00

  • Bacterial contamination of eyedrop dispensers.

    abstract::We undertook an in vitro investigation of the role of the design of the eyedrop dispenser in bacterial contamination. The nozzle tips of pipette and squeeze bottles containing Fluress (pH 5.0) were inoculated with 10 microliter of an ocular isolate of Pseudomonas aeruginosa (5.5 X 10(5) bacteria/ml). Cultures of singl...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Coad CT,Osato MS,Wilhelmus KR

    更新日期:1984-11-01 00:00:00

  • The changing scene of intraocular implant lens surgery.

    abstract::A review of lens implant surgery using different implant styles and both methods of cataract extraction revealed that there is little difference in the final visual acuity regardless of which implant or cataract technique is used. There appears to be a higher rate of cystoid macular edema with the intracapsular techni...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Jaffe NS

    更新日期:1979-11-01 00:00:00

  • The effect of long-term medical therapy on the outcome of filtration surgery.

    abstract::Long-term medical therapy and laser trabeculoplasty have been implicated as risk factors in the outcome of glaucoma filtration surgery. A retrospective analysis was performed of patients undergoing primary trabeculectomy during three key periods: before use of beta-blockers and laser trabeculoplasty (1975 and 1976), a...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Johnson DH,Yoshikawa K,Brubaker RF,Hodge DO

    更新日期:1994-02-15 00:00:00

  • Effect of anti-cytomegalovirus therapy on the incidence of immune recovery uveitis in AIDS patients with healed cytomegalovirus retinitis.

    abstract:PURPOSE:To determine the association between anticytomegalovirus (CMV) maintenance therapy after immune recovery and immune recovery uveitis in acquired immunodeficiency syndrome (AIDS) patients on highly active antiretroviral therapy (HAART). DESIGN:Observational cohort study. METHODS:Data were obtained on AIDS pati...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Song MK,Azen SP,Buley A,Torriani F,Cheng L,Chaidhawangul S,Ozerdem U,Scholz B,Freeman WR

    更新日期:2003-10-01 00:00:00

  • Pulfrich stereo-illusion phenomenon in serous sensory retinal detachment of the macula.

    abstract::Four patients (three men, 68, 35, and 33 years old, and one woman, 46 years old) had central serous elevation of the macula with abnormal latency of the visual-evoked potential and spontaneous Pulfrich phenomenon. In three instances both the electrophysiologic test and the clinical Pulfrich test reverted to normal on ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Hofeldt AJ,Leavitt J,Behrens MM

    更新日期:1985-10-15 00:00:00

  • Spontaneous retrobulbar hemorrhage in type IV Ehlers-Danlos syndrome.

    abstract:PURPOSE:To describe a case of spontaneous retrobulbar hemorrhage in type IV Ehlers-Danlos syndrome, a disorder characterized by vascular fragility and associated severe bleeding problems. METHODS:Observational case report. Spontaneous unilateral retrobulbar hemorrhage in a 22-year-old man with type IV Ehlers-Danlos sy...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Shaikh S,Braun M,Eliason J

    更新日期:2002-03-01 00:00:00

  • Prolonged complementary chromatopsia in users of video display terminals.

    abstract::Induced prolonged complementary chromatopsia in four subjects (two men, 26 and 34 years old, and two women, 34 and 45 years old) was documented by abnormal responses to pseudoisochromatic color plates 30 minutes after cessation of monochrome video display terminal use. This phenomenon was unrelated to preexisting colo...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Khan JA,Fitz J,Psaltis P,Ide CH

    更新日期:1984-12-15 00:00:00

  • Acquired pit of the optic nerve: a risk factor for progression of glaucoma.

    abstract:PURPOSE:To examine acquired pit of the optic nerve as a risk factor for progression of glaucoma. METHODS:In a retrospective longitudinal study, 25 open-angle glaucoma patients with acquired pit of the optic nerve were compared with a group of 24 open-angle glaucoma patients without acquired pit of the optic nerve. The...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Ugurlu S,Weitzman M,Nduaguba C,Caprioli J

    更新日期:1998-04-01 00:00:00

  • Visual results in aphakic children.

    abstract::Sixty-five patients less than 10 years of age had cataract surgery on 99 eyes. The visual prognosis depended on the cataract type and whether the treatment was undertaken during the critical period for development of the fixation reflex. All patients received the same surgical technique, aggressive optical correction,...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Parks MM

    更新日期:1982-10-01 00:00:00

  • Boston Type I Keratoprosthesis: Antibacterial Resistance and Microbiota Evaluation of Soft Contact Lenses.

    abstract:PURPOSE:To evaluate microbiota colonizing soft contact lenses (CL) in eyes with Boston type I keratoprosthesis (BKPro), and determine the prevalence of resistance to fourth-generation fluoroquinolone (FQ). DESIGN:Prospective, observational study. SUBJECTS:Patients with BKPro using CL as routine who were in postoperat...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Torres-Netto EA,Silva LD,Bordon Riveros MA,Santos A,Sousa LB,Oliveira LA

    更新日期:2018-08-01 00:00:00

  • Indocyanine green selectively stains the internal limiting membrane.

    abstract:PURPOSE:To demonstrate whether indocyanine green stains the inner limiting membrane of the retina or residual vitreous cortex. METHODS:We report on the intraoperative staining patterns of the vitreomacular interface in 10 eyes of 10 consecutive patients who underwent vitrectomy with indocyanine green staining for macu...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Gandorfer A,Messmer EM,Ulbig MW,Kampik A

    更新日期:2001-03-01 00:00:00

  • Iris color and intraocular pressure: the Blue Mountains Eye Study.

    abstract:PURPOSE:To assess the relationship between iris color and intraocular pressure (IOP). DESIGN:Population-based, cross-sectional study. METHODS:The Blue Mountains Eye Study examined 3,654 largely Caucasian participants, aged 49 to 97 years, from 1992 to 1994. Information was collected about glaucoma risk factors, and G...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Mitchell R,Rochtchina E,Lee A,Wang JJ,Mitchell P,Blue Mountains Eye Study.

    更新日期:2003-03-01 00:00:00

  • Management paradigms for diabetic macular edema.

    abstract:PURPOSE:To provide evidence-based recommendations for diabetic macular edema (DME) management based on updated information from publications on DME treatment modalities. DESIGN:Perspective. METHODS:A literature search for "diabetic macular edema" or "diabetic maculopathy" was performed using the PubMed, Cochrane Libr...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章,实务指引


    authors: Mitchell P,Wong TY,Diabetic Macular Edema Treatment Guideline Working Group.

    更新日期:2014-03-01 00:00:00

  • Transplantation of congenitally opaque corneas from eyes with exaggerated buphthalmos.

    abstract::We treated three eyes with marked buphthalmos and congenitally opaque corneas with cyclocryotherapy, one application in one eye and two applications in two eyes. The size of the eyes became rapidly smaller during the first two weeks postoperatively. Thereafter, corneal transplantation improved vision in each eye. ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Frucht-Pery J,Feldman ST,Brown SI

    更新日期:1989-06-15 00:00:00