Abstract：
PURPOSE:To evaluate reported ocular side effects associated with isotretinoin usage. METHODS:One thousand seven hundred forty-one case reports received from spontaneous reporting systems, data from the Drug Safety Section of Roche Pharmaceuticals, and the world's literature were evaluated using the World Health Organization Causality Assessment Guide of Suspected Adverse Reactions. RESULTS:Thirty-eight different signs or symptoms of ocular abnormalities associated with isotretinoin usage have been classified as "certain," "probable/likely," "possible," "unlikely," or "conditional/unclassifiable." CONCLUSION:Adverse ocular side effects secondary to isotretinoin that are "certain" include abnormal meibomian gland secretion, blepharoconjunctivitis, corneal opacities, decreased dark adaptation, decreased tolerance to contact lens, decreased vision, increased tear osmolarity, keratitis, meibomian gland atrophy, myopia, ocular discomfort, ocular sicca, photophobia, and teratogenic ocular abnormalities. Those that are "probable/likely" are decreased color vision (reversible) and permanent loss of dark adaptation. Those that have a "possible" association include permanent keratoconjunctivitis sicca. Suggested guidelines for ocular examination for patients on isotretinoin are given.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Fraunfelder FT,Fraunfelder FW,Edwards Rdoi
10.1016/s0002-9394(01)01024-8subject
Has Abstractpub_date
2001-09-01 00:00:00pages
299-305issue
3eissn
0002-9394issn
1879-1891pii
S0002939401010248journal_volume
132pub_type
杂志文章abstract：:A 14-year-old boy was stabbed above the left eye and had subsequent loss of both retinal and choroidal perfusion to the posterior segment. Ophthalmoscopic examination ten days after the injury disclosed intense nerve fiber layer edema, most prominent in the posterior pole, and absence of a cherry-red spot. Intravenous...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1979-10-01 00:00:00
abstract：:Topical ketoconazole (2% ointment three times per day for three weeks) markedly reduced the severity of keratitis produced with Candida albicans inoculation in the right eyes of 20 rabbits. Clinical scores of affected eyes were significantly lower in the treated eyes than in the controls, which consisted of the 20 ino...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90499-2
更新日期：1976-09-01 00:00:00
abstract：PURPOSE:To evaluate the role of diffusion-weighted magnetic resonance imaging (DWIMRI) in the diagnosis and management of children with suspected or confirmed Shaken Baby Syndrome (SBS). METHODS:This was a retrospective interventional case series of all infants and children younger than 2 years of age admitted to a ch...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(01)01366-6
更新日期：2002-02-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2002-12-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2017-02-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00610-3
更新日期：2000-12-01 00:00:00
abstract：PURPOSE:To report molluscum contagiosum as the initial manifestation in acquired immunodeficiency syndrome (AIDS). METHOD:Case report. A 34-year-old man was examined with atypical, extensive molluscum contagiosum of the eyelids. RESULTS:Biopsy of the lesions confirmed molluscum contagiosum, and a previously normal fu...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2013.12.014
更新日期：2014-03-01 00:00:00
abstract：:The transmission characteristics of a new filter combination for fluorescein angiography were selected on the basis of in vivo measurements of the excitation and emission spectra of fluorescein dye during its transit in the fundus. This combination of filters was characterized by separation of 530 nm between the spect...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90542-0
更新日期：1976-10-01 00:00:00
abstract：PURPOSE:To describe a case of severe dry eye syndrome in a child. METHODS:Observational case report. The authors describe a 10-year-old male with severe dry eyes who was profoundly disabled by pain and photophobia despite aggressive conventional therapy. Lacrimal gland histology was consistent with the primary Sjögren...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(01)01182-5
更新日期：2001-12-01 00:00:00
abstract：:Two homosexual men, 35 and 42 years old, had bilateral acute angle-closure glaucoma in association with the acquired immune deficiency syndrome. In one patient, the angle-closure attack was the initial manifestation of AIDS. Choroidal effusion with secondary anterior rotation of the ciliary body at the scleral spur ap...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(86)90639-2
更新日期：1986-04-15 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.04.025
更新日期：2004-10-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71242-5
更新日期：1995-04-01 00:00:00
abstract：PURPOSE:To analyze the biological stability of autologous serum eyedrops after lyophilization. DESIGN:Prospective, comparative experimental study. METHODS:This was a comparative study with serum obtained from 12 healthy volunteers. The concentrations of different epitheliotropic factors (eg, transforming growth facto...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.01.027
更新日期：2020-05-01 00:00:00
abstract：:In this prospective evaluation of the reliability and efficiency of an optimized visual field screening protocol for glaucoma, we tested 145 eyes (73 patients) with increased intraocular pressures to determine the location of early glaucomatous visual field defects. The field examination, which was used as a control, ...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：
更新日期：1981-10-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00485-9
更新日期：2003-11-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90605-4
更新日期：1975-03-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2012.08.007
更新日期：2013-02-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/0002-9394(75)90740-0
更新日期：1975-05-01 00:00:00
abstract：PURPOSE:This study is a systematic exploration of why some patients with glaucoma continue to lose visual field long after therapeutic normalization of their increased intraocular pressures. METHODS:Three cases of glaucoma are described that had increased intraocular pressures and good initial visual fields. RESULTS:...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75421-2
更新日期：1996-05-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ajo.2012.04.014
更新日期：2012-10-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.12.006
更新日期：2007-04-01 00:00:00
abstract：PURPOSE:To describe the pre-exudative stage of exudative perifoveal vascular anomalous complex (ePVAC), referred to as nonexudative PVAC (nePVAC). DESIGN:Retrospective noncomparative case series. METHODS:Patients diagnosed with nePVAC were identified at 4 retina referral centers worldwide. Multimodal retinal imaging,...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ajo.2020.04.025
更新日期：2020-10-01 00:00:00
abstract：PURPOSE:To report intraocular oxygen tension in eyes of diabetic and nondiabetic patients. DESIGN:A prospective, interventional consecutive case series. METHODS:Oxygen was measured with an optical oxygen sensor in patients who were undergoing vitrectomy. Before turning on the infusion fluid, intraocular oxygen tensio...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.01.016
更新日期：2006-06-01 00:00:00
abstract：:Six patients (all male, five homosexual and one bisexual, 23 to 48 years old) with the acquired immune deficiency syndrome (AIDS) who had cytomegalovirus retinitis were treated with a new antiviral drug as a part of a prospective open-labeled trial for serious cytomegalovirus infections. The drug, 9-[2-hydroxy-1-(hydr...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(86)90638-0
更新日期：1986-04-15 00:00:00
abstract：PURPOSE:To determine the safety and efficacy of verteporfin photodynamic therapy (PDT) for the treatment of persistent choroidal neovascularization (CNV) previously treated with external beam radiotherapy (EBRT). DESIGN:Retrospective case series. METHODS:Verteporfin PDT was performed on 14 eyes of 13 patients with sy...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.09.019
更新日期：2005-03-01 00:00:00
abstract：:We evaluated carbonic anhydrase inhibitors in a crossover study with a placebo and random allocation of treatment administration. Drugs evaluated included acetazolamide tablets and Sequels, dichlorphenamide, ethoxzolamide, methazolamide, and an ascorbic acid placebo. The best tolerated drug was acetazolamide Sequels. ...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0002-9394(14)75247-x
更新日期：1978-04-01 00:00:00
