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Corneal toxicity with systemic cytarabine.

Abstract：

:Three patients with leukemia developed corneal toxicity while receiving high doses (3 g/m2) of systemic cytarabine. Symptoms began five to seven days after initiation of treatment with high doses of systemic cytarabine and consisted of ocular pain, tearing, foreign-body sensation, photophobia, and blurred vision. All three patients developed bilateral conjunctival hyperemia and fine corneal epithelial opacities and refractile microcysts that were more numerous in the central than in the peripheral cornea. The symptoms disappeared without treatment in approximately one week. The corneal changes we observed with high doses of systemic cytarabine resembled descriptions of corneal toxicity from topical cytarabine and were probably secondary to inhibition of DNA synthesis in the corneal epithelium.

journal_name

Am J Ophthalmol

journal_title

American journal of ophthalmology

authors

Hopen G,Mondino BJ,Johnson BL,Chervenick PA

doi

10.1016/0002-9394(81)90240-3

subject

Has Abstract

pub_date

1981-04-01 00:00:00

pages

500-4

issue

4

eissn

0002-9394

issn

1879-1891

pii

0002-9394(81)90240-3

journal_volume

91

pub_type

杂志文章

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