Abstract:
:The aim of the present study was to investigate the antihyperglycemic and protective potential of crocin, a pharmacologically active constituent of Crocus sativus L., in streptozotocin-induced diabetic rats. Rats were administered crocin intraperitoneally at doses of 15, 30, and 60 mg/kg of body weight for 6 weeks. The levels of thiobarbituric acid reactive substance (TBARS) and total thiol (SH) groups were measured in the liver and kidney at the end of 6 weeks. Under our experimental conditions, crocin at a dose of 60 mg/kg was found to significantly reduce the blood glucose level in diabetic animals. In addition, there was a significant increase in TBARS levels and decreased total thiol concentrations in the liver and kidney of diabetic animals. Crocin, at doses of 30 and 60 mg/kg, appears to exert an antioxidative activity demonstrated by a lowering of lipid peroxidation levels in these organs. In conclusion, our findings suggest that crocin has the hypoglycemic and antioxidative properties in streptozotocin-induced diabetes and it may be useful in the management of diabetic patients.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Rajaei Z,Hadjzadeh MA,Nemati H,Hosseini M,Ahmadi M,Shafiee Sdoi
10.1089/jmf.2012.2407subject
Has Abstractpub_date
2013-03-01 00:00:00pages
206-10issue
3eissn
1096-620Xissn
1557-7600journal_volume
16pub_type
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