Turnera subulata Anti-Inflammatory Properties in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages.

Abstract:

:In South America, particularly in the Northeastern regions of Brazil, Turnera subulata leaf extract is used as an alternative traditional medicine approach for several types of chronic diseases, such as diabetes, hypertension, chronic pain, and general inflammation. Despite its widespread use, little is known about the medicinal properties of the plants of this genus. In this study, we evaluate the antioxidant and anti-inflammatory of T. subulata leaf extract in an in vitro model of inflammation, using lipopolysaccharide-stimulated RAW-264.7 macrophage cell line. We observed that cotreatment with T. subulata leaf extract was able to reduce the oxidative stress in cells due to inflammatory response. More importantly, we observed that the leaf extract was able to directly modulate inflammatory response by altering activity of members of the mitogen-activated protein kinase pathways. Our results demonstrate for the first time that T. subulata have antioxidant and anti-inflammatory properties, which warrant further investigation of the medicinal potential of this species.

journal_name

J Med Food

authors

Souza NC,de Oliveira JM,Morrone MDS,Albanus RD,Amarante MDSM,Camillo CDS,Langassner SMZ,Gelain DP,Moreira JCF,Dalmolin RJS,de Bittencourt Pasquali MA

doi

10.1089/jmf.2016.0047

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

922-930

issue

10

eissn

1096-620X

issn

1557-7600

journal_volume

19

pub_type

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