Antioxidant effect of Hemidesmus indicus on ethanol-induced hepatotoxicity in rats.

Abstract:

:The antioxidant effect of the ethanolic root extract of Hemidesmus indicus, an indigenous Ayurvedic medicinal plant used in soft drinks in India, was studied in rats with ethanol-induced hepatotoxicity. Administering 20% ethanol (5 g/kg of body weight/day) for 60 days to male Wistar rats resulted in significantly decreased body weight and increased liver/body weight ratio. The liver marker enzymes, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatae (ALP), gamma-glutamyl transpeptidase (GGT), and lactate dehydrogenase (LDH), were elevated. In addition, the levels of plasma, erythrocyte, and hepatic thiobarbituric acid-reactive substances (TBARS), hydroperoxides (LOOH), and conjugated dienes (CD) were also elevated in ethanol-fed rats as compared to those of the experimental control rats. Decreased activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin C, and alpha-tocopherol (vitamin E) were also observed in ethanol-administered as compared to control rats. Ethanolic root extract of H. indicus was administered at a dose of 500 mg/kg of body weight/day for the last 30 days of the experiment to rats with ethanol-induced liver injury, which significantly increased body weight, significantly decreased the liver/body weight ratio, AST, ALT, ALP, GGT, and LDH activities, and also the levels of TBARS, LOOH, and CD, significantly elevated the activities of SOD, CAT, GPx, and GSH in plasma, erythrocytes, and liver, and also increased levels of plasma and liver vitamin C and vitamin E at the end of the experimental period as compared to those of untreated ethanol-administered rats. Thus, our data indicate that treatment with H. indicus extract offers protection against free radical-mediated oxidative stress in plasma, erythrocytes, and liver of animals with ethanol-induced liver injury.

journal_name

J Med Food

authors

Saravanan N,Nalini N

doi

10.1089/jmf.2006.110

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

675-82

issue

4

eissn

1096-620X

issn

1557-7600

journal_volume

10

pub_type

杂志文章
  • Glyceollins Modulate Tumor Development and Growth in a Mouse Xenograft Model of Human Colon Cancer in a p53-Dependent Manner.

    abstract::Glyceollins are soybean-derived phytoalexins that induce the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling pathway, which is involved in the detoxification of carcinogens and the removal of reactive oxygen species (ROS). Recent studies, however, have indicated that Nrf2 induction stimulates the developm...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2018.4290

    authors: Jeong G,Oh J,Kim JS

    更新日期:2019-05-01 00:00:00

  • The potential effects of ethyl acetate fraction from Curcuma longa L. on lipolysis in differentiated 3T3-L1 adipocytes.

    abstract::The effects of the turmeric ethyl acetate fraction (TEF) from the methanolic extract from Curcuma longa L. on lipid metabolism and underlying mechanisms of lipolysis were investigated in 3T3-L1 adipocytes. The intracellular lipid droplets were stained with Oil red O dye and quantified. Compared to the control, lipid a...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.1276

    authors: Lee J,Yoon HG,Lee YH,Park J,You Y,Kim K,Jang JY,Yang JW,Jun W

    更新日期:2010-04-01 00:00:00

  • Therapeutic Potential of Bauhinia forficata Link in Dental Biofilm Treatment.

    abstract::The oral cytotoxicity, antimicrobial and anti-demineralizing effects of a tincture from Bauhinia forficata Link tincture (BFLT) were evaluated in vitro and ex vivo. Susceptibility tests (minimum inhibitory and microbicidal concentrations-MIC and time-kill assay-MMC) were performed against planktonic oral microorganism...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2019.0277

    authors: Ferreira-Filho JCC,Marre ATO,de Sá Almeida JS,Lobo LA,Farah A,Romanos MTV,Maia LC,Valença AMG,Fonseca-Gonçalves A

    更新日期:2020-09-01 00:00:00

  • Antioxidant and antimicrobial activity of Cissus quadrangularis L.

    abstract::Extracts of Cissus quadrangularis L. were tested for antioxidant activity by beta-carotene linoleic acid model and also by 1,1-diphenyl-2-picrylhydrazyl model. The ethyl acetate fraction of both fresh and dry stem extracts at a concentration of 100 ppm showed 64.8% antioxidant activity in the beta-carotene linoleic ac...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/109662003322233495

    authors: Chidambara Murthy KN,Vanitha A,Mahadeva Swamy M,Ravishankar GA

    更新日期:2003-07-01 00:00:00

  • Marine collagen peptides prepared from chum salmon (Oncorhynchus keta) skin extend the life span and inhibit spontaneous tumor incidence in Sprague-Dawley Rats.

    abstract::To observe the effects of marine collagen peptides (MCPs) prepared from chum salmon (Oncorhynchus keta) skin on life span and spontaneous tumor incidence, Sprague-Dawley rats were fed diets supplemented with MCP at concentrations of 0%, 2.25%, 4.5%, and 9% (wt/wt) from the age of 4 weeks until natural death. There wer...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.1279

    authors: Liang J,Pei XR,Wang N,Zhang ZF,Wang JB,Li Y

    更新日期:2010-08-01 00:00:00

  • Drinking orange juice increases total antioxidant status and decreases lipid peroxidation in adults.

    abstract::Cardiovascular disease (CVD) is the leading cause of death in the world and is the primary cause of mortality among Americans. One of the many reasons for the pathogenesis of CVD is attributed to eating diets high in saturated fat and refined carbohydrates and low in fruits and vegetables. Epidemiological evidence has...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2013.0034

    authors: Foroudi S,Potter AS,Stamatikos A,Patil BS,Deyhim F

    更新日期:2014-05-01 00:00:00

  • Antioxidant Effects of Bioactive Compounds Isolated from Pressurized Steam-Treated Corni Fructus and Their Protective Effects Against UVB-Irradiated HS68 Cells.

    abstract::This study evaluated the antioxidant and protective effects of bioactive compounds isolated from pressurized steam-treated Corni Fructus (PSC). We had previously tested the protective effects of the furan fraction containing 5-hydroxymethylfurfural (5-HMF), polyphenol fraction containing gallic acid, and iridoid glyco...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2017.4149

    authors: Park HM,Hong JH

    更新日期:2018-11-01 00:00:00

  • Bioactive compounds and antioxidant and antiproliferative activities of Korean white lotus cultivars.

    abstract::In traditional Korean medicine, lotus (Nelumbo nucifera Gaertn) roots have been used as an antidiabetic and an antiproliferative remedy. However, scientific publications on lotus properties are very limited. Therefore, it was decided to investigate the Korean white lotus cultivars in order to find out their bioactivit...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.0018

    authors: Park YS,Towantakavanit K,Kowalska T,Jung ST,Ham KS,Heo BG,Cho JY,Yun JG,Kim HJ,Gorinstein S

    更新日期:2009-10-01 00:00:00

  • Influence of sesame oil on blood glucose, lipid peroxidation, and antioxidant status in streptozotocin diabetic rats.

    abstract::The present study was carried out to assess the influence of sesame oil on blood glucose, lipid peroxidation, and status of antioxidants in normal and streptozotocin (STZ) diabetic rats. Diabetes was induced in adult female albino Wistar rats weighing 180-200 g by administration of STZ (40 mg/kg of body weight) intrap...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2005.8.377

    authors: Ramesh B,Saravanan R,Pugalendi KV

    更新日期:2005-10-01 00:00:00

  • A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia.

    abstract::Ganoderma lucidum has been widely used to treat various diseases, including cancer, diabetes, and neurasthenia in many Asian countries. This randomized, double-blind, placebo-controlled parallel study aimed to investigate the efficacy and safety of a polysaccharide extract of G. lucidum (Ganopoly) in Chinese patients ...

    journal_title:Journal of medicinal food

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1089/jmf.2005.8.53

    authors: Tang W,Gao Y,Chen G,Gao H,Dai X,Ye J,Chan E,Huang M,Zhou S

    更新日期:2005-04-01 00:00:00

  • Aqueous Extract of Humulus japonicus Attenuates Hyperlipidemia and Fatty Liver in Obese Mice.

    abstract::In this study, the effects of Humulus japonicus (HJ) aqueous extract on 3T3-L1 preadipocytes and HepG2 cells (in vitro model) as well as on C57BL/6 mice fed on high-fat diet (HFD) (in vivo model) were evaluated. Mice fed on HFD for 12-weeks were taken the HJ water extract (HJW) at various doses, 50, 150, and 250 mg/kg...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2017.4135

    authors: Chung YH,Bang JS,Kang CM,Goh JW,Lee HS,Hong SM,Kim DS,Park ES,Jung TW,Shin YK,Lee JH,Jeong JH

    更新日期:2018-10-01 00:00:00

  • Oral green tea catechins transiently lower plasma glucose concentrations in female db/db mice.

    abstract::Polyphenols, including green tea catechins, are secondary plant compounds often discussed in the context of health-promoting potential. Evidence for such effects is mainly derived from epidemiological and cell culture studies. The aim of the present study was to investigate antidiabetic, antiadipogenic, and anti-infla...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.0205

    authors: Wein S,Schrader E,Rimbach G,Wolffram S

    更新日期:2013-04-01 00:00:00

  • Effect of a Western-style diet fortified with increased calcium and vitamin D on mammary gland of C57BL/6 mice.

    abstract::We previously reported hyperproliferation and hyperplasia in C57Bl/6 mouse mammary gland after feeding a Western-style diet (WD); these findings decreased after supplementing WD with increased calcium and vitamin D(3). We now again fortified WD with increased calcium and vitamin D(3) from two sources: (1) a food sourc...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2007.619

    authors: Kurihara N,Fan K,Thaler HT,Yang K,Lipkin M

    更新日期:2008-06-01 00:00:00

  • Protein supplementation increases postexercise plasma myostatin concentration after 8 weeks of resistance training in young physically active subjects.

    abstract::Myostatin (MSTN) is a negative regulator of muscle growth even if some studies have shown a counterintuitive positive correlation between MSTN and muscle mass (MM). Our aim was to investigate the influence of 2 months of resistance training (RT) and diets with different protein contents on plasma MSTN, interleukin 1 b...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jmf.2014.0004

    authors: Paoli A,Pacelli QF,Neri M,Toniolo L,Cancellara P,Canato M,Moro T,Quadrelli M,Morra A,Faggian D,Plebani M,Bianco A,Reggiani C

    更新日期:2015-01-01 00:00:00

  • Antibacterial and antifungal activities of some Mexican medicinal plants.

    abstract::In Mexico about 4,000 plant species have some medicinal use. The aim of this work was to evaluate the antimicrobial activity of six Mexican medicinal plants against fungi and Gram-positive and Gram-negative bacteria. Methanolic extracts were prepared from the Mexican medicinal plants Amphypteringium adstrigens, Castel...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2008.0205

    authors: Ruiz-Bustos E,Velazquez C,Garibay-Escobar A,García Z,Plascencia-Jatomea M,Cortez-Rocha MO,Hernandez-Martínez J,Robles-Zepeda RE

    更新日期:2009-12-01 00:00:00

  • Dietary Biotin Supplementation Impairs Testis Morphology and Sperm Quality.

    abstract::Supplements containing pharmacological concentrations of biotin are commercially available over the counter. Classical toxicity studies have considered biotin administration as harmless; however, recent investigations have shown that biotin supplementation modifies tissue morphology without changes in toxicity markers...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2019.0137

    authors: Pastén-Hidalgo K,Riverón-Negrete L,Sicilia-Argumedo G,Canul-Medina G,Salazar-Anzures T,Tapia-Rodríguez M,Hernández-González EO,Roa-Espitia AL,Cedillo-Peláez C,Fernandez-Mejia C

    更新日期:2020-05-01 00:00:00

  • Garlic allicin as a potential agent for controlling oral pathogens.

    abstract::Garlic has been used medicinally throughout human history. Allicin is considered the most therapeutic constituent of garlic. This study tested the antimicrobial activity of garlic allicin on oral pathogens associated with dental caries and periodontitis. Allicin was found effective against all the tested bacteria. The...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2010.0165

    authors: Bachrach G,Jamil A,Naor R,Tal G,Ludmer Z,Steinberg D

    更新日期:2011-11-01 00:00:00

  • The I148M variant of PNPLA3 reduces the response to docosahexaenoic acid in children with non-alcoholic fatty liver disease.

    abstract::The aim of this secondary analysis of a randomized controlled trial was to test whether the I148M variant of Patatin-like phospholipase domain-containing protein-3 (PNPLA3) is associated with the response to docosahexaenoic acid (DHA) in children with non-alcoholic fatty liver disease (NAFLD). Sixty children with NAFL...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jmf.2013.0043

    authors: Nobili V,Bedogni G,Donati B,Alisi A,Valenti L

    更新日期:2013-10-01 00:00:00

  • Anti-Candida activity of Mentha arvensis and Turnera ulmifolia.

    abstract::Candidiasis is the most frequent infection by opportunistic fungi, frequently caused by Candida albicans, Candida tropicalis, Candida parapsilosis, Candida glabrata, and Candida krusei. Mentha arvensis L. is a herbaceous plant that occurs throughout South America and is used as a tea and in the folk medicine. Turnera ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2011.0128

    authors: Santos KK,Matias EF,Souza CE,Tintino SR,Braga MF,Guedes GM,Nogueira LF,Morais EC,Costa JG,Menezes IR,Coutinho HD

    更新日期:2012-03-01 00:00:00

  • Carica papaya (Paw-Paw) unripe fruit may be beneficial in ulcer.

    abstract::The anti-ulcer potentials of aqueous (AE) and methanol (ME) extracts of whole unripe Carica papaya fruit were evaluated using ethanol- and indomethacin-induced gastric ulcer models in rats. The effect of the extracts on small intestinal propulsion was also investigated. The extracts significantly reduced the ulcer ind...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2008.0197

    authors: Ezike AC,Akah PA,Okoli CO,Ezeuchenne NA,Ezeugwu S

    更新日期:2009-12-01 00:00:00

  • Phenethyl isothiocyanate inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory responses in mouse skin.

    abstract::Phenethyl isothiocyanate (PITC) is the hydrolysis product of the glucosinolate gluconasturtiin in cruciferous vegetables. This study was conducted to determine whether PITC inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in the mouse ear. Topical application of 5 nmol of TPA to mouse ears mark...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2010.1296

    authors: Lee YM,Cho HJ,Ponnuraj SP,Kim J,Kim JS,Kim SG,Park JH

    更新日期:2011-04-01 00:00:00

  • Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice.

    abstract::Pomegranate seed oil was investigated for possible skin cancer chemopreventive efficacy in mice. In the main experiment, two groups consisting each of 30, 4-5-week-old, female CD(1) mice were used. Both groups had skin cancer initiated with an initial topical exposure of 7,12-dimethylbenzanthracene and with biweekly p...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/10966200360716553

    authors: Hora JJ,Maydew ER,Lansky EP,Dwivedi C

    更新日期:2003-10-01 00:00:00

  • Radical quenching activity, ferric-reducing antioxidant power, and ferrous ion-chelating capacity of 16 Ballota species and their total phenol and flavonoid contents.

    abstract::The ethyl acetate, methanol, and water extracts of 16 Ballota species (Family Lamiaceae)-Ballota acetabulosa, Ballota antalyanse, Ballota cristata, Ballota glandulosissima, Ballota inaequidens, Ballota larendana, Ballota latibracteolata, Ballota macrodonta, Ballota nigra ssp. anatolica, B. nigra ssp. foetida, B. nigra...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.0237

    authors: Erdogan-Orhan I,Sever-Yılmaz B,Altun ML,Saltan G

    更新日期:2010-12-01 00:00:00

  • Curcumin downregulates aquaporin-1 expression in cultured rat choroid plexus cells.

    abstract::Aquaporin-1 (AQP1) is a water channel that is highly expressed on the apical side of the choroid plexus epithelium (CP) and thought to be one of the major pathways for the high water permeability of this structure. Blockade of AQP1 in the CP reduce the production of cerebrospinal fluid (CSF). Downregulation of AQP1 mi...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.0208

    authors: Nabiuni M,Nazari Z,Safaeinejad Z,Delfan B,Miyan JA

    更新日期:2013-06-01 00:00:00

  • Immunomodulatory properties of frondoside A, a major triterpene glycoside from the North Atlantic commercially harvested sea cucumber Cucumaria frondosa.

    abstract::Frondoside A, a major triterpene glycoside from North Atlantic commercially harvested sea cucumber Cucumaria frondosa, possesses strong immunomodulatory properties in subtoxic doses. Frondoside A stimulates lysosomal activity of mouse macrophages in vivo at a maximal effective stimulatory dose of 0.2 microg per mouse ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2007.0530

    authors: Aminin DL,Agafonova IG,Kalinin VI,Silchenko AS,Avilov SA,Stonik VA,Collin PD,Woodward C

    更新日期:2008-09-01 00:00:00

  • Protective effects against H2O2-induced damage by enzymatic hydrolysates of an edible brown seaweed, sea tangle (Laminaria japonica).

    abstract::Enzymatic hydrolysates of Laminaria japonica were evaluated for antioxidative activities using hydroxyl radical scavenging activity and protective effects against H(2)O(2)-induced DNA and cell damage. In addition, activities of antioxidative enzymes, including catalase, glutathione peroxidase, and glutathione S-transf...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2007.0675

    authors: Park PJ,Kim EK,Lee SJ,Park SY,Kang DS,Jung BM,Kim KS,Je JY,Ahn CB

    更新日期:2009-02-01 00:00:00

  • Dietary conjugated linoleic acid increases endurance capacity of mice during treadmill exercise.

    abstract::This study was designed to evaluate the effect of dietary conjugated linoleic acid (CLA) on endurance exercise and availability of metabolic substrates in mice. Four-week-old male BALB/c mice were randomized to a control group (normal diet) and a CLA group (normal diet + 1% CLA). Each animal group received its respect...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.1358

    authors: Kim JH,Park HG,Pan JH,Kim SH,Yoon HG,Bae GS,Lee H,Eom SH,Kim YJ

    更新日期:2010-10-01 00:00:00

  • Apple pomace, a by-product from the asturian cider industry, inhibits herpes simplex virus types 1 and 2 in vitro replication: study of its mechanisms of action.

    abstract::The anti-herpes simplex virus type 1 and anti-herpes simplex virus type 2 effects of apple pomace, a by-product from the cider-processing industry, were investigated. The mechanisms of antiviral action were assessed using a battery of experiments targeting sequential steps in the viral replication cycle. The anti-herp...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2011.0308

    authors: Alvarez AL,Melón S,Dalton KP,Nicieza I,Roque A,Suárez B,Parra F

    更新日期:2012-06-01 00:00:00

  • Effect of Daily Consumption of Orange Juice on the Levels of Blood Glucose, Lipids, and Gut Microbiota Metabolites: Controlled Clinical Trials.

    abstract::Ingestion of bioactive compounds, such as hesperidin and naringin, found in citrus fruits and orange juice, can improve the homeostasis of gut microbiota. A controlled clinical study with temporal series intergroup design with 10 apparently healthy women (28.5 ± 8.4 years, 24.1 ± 3.3 kg/m2) were evaluated after contin...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2018.0080

    authors: Lima ACD,Cecatti C,Fidélix MP,Adorno MAT,Sakamoto IK,Cesar TB,Sivieri K

    更新日期:2019-02-01 00:00:00

  • Effects of different processing methods on induction of quinone reductase by dietary broccoli in rats.

    abstract::Broccoli belongs to a group of cruciferous vegetables characterized by its content of glucosinolates, secondary metabolites that, upon hydrolysis, release bioactive isothiocyanates (ITCs). Sulforaphane, the major ITC from broccoli, is believed to protect the body from cancer by induction of detoxification enzymes such...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/109662004322984770

    authors: Hwang ES,Jeffery EH

    更新日期:2004-04-01 00:00:00