Abstract:
:The anti-ulcer potentials of aqueous (AE) and methanol (ME) extracts of whole unripe Carica papaya fruit were evaluated using ethanol- and indomethacin-induced gastric ulcer models in rats. The effect of the extracts on small intestinal propulsion was also investigated. The extracts significantly reduced the ulcer index in both experimental models (P < .05) compared to the control group. ME showed a better protection against indomethacin-induced ulcers, whereas AE was more effective against ethanol-induced gastric ulcers. The extracts also significantly (P < .05) inhibited intestinal motility, with ME showing greater activity. Oral administration of AE and ME up to 5,000 mg/kg did not produce lethality or signs of acute toxicity in mice after 24 hours. The extracts of unripe C. papaya contain terpenoids, alkaloids, flavonoids, carbohydrates, glycosides, saponins, and steroids. The cytoprotective and antimotility properties of the extracts may account for the anti-ulcer property of the unripe fruit.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Ezike AC,Akah PA,Okoli CO,Ezeuchenne NA,Ezeugwu Sdoi
10.1089/jmf.2008.0197subject
Has Abstractpub_date
2009-12-01 00:00:00pages
1268-73issue
6eissn
1096-620Xissn
1557-7600journal_volume
12pub_type
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