Abstract:
:Rheumatoid arthritis (RA) is an autoimmune and chronic inflammatory disease resulting in joint destruction and disability in the adult population. The etiology of RA is not well understood and presently there is no known cure for this disease. The accumulation and proliferation of fibroblast-like synoviocytes may be involved in cartilage destruction. Both in vitro and in vivo studies support an anti-inflammatory role of dietary polyphenols, the bioactive constituents found in fruits and vegetables. The objective of this study was to investigate the anti-inflammatory role of blueberry polyphenols (BBPs) using rabbit synoviocytes stimulated with tumor necrosis factor alpha (TNFα). Rabbit synoviocytes (HIG-82) were treated with varying doses of BBPs and stimulated with TNFα. Stimulation of rabbit synoviocytes with the proinflammatory cytokine TNFα increased cell proliferation by ∼19% compared with the nonstimulated control. Cell proliferation was significantly decreased in a dose-dependent manner by the treatment with BBPs. Post-TNFα stimulation, cells treated with BBPs resulted in decreases in interleukin 1 beta and nuclear factor kappa B (NFκB) concentration. Reverse transcription-polymerase chain reaction analysis showed that matrix metalloproteinase 3 increased fivefold in the control TNFα-stimulated group, but was decreased by threefold in the blueberry treatment group. These results suggest that downregulation of proinflammatory cytokines and transcription factor NFκB by naturally occurring bioactives such as BBPs may be a potential therapeutic strategy for reducing inflammation associated with RA.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
South S,Lucero J,Vijayagopal P,Juma Sdoi
10.1089/jmf.2019.0046subject
Has Abstractpub_date
2019-10-01 00:00:00pages
1032-1040issue
10eissn
1096-620Xissn
1557-7600journal_volume
22pub_type
杂志文章abstract::Abnormal expression of pro-inflammatory mediators such as cell adhesion molecules and cytokines has been implicated in various inflammatory skin diseases, including atopic dermatitis. In this study, we investigated the anti-inflammatory activity of Aronia melanocarpa concentrate (AC) and its action mechanisms using in...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2015.3624
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
pub_type: 杂志文章,评审
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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doi:10.1089/jmf.2017.3941
更新日期:2018-03-01 00:00:00
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
pub_type: 杂志文章,随机对照试验
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更新日期:2009-08-01 00:00:00
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journal_title:Journal of medicinal food
pub_type: 杂志文章,评审
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更新日期:2018-05-01 00:00:00
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journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2017.0128
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journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2007.009
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journal_title:Journal of medicinal food
pub_type: 杂志文章
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journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2012.2297
更新日期:2012-11-01 00:00:00
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journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2010.0284
更新日期:2011-11-01 00:00:00
abstract::Oxidative stress and lipid peroxidation are considered key factors linking obesity with its associated complications. Epigallo catechin-3-gallate (EGCG) and oleoylethanolamide, together with its phospholipid precursor N-oleoyl-phosphatidylethanolamine (NOPE), are nutritional compounds that might improve the oxidative ...
journal_title:Journal of medicinal food
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doi:10.1089/jmf.2019.0145
更新日期:2020-03-01 00:00:00
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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更新日期:2000-04-01 00:00:00
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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更新日期:2015-05-01 00:00:00
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journal_title:Journal of medicinal food
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更新日期:2019-09-01 00:00:00
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