Almond Skin Polyphenol Extract Inhibits Inflammation and Promotes Lipolysis in Differentiated 3T3-L1 Adipocytes.

Abstract:

:Studies have shown that polyphenols reduce the risk of inflammation-related diseases and upregulates energy expenditure in adipose tissue. Here, we investigated the mechanism of the anti-inflammatory and antiobesity effects of almond skin polyphenol extract (ASP) in differentiated 3T3-L1 adipocytes. The antioxidant effects of ASP were measured based on DPPH radical scavenging activity, Trolox equivalent antioxidant capacity, and total phenolic content. Differentiated 3T3-L1 cells were treated with ASP. Subsequently, lipolysis proteins and transcription factors of adipogenesis were measured. The proinflammatory mediators monocyte chemotactic protein-1 (MCP-1) and chemokine ligand 5 (CCL-5) were determined by enzyme-linked immunosorbent assay. We found that ASP significantly promoted phosphorylation of AMP-activated protein kinase (AMPK), increased activity of adipose triglyceride lipase and hormone-sensitive lipase, and inhibited adipogenesis-related transcription factors. In addition, ASP inhibited the tumor necrosis factor-α (TNF-α)-induced cell inflammatory response via downregulation of MCP-1 and CCL-5 secretion. This study suggests that ASP regulates lipolysis through activation of AMPK, reduced adipogenesis, and suppresses proinflammatory cytokines in adipocytes.

journal_name

J Med Food

authors

Huang WC,Chen CY,Wu SJ

doi

10.1089/jmf.2016.3806

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

103-109

issue

2

eissn

1096-620X

issn

1557-7600

journal_volume

20

pub_type

杂志文章
  • The antioxidant property of chitosan green tea polyphenols complex induces transglutaminase activation in wound healing.

    abstract::The present study examined, for the first time, the in vitro wound healing potential of chitosan green tea polyphenols (CGP) complex based on the activation of transglutaminase (TGM) genes in epidermal morphogenesis. Response surface methodology was applied to determine the optimal processing condition that gave maxim...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.2623

    authors: Qin Y,Guo XW,Li L,Wang HW,Kim W

    更新日期:2013-06-01 00:00:00

  • Effects of Cassia tora fiber supplement on serum lipids in Korean diabetic patients.

    abstract::Cassia tora fiber supplement consisting of 2 g of soluble fiber extracted from Cassia semen (C. tora L.), 200 mg of alpha-tocopherol, 500 mg of ascorbic acid, and 300 mg of maltodextrin was formulated in a pack, and given to 15 type II diabetic subjects (seven men and eight women 57.1 +/- 2.9 years old) with instructi...

    journal_title:Journal of medicinal food

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1089/jmf.2005.8.311

    authors: Cho SH,Kim TH,Lee NH,Son HS,Cho IJ,Ha TY

    更新日期:2005-10-01 00:00:00

  • The mediterranean diet in cancer prevention: a review.

    abstract::The Mediterranean dietary pattern has a well-established beneficial role in health promotion. Epidemiologic studies reveal the protective role of adherence to this pattern on overall cancer incidence and mortality. This review examines results from prospective cohort, cross-sectional, and case-control studies assessin...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,评审

    doi:10.1089/jmf.2010.0244

    authors: Kontou N,Psaltopoulou T,Panagiotakos D,Dimopoulos MA,Linos A

    更新日期:2011-10-01 00:00:00

  • Reduced Coenzyme Q10 Decreases Urinary 8-Oxo-7,8-Dihydro-2'-Deoxyguanosine Concentrations in Healthy Young Female Subjects.

    abstract::It remains unclear whether dietary supplementation with coenzyme Q10 (CoQ10) provides beneficial effects for healthy individuals, especially young subjects. This study investigated the effects of dietary supplementation with CoQ10 on oxidative stress in healthy young females. We performed a placebo-controlled trial us...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2014.3302

    authors: Ito K,Watanabe C,Nakamura A,Oikawa-Tada S,Murata M

    更新日期:2015-08-01 00:00:00

  • Beneficial effects of a synbiotic supplement on self-perceived gastrointestinal well-being and immunoinflammatory status of healthy adults.

    abstract::The use of synbiotics as health promoters is still poorly defined, and human intervention studies are scarce. This study was designed to evaluate the effects of a commercialized synbiotic product containing Lactobacillus acidophilus La5, Bifidobacterium animalis ssp. lactis Bb-12, Lactobacillus delbrueckii ssp. bulgar...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jmf.2008.0328

    authors: Nova E,Viadel B,Wärnberg J,Carreres JE,Marcos A

    更新日期:2011-01-01 00:00:00

  • Gustatory Evaluation of Still and Carbonated Waters: A Preference Rating Study.

    abstract::We studied the sensory preference for six still waters and four carbonated waters, nonflavored, by 11 tasting experts (4 women and 7 men). Five tasters rated the still waters, four tasters rated the carbonated water, and seven tasters rated twice on each of the still waters when evaluated with a dry red wine. All rati...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/109662001753165747

    authors: Fong DY,Halpern GM,Wan V

    更新日期:2001-10-01 00:00:00

  • Intravenous and intrapulmonary administration of honey solution to healthy sheep: effects on blood sugar, renal and liver function tests, bone marrow function, lipid profile, and carbon tetrachloride-induced liver injury.

    abstract::Safety of intravenous (i.v.) or intrapulmonary administration of different concentrations of honey and their effects on blood sugar, renal and liver function tests, bone marrow function, lipid profile, and carbon tetrachloride (CCl(4))-induced liver damage were studied. Healthy sheep of either sex, 6-8 months old, wer...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/10966200360716652

    authors: Al-Waili NS

    更新日期:2003-10-01 00:00:00

  • Genes related to suppression of malignant phenotype induced by Maitake D-Fraction in breast cancer cells.

    abstract::It is already known that the Maitake (D-Fraction) mushroom is involved in stimulating the immune system and activating certain cells that attack cancer, including macrophages, T-cells, and natural killer cells. According to the U.S. National Cancer Institute, polysaccharide complexes present in Maitake mushrooms appea...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.0222

    authors: Alonso EN,Orozco M,Eloy Nieto A,Balogh GA

    更新日期:2013-07-01 00:00:00

  • Hibiscus Sabdariffa L. Flowers and Olea Europea L. Leaves Extract-Based Formulation for Hypertension Care: In Vitro Efficacy and Toxicological Profile.

    abstract::Olea europaea L. leaves extract (Oe) and Hybiscus sabdariffa L. flowers extract (Hs) have calcium antagonistic properties. Aim of this work was to study the cardiovascular effects of Pres Phytum(®), a nutraceutical formulation containing a mixture of the two extracts and the excipients, and investigate its possible of...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2015.0072

    authors: Micucci M,Angeletti A,Cont M,Corazza I,Aldini R,Donadio E,Chiarini A,Budriesi R

    更新日期:2016-05-01 00:00:00

  • Antihyperglycemic and antioxidant activity of crocin in streptozotocin-induced diabetic rats.

    abstract::The aim of the present study was to investigate the antihyperglycemic and protective potential of crocin, a pharmacologically active constituent of Crocus sativus L., in streptozotocin-induced diabetic rats. Rats were administered crocin intraperitoneally at doses of 15, 30, and 60 mg/kg of body weight for 6 weeks. Th...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.2407

    authors: Rajaei Z,Hadjzadeh MA,Nemati H,Hosseini M,Ahmadi M,Shafiee S

    更新日期:2013-03-01 00:00:00

  • Dolichos lablab Protects Against Nonalcoholic Fatty Liver Disease in Mice Fed High-Fat Diets.

    abstract::Hyacinth bean, Dolichos lablab or Lablab purpureus, has been used for centuries in India and China as an edible pod and animal forage, as well as to treat diarrhea and other gastrointestinal disease in traditional Korean medicine. Recently, we have demonstrated that D. lablab extract (DLL-Ex) prevented free fatty acid...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2017.4036

    authors: Im AR,Kim YH,Kim YH,Yang WK,Kim SH,Song KH

    更新日期:2017-12-01 00:00:00

  • Red Pepper (Capsicum baccatum) Extracts Present Anti-Inflammatory Effects In Vivo and Inhibit the Production of TNF-α and NO In Vitro.

    abstract::Capsicum baccatum is the most consumed red pepper species in Brazil. Our previous studies demonstrated the anti-inflammatory properties of its crude extract, whose activity is yet to be fully characterized. Herein, we examined the anti-inflammatory in vivo effects of enriched extracts obtained through bioguided fracti...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2015.0101

    authors: Allemand A,Leonardi BF,Zimmer AR,Moreno S,Romão PR,Gosmann G

    更新日期:2016-08-01 00:00:00

  • Methylglyoxal may affect hydrogen peroxide accumulation in manuka honey through the inhibition of glucose oxidase.

    abstract::Although hydrogen peroxide (H₂O₂) is one of the major antibacterial factors in most honeys, it does not accumulate in medical-grade manuka honey. The goal of this study was to investigate the effect of artificially added methylglyoxal (MGO) on H₂O₂ accumulation in natural non-manuka honeys. H₂O₂ concentrations in the ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.0201

    authors: Majtan J,Bohova J,Prochazka E,Klaudiny J

    更新日期:2014-02-01 00:00:00

  • Bioactive compounds and antioxidant and antiproliferative activities of Korean white lotus cultivars.

    abstract::In traditional Korean medicine, lotus (Nelumbo nucifera Gaertn) roots have been used as an antidiabetic and an antiproliferative remedy. However, scientific publications on lotus properties are very limited. Therefore, it was decided to investigate the Korean white lotus cultivars in order to find out their bioactivit...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.0018

    authors: Park YS,Towantakavanit K,Kowalska T,Jung ST,Ham KS,Heo BG,Cho JY,Yun JG,Kim HJ,Gorinstein S

    更新日期:2009-10-01 00:00:00

  • Antimicrobial effect of mastic gum methanolic extract against Porphyromonas gingivalis.

    abstract::The antimicrobial effect of mastic gum, an ancient remedy for oral malodor, against Porphyromonas gingivalis, a known odorogenic periopathogenic oral bacterium, was tested using the agar diffusion test. Paper discs impregnated with mastic gum methanolic extract (MME) [0.5-4% (wt/vol)] produced inhibition zones of 10.5...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2006.9.290

    authors: Sterer N

    更新日期:2006-07-01 00:00:00

  • Therapeutic Potential of Ocimum tenuiflorum as MPO Inhibitor with Implications for Atherosclerosis Prevention.

    abstract::Current experimental studies show that Ocimum tenuiflorum (commonly known as basil or Tulsi) possesses many health benefits. Ocimum is suggested to be antioxidative and anti-inflammatory. Eugenol, an orthomethoxyphenol, and ursolic acid have been identified as important components of basil. Myeloperoxidase (MPO), an o...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2014.0125

    authors: Narasimhulu CA,Vardhan S

    更新日期:2015-05-01 00:00:00

  • Anti-inflammatory and cicatrizing activities of a carbohydrate fraction isolated from sugary kefir.

    abstract::Kefir is an association of microrganisms generally grown in milk, with known probiotic activities identified from its soured suspensions. Aqueous media are also able to grow kefir, but little is known about the probiotic properties of its fermented products. This work aimed to evaluate some probiotic properties of a c...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2007.329

    authors: Moreira ME,Dos Santos MH,Zolini GP,Wouters AT,Carvalho JC,Schneedorf JM

    更新日期:2008-06-01 00:00:00

  • In vitro antimicrobial properties of coconut oil on Candida species in Ibadan, Nigeria.

    abstract::The emergence of antimicrobial resistance, coupled with the availability of fewer antifungal agents with fungicidal actions, prompted this present study to characterize Candida species in our environment and determine the effectiveness of virgin coconut oil as an antifungal agent on these species. In 2004, 52 recent i...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2006.1209

    authors: Ogbolu DO,Oni AA,Daini OA,Oloko AP

    更新日期:2007-06-01 00:00:00

  • 4-methylcoumarin derivatives inhibit human neutrophil oxidative metabolism and elastase activity.

    abstract::Increased neutrophil activation significantly contributes to the tissue damage in inflammatory illnesses; this phenomenon has motivated the search for new compounds to modulate their effector functions. Coumarins are natural products that are widely consumed in the human diet. We have evaluated the antioxidant and imm...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.0184

    authors: Kabeya LM,Fuzissaki CN,Andrade MF,Azzolini AE,Taleb-Contini SH,Vermelho RB,Lopes JL,Lucisano-Valim YM

    更新日期:2013-08-01 00:00:00

  • Antioxidant and antimicrobial activity of Cissus quadrangularis L.

    abstract::Extracts of Cissus quadrangularis L. were tested for antioxidant activity by beta-carotene linoleic acid model and also by 1,1-diphenyl-2-picrylhydrazyl model. The ethyl acetate fraction of both fresh and dry stem extracts at a concentration of 100 ppm showed 64.8% antioxidant activity in the beta-carotene linoleic ac...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/109662003322233495

    authors: Chidambara Murthy KN,Vanitha A,Mahadeva Swamy M,Ravishankar GA

    更新日期:2003-07-01 00:00:00

  • Sweet Dream Liquid Chinese Medicine Ameliorates Learning and Memory Deficit in a Rat Model of Paradoxical Sleep Deprivation through the ERK/CREB Signaling Pathway.

    abstract::Sweet dream oral liquid (SDOL), a traditional Chinese herbal compound contains 17 traditional Chinese medicines. It has various pharmacological effects, such as improving brain dysfunction and increasing sleeping quality. This study investigated the neuroprotective effect and the underlying mechanisms of SDOL-impaired...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2015.3530

    authors: Su X,Wang C,Wang X,Han F,Lv C,Zhang X

    更新日期:2016-05-01 00:00:00

  • Effect of procyanidin C1 on nitric oxide production and hyperpolarization through Ca(2+)-dependent pathway in endothelial cells.

    abstract::Polyphenol-rich foods, such as fruits and vegetables, are protective against cardiovascular diseases, but the mechanisms of the beneficial effects are still unknown. The goal of this research was to clarify actions of procyanidin trimer (C1) in rat aortic endothelial cells (RAECs). Procyanidin C1 at concentrations up ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.2297

    authors: Byun MW

    更新日期:2012-11-01 00:00:00

  • No Synergistic Effect of Silibinin and Morin in a Kainic Acid-Induced Epileptic Mouse Model.

    abstract::Temporal lobe epilepsy (TLE) is the most common form of localization-related epilepsy, with the highest prevalence rate in adulthood. Recently, we reported the beneficial effects of the individual treatment with flavonoids such as silibinin and morin in kainic acid (KA)-treated mouse model for TLE. In this study, we i...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2019.4522

    authors: Hong J,Lee JM,Yoon D,Jung UJ,Kim SR

    更新日期:2020-02-01 00:00:00

  • Cytotoxic effects of bilberry extract on MCF7-GFP-tubulin breast cancer cells.

    abstract::Bilberry (European blueberry) has been reported to have many biological effects, including anticancer activity. In this study, we investigated the antiproliferative effects of bilberry extract in relation to its ability to induce apoptosis and affect microtubule assembly and organization in MCF7 human breast cancer ce...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.0053

    authors: Nguyen V,Tang J,Oroudjev E,Lee CJ,Marasigan C,Wilson L,Ayoub G

    更新日期:2010-04-01 00:00:00

  • Bioactive chemicals from carrot (Daucus carota) juice extracts for the treatment of leukemia.

    abstract::Overwhelming evidence indicates that consumption of fruits and vegetables with antioxidant properties correlates with reduced risk for cancers, including leukemia. Carrots contain beneficial agents, such as β-carotene and polyacetylenes, which could be effective in the treatment of leukemia. This study investigated th...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2010.0284

    authors: Zaini R,Clench MR,Le Maitre CL

    更新日期:2011-11-01 00:00:00

  • Effect of Tart Cherry Polyphenols on Osteoclast Differentiation and Activity.

    abstract::Bone is maintained by an intricate balance between bone formation and bone resorption. The presence of inflammation can contribute to an imbalance in bone homeostasis by enhancing differentiation and activity of osteoclasts, the cells that participate in the breakdown of bone. Polyphenols such as flavonoids found in p...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2019.0050

    authors: Thomas A,South S,Vijayagopal P,Juma S

    更新日期:2020-01-01 00:00:00

  • Diabetes-ameliorating effects of fermented red ginseng and causal effects on hormonal interactions: testing the hypothesis by multiple group path analysis.

    abstract::Although diagnostic criteria for metabolic syndrome (MtS) vary among various health professionals and organizations, blood glucose dysregulation and insulin resistance are common to all definitions. Red ginseng is beneficial for glucose regulation and insulin sensitivity but the mechanism is not yet elucidated. Ginsen...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jmf.2012.2583

    authors: Lee KJ,Lee SY,Ji GE

    更新日期:2013-05-01 00:00:00

  • Effect of Berberine Plus Bezafibrate Administration on the Lipid Profile of Patients with Mixed Dyslipidemia: A Pilot Clinical Trial.

    abstract::To evaluate the effect of berberine (BBR) plus bezafibrate administration on the lipid profile of patients with mixed dyslipidemia. A double-blind randomized pilot clinical trial with parallel groups was carried out in 36 patients, aged 30-60 years with mixed dyslipidemia [triglycerides (TG) ≥1.7 mM and total choleste...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2020.0029

    authors: León-Martínez JM,Martínez-Abundis E,González-Ortiz M,Pérez-Rubio KG

    更新日期:2020-05-12 00:00:00

  • Development of a database for government-funded health/functional food research.

    abstract::The Korean Health/Functional Food Act of 2002 has led to the promotion of research on health/functional foods (HFFs). In order to track government-funded studies on HFFs, a free accessible database (National Research & Development on Functional Food, NaReaD(ff)) has been established by the Korea Food and Drug Administ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,评审

    doi:10.1089/jmf.2009.1036

    authors: Kim JY,Park J,Kwon O

    更新日期:2009-12-01 00:00:00

  • The Effects of Curcuma longa L., Purple Sweet Potato, and Mixtures of the Two on Immunomodulation in C57BL/6J Mice Infected with LP-BM5 Murine Leukemia Retrovirus.

    abstract::The immune response is stimulated to protect the body from external antigens and is controlled by several types of immune cells. In the present study, the immunomodulatory effects of Curcuma longa L., purple sweet potato, and mixtures of the two (CPM) were investigated in C57BL/6 mice infected with LP-BM5 murine leuke...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2017.4093

    authors: Park SJ,Lee D,Lee M,Kwon HO,Kim H,Park J,Jeon W,Cha M,Jun S,Park K,Lee J

    更新日期:2018-07-01 00:00:00