Ginsenoside Rh2 improves learning and memory in mice.

Abstract:

:A wide range of plant foods and dietary supplements are able to modify the functioning of the central nervous system. In the present study, we observed that oral administration of ginsenoside Rh2 (10 mg/mL) for 3 weeks significantly improved spatial learning and memory. Spatial memory and learning was evaluated in mice by hippocampus-dependent tasks (Morris water maze test) and immunohistochemical marker of cell genesis bromodeoxyuridine. Ginsenoside Rh2 treatment (30 days) promoted cell survival and genesis. Further, ginsenoside Rh2 treatment in enriched condition had no significant effects on cell survival compared with standard condition exposure. These results revealed that ginsenoside Rh2-mediated spatial learning and memory improvement was associated with cell genesis and survival and may be parallel to the mechanism of environmental enrichment. Therefore, ginsenoside Rh2 may have efficacy as a dietary supplement for spatial learning and memory improvement.

journal_name

J Med Food

authors

Hou J,Xue J,Lee M,Liu L,Zhang D,Sun M,Zheng Y,Sung C

doi

10.1089/jmf.2012.2564

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

772-6

issue

8

eissn

1096-620X

issn

1557-7600

journal_volume

16

pub_type

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