Abstract:
:A wide range of plant foods and dietary supplements are able to modify the functioning of the central nervous system. In the present study, we observed that oral administration of ginsenoside Rh2 (10 mg/mL) for 3 weeks significantly improved spatial learning and memory. Spatial memory and learning was evaluated in mice by hippocampus-dependent tasks (Morris water maze test) and immunohistochemical marker of cell genesis bromodeoxyuridine. Ginsenoside Rh2 treatment (30 days) promoted cell survival and genesis. Further, ginsenoside Rh2 treatment in enriched condition had no significant effects on cell survival compared with standard condition exposure. These results revealed that ginsenoside Rh2-mediated spatial learning and memory improvement was associated with cell genesis and survival and may be parallel to the mechanism of environmental enrichment. Therefore, ginsenoside Rh2 may have efficacy as a dietary supplement for spatial learning and memory improvement.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Hou J,Xue J,Lee M,Liu L,Zhang D,Sun M,Zheng Y,Sung Cdoi
10.1089/jmf.2012.2564subject
Has Abstractpub_date
2013-08-01 00:00:00pages
772-6issue
8eissn
1096-620Xissn
1557-7600journal_volume
16pub_type
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