N-Oleoyl-Phosphatidyl-Ethanolamine and Epigallo Catechin-3-Gallate Mitigate Oxidative Stress in Overweight and Class I Obese People on a Low-Calorie Diet.

Abstract:

:Oxidative stress and lipid peroxidation are considered key factors linking obesity with its associated complications. Epigallo catechin-3-gallate (EGCG) and oleoylethanolamide, together with its phospholipid precursor N-oleoyl-phosphatidylethanolamine (NOPE), are nutritional compounds that might improve the oxidative stress status of obese people. Unfortunately, the bioavailability of these compounds is low; however, the coadministration of NOPE with EGCG has been shown to ameliorate both the plasma availability of EGCG and the intestinal levels of NOPE in rats. This double-blind placebo-controlled study investigated the effects of 2 months' supplementation with EGCG complexed with NOPE, combined with moderate energy restriction, on plasma oxidative status of overweight and class I obese subjects. A total of 138 subjects (body mass index: 25-35 kg/m2) were recruited and randomized into two groups: the first (n = 67) received caps of placebo and the second (n = 71) caps of an oily dispersion of EGCG complexed with NOPE for 2 months. Subjects' supplementation was combined with moderate energy restriction (-800 kcal/day). Plasma oxidative status was determined by measuring the levels of oxidized low-density lipoprotein (Ox-LDL), malondialdehyde and reactive oxygen metabolites, and by calculating the lag time and the slope of Cu-induced lipid peroxidation kinetics. In total 116 subjects (27 M/89 F) completed the supplementation period, 49 in the placebo group and 67 in the treated group. Treatment induced a similar significant weight reduction in the two groups. Moreover, we found the mean changes of Ox-LDL significantly lower and the mean changes of antioxidant capacity (lag time) significantly higher in NOPE-EGCG group than in placebo group (treatment effect mean difference: -3.15 UL, P < .044 and +5.37 min, P < .0347, respectively). EGCG plasma levels were detectable only after 2 months of NOPE-EGCG diet. The NOPE-EGCG integration to a low-energy diet seems, therefore, useful for ameliorating oxidative stress-related markers, which are concomitant causes of obesity-induced disorders.

journal_name

J Med Food

authors

Cazzola R,Rondanelli M

doi

10.1089/jmf.2019.0145

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

319-325

issue

3

eissn

1096-620X

issn

1557-7600

journal_volume

23

pub_type

杂志文章,随机对照试验
  • Natural products from Garcinia brasiliensis as Leishmania protease inhibitors.

    abstract::The infections by protozoans of the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials, which cause renal and cardiac toxicity. As part of a search for new drugs against leishmaniasi...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2010.0018

    authors: Pereira IO,Assis DM,Juliano MA,Cunha RL,Barbieri CL,do Sacramento LV,Marques MJ,dos Santos MH

    更新日期:2011-06-01 00:00:00

  • Drinking orange juice increases total antioxidant status and decreases lipid peroxidation in adults.

    abstract::Cardiovascular disease (CVD) is the leading cause of death in the world and is the primary cause of mortality among Americans. One of the many reasons for the pathogenesis of CVD is attributed to eating diets high in saturated fat and refined carbohydrates and low in fruits and vegetables. Epidemiological evidence has...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2013.0034

    authors: Foroudi S,Potter AS,Stamatikos A,Patil BS,Deyhim F

    更新日期:2014-05-01 00:00:00

  • Gustatory Evaluation of Still and Carbonated Waters: A Preference Rating Study.

    abstract::We studied the sensory preference for six still waters and four carbonated waters, nonflavored, by 11 tasting experts (4 women and 7 men). Five tasters rated the still waters, four tasters rated the carbonated water, and seven tasters rated twice on each of the still waters when evaluated with a dry red wine. All rati...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/109662001753165747

    authors: Fong DY,Halpern GM,Wan V

    更新日期:2001-10-01 00:00:00

  • Aronia melanocarpa Concentrate Ameliorates Pro-Inflammatory Responses in HaCaT Keratinocytes and 12-O-Tetradecanoylphorbol-13-Acetate-Induced Ear Edema in Mice.

    abstract::Abnormal expression of pro-inflammatory mediators such as cell adhesion molecules and cytokines has been implicated in various inflammatory skin diseases, including atopic dermatitis. In this study, we investigated the anti-inflammatory activity of Aronia melanocarpa concentrate (AC) and its action mechanisms using in...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2015.3624

    authors: Goh AR,Youn GS,Yoo KY,Won MH,Han SZ,Lim SS,Lee KW,Choi SY,Park J

    更新日期:2016-07-01 00:00:00

  • Cell cycle arrest and induction of apoptosis by lycopene in LNCaP human prostate cancer cells.

    abstract::Lycopene is one of the major carotenoids and is found almost exclusively in tomatoes and tomato products. Since tomato consumption is associated with decreased risk of prostate cancer, characterizing the effects of lycopene on cell growth or survival, cell cycle progression, and apoptosis in LCNaP human prostate cance...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2004.7.284

    authors: Hwang ES,Bowen PE

    更新日期:2004-10-01 00:00:00

  • Hepatoprotective and antioxidant activities of Vernonia amygdalina on acetaminophen-induced hepatic damage in mice.

    abstract::Vernonia amygdalina Del. (Family Compositae) is used in Nigerian folk medicine as a tonic and remedy against constipation, fever, high blood pressure, and many infectious diseases. We have evaluated the hepatoprotective and antioxidant effects of an aqueous extract of V. amygdalina leaves against acetaminophen-induced...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2006.9.524

    authors: Iwalokun BA,Efedede BU,Alabi-Sofunde JA,Oduala T,Magbagbeola OA,Akinwande AI

    更新日期:2006-01-01 00:00:00

  • Therapeutic Potential of Bauhinia forficata Link in Dental Biofilm Treatment.

    abstract::The oral cytotoxicity, antimicrobial and anti-demineralizing effects of a tincture from Bauhinia forficata Link tincture (BFLT) were evaluated in vitro and ex vivo. Susceptibility tests (minimum inhibitory and microbicidal concentrations-MIC and time-kill assay-MMC) were performed against planktonic oral microorganism...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2019.0277

    authors: Ferreira-Filho JCC,Marre ATO,de Sá Almeida JS,Lobo LA,Farah A,Romanos MTV,Maia LC,Valença AMG,Fonseca-Gonçalves A

    更新日期:2020-09-01 00:00:00

  • Antioxidant and antimicrobial properties of some lichens and their constituents.

    abstract::The aim of this study is to examine the in vitro antioxidant and antimicrobial activities of the acetone, methanol, and aqueous extracts of the lichens Cladonia furcata (many-forked Cladonia), Hypogymnia physodes (puffed lichen), and Umbilicaria polyphylla (manyleaf navel lichen) and the antimicrobial activity of fuma...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2010.0316

    authors: Kosanić M,Ranković B

    更新日期:2011-12-01 00:00:00

  • Effect of supplementation of traditional medicinal plants on blood glucose in non-insulin-dependent diabetics: a pilot study.

    abstract::The effect of supplementation of a powdered mixture of three traditional medicinal plants-bittergourd, jamun seeds, and fenugreek seeds-in raw and cooked form on blood glucose was studied in 60 non-insulin-dependent male diabetics. The patients were divided into two groups of 30 each. The patients of group I were give...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2005.8.545

    authors: Kochhar A,Nagi M

    更新日期:2005-01-01 00:00:00

  • Orostachys japonicus A. Berger (Crassulaceae) Exerts Antidiabetic Activity by Improving Glucose and Lipid Levels in Type 2 Diabetic Mice.

    abstract::Orostachys japonicus A. Berger and Momordica charantia Linn have been widely used as an alternative medicine. Recently, patients with type 2 diabetes (T2D) have paid increasing attention to medical nutrition therapy due to its safety and cost-effectiveness. Therefore, we have developed a new health functional food tha...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2018.4391

    authors: Jeong H,Kim JW,Yang D,Jeong TW,Zhao J,Seo JH,Shin DG,Cha JD,Han KM,Lim CW,Kim B

    更新日期:2019-08-01 00:00:00

  • Increase of bioavailability of coenzyme Q(10) and vitamin E.

    abstract::Commercial coenzyme Q(10) (CoQ(10)) and alpha-tocopherol (vitamin E) formulations often show poor intestinal absorption. Delivery of CoQ(10) and vitamin E was enhanced when used with a new formulation, NanoSolve (Lipoid GmbH, Ludwigshafen, Germany), as shown by an open, comparative monocenter, crossover study of 24 vo...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jmf.2006.254

    authors: Wajda R,Zirkel J,Schaffer T

    更新日期:2007-12-01 00:00:00

  • The Antiproliferative Effect of Moringa oleifera Crude Aqueous Leaf Extract on Human Esophageal Cancer Cells.

    abstract::Esophageal cancer (EC) is commonly diagnosed in South Africa (SA), with high incidences occurring in SA's black population. Moringa oleifera (MO), a multipurpose tree, is used traditionally for its nutritional and medicinal properties. It has been used for the treatment of a variety of ailments, including cancer. We i...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2015.0113

    authors: Tiloke C,Phulukdaree A,Chuturgoon AA

    更新日期:2016-04-01 00:00:00

  • The aqueous extracts of Passiflora alata and Passiflora edulis reduce anxiety-related behaviors without affecting memory process in rats.

    abstract::Several species of Passiflora have been employed widely as a folk medicine because of sedative and tranquillizer activities. In this study, we evaluate the effects on anxiety and memory process of two popularly used Passiflora species. To this aim, male Wistar rats (weighing 250-300 g) were intraperitoneally injected ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2007.722

    authors: Barbosa PR,Valvassori SS,Bordignon CL Jr,Kappel VD,Martins MR,Gavioli EC,Quevedo J,Reginatto FH

    更新日期:2008-06-01 00:00:00

  • A comparison of the effects of commercially available hawthorn preparations on calcium transients of isolated cardiomyocytes.

    abstract::We studied the potential cardiac effects of two alcohol extracts of commercially available hawthorn using rat cardiomyocytes and measuring calcium transients by real-time fluorescence spectrophotometry. One preparation was a blend of hawthorn flowers, leaves, and berries (extract #1), and the other (extract #2) was fr...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2008.0080

    authors: Rodriguez ME,Poindexter BJ,Bick RJ,Dasgupta A

    更新日期:2008-12-01 00:00:00

  • Potentiation of antibiotic activity by Eugenia uniflora and Eugenia jambolanum.

    abstract::This is the first report about the modifying antibiotic activity of Eugenia uniflora L. and Eugenia jambolanum L. In this study the ethanol extract of E. uniflora and E. jambolanum was tested for their antimicrobial activity against strains of Escherichia coli. The growth of the two strains of E. coli bacteria tested ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.0158

    authors: Coutinho HD,Costa JG,Falcão-Silva VS,Siqueira-Júnior JP,Lima EO

    更新日期:2010-08-01 00:00:00

  • Flow cytometric analysis of age-related changes in intestine intraepithelial lymphocyte subsets and their functional preservation after feeding mice on spirulina.

    abstract::We investigated age-related changes in intestinal intraepithelial lymphocyte (IEL) subsets in mice by flow cytometric analysis and their functional preservation as affected by feeding Spirulina, a cyanobacterium that is known to possess various therapeutic effects, including immune modulation activity. The number of c...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2008.1260

    authors: Hayashi O,Katayanagi Y,Ishii K,Kato T

    更新日期:2009-10-01 00:00:00

  • Anti-allergic effects of herbal product from Allium cepa (bulb).

    abstract::Allium cepa (Family Liliaceae) is a reputed Indian medicinal herb that is prescribed as an effective remedy for several ailments in the Ayurvedic system of medicine. The aim of this study was to evaluate its efficacy against various events responsible for Type I allergic reactions. A herbal fraction (ALC-02) from A. c...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2007.0642

    authors: Kaiser P,Youssouf MS,Tasduq SA,Singh S,Sharma SC,Singh GD,Gupta VK,Gupta BD,Johri RK

    更新日期:2009-04-01 00:00:00

  • Safety of an astaxanthin-rich Haematococcus pluvialis algal extract: a randomized clinical trial.

    abstract::A growing body of scientific literature indicates that astaxanthin is a more powerful antioxidant than other carotenoids and vitamin E and may confer numerous health benefits. The purpose of this investigation was to conduct a human safety study with a Haematococcus pluvialis algal extract with high levels of astaxant...

    journal_title:Journal of medicinal food

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1089/109662003765184741

    authors: Spiller GA,Dewell A

    更新日期:2003-04-01 00:00:00

  • Protective Effect of Glyceollins in a Mouse Model of Dextran Sulfate Sodium-Induced Colitis.

    abstract::Glyceollins, which are derived from daidzein in soybean in response to various stimuli or stresses, have been reported to activate antioxidant/detoxifying enzymes in a nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-dependent manner, in addition to exerting anti-inflammatory effects in murine macrophages. As the Nr...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2017.3960

    authors: Seo H,Oh J,Hahn D,Kwon CS,Lee JS,Kim JS

    更新日期:2017-11-01 00:00:00

  • Memory-strengthening activity of Glycyrrhiza glabra in exteroceptive and interoceptive behavioral models.

    abstract::In the traditional system of medicine, the roots and rhizomes of Glycyrrhiza glabra have been employed clinically for centuries for their anti-inflammatory, anti-ulcer, expectorant, antimicrobial, and anxiolytic activities. The present study was undertaken to investigate the effects of G. glabra, popularly known as li...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2004.7.462

    authors: Parle M,Dhingra D,Kulkarni SK

    更新日期:2004-01-01 00:00:00

  • Effect of kaikasaponin III obtained from Pueraria thunbergiana flowers on serum and hepatic lipid peroxides and tissue factor activity in the streptozotocin-induced diabetic rat.

    abstract::We investigated the effect of kaikasaponin III (KS-III) on Phase I and II enzymes and tissue factor (TF) activity to elucidate the pharmacological actions of this immunosuppressive saponin in the diabetic rat. This compound was obtained from the flower of Pueraria thunbergiana (Leguminosae) by chromatographic isolatio...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/109662004322984671

    authors: Choi J,Shin MH,Park KY,Lee KT,Jung HJ,Lee MS,Park HJ

    更新日期:2004-04-01 00:00:00

  • Phytochemical, antibacterial, antiproliferative, and antioxidant potentials and DNA damage-protecting activity of Acacia salicina extracts.

    abstract::The extract enriched in total oligomer flavonoids (TOF), and the aqueous, methanol, and ethyl acetate extracts of Acacia salicina were investigated for their polyphenolic compound content, antioxidative activity in the nitro blue tetrazolium/riboflavin assay system, antibacterial activity against Gram-positive and Gra...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2008.0120

    authors: Chatti IB,Limem I,Boubaker J,Skandrani I,Kilani S,Bhouri W,Ben Sghaier M,Nefatti A,Ben Mansour H,Ghedira K,Chekir-Ghedira L

    更新日期:2009-06-01 00:00:00

  • Effect of spices on lipid metabolism in 1,2-dimethylhydrazine-induced rat colon carcinogenesis.

    abstract::Colon cancer is the second most common cancer among men and women worldwide. We investigated the effect of red chilli (Capsicum annum L.), cumin (Cuminum cyminum L.), and black pepper (Piper nigrum L.) on colon cancer induced in rats by a colon-specific carcinogen, 1,2-dimethylhydrazine (DMH). Colon cancer was induced...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2006.9.237

    authors: Nalini N,Manju V,Menon VP

    更新日期:2006-07-01 00:00:00

  • Antioxidant, mutagenic, and antimutagenic activity of frozen fruits.

    abstract::Many studies have focused on the effect of fresh fruits on the risk of developing cancer and other diseases involved with reactive species and free radicals. The intake of frozen fruits has spread widely in the last years, but, until now, their biological activity is not completely known. In this study, 23 samples of ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2007.598

    authors: Spada PD,de Souza GG,Bortolini GV,Henriques JA,Salvador M

    更新日期:2008-03-01 00:00:00

  • Curcumin downregulates aquaporin-1 expression in cultured rat choroid plexus cells.

    abstract::Aquaporin-1 (AQP1) is a water channel that is highly expressed on the apical side of the choroid plexus epithelium (CP) and thought to be one of the major pathways for the high water permeability of this structure. Blockade of AQP1 in the CP reduce the production of cerebrospinal fluid (CSF). Downregulation of AQP1 mi...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.0208

    authors: Nabiuni M,Nazari Z,Safaeinejad Z,Delfan B,Miyan JA

    更新日期:2013-06-01 00:00:00

  • High environmental stress yields greater tocotrienol content while changing vitamin e profiles of wild emmer wheat seeds.

    abstract::Vitamin E is an essential human nutrient that was first isolated from wheat. Emmer wheat, the cereal of Old World agriculture and a precursor to durum wheat, grows wild in the Fertile Crescent. Evolution Canyon, Israel, provides a microsite that models effects of contrasting environments. The north-facing and south-fa...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2014.0017

    authors: Watts EJ,Shen Y,Lansky EP,Nevo E,Bobe G,Traber MG

    更新日期:2015-02-01 00:00:00

  • A Randomized Double-Blind Placebo-Control Study to Assess the Efficacy and Safety of OLNP-05 Versus Placebo for the Treatment of Subjects with Premature Ejaculation.

    abstract::Premature ejaculation (PE) is one of the foremost sex-related health problems among men. The global occurrence ranges from 20% to 30%, according to various studies. PE has a great impact on the men's quality of life, with deleterious effects such as embarrassment, frustration, and feeling of incompetence. Considering ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2019.4661

    authors: Panda SK,Nirvanashetty S,Parachur VA,Mohanty N

    更新日期:2020-09-01 00:00:00

  • 4-methylcoumarin derivatives inhibit human neutrophil oxidative metabolism and elastase activity.

    abstract::Increased neutrophil activation significantly contributes to the tissue damage in inflammatory illnesses; this phenomenon has motivated the search for new compounds to modulate their effector functions. Coumarins are natural products that are widely consumed in the human diet. We have evaluated the antioxidant and imm...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.0184

    authors: Kabeya LM,Fuzissaki CN,Andrade MF,Azzolini AE,Taleb-Contini SH,Vermelho RB,Lopes JL,Lucisano-Valim YM

    更新日期:2013-08-01 00:00:00

  • The natural flavonoid apigenin suppresses Th1- and Th2-related chemokine production by human monocyte THP-1 cells through mitogen-activated protein kinase pathways.

    abstract::Dietary flavonoids have various biological functions, and there is increasing evidence that reduced prevalence and severity of allergic reactions are associated with the intake of flavonoids. Among natural flavonoids, apigenin is a potent anti-inflammatory agent. However, the mechanisms of apigenin's effect remain unc...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.1229

    authors: Huang CH,Kuo PL,Hsu YL,Chang TT,Tseng HI,Chu YT,Kuo CH,Chen HN,Hung CH

    更新日期:2010-04-01 00:00:00

  • Effects of heating, storage, and ultraviolet exposure on antimicrobial activity of garlic juice.

    abstract::This study was designed to investigate the effect of heating, storage, and ultraviolet exposure on antimicrobial activity of garlic juice and its bacteriocidal activity against common human pathogens. Antimicrobial activity of fresh garlic juice was tested against Escherichia coli, Staphylococcus aureus, Streptococcus...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2005.067

    authors: Al-Waili NS,Saloom KY,Akmal M,Al-Waili TN,Al-Waili AN,Al-Waili H,Ali A,Al-Sahlani K

    更新日期:2007-03-01 00:00:00