Abstract:
:cis-Diamminedichloroplatinum (II) (cisplatin) is an effective chemotherapeutic agent successfully used in the treatment of a wide range of tumors. Nevertheless, nephrotoxicity has restricted its clinical use. The use of more than a few antioxidants has shown that reactive oxygen species are involved in cisplatin-induced nephrotoxicity. In the present work the effect of garlic powder, a recognized antioxidant, on cisplatin-induced nephrotoxicity and oxidative and nitrosative stress was studied. Rats were fed with a 2% garlic powder diet for 4 weeks. A single injection of cisplatin (7.5 mg/kg) induced tubular damage and an increase in the following markers of renal injury 3 days later: blood urea nitrogen, serum creatinine, and urinary excretion of N-acetyl-beta-D-glucosaminidase. The cisplatin injection also increased 3-nitrotyrosine and 4-hydroxy-2-nonenal immunostaining in renal cortex and medulla. It was found that the garlic powder feeding was able to prevent by 40-59% the alterations in the markers of renal injury studied, by 33% the histological damage, and by 38-75% the increase in markers of oxidative and nitrosative stress. It is concluded that the ability of garlic powder to ameliorate cisplatin-induced renal injury is associated with its antioxidant properties. Our data support the use of garlic powder as a renoprotective agent.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Razo-Rodríguez AC,Chirino YI,Sánchez-González DJ,Martínez-Martínez CM,Cruz C,Pedraza-Chaverri Jdoi
10.1089/jmf.2008.0033subject
Has Abstractpub_date
2008-09-01 00:00:00pages
582-6issue
3eissn
1096-620Xissn
1557-7600journal_volume
11pub_type
杂志文章abstract::Extracts obtained from the seeds of Nigella sativa are used as a spice or remedy for the treatment of various inflammatory diseases. The purpose of this study was to examine the analgesic and anti-inflammatory effects of its polyphenols. N. sativa seed polyphenols were prepared, and analgesic and anti-inflammatory eff...
journal_title:Journal of medicinal food
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abstract::Although hydrogen peroxide (H₂O₂) is one of the major antibacterial factors in most honeys, it does not accumulate in medical-grade manuka honey. The goal of this study was to investigate the effect of artificially added methylglyoxal (MGO) on H₂O₂ accumulation in natural non-manuka honeys. H₂O₂ concentrations in the ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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abstract::Twenty soybean cultivars, originating from the United States, Russia, Serbia, and China, were analyzed for their isoflavone composition, total polyphenolic content, and antioxidant activity. Isoflavones were extracted by aqueous methanol (80%) and analyzed by high-performance liquid chromatography/diode array detectio...
journal_title:Journal of medicinal food
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doi:10.1089/jmf.2009.0050
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abstract::ABSTRACT This study reports the hypoglycemic effects of the crude exopolysaccharide (EPS) produced from submerged mycelial culture of Lentinus strigosus (Schwein.) Fr. (Family Polyporaceae) in streptozotocin (STZ)-induced diabetic rats. In a dose-dependent study, diabetic rats were treated with EPS at doses of 50-150 ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2007.0551
更新日期:2008-09-01 00:00:00
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journal_title:Journal of medicinal food
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更新日期:2005-07-01 00:00:00
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journal_title:Journal of medicinal food
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更新日期:2008-06-01 00:00:00
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journal_title:Journal of medicinal food
pub_type: 杂志文章
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更新日期:2008-06-01 00:00:00
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journal_title:Journal of medicinal food
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doi:10.1089/109662003772519877
更新日期:2003-01-01 00:00:00
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journal_title:Journal of medicinal food
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doi:10.1089/109662001753165747
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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abstract::Panduratin A, a prenylated chalcone compound, has anti-obesity, anti-bacterial, anti-cancer, anti-inflammatory, and anti-oxidative activities. However, its preventive effect on muscle atrophy has not been studied. The purpose of this study was to evaluate the inhibitory effect of panduratin A on muscle atrophy and to ...
journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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abstract::Adipose tissue is a key organ with substantial senescent cell accumulation under both obesity and aging conditions. Chia seed is an ancient seed and is the richest plant source of α-linolenic acid. We aimed to determine how cellular senescence markers will be altered in adipose tissue of senescence-accelerated mouse-p...
journal_title:Journal of medicinal food
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abstract::Oxidative stress and lipid peroxidation are considered key factors linking obesity with its associated complications. Epigallo catechin-3-gallate (EGCG) and oleoylethanolamide, together with its phospholipid precursor N-oleoyl-phosphatidylethanolamine (NOPE), are nutritional compounds that might improve the oxidative ...
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abstract::The present study evaluated the protective effect of Centella asiatica (gotu kola) leaf extract (CAE) against indomethacin (IND)-induced gastric mucosal injury in rats. Gastric mucosal injury was induced by the oral administration of IND to the rats after a 24 h fast. CAE (50 or 250 mg/kg) or lansoprazole (a reference...
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