Perilla frutescens Extract Ameliorates Acetylcholinesterase and Trimethyltin Chloride-Induced Neurotoxicity.

Abstract:

:One of the critical features of Alzheimer's disease is cognitive dysfunction, which is, in part, due to decreases in acetylcholine (ACh). The ethanol extract of Perilla frutescens was selected for isolating the acetylcholinesterase (AChE) inhibitor based on preliminary screening. In vivo behavioral tests were performed to examine the effects of the P. frutescens extract on trimethyltin chloride-induced impairment of learning and memory in mice. A diet containing P. frutescens extract effectively reversed learning and memory impairment on the Y-maze and passive avoidance tests. To isolate the active compound from the P. frutescens extract, solvent partitioning, silica gel open column chromatography, thin-layer chromatography, and high-performance liquid chromatography were used. The AChE inhibitor was identified as rosmarinic acid.

journal_name

J Med Food

authors

Choi SJ,Oh SS,Kim CR,Kwon YK,Suh SH,Kim JK,Park GG,Son SY,Shin DH

doi

10.1089/jmf.2015.3540

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

281-9

issue

3

eissn

1096-620X

issn

1557-7600

journal_volume

19

pub_type

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