Abstract:
:Four randomized, blind, placebo-controlled clinical trials were pooled to study the general effects of oral consumption of Lycium barbarum at 120 mL/day, as a standardized juice, GoChi(®) (FreeLife International, Phoenix, AZ, USA). A questionnaire consisting of symptoms graded 0-5 was given to the participants. For each question, the score changes in the questionnaire between pre- and postintervention were summarized by the standardized mean difference and associated SE to perform the meta-analysis. The change was also characterized into a binary outcome, improved or not, to derive odds ratio (OR) and associated SE derived by a binary outcome using the Mantel-Haenszel method. The meta-analysis and heterogeneity were evaluated with the R program using the rmeta package. Statistical significance was set at 5%. In total, 161 participants (18-72 years old) were included in the meta-analysis. Compared with the placebo group (n=80), the active group (n=81) showed significant improvements in weakness, stress, mental acuity, ease of awakening, shortness of breath, focus on activity, sleep quality, daydreaming, and overall feelings of health and well-being under a random effects model. A fixed effects model showed additional improvements in fatigue, depression, circulation, and calmness. The OR indicated significantly higher chance to improve fatigue, dizziness, and sleep quality. Three studies had statistically significant heterogeneity in procrastination, shoulder stiffness, energy, and calmness. The present meta-analysis confirmed the various health effects of L. barbarum polysaccharides-standardized L. barbarum intake found in the previous randomized, double-blind, placebo-controlled human clinical trials and revealed it resulted in statistically significant improvements in neurological/psychological performance and overall feelings of health and well-being compared with the placebo group under both the fixed and the random effects models of the R program.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Paul Hsu CH,Nance DM,Amagase Hdoi
10.1089/jmf.2012.0013subject
Has Abstractpub_date
2012-11-01 00:00:00pages
1006-14issue
11eissn
1096-620Xissn
1557-7600journal_volume
15pub_type
杂志文章,meta分析abstract::The anti-herpes simplex virus type 1 and anti-herpes simplex virus type 2 effects of apple pomace, a by-product from the cider-processing industry, were investigated. The mechanisms of antiviral action were assessed using a battery of experiments targeting sequential steps in the viral replication cycle. The anti-herp...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2011.0308
更新日期:2012-06-01 00:00:00
abstract::It is already known that the Maitake (D-Fraction) mushroom is involved in stimulating the immune system and activating certain cells that attack cancer, including macrophages, T-cells, and natural killer cells. According to the U.S. National Cancer Institute, polysaccharide complexes present in Maitake mushrooms appea...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2012.0222
更新日期:2013-07-01 00:00:00
abstract::ABSTRACT This study reports the hypoglycemic effects of the crude exopolysaccharide (EPS) produced from submerged mycelial culture of Lentinus strigosus (Schwein.) Fr. (Family Polyporaceae) in streptozotocin (STZ)-induced diabetic rats. In a dose-dependent study, diabetic rats were treated with EPS at doses of 50-150 ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2007.0551
更新日期:2008-09-01 00:00:00
abstract::3,3'-diindolylmethane is a major in vivo metabolite of indole-3-carbinol, a bioactive compound found in cruciferous vegetables. Although 3,3'-diindolylmethane has been implicated to possess antitumorigenic and anti-inflammatory properties, the effect of 3,3'-diindolylmethane on adipogenesis has not been explored previ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2016.0165
更新日期:2017-07-01 00:00:00
abstract::The underlying causes of denervation of the neuromuscular junction and eventual motor neuron death in amyotrophic lateral sclerosis (ALS) have not been resolved. The superoxide dismutase 1 (SOD1)(G93A) mutant mouse is a frequently used animal model of ALS. We hypothesized that resveratrol (RSV), a polyphenolic molecul...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2009.0243
更新日期:2010-10-01 00:00:00
abstract::The anticonvulsant properties of ethanol leaf extract of Spathodea campanulata, a plant used in traditional medicine to treat convulsion and epilepsy, were studied in mice using pentylenetetrazole-, picrotoxin-, and electroshock-induced models in mice. Other central nervous system effects and anticonvulsant-related ac...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2009.0144
更新日期:2010-08-01 00:00:00
abstract::The transport behavior and absorption mechanism of Ala-His-Leu-Leu (AHLL) intestinal absorption in Caco-2 cell monolayers were clarified systemically. The safe absorptive concentration of AHLL was 200 μg/mL, which was determined by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay. The permeat...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2016.3842
更新日期:2017-03-01 00:00:00
abstract::Eugenol (4-allyl-2-methoxyphenol), a major phenolic component from clove oil (Eugenia caryophyllata), has several biological activities. To estimate the capacity of eugenol to act as an antioxidant, the following were studied: 1,1-diphenyl-2-picryl-hydrazyl-, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid)-, and...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2010.0197
更新日期:2011-09-01 00:00:00
abstract::This study evaluated the antioxidant and protective effects of bioactive compounds isolated from pressurized steam-treated Corni Fructus (PSC). We had previously tested the protective effects of the furan fraction containing 5-hydroxymethylfurfural (5-HMF), polyphenol fraction containing gallic acid, and iridoid glyco...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2017.4149
更新日期:2018-11-01 00:00:00
abstract::Esophageal cancer (EC) is commonly diagnosed in South Africa (SA), with high incidences occurring in SA's black population. Moringa oleifera (MO), a multipurpose tree, is used traditionally for its nutritional and medicinal properties. It has been used for the treatment of a variety of ailments, including cancer. We i...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2015.0113
更新日期:2016-04-01 00:00:00
abstract::Tamoxifen is effective in breast cancer therapy in postmenopausal women; however, it causes adverse effects that alter the glycolytic pathway and induce hyperglycemia. Quercetin, a flavonoid with antioxidant potential, inhibits butyrylcholinesterase (BuChE), which is positively associated with hyperglycemia. Therefore...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2016.0078
更新日期:2017-03-01 00:00:00
abstract::Rice (Oryza sativa L.) has been a major dietary staple worldwide for centuries. Growing interest in the beneficial effects of antioxidants has inspired investigation of rice hulls as an attractive source of chemopreventive compounds for breast cancer intervention. We prepared methanol extracts from rice hulls of three...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2014.3181
更新日期:2015-03-01 00:00:00
abstract::Atherosclerosis, a progressive disease characterized by the accumulation of lipids and fibrous elements in the arteries, is a most important contributor to cardiovascular diseases. Resveratrol is a naturally occurring phytopolyphenol compound and shows the ability to reduce the risk of cardiovascular diseases. In this...
journal_title:Journal of medicinal food
pub_type: 杂志文章,评审
doi:10.1089/jmf.2007.0091
更新日期:2008-12-01 00:00:00
abstract::Allium cepa (Family Liliaceae) is a reputed Indian medicinal herb that is prescribed as an effective remedy for several ailments in the Ayurvedic system of medicine. The aim of this study was to evaluate its efficacy against various events responsible for Type I allergic reactions. A herbal fraction (ALC-02) from A. c...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2007.0642
更新日期:2009-04-01 00:00:00
abstract::This study researched the effects of Lactobacillus plantarum PMO 08 alone and combined with chia seeds on metabolic syndrome and parameters related to microbiota modulation and intestinal barrier integrity in obese mice fed high-fat diets (HFDs; 45% kcal fat). Male C57BL/6J mice were acclimated for a period of 2 weeks...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2018.4349
更新日期:2019-12-01 00:00:00
abstract::Adipose tissue is a key organ with substantial senescent cell accumulation under both obesity and aging conditions. Chia seed is an ancient seed and is the richest plant source of α-linolenic acid. We aimed to determine how cellular senescence markers will be altered in adipose tissue of senescence-accelerated mouse-p...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2017.4129
更新日期:2018-08-01 00:00:00
abstract::This is the first report about the modifying antibiotic activity of Eugenia uniflora L. and Eugenia jambolanum L. In this study the ethanol extract of E. uniflora and E. jambolanum was tested for their antimicrobial activity against strains of Escherichia coli. The growth of the two strains of E. coli bacteria tested ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2009.0158
更新日期:2010-08-01 00:00:00
abstract::The omega-3 (n-3) polyunsaturated fatty acids have a wide range of beneficial effects in several human health conditions. Animal and in vitro studies have indicated that omega-3 fatty acids affect blood lipid profiles, cardiovascular health, membrane lipid composition, eicosanoid biosynthesis, cell signaling cascades,...
journal_title:Journal of medicinal food
pub_type: 杂志文章,评审
doi:10.1089/jmf.2004.7.387
更新日期:2004-01-01 00:00:00
abstract::The liver and kidney functional indices of weanling albino rats (Rattus norvegicus) maintained on different accessions (offspring of a variety planted/collected at a specific location and time but differing in certain morphological characteristics) of cooked Colocasia esculenta (cocoyam)-based diets (UFCe1-UFCe7) for ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2009.0211
更新日期:2010-10-01 00:00:00
abstract::Obesity is generally associated with low-grade chronic inflammation that involves the recruitment of macrophages and other inflammation factors to the adipocytes of obese individuals. Tumor necrosis factor-alpha (TNF-α), a cytokine associated with systemic inflammation, is elevated in conditions of obesity. TNF-α is a...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2017.3941
更新日期:2018-03-01 00:00:00
abstract::Premature ejaculation (PE) is one of the foremost sex-related health problems among men. The global occurrence ranges from 20% to 30%, according to various studies. PE has a great impact on the men's quality of life, with deleterious effects such as embarrassment, frustration, and feeling of incompetence. Considering ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2019.4661
更新日期:2020-09-01 00:00:00
abstract::Peroxisome proliferator activated receptor (PPAR) is a nuclear receptor that is one of the transcription factors regulating lipid and glucose metabolism. Fermented ginseng (FG) is a ginseng fermented by Lactobacillus paracasei A221 containing minor ginsenosides and metabolites of fermentation. DNA microarray analysis ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2016.3673
更新日期:2016-09-01 00:00:00
abstract::Oxidative stress and lipid peroxidation are considered key factors linking obesity with its associated complications. Epigallo catechin-3-gallate (EGCG) and oleoylethanolamide, together with its phospholipid precursor N-oleoyl-phosphatidylethanolamine (NOPE), are nutritional compounds that might improve the oxidative ...
journal_title:Journal of medicinal food
pub_type: 杂志文章,随机对照试验
doi:10.1089/jmf.2019.0145
更新日期:2020-03-01 00:00:00
abstract::Frondoside A, a major triterpene glycoside from North Atlantic commercially harvested sea cucumber Cucumaria frondosa, possesses strong immunomodulatory properties in subtoxic doses. Frondoside A stimulates lysosomal activity of mouse macrophages in vivo at a maximal effective stimulatory dose of 0.2 microg per mouse ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2007.0530
更新日期:2008-09-01 00:00:00
abstract::High-performance liquid chromatography (HPLC) or capillary electrophoresis (CE) is particularly suited to the separation and analysis of a wide range of biological compounds. When investigating such compounds in complex matrices (e.g., blood, tissue, urine, foods), specificity of the detection method becomes an import...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.1999.2.111
更新日期:1999-01-01 00:00:00
abstract::The oxidation of lipids is an autocatalytic process consisting of a number of well-defined interrelated chemical reactions. Its importance has long been recognized in the food and polymer industry, and recent advances in the understanding of vascular diseases have shown that lipid peroxidation also contributes to huma...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.1999.2.163
更新日期:1999-01-01 00:00:00
abstract::Metabolic diseases, such as glucose intolerance and nonalcoholic fatty-liver disease (NAFLD), are primary risk factors for life-threatening conditions such as diabetes, heart attack, stroke, and hepatic cancer. Extracts from the tropical tree Moringa oleifera show antidiabetic, antioxidant, anti-inflammatory, and anti...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2016.3860
更新日期:2017-05-01 00:00:00
abstract::Neuropathic pain (NP) is associated with chronic hyperglycemia and emotional disorders such as depression in diabetic patients, complicating the course of treatment. Drugs currently used to treat NP have undesirable side effects, so research on other natural sources has been required. β-caryophyllene (BCP), a natural ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2018.0157
更新日期:2019-05-01 00:00:00
abstract::This study aimed to determine whether a shark muscle oil-olive oil mixture influences activators of human angiogenesis. The mixture completely abolished the stimulation induced by vascular endothelial growth factor (VEGF), fibroblast growth factor-2, transforming growth factor-beta, and platelet-derived growth factor....
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2006.9.300
更新日期:2006-10-01 00:00:00
abstract::Post-traumatic stress disorder (PTSD) is a stress-associated mental disorder characterized by an imbalance of neurotransmitters in response to traumatic events or fear. Genistein (GEN), a natural isoflavone, has been shown to exhibit neuroprotective effects. Here, we used the Morris water maze (MWM) and object recogni...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2019.4519
更新日期:2020-05-01 00:00:00