Anti-allergic effects of herbal product from Allium cepa (bulb).

Abstract:

:Allium cepa (Family Liliaceae) is a reputed Indian medicinal herb that is prescribed as an effective remedy for several ailments in the Ayurvedic system of medicine. The aim of this study was to evaluate its efficacy against various events responsible for Type I allergic reactions. A herbal fraction (ALC-02) from A. cepa (bulb) inhibited histamine release and attenuated intracellular calcium levels in Compound 48/80-induced rat peritoneal mast cells. It also prevented Compound 48/80-mediated systemic anaphylaxis while lowering histamine levels in plasma. ALC-02 suppressed carrageenan-induced rat paw edema. It inhibited eosinophil peroxidase activity and protein content in bronchoalveolar lavage fluid (BALF) of ovalbumin-challenged mice. In this experiment ALC-02 also caused a substantial reduction in lipid peroxidation in BALF/lung tissue and augmented superoxide dismutase activity in lung tissue. ALC-02 suppressed erythrocytic lysis caused by Triton X-100. A significant quenching of 1,1-diphenyl-2-picrylhydrazyl radical by ALC-02 was observed. The results have shown a promising anti-allergic profile of ALC-02 that could be attributed to its potential antihistaminic, anti-inflammatory, and antioxidant activities.

journal_name

J Med Food

authors

Kaiser P,Youssouf MS,Tasduq SA,Singh S,Sharma SC,Singh GD,Gupta VK,Gupta BD,Johri RK

doi

10.1089/jmf.2007.0642

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

374-82

issue

2

eissn

1096-620X

issn

1557-7600

journal_volume

12

pub_type

杂志文章
  • Aronia melanocarpa Concentrate Ameliorates Pro-Inflammatory Responses in HaCaT Keratinocytes and 12-O-Tetradecanoylphorbol-13-Acetate-Induced Ear Edema in Mice.

    abstract::Abnormal expression of pro-inflammatory mediators such as cell adhesion molecules and cytokines has been implicated in various inflammatory skin diseases, including atopic dermatitis. In this study, we investigated the anti-inflammatory activity of Aronia melanocarpa concentrate (AC) and its action mechanisms using in...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2015.3624

    authors: Goh AR,Youn GS,Yoo KY,Won MH,Han SZ,Lim SS,Lee KW,Choi SY,Park J

    更新日期:2016-07-01 00:00:00

  • Hypoglycemic effect of Lentinus strigosus (Schwein.) Fr. crude exopolysaccharide in streptozotocin-induced diabetic rats.

    abstract::ABSTRACT This study reports the hypoglycemic effects of the crude exopolysaccharide (EPS) produced from submerged mycelial culture of Lentinus strigosus (Schwein.) Fr. (Family Polyporaceae) in streptozotocin (STZ)-induced diabetic rats. In a dose-dependent study, diabetic rats were treated with EPS at doses of 50-150 ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2007.0551

    authors: Yamac M,Kanbak G,Zeytinoglu M,Bayramoglu G,Senturk H,Uyanoglu M

    更新日期:2008-09-01 00:00:00

  • Effect of Tart Cherry Polyphenols on Osteoclast Differentiation and Activity.

    abstract::Bone is maintained by an intricate balance between bone formation and bone resorption. The presence of inflammation can contribute to an imbalance in bone homeostasis by enhancing differentiation and activity of osteoclasts, the cells that participate in the breakdown of bone. Polyphenols such as flavonoids found in p...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2019.0050

    authors: Thomas A,South S,Vijayagopal P,Juma S

    更新日期:2020-01-01 00:00:00

  • Glyceollins Modulate Tumor Development and Growth in a Mouse Xenograft Model of Human Colon Cancer in a p53-Dependent Manner.

    abstract::Glyceollins are soybean-derived phytoalexins that induce the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling pathway, which is involved in the detoxification of carcinogens and the removal of reactive oxygen species (ROS). Recent studies, however, have indicated that Nrf2 induction stimulates the developm...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2018.4290

    authors: Jeong G,Oh J,Kim JS

    更新日期:2019-05-01 00:00:00

  • Fermented Moringa oleifera Decreases Hepatic Adiposity and Ameliorates Glucose Intolerance in High-Fat Diet-Induced Obese Mice.

    abstract::Metabolic diseases, such as glucose intolerance and nonalcoholic fatty-liver disease (NAFLD), are primary risk factors for life-threatening conditions such as diabetes, heart attack, stroke, and hepatic cancer. Extracts from the tropical tree Moringa oleifera show antidiabetic, antioxidant, anti-inflammatory, and anti...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2016.3860

    authors: Joung H,Kim B,Park H,Lee K,Kim HH,Sim HC,Do HJ,Hyun CK,Do MS

    更新日期:2017-05-01 00:00:00

  • Review of Clinical Effects and Presumed Mechanism of Action of the French Oak Wood Extract Robuvit.

    abstract::Since ancient times, oak wood polyphenols are consumed concomitantly with beverages that are stored and aged in oak wood barrels. Among these polyphenols are roburins, which belong to the class of ellagitannins and only occur in oak. To date, water-extracted standardized French Quercus robur wood extract, commercially...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2020.0165

    authors: Weichmann F,Avaltroni F,Burki C

    更新日期:2021-01-28 00:00:00

  • Marine collagen peptides prepared from chum salmon (Oncorhynchus keta) skin extend the life span and inhibit spontaneous tumor incidence in Sprague-Dawley Rats.

    abstract::To observe the effects of marine collagen peptides (MCPs) prepared from chum salmon (Oncorhynchus keta) skin on life span and spontaneous tumor incidence, Sprague-Dawley rats were fed diets supplemented with MCP at concentrations of 0%, 2.25%, 4.5%, and 9% (wt/wt) from the age of 4 weeks until natural death. There wer...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.1279

    authors: Liang J,Pei XR,Wang N,Zhang ZF,Wang JB,Li Y

    更新日期:2010-08-01 00:00:00

  • Propolis Protects Endotoxin Induced Acute Lung and Liver Inflammation Through Attenuating Inflammatory Responses and Oxidative Stress.

    abstract::Propolis is a natural bee product, and it has many effects, including antioxidant, anti-inflammatory, antihepatotoxic, and anticancer activity. In this study, we aimed to explore the potential in vivo anti-inflammatory, antioxidant, and antiapoptotic properties of propolis extract on lipopolysaccharide (LPS)-induced i...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2017.0151

    authors: Yangi B,Cengiz Ustuner M,Dincer M,Ozbayer C,Tekin N,Ustuner D,Colak E,Kolac UK,Entok E

    更新日期:2018-11-01 00:00:00

  • Effects of Cassia tora fiber supplement on serum lipids in Korean diabetic patients.

    abstract::Cassia tora fiber supplement consisting of 2 g of soluble fiber extracted from Cassia semen (C. tora L.), 200 mg of alpha-tocopherol, 500 mg of ascorbic acid, and 300 mg of maltodextrin was formulated in a pack, and given to 15 type II diabetic subjects (seven men and eight women 57.1 +/- 2.9 years old) with instructi...

    journal_title:Journal of medicinal food

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1089/jmf.2005.8.311

    authors: Cho SH,Kim TH,Lee NH,Son HS,Cho IJ,Ha TY

    更新日期:2005-10-01 00:00:00

  • Effects of Telfairia occidentalis (fluted pumpkin; Cucurbitaceae) in mouse models of convulsion, muscle relaxation, and depression.

    abstract::Telfairia occidentalis (Cucurbitaceae) is a leafy vegetable used in soup and folk medicine in southern Nigeria. Ethnobotanical survey revealed that preparations of the plant are used in the treatment of central nervous system-related disorders including convulsion. This study was conducted to investigate the effect of...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.0211

    authors: Akindele AJ,Ajao MY,Aigbe FR,Enumah US

    更新日期:2013-09-01 00:00:00

  • A comparison of the effects of commercially available hawthorn preparations on calcium transients of isolated cardiomyocytes.

    abstract::We studied the potential cardiac effects of two alcohol extracts of commercially available hawthorn using rat cardiomyocytes and measuring calcium transients by real-time fluorescence spectrophotometry. One preparation was a blend of hawthorn flowers, leaves, and berries (extract #1), and the other (extract #2) was fr...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2008.0080

    authors: Rodriguez ME,Poindexter BJ,Bick RJ,Dasgupta A

    更新日期:2008-12-01 00:00:00

  • Antihyperglycemic and antioxidant activity of crocin in streptozotocin-induced diabetic rats.

    abstract::The aim of the present study was to investigate the antihyperglycemic and protective potential of crocin, a pharmacologically active constituent of Crocus sativus L., in streptozotocin-induced diabetic rats. Rats were administered crocin intraperitoneally at doses of 15, 30, and 60 mg/kg of body weight for 6 weeks. Th...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.2407

    authors: Rajaei Z,Hadjzadeh MA,Nemati H,Hosseini M,Ahmadi M,Shafiee S

    更新日期:2013-03-01 00:00:00

  • The I148M variant of PNPLA3 reduces the response to docosahexaenoic acid in children with non-alcoholic fatty liver disease.

    abstract::The aim of this secondary analysis of a randomized controlled trial was to test whether the I148M variant of Patatin-like phospholipase domain-containing protein-3 (PNPLA3) is associated with the response to docosahexaenoic acid (DHA) in children with non-alcoholic fatty liver disease (NAFLD). Sixty children with NAFL...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jmf.2013.0043

    authors: Nobili V,Bedogni G,Donati B,Alisi A,Valenti L

    更新日期:2013-10-01 00:00:00

  • Morus alba, a Medicinal Plant for Appetite Suppression and Weight Loss.

    abstract::The prevalence of obesity is expanding rapidly worldwide, making the disease a global burden with limited treatment options. The current obesity drug development trends suggest the possibility of reducing weight and reverse metabolic disturbances of obesity by controlling appetite. In this study, we screened more than...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2017.0142

    authors: Yimam M,Jiao P,Hong M,Brownell L,Lee YC,Kim HJ,Nam JB,Kim MR,Jia Q

    更新日期:2019-07-01 00:00:00

  • Green tea polyphenols improve bone microarchitecture in high-fat-diet-induced obese female rats through suppressing bone formation and erosion.

    abstract::This study evaluates the effects of green tea polyphenols (GTPs) on bone microarchitecture in high-fat-diet (HFD)-induced obese female rats. Thirty-six 3-month-old female rats were fed either a control diet or a HFD for 4 months. Animals in the control group continued on the control diet for another 4 months. Animals ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.0199

    authors: Shen CL,Chyu MC,Cao JJ,Yeh JK

    更新日期:2013-05-01 00:00:00

  • Phloretin inhibits phorbol ester-induced tumor promotion and expression of cyclooxygenase-2 in mouse skin: extracellular signal-regulated kinase and nuclear factor-κB as potential targets.

    abstract::The present study investigated the effect of phloretin [2',4',6'-trihydroxy-3-(4-hydroxyphenyl)-propiophenone] on 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression and tumor promotion in mouse skin and explored the underlying molecular mechanisms. Topical application of phloretin s...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2011.1851

    authors: Shin JW,Kundu JK,Surh YJ

    更新日期:2012-03-01 00:00:00

  • The antioxidant property of chitosan green tea polyphenols complex induces transglutaminase activation in wound healing.

    abstract::The present study examined, for the first time, the in vitro wound healing potential of chitosan green tea polyphenols (CGP) complex based on the activation of transglutaminase (TGM) genes in epidermal morphogenesis. Response surface methodology was applied to determine the optimal processing condition that gave maxim...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.2623

    authors: Qin Y,Guo XW,Li L,Wang HW,Kim W

    更新日期:2013-06-01 00:00:00

  • Protective effect of royal jelly and green tea extracts effect against cisplatin-induced nephrotoxicity in mice: a comparative study.

    abstract::The aim of the present study was to investigate the protective role of royal jelly (RJ) and green tea (GT) extracts on cisplatin (cDDP)-induced nephrotoxicity in adult albino mice. Albino mice were randomly divided into six groups: Group I (control) received a single intraperitoneal injection of isotonic saline (0.02 ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.0036

    authors: Yapar K,Cavuşoğlu K,Oruç E,Yalçin E

    更新日期:2009-10-01 00:00:00

  • Adlay Bran Oil Suppresses Hepatic Gluconeogenesis and Attenuates Hyperlipidemia in Type 2 Diabetes Rats.

    abstract::This study aimed to examine the antidiabetic effects of various concentrations of adlay bran oil (ABO) in high fat diet and streptozotocin-induced diabetic rats. Dietary supplementation with 10% ABO for 4 weeks effectively decreased the blood triacylglycerol, glucose, and total cholesterol levels in diabetic rats, alt...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2018.4237

    authors: Tseng YH,Chang CW,Chiang W,Hsieh SC

    更新日期:2019-01-01 00:00:00

  • Natural Products from Single Plants as Sleep Aids: A Systematic Review.

    abstract::Insufficient sleep, insomnia, and sleep-related problems are important health issues, as their overall prevalence accounts for about 30% of the general population. The aim of this study was to systematically review previous studies investigating the effects of orally administered single plant-derived extracts on sleep...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,评审

    doi:10.1089/jmf.2017.4064

    authors: Kim J,Lee SL,Kang I,Song YA,Ma J,Hong YS,Park S,Moon SI,Kim S,Jeong S,Kim JE

    更新日期:2018-05-01 00:00:00

  • Inhibitory effects of salidroside on nitric oxide and prostaglandin E₂ production in lipopolysaccharide-stimulated RAW 264.7 macrophages.

    abstract::The aim of this study was to evaluate the effect of salidroside on lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E₂ (PGE₂) production in RAW 264.7 macrophages and related anti-inflammatory mechanism. PGE₂ production was measured by enzyme-linked immunosorbent assay (ELISA); NO production was tes...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.2473

    authors: Song B,Huang G,Xiong Y,Liu J,Xu L,Wang Z,Li G,Lu J,Guan S

    更新日期:2013-11-01 00:00:00

  • Antimicrobial effect of mastic gum methanolic extract against Porphyromonas gingivalis.

    abstract::The antimicrobial effect of mastic gum, an ancient remedy for oral malodor, against Porphyromonas gingivalis, a known odorogenic periopathogenic oral bacterium, was tested using the agar diffusion test. Paper discs impregnated with mastic gum methanolic extract (MME) [0.5-4% (wt/vol)] produced inhibition zones of 10.5...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2006.9.290

    authors: Sterer N

    更新日期:2006-07-01 00:00:00

  • Antihypertensive effects of Gynura procumbens extract in spontaneously hypertensive rats.

    abstract::Aqueous extracts of Gynura procumbens (Lour.) Merr. were orally administered to spontaneously hypertensive (SHR) rats for 4 weeks, and antihypertensive effects were determined. Oral administration of 500 mg/kg of G. procumbens (Lour.) Merr. extract (GPE) resulted in significantly lower blood pressure in SHR rats compa...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2006.9.587

    authors: Kim MJ,Lee HJ,Wiryowidagdo S,Kim HK

    更新日期:2006-01-01 00:00:00

  • Antioxidant properties of phytoestrogens.

    abstract::The oxidation of lipids is an autocatalytic process consisting of a number of well-defined interrelated chemical reactions. Its importance has long been recognized in the food and polymer industry, and recent advances in the understanding of vascular diseases have shown that lipid peroxidation also contributes to huma...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.1999.2.163

    authors: Patel RP,Crawford J,Boersma B,Barnes S,Darley-Usmar VM

    更新日期:1999-01-01 00:00:00

  • Protective Effect of Glyceollins in a Mouse Model of Dextran Sulfate Sodium-Induced Colitis.

    abstract::Glyceollins, which are derived from daidzein in soybean in response to various stimuli or stresses, have been reported to activate antioxidant/detoxifying enzymes in a nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-dependent manner, in addition to exerting anti-inflammatory effects in murine macrophages. As the Nr...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2017.3960

    authors: Seo H,Oh J,Hahn D,Kwon CS,Lee JS,Kim JS

    更新日期:2017-11-01 00:00:00

  • Fermented Ginseng Contains an Agonist of Peroxisome Proliferator Activated Receptors α and γ.

    abstract::Peroxisome proliferator activated receptor (PPAR) is a nuclear receptor that is one of the transcription factors regulating lipid and glucose metabolism. Fermented ginseng (FG) is a ginseng fermented by Lactobacillus paracasei A221 containing minor ginsenosides and metabolites of fermentation. DNA microarray analysis ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2016.3673

    authors: Igami K,Shimojo Y,Ito H,Miyazaki T,Nakano F,Kashiwada Y

    更新日期:2016-09-01 00:00:00

  • Limiting Dietary Sugar Improves Pediatric Sinonasal Symptoms and Reduces Inflammation.

    abstract::Excessive sugar consumption is associated with many chronic inflammatory diseases in adults. The effects of excessive sugar consumption in children have not been determined. In this study, we hypothesized that sinonasal symptoms and proinflammatory cytokine levels would be related and could be altered through reductio...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2017.0126

    authors: Sawani A,Farhangi M,N CA,Maul TM,Parthasarathy S,Smallwood J,Wei JL

    更新日期:2018-06-01 00:00:00

  • Beneficial effects of resveratrol on atherosclerosis.

    abstract::Atherosclerosis, a progressive disease characterized by the accumulation of lipids and fibrous elements in the arteries, is a most important contributor to cardiovascular diseases. Resveratrol is a naturally occurring phytopolyphenol compound and shows the ability to reduce the risk of cardiovascular diseases. In this...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,评审

    doi:10.1089/jmf.2007.0091

    authors: Fan E,Zhang L,Jiang S,Bai Y

    更新日期:2008-12-01 00:00:00

  • Micellarization and intestinal cell uptake of beta-carotene and lutein from drumstick (Moringa oleifera) leaves.

    abstract::The leaves and pods of the drumstick tree are used as food and medicine in some Asian and African countries. Although relatively high concentrations of beta-carotene and lutein have been reported in the leaves, the bioavailability of these carotenoids from this source is unknown. We have analyzed the digestive stabili...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2006.250

    authors: Pullakhandam R,Failla ML

    更新日期:2007-06-01 00:00:00

  • The natural flavonoid apigenin suppresses Th1- and Th2-related chemokine production by human monocyte THP-1 cells through mitogen-activated protein kinase pathways.

    abstract::Dietary flavonoids have various biological functions, and there is increasing evidence that reduced prevalence and severity of allergic reactions are associated with the intake of flavonoids. Among natural flavonoids, apigenin is a potent anti-inflammatory agent. However, the mechanisms of apigenin's effect remain unc...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.1229

    authors: Huang CH,Kuo PL,Hsu YL,Chang TT,Tseng HI,Chu YT,Kuo CH,Chen HN,Hung CH

    更新日期:2010-04-01 00:00:00