Abstract:
:To observe the effects of marine collagen peptides (MCPs) prepared from chum salmon (Oncorhynchus keta) skin on life span and spontaneous tumor incidence, Sprague-Dawley rats were fed diets supplemented with MCP at concentrations of 0%, 2.25%, 4.5%, and 9% (wt/wt) from the age of 4 weeks until natural death. There were 40 rats in each group (male:female ratio = 1:1). The results showed that the MCP did not significantly influence body weight or food consumption of rats of either sex throughout the life span; it did dose-dependently inhibit the age-related decrease in the activities of antioxidant enzymes and the age-related increase in the levels of lipid peroxidation product in both sexes. MCP notably increased the mean life span, the life span of the last 30% of the survivors, and the maximal life span; it decreased overall spontaneous tumor incidence of both sexes with significance in the 4.5% and 9% MCP-treated male groups and 9% MCP-treated female group. Compared to the control group, the incidence of death from tumors was decreased in MCP groups in comparison with the control group of both sexes. Therefore, we concluded that MCPs dose-dependently increase life span and decrease spontaneous tumor incidence in Sprague-Dawley rats. Moreover, the antioxidative property of MCPs may be responsible for the increased life span and protection against tumor development.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Liang J,Pei XR,Wang N,Zhang ZF,Wang JB,Li Ydoi
10.1089/jmf.2009.1279subject
Has Abstractpub_date
2010-08-01 00:00:00pages
757-70issue
4eissn
1096-620Xissn
1557-7600journal_volume
13pub_type
杂志文章abstract::The quantitative distribution of flavan-3-ols was determined using high-performance liquid chromatography in several grape seed extracts (GSEs). In all GSEs, polymers of four or more carbon units were the group of procyanidins present in the highest concentration, the real quantity ranging between 60% and 99.5%. In a ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/109662001300341770
更新日期:2001-07-01 00:00:00
abstract::The cytotoxic effects of extracts of the tomato variety "Racimo" have been evaluated through the use of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay at several concentrations. Three extracts-ethanol-water, petroleum ether, and in vitro digested tomato-exhibited in vitro cytotoxicity aga...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2010.0051
更新日期:2011-01-01 00:00:00
abstract::Dietary flavonoids have various biological functions, and there is increasing evidence that reduced prevalence and severity of allergic reactions are associated with the intake of flavonoids. Among natural flavonoids, apigenin is a potent anti-inflammatory agent. However, the mechanisms of apigenin's effect remain unc...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2009.1229
更新日期:2010-04-01 00:00:00
abstract::Irradiation technology can improve the biological activities of natural molecules through a structural modification. This study was conducted to investigate the enhancement of the anticancer effects of chrysin upon exposure to gamma irradiation. Gamma irradiation induces the production of new radiolytic peaks simultan...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2018.4320
更新日期:2019-07-01 00:00:00
abstract::The antioxidant effect of the ethanolic root extract of Hemidesmus indicus, an indigenous Ayurvedic medicinal plant used in soft drinks in India, was studied in rats with ethanol-induced hepatotoxicity. Administering 20% ethanol (5 g/kg of body weight/day) for 60 days to male Wistar rats resulted in significantly decr...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2006.110
更新日期:2007-12-01 00:00:00
abstract::Probiotic complex, zinc, and coenzyme Q10 (CoQ10) are recognized dietary supplements with an anti-inflammatory role. Although these supplementations are individually known to benefit rheumatoid arthritis (RA), there is no evidence suggesting any synergic effect. The primary goal of this study is to determine whether p...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2017.3952
更新日期:2018-01-01 00:00:00
abstract::Glucomannan-enriched squid surimi improves cholesterolemia and liver antioxidant status. The effect of squid surimi enriched with glucomannan or glucomannan plus spirulina on liver and heart structures and cell damage markers was tested in fa/fa rats fed highly saturated-hyper-energetic diets. Animals were fed 70% AIN...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2016.0157
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abstract::Cytokine-induced cell death is recognized as a major cause of progressive β-cell loss. Tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and interferon γ (IFN-γ) in combination trigger a series of events that lead to β-cell death. In the past few decades, the use of myricetin as an anti-inflammatory and cytopro...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2011.2033
更新日期:2012-08-01 00:00:00
abstract::Myostatin (MSTN) is a negative regulator of muscle growth even if some studies have shown a counterintuitive positive correlation between MSTN and muscle mass (MM). Our aim was to investigate the influence of 2 months of resistance training (RT) and diets with different protein contents on plasma MSTN, interleukin 1 b...
journal_title:Journal of medicinal food
pub_type: 杂志文章,随机对照试验
doi:10.1089/jmf.2014.0004
更新日期:2015-01-01 00:00:00
abstract::The present study investigated the effect of phloretin [2',4',6'-trihydroxy-3-(4-hydroxyphenyl)-propiophenone] on 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression and tumor promotion in mouse skin and explored the underlying molecular mechanisms. Topical application of phloretin s...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2011.1851
更新日期:2012-03-01 00:00:00
abstract::Daily consumption of an antioxidant-rich leafy vegetable mix (LVM) was assessed for beneficial effects on plasma lipid profiles, tissue lipid peroxidation, and oxidative DNA damage in C57BL/6J mice fed a high fat and high cholesterol diet (20% fat and 1% cholesterol, wt/wt) for 4 weeks. The LVM contained beet leaf, an...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2008.1125
更新日期:2009-08-01 00:00:00
abstract::Obesity is generally associated with low-grade chronic inflammation that involves the recruitment of macrophages and other inflammation factors to the adipocytes of obese individuals. Tumor necrosis factor-alpha (TNF-α), a cytokine associated with systemic inflammation, is elevated in conditions of obesity. TNF-α is a...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2017.3941
更新日期:2018-03-01 00:00:00
abstract::Studies have shown that polyphenols reduce the risk of inflammation-related diseases and upregulates energy expenditure in adipose tissue. Here, we investigated the mechanism of the anti-inflammatory and antiobesity effects of almond skin polyphenol extract (ASP) in differentiated 3T3-L1 adipocytes. The antioxidant ef...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2016.3806
更新日期:2017-02-01 00:00:00
abstract::Extracts obtained from the seeds of Nigella sativa are used as a spice or remedy for the treatment of various inflammatory diseases. The purpose of this study was to examine the analgesic and anti-inflammatory effects of its polyphenols. N. sativa seed polyphenols were prepared, and analgesic and anti-inflammatory eff...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2005.8.488
更新日期:2005-01-01 00:00:00
abstract::Obesity is characterized by an increase in the infiltration of monocytes into the adipose tissue, causing an inflammatory condition associated with, for example, the development of insulin resistance. Thus, anti-inflammatory-based treatments could emerge as a novel and interesting approach. It has been reported that C...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2014.0031
更新日期:2015-05-01 00:00:00
abstract::The study was designed to carry out the phytochemical screening and the proximate analysis of Cnidoscolus aconitifolius leaves. The results obtained showed the presence of tannins, saponin, alkaloids, and flavonoids with the absence of glycosides. The proximate analysis and mineral composition of C. aconitifolius leav...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2008.0321
更新日期:2011-03-01 00:00:00
abstract::One of the critical features of Alzheimer's disease is cognitive dysfunction, which is, in part, due to decreases in acetylcholine (ACh). The ethanol extract of Perilla frutescens was selected for isolating the acetylcholinesterase (AChE) inhibitor based on preliminary screening. In vivo behavioral tests were performe...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2015.3540
更新日期:2016-03-01 00:00:00
abstract::Isoliquiritigenin (ISL), a flavonoid chalcone that is present in licorice, shallot, and bean sprouts, is known to have antitumorigenic activities. The present study examined whether ISL alters prostate cancer cell cycle progression. DU145 human and MatLyLu (MLL) rat prostate cancer cells were cultured with various con...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2008.0039
更新日期:2009-02-01 00:00:00
abstract::Ganoderma lucidum has been widely used to treat various diseases, including cancer, diabetes, and neurasthenia in many Asian countries. This randomized, double-blind, placebo-controlled parallel study aimed to investigate the efficacy and safety of a polysaccharide extract of G. lucidum (Ganopoly) in Chinese patients ...
journal_title:Journal of medicinal food
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1089/jmf.2005.8.53
更新日期:2005-04-01 00:00:00
abstract::The oxidation of lipids is an autocatalytic process consisting of a number of well-defined interrelated chemical reactions. Its importance has long been recognized in the food and polymer industry, and recent advances in the understanding of vascular diseases have shown that lipid peroxidation also contributes to huma...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.1999.2.163
更新日期:1999-01-01 00:00:00
abstract::The Asteraceae family is widely known for its therapeutic, aromatic, and nutritional properties. Chaptalia nutans (C. nutans), a member of the family, is widely used in folk medicine in southern Brazil. In this study, we aim to assess compounds present in root extracts of C. nutans, and evaluate their antioxidant capa...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2019.0309
更新日期:2020-06-16 00:00:00
abstract::Garlic has been used medicinally throughout human history. Allicin is considered the most therapeutic constituent of garlic. This study tested the antimicrobial activity of garlic allicin on oral pathogens associated with dental caries and periodontitis. Allicin was found effective against all the tested bacteria. The...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2010.0165
更新日期:2011-11-01 00:00:00
abstract::In the traditional system of medicine, the roots and rhizomes of Glycyrrhiza glabra have been employed clinically for centuries for their anti-inflammatory, anti-ulcer, expectorant, antimicrobial, and anxiolytic activities. The present study was undertaken to investigate the effects of G. glabra, popularly known as li...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2004.7.462
更新日期:2004-01-01 00:00:00
abstract::Worldwide prevalence of noncommunicable chronic degenerative diseases is among the main causes of death worldwide. The consumption of some foods such as nuts and seeds may be beneficial in preventing these diseases. Dipteryx alata Vogel (DA), known popularly as Baru, belongs to the family Fabaceae and is a native frui...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2017.0052
更新日期:2017-11-01 00:00:00
abstract::The aim of this study is to examine the in vitro antioxidant and antimicrobial activities of the acetone, methanol, and aqueous extracts of the lichens Cladonia furcata (many-forked Cladonia), Hypogymnia physodes (puffed lichen), and Umbilicaria polyphylla (manyleaf navel lichen) and the antimicrobial activity of fuma...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2010.0316
更新日期:2011-12-01 00:00:00
abstract::Different polysaccharides were isolated from the leaves of Aloe arborescens using the gradient power of hydrogen followed by antitumor and immunomodulatory assay. The total polysaccharide content of different fractions, water-soluble polysaccharide (WAP), acid-soluble polysaccharide (ACP), and alkaline-soluble polysac...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2016.0148
更新日期:2017-05-01 00:00:00
abstract::The DNA topoisomerase inhibitor beta-lapachone is a quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) in South America. It has been reported to possess a wide range of pharmacological properties, and is a promising cancer chemopreventive agent. In this study, the effects of beta-lapachone on th...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2006.9.161
更新日期:2006-07-01 00:00:00
abstract::Telfairia occidentalis (fluted pumpkin) is one of the commonly consumed leafy vegetables in Nigeria. In order to justify its inclusion in herbal preparations in African traditional medicine, the possible hypolipidemic effect of this vegetable was investigated in rats fed a cholesterol-rich diet. The ability of Questra...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2006.213
更新日期:2007-06-01 00:00:00
abstract::The omega-3 (n-3) polyunsaturated fatty acids have a wide range of beneficial effects in several human health conditions. Animal and in vitro studies have indicated that omega-3 fatty acids affect blood lipid profiles, cardiovascular health, membrane lipid composition, eicosanoid biosynthesis, cell signaling cascades,...
journal_title:Journal of medicinal food
pub_type: 杂志文章,评审
doi:10.1089/jmf.2004.7.387
更新日期:2004-01-01 00:00:00
abstract::Peroxisome proliferator activated receptor (PPAR) is a nuclear receptor that is one of the transcription factors regulating lipid and glucose metabolism. Fermented ginseng (FG) is a ginseng fermented by Lactobacillus paracasei A221 containing minor ginsenosides and metabolites of fermentation. DNA microarray analysis ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2016.3673
更新日期:2016-09-01 00:00:00