Abstract:
:Post-traumatic stress disorder (PTSD) is a stress-associated mental disorder characterized by an imbalance of neurotransmitters in response to traumatic events or fear. Genistein (GEN), a natural isoflavone, has been shown to exhibit neuroprotective effects. Here, we used the Morris water maze (MWM) and object recognition task (ORT) tests to examine the effects of GEN on cognitive impairment in rats after exposure to single prolonged stress (SPS), and its interaction with the serotonergic system. After exposure to SPS, male rats received GEN (2, 4, and 10 mg/kg, i.p.) for 14 days. Daily GEN administration significantly improved cognitive function in the ORT and MWM tests. GEN treatment also inhibited SPS-induced decreases in serotonin (5-HT) levels in the medial prefrontal cortex and hippocampus. These increased 5-HT concentrations in response to GEN treatment could be partially attributed to the ratio of 5-hydroxyindoleacetic acid/5-HT in the hippocampus. Our findings suggest that GEN significantly attenuates SPS-induced memory deficits in rats and may represent an effective therapeutic option for the treatment of PTSD.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Lee B,Choi GM,Shim I,Lee Hdoi
10.1089/jmf.2019.4519subject
Has Abstractpub_date
2020-05-01 00:00:00pages
476-484issue
5eissn
1096-620Xissn
1557-7600journal_volume
23pub_type
杂志文章abstract::Sarcopenia, loss of muscle mass and function, is mainly observed in elderly people. In this study, we investigated whether fermented rice germ extract (FRGE) has some effects on the mouse gastrocnemius muscle by using behavioral and morphological analyses, Western blotting, and a murine model of immobilization-induced...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2016.3906
更新日期:2017-10-01 00:00:00
abstract::Aqueous extracts of Gynura procumbens (Lour.) Merr. were orally administered to spontaneously hypertensive (SHR) rats for 4 weeks, and antihypertensive effects were determined. Oral administration of 500 mg/kg of G. procumbens (Lour.) Merr. extract (GPE) resulted in significantly lower blood pressure in SHR rats compa...
journal_title:Journal of medicinal food
pub_type: 杂志文章
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2005.8.251
更新日期:2005-07-01 00:00:00
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journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2018.0198
更新日期:2019-10-01 00:00:00
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journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2008.0321
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journal_title:Journal of medicinal food
pub_type: 杂志文章
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journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/109662001753165747
更新日期:2001-10-01 00:00:00
abstract::Traditional herbal remedies stimulate and modulate the immune system, and it is thought that their glycoproteins and polysaccharides are responsible for this activity. We prepared crude water, protein, and polysaccharide extracts from Atractylodes macrocephala Koidz, Helianthus annuus L., Scutellaria barbata D. Don, a...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2017.3943
更新日期:2017-10-01 00:00:00
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journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2014.3242
更新日期:2015-05-01 00:00:00
abstract::The effect of the administration of a whey protein isolate (WPI) and collagen hydrolysates on ethanol-induced ulcerative lesions was studied in rats. WPI and bovine or porcine collagen hydrolysate (BCH and PCH, respectively) were given to rats by gavage. In acute experiments, (single-dose) physiological saline (10 mL/...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2008.0277
更新日期:2010-02-01 00:00:00
abstract::Diabetes is a chronic degenerative disease with no cure, is found in millions of people worldwide, and can cause life-threatening complications at any age. The plant Cissus sicyoides L. is a runner plant found abundantly in Brazil, especially in the Amazon. Its therapeutic properties are widely used in popular medicin...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2008.0157
更新日期:2009-08-01 00:00:00
abstract::Propolis is a natural bee product, and it has many effects, including antioxidant, anti-inflammatory, antihepatotoxic, and anticancer activity. In this study, we aimed to explore the potential in vivo anti-inflammatory, antioxidant, and antiapoptotic properties of propolis extract on lipopolysaccharide (LPS)-induced i...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2017.0151
更新日期:2018-11-01 00:00:00
abstract::In South America, particularly in the Northeastern regions of Brazil, Turnera subulata leaf extract is used as an alternative traditional medicine approach for several types of chronic diseases, such as diabetes, hypertension, chronic pain, and general inflammation. Despite its widespread use, little is known about th...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2016.0047
更新日期:2016-10-01 00:00:00
abstract::Several species of Passiflora have been employed widely as a folk medicine because of sedative and tranquillizer activities. In this study, we evaluate the effects on anxiety and memory process of two popularly used Passiflora species. To this aim, male Wistar rats (weighing 250-300 g) were intraperitoneally injected ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2007.722
更新日期:2008-06-01 00:00:00
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journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2008.1069
更新日期:2009-06-01 00:00:00
abstract::Many studies have focused on the effect of fresh fruits on the risk of developing cancer and other diseases involved with reactive species and free radicals. The intake of frozen fruits has spread widely in the last years, but, until now, their biological activity is not completely known. In this study, 23 samples of ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2007.598
更新日期:2008-03-01 00:00:00
abstract::Propolis was included in the Argentine Food Code as a functional food. The chemical parameters and antioxidant properties of propolis samples from the same colonies of Apis mellifera in San Juan (Cuyo region, Western Argentine) were compared every month for 1 year using two collection methods. Chemical parameters were...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2008.0286
更新日期:2009-12-01 00:00:00
abstract:UNLABELLED:Opuntia ficus-indica (OFI) is a cactus species widely used as an anti-inflammatory, antilipidemic, and hypoglycemic agent. It has been shown that OFI extract (OFIE) inhibits oxidative stress in animal models of diabetes and hepatic disease; however, its antioxidant mechanism remains largely unknown. In this ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2014.3396
更新日期:2015-10-01 00:00:00
abstract::Although diagnostic criteria for metabolic syndrome (MtS) vary among various health professionals and organizations, blood glucose dysregulation and insulin resistance are common to all definitions. Red ginseng is beneficial for glucose regulation and insulin sensitivity but the mechanism is not yet elucidated. Ginsen...
journal_title:Journal of medicinal food
pub_type: 杂志文章,随机对照试验
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更新日期:2013-05-01 00:00:00
abstract::Astaxanthine (ASTx) is a novel carotenoid nutraceutical occurring in many crustaceans and red yeasts. It has potent antioxidant, photoprotective, hepatodetoxicant, and anti-inflammatory activities. Documented effect of ASTx on treatment of neurodegenerative disease is still lacking. We used the beta-amyloid peptide (A...
journal_title:Journal of medicinal food
pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00
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journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2006.9.62
更新日期:2006-04-01 00:00:00
abstract::Previously, we reported that bamboo culms possess a stronger antioxidative capacity than bamboo leaves in vitro. In this study, we investigated whether bamboo culm extract (BCE) supplementation ameliorates oxidative stress and hepatic nuclear factor kappaB (NF kappa B) activation in C57BL/6 mice fed an atherogenic die...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2007.009
更新日期:2008-03-01 00:00:00
abstract::The anticonvulsant properties of ethanol leaf extract of Spathodea campanulata, a plant used in traditional medicine to treat convulsion and epilepsy, were studied in mice using pentylenetetrazole-, picrotoxin-, and electroshock-induced models in mice. Other central nervous system effects and anticonvulsant-related ac...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2009.0144
更新日期:2010-08-01 00:00:00
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journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2020.0064
更新日期:2020-07-15 00:00:00
abstract::The infections by protozoans of the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials, which cause renal and cardiac toxicity. As part of a search for new drugs against leishmaniasi...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2010.0018
更新日期:2011-06-01 00:00:00
abstract::Kefir is an association of microrganisms generally grown in milk, with known probiotic activities identified from its soured suspensions. Aqueous media are also able to grow kefir, but little is known about the probiotic properties of its fermented products. This work aimed to evaluate some probiotic properties of a c...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2007.329
更新日期:2008-06-01 00:00:00
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journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2019.0277
更新日期:2020-09-01 00:00:00
abstract::This study was aimed at evaluating the antioxidant activity and efficacy of the ethanolic extract of the endemic plant species Kitaibelia vitifolia in inhibiting the growth of selected fungi and bacteria. Antimicrobial activity was tested using the broth dilution procedure for determination of minimum inhibitory conce...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2011.0013
更新日期:2011-12-01 00:00:00
abstract::Irradiation technology can improve the biological activities of natural molecules through a structural modification. This study was conducted to investigate the enhancement of the anticancer effects of chrysin upon exposure to gamma irradiation. Gamma irradiation induces the production of new radiolytic peaks simultan...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2018.4320
更新日期:2019-07-01 00:00:00