Bioactivity of Peptides Released During Lactic Fermentation of Amaranth Proteins with Potential Cardiovascular Protective Effect: An In Vitro Study.

Abstract:

:Fermentation has shown to be an effective technique in bioactive peptides release. That is why in this study antihypertensive, antithrombotic, and antioxidant activity was evaluated during amaranth proteins fermentation with Lactobacillus casei Shirota and Streptococcus thermophilus 54102 in mono and combined culture. During fermentation an increase of free amine groups was observed, and no statistical differences among monocultures were shown, getting higher concentration in combined culture. This was related to antihypertensive and antioxidant activities, where the highest values were also found in the combined process (45% of angiotensin-converting enzyme inhibition, and 168 μmol Trolox equivalents per liter [TE/L] for 2,2-diphenyl-1-picrylhydrazyl, 268 μmol TE/L for 2,2'-azino-bis 3-ethylbenzothiazoline-6-sulfonic acid, and 381 μmol Fe2E/L for ferric reducing ability of plasma). On the contrary, antithrombotic activity was not related to free amine groups during fermentation, having the highest bioactivity in different moments in each experiment. L. casei Shirota and S. thermophilus 54102 are strains that are able to release bioactive peptides from amaranth protein, although amaranth is not a common matrix for the development of lactic acid bacteria. In addition, in this study it was observed for the first time that lactic acid strains are able to release bioactive peptides from amaranth protein. In addition, this methodology could be part for the development of fermented beverages, different from fermented milk, to diversify matrix to obtain a novel functional food.

journal_name

J Med Food

authors

Ayala-Niño A,Rodríguez-Serrano GM,Jiménez-Alvarado R,Bautista-Avila M,Sánchez-Franco JA,González-Olivares LG,Cepeda-Saez A

doi

10.1089/jmf.2019.0039

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

976-981

issue

10

eissn

1096-620X

issn

1557-7600

journal_volume

22

pub_type

杂志文章
  • Effects of Telfairia occidentalis (fluted pumpkin; Cucurbitaceae) in mouse models of convulsion, muscle relaxation, and depression.

    abstract::Telfairia occidentalis (Cucurbitaceae) is a leafy vegetable used in soup and folk medicine in southern Nigeria. Ethnobotanical survey revealed that preparations of the plant are used in the treatment of central nervous system-related disorders including convulsion. This study was conducted to investigate the effect of...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.0211

    authors: Akindele AJ,Ajao MY,Aigbe FR,Enumah US

    更新日期:2013-09-01 00:00:00

  • Stability of lycopene during food processing and storage.

    abstract::With an increasing understanding of the health benefit of lycopene, how to preserve lycopene during food processing and storage has caused much attention. Lycopene belongs to the carotenoid family and mostly exists in nature as the all-trans form. Heat, light, oxygen, and different food matrices are factors that have ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,评审

    doi:10.1089/jmf.2005.8.413

    authors: Xianquan S,Shi J,Kakuda Y,Yueming J

    更新日期:2005-01-01 00:00:00

  • Hepatoprotective and antioxidant activities of Vernonia amygdalina on acetaminophen-induced hepatic damage in mice.

    abstract::Vernonia amygdalina Del. (Family Compositae) is used in Nigerian folk medicine as a tonic and remedy against constipation, fever, high blood pressure, and many infectious diseases. We have evaluated the hepatoprotective and antioxidant effects of an aqueous extract of V. amygdalina leaves against acetaminophen-induced...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2006.9.524

    authors: Iwalokun BA,Efedede BU,Alabi-Sofunde JA,Oduala T,Magbagbeola OA,Akinwande AI

    更新日期:2006-01-01 00:00:00

  • Gustatory Evaluation of Still and Carbonated Waters: A Preference Rating Study.

    abstract::We studied the sensory preference for six still waters and four carbonated waters, nonflavored, by 11 tasting experts (4 women and 7 men). Five tasters rated the still waters, four tasters rated the carbonated water, and seven tasters rated twice on each of the still waters when evaluated with a dry red wine. All rati...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/109662001753165747

    authors: Fong DY,Halpern GM,Wan V

    更新日期:2001-10-01 00:00:00

  • Effect of supplementation of traditional medicinal plants on blood glucose in non-insulin-dependent diabetics: a pilot study.

    abstract::The effect of supplementation of a powdered mixture of three traditional medicinal plants-bittergourd, jamun seeds, and fenugreek seeds-in raw and cooked form on blood glucose was studied in 60 non-insulin-dependent male diabetics. The patients were divided into two groups of 30 each. The patients of group I were give...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2005.8.545

    authors: Kochhar A,Nagi M

    更新日期:2005-01-01 00:00:00

  • Protective effect of royal jelly and green tea extracts effect against cisplatin-induced nephrotoxicity in mice: a comparative study.

    abstract::The aim of the present study was to investigate the protective role of royal jelly (RJ) and green tea (GT) extracts on cisplatin (cDDP)-induced nephrotoxicity in adult albino mice. Albino mice were randomly divided into six groups: Group I (control) received a single intraperitoneal injection of isotonic saline (0.02 ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.0036

    authors: Yapar K,Cavuşoğlu K,Oruç E,Yalçin E

    更新日期:2009-10-01 00:00:00

  • Effects of Chungkookjang supplementation on obesity and atherosclerotic indices in overweight/obese subjects: a 12-week, randomized, double-blind, placebo-controlled clinical trial.

    abstract::This study was designed to investigate the anti-obesity and anti-atherosclerotic effects of supplementation with Chungkookjang (CKJ), a traditional fermented soybean food, in overweight/obese subjects. The study was a 12-week, randomized, double-blind, placebo-controlled clinical trial followed by a 3-week screening p...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jmf.2010.1199

    authors: Back HI,Kim SR,Yang JA,Kim MG,Chae SW,Cha YS

    更新日期:2011-05-01 00:00:00

  • Effects of heating, storage, and ultraviolet exposure on antimicrobial activity of garlic juice.

    abstract::This study was designed to investigate the effect of heating, storage, and ultraviolet exposure on antimicrobial activity of garlic juice and its bacteriocidal activity against common human pathogens. Antimicrobial activity of fresh garlic juice was tested against Escherichia coli, Staphylococcus aureus, Streptococcus...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2005.067

    authors: Al-Waili NS,Saloom KY,Akmal M,Al-Waili TN,Al-Waili AN,Al-Waili H,Ali A,Al-Sahlani K

    更新日期:2007-03-01 00:00:00

  • Supplementation with soybean peptides, taurine, Pueraria isoflavone, and ginseng saponin complex improves endurance exercise capacity in humans.

    abstract::The purpose of this study was to investigate the effects of a proprietary blend of soybean peptides, taurine, Pueraria isoflavone, and ginseng saponin complex (STPG capsule) on exercise performance in humans. Fourteen male volunteers were randomly assigned to two crossover treatments in which they consumed either four...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jmf.2010.1096

    authors: Yeh TS,Chan KH,Hsu MC,Liu JF

    更新日期:2011-03-01 00:00:00

  • Crude ethanolic extracts of Garcinia kola seeds Heckel (Guttiferae) prolong the lag phase of Helicobacter pylori: inhibitory and bactericidal potential.

    abstract::Problems associated with current treatment regimens have generated a considerable interest in alternative approaches for the eradication of Helicobacter pylori infections using phytochemical compounds. In an attempt to identify potential sources of such compounds, the antimicrobial activity of five solvent extracts of...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2010.0127

    authors: Njume C,Afolayan AJ,Clarke AM,Ndip RN

    更新日期:2011-07-01 00:00:00

  • Tagatose, the new GRAS sweetener and health product.

    abstract::Tagatose, a low-calorie, full-bulk natural sugar, has just attained GRAS (Generally Recognized As Safe) status under U.S. Food and Drug Administration (FDA) regulations, thereby permitting its use as a sweetener in foods and beverages. This paper presents all current aspects of tagatose with respect to demonstrated fo...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,评审

    doi:10.1089/109662002753723197

    authors: Levin GV

    更新日期:2002-04-01 00:00:00

  • A meta-analysis of clinical improvements of general well-being by a standardized Lycium barbarum.

    abstract::Four randomized, blind, placebo-controlled clinical trials were pooled to study the general effects of oral consumption of Lycium barbarum at 120 mL/day, as a standardized juice, GoChi(®) (FreeLife International, Phoenix, AZ, USA). A questionnaire consisting of symptoms graded 0-5 was given to the participants. For ea...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,meta分析

    doi:10.1089/jmf.2012.0013

    authors: Paul Hsu CH,Nance DM,Amagase H

    更新日期:2012-11-01 00:00:00

  • Ginsenoside Rh2 improves learning and memory in mice.

    abstract::A wide range of plant foods and dietary supplements are able to modify the functioning of the central nervous system. In the present study, we observed that oral administration of ginsenoside Rh2 (10 mg/mL) for 3 weeks significantly improved spatial learning and memory. Spatial memory and learning was evaluated in mic...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.2564

    authors: Hou J,Xue J,Lee M,Liu L,Zhang D,Sun M,Zheng Y,Sung C

    更新日期:2013-08-01 00:00:00

  • High temperature- and high pressure-processed garlic improves lipid profiles in rats fed high cholesterol diets.

    abstract::Garlic protects against degenerative diseases such as hyperlipidemia and cardiovascular diseases. However, raw garlic has a strong pungency, which is unpleasant. In this study, we examined the effect of high temperature/high pressure-processed garlic on plasma lipid profiles in rats. Sprague-Dawley rats were fed a nor...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2011.1922

    authors: Sohn CW,Kim H,You BR,Kim MJ,Kim HJ,Lee JY,Sok DE,Kim JH,Lee KJ,Kim MR

    更新日期:2012-05-01 00:00:00

  • Effects of chlorella on activities of protein tyrosine phosphatases, matrix metalloproteinases, caspases, cytokine release, B and T cell proliferations, and phorbol ester receptor binding.

    abstract::A Chlorella powder was screened using 52 in vitro assay systems for enzyme activity, receptor binding, cellular cytokine release, and B and T cell proliferation. The screening revealed a very potent inhibition of human protein tyrosine phosphatase (PTP) activity of CD45 and PTP1C with 50% inhibitory concentration (IC(...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/1096620041224076

    authors: Cheng FC,Lin A,Feng JJ,Mizoguchi T,Takekoshi H,Kubota H,Kato Y,Naoki Y

    更新日期:2004-07-01 00:00:00

  • Bioactive compounds and antioxidant and antiproliferative activities of Korean white lotus cultivars.

    abstract::In traditional Korean medicine, lotus (Nelumbo nucifera Gaertn) roots have been used as an antidiabetic and an antiproliferative remedy. However, scientific publications on lotus properties are very limited. Therefore, it was decided to investigate the Korean white lotus cultivars in order to find out their bioactivit...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.0018

    authors: Park YS,Towantakavanit K,Kowalska T,Jung ST,Ham KS,Heo BG,Cho JY,Yun JG,Kim HJ,Gorinstein S

    更新日期:2009-10-01 00:00:00

  • Isoflavone composition, total polyphenolic content, and antioxidant activity in soybeans of different origin.

    abstract::Twenty soybean cultivars, originating from the United States, Russia, Serbia, and China, were analyzed for their isoflavone composition, total polyphenolic content, and antioxidant activity. Isoflavones were extracted by aqueous methanol (80%) and analyzed by high-performance liquid chromatography/diode array detectio...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.0050

    authors: Tepavcević V,Atanacković M,Miladinović J,Malencić D,Popović J,Cvejić J

    更新日期:2010-06-01 00:00:00

  • Inhibitory Effects of Standardized Boesenbergia pandurata Extract and Its Active Compound Panduratin A on Lipopolysaccharide-Induced Periodontal Inflammation and Alveolar Bone Loss in Rats.

    abstract::Periodontitis, an inflammatory disease of the gingival tissue, triggered by microbial-derived elements, such as lipopolysaccharide (LPS), collapses the periodontal tissues and resorbs the alveolar bone. This study evaluated the inhibitory effects of standardized Boesenbergia pandurata extract (BPE) and panduratin A (P...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2017.4155

    authors: Kim H,Kim C,Kook KE,Yanti,Choi S,Kang W,Hwang JK

    更新日期:2018-10-01 00:00:00

  • N-Oleoyl-Phosphatidyl-Ethanolamine and Epigallo Catechin-3-Gallate Mitigate Oxidative Stress in Overweight and Class I Obese People on a Low-Calorie Diet.

    abstract::Oxidative stress and lipid peroxidation are considered key factors linking obesity with its associated complications. Epigallo catechin-3-gallate (EGCG) and oleoylethanolamide, together with its phospholipid precursor N-oleoyl-phosphatidylethanolamine (NOPE), are nutritional compounds that might improve the oxidative ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jmf.2019.0145

    authors: Cazzola R,Rondanelli M

    更新日期:2020-03-01 00:00:00

  • Cuscuta chinensis extract promotes osteoblast differentiation and mineralization in human osteoblast-like MG-63 cells.

    abstract::The aim of the present study was to investigate whether the aqueous extract of To-Sa-Za (TSZ-AE), the seed of Cuscuta chinensis Lam., which is a traditional medicinal herb commonly used in Korea and other oriental countries, could induce osteogenic activity in human osteoblast-like MG-63 cells. TSZ-AE treatment mildly...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2007.0665

    authors: Yang HM,Shin HK,Kang YH,Kim JK

    更新日期:2009-02-01 00:00:00

  • 4-methylcoumarin derivatives inhibit human neutrophil oxidative metabolism and elastase activity.

    abstract::Increased neutrophil activation significantly contributes to the tissue damage in inflammatory illnesses; this phenomenon has motivated the search for new compounds to modulate their effector functions. Coumarins are natural products that are widely consumed in the human diet. We have evaluated the antioxidant and imm...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.0184

    authors: Kabeya LM,Fuzissaki CN,Andrade MF,Azzolini AE,Taleb-Contini SH,Vermelho RB,Lopes JL,Lucisano-Valim YM

    更新日期:2013-08-01 00:00:00

  • Effect of spices on lipid metabolism in 1,2-dimethylhydrazine-induced rat colon carcinogenesis.

    abstract::Colon cancer is the second most common cancer among men and women worldwide. We investigated the effect of red chilli (Capsicum annum L.), cumin (Cuminum cyminum L.), and black pepper (Piper nigrum L.) on colon cancer induced in rats by a colon-specific carcinogen, 1,2-dimethylhydrazine (DMH). Colon cancer was induced...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2006.9.237

    authors: Nalini N,Manju V,Menon VP

    更新日期:2006-07-01 00:00:00

  • Effect of procyanidin C1 on nitric oxide production and hyperpolarization through Ca(2+)-dependent pathway in endothelial cells.

    abstract::Polyphenol-rich foods, such as fruits and vegetables, are protective against cardiovascular diseases, but the mechanisms of the beneficial effects are still unknown. The goal of this research was to clarify actions of procyanidin trimer (C1) in rat aortic endothelial cells (RAECs). Procyanidin C1 at concentrations up ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.2297

    authors: Byun MW

    更新日期:2012-11-01 00:00:00

  • Honey and microbial infections: a review supporting the use of honey for microbial control.

    abstract::Honey has been used as a medicine throughout the ages and has recently been reintroduced to modern medical practice. Much of the research to date has addressed honey's antibacterial properties and its effects on wound healing. Laboratory studies and clinical trials have shown that honey is an effective broad-spectrum ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,评审

    doi:10.1089/jmf.2010.0161

    authors: Al-Waili NS,Salom K,Butler G,Al Ghamdi AA

    更新日期:2011-10-01 00:00:00

  • Antioxidant properties of phytoestrogens.

    abstract::The oxidation of lipids is an autocatalytic process consisting of a number of well-defined interrelated chemical reactions. Its importance has long been recognized in the food and polymer industry, and recent advances in the understanding of vascular diseases have shown that lipid peroxidation also contributes to huma...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.1999.2.163

    authors: Patel RP,Crawford J,Boersma B,Barnes S,Darley-Usmar VM

    更新日期:1999-01-01 00:00:00

  • Antioxidant Opuntia ficus-indica Extract Activates AHR-NRF2 Signaling and Upregulates Filaggrin and Loricrin Expression in Human Keratinocytes.

    abstract:UNLABELLED:Opuntia ficus-indica (OFI) is a cactus species widely used as an anti-inflammatory, antilipidemic, and hypoglycemic agent. It has been shown that OFI extract (OFIE) inhibits oxidative stress in animal models of diabetes and hepatic disease; however, its antioxidant mechanism remains largely unknown. In this ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2014.3396

    authors: Nakahara T,Mitoma C,Hashimoto-Hachiya A,Takahara M,Tsuji G,Uchi H,Yan X,Hachisuka J,Chiba T,Esaki H,Kido-Nakahara M,Furue M

    更新日期:2015-10-01 00:00:00

  • Cudrania Tricuspidata Extract and Its Major Constituents Inhibit Oxidative Stress-Induced Liver Injury.

    abstract::The fruits, leaves, and roots of Cudrania tricuspidata have been reported to contain large amounts of vitamin B, vitamin C, and flavonoids. They exhibit various physiological activities such as antitumor and anti-inflammatory effects. However, the hepatoprotective effects of C. tricuspidata extracts against oxidative ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2018.4322

    authors: Cho SS,Yang JH,Seo KH,Shin SM,Park EY,Cho SS,Jo GU,Eo JH,Park JS,Oh DS,Kim JB,Na CS,Ku SK,Cho IJ,Ki SH

    更新日期:2019-06-01 00:00:00

  • Genes related to suppression of malignant phenotype induced by Maitake D-Fraction in breast cancer cells.

    abstract::It is already known that the Maitake (D-Fraction) mushroom is involved in stimulating the immune system and activating certain cells that attack cancer, including macrophages, T-cells, and natural killer cells. According to the U.S. National Cancer Institute, polysaccharide complexes present in Maitake mushrooms appea...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.0222

    authors: Alonso EN,Orozco M,Eloy Nieto A,Balogh GA

    更新日期:2013-07-01 00:00:00

  • Partial Molecular Characterization of Arctium minus Aspartylendopeptidase and Preparation of Bioactive Peptides by Whey Protein Hydrolysis.

    abstract::In this article, we report the cloning of an aspartic protease (AP) from flowers of Arctium minus (Hill) Bernh. (Asteraceae) along with the use of depigmented aqueous flower extracts, as a source of APs, for the hydrolysis of whey proteins. The isolated cDNA encoded a protein product with 509 amino acids called arctiu...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2014.0101

    authors: Cimino CV,Colombo ML,Liggieri C,Bruno M,Vairo-Cavalli S

    更新日期:2015-08-01 00:00:00

  • Limiting Dietary Sugar Improves Pediatric Sinonasal Symptoms and Reduces Inflammation.

    abstract::Excessive sugar consumption is associated with many chronic inflammatory diseases in adults. The effects of excessive sugar consumption in children have not been determined. In this study, we hypothesized that sinonasal symptoms and proinflammatory cytokine levels would be related and could be altered through reductio...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2017.0126

    authors: Sawani A,Farhangi M,N CA,Maul TM,Parthasarathy S,Smallwood J,Wei JL

    更新日期:2018-06-01 00:00:00