Abstract：
:Impaired fasting blood glucose is one of the landmark signs of metabolic syndrome, together with hyperinsulinemia, dyslipidemia, hypertension, and a chronic proinflammatory, pro-oxidative, and prothrombotic environment. This study investigates the effect of wild blueberry (WB) consumption on blood glucose levels and other parameters involved in glucose metabolism in the obese Zucker rat (OZR), an experimental model of metabolic syndrome. Sixteen OZRs and 16 lean littermate controls (lean Zucker rat [LZR]) were fed an 8% enriched WB diet or a control (C) diet for 8 weeks. Plasma concentrations of glucose, insulin, glycated hemoglobin GHbA1c, resistin, and retinol-binding protein 4 (RBP4) were measured. Expression of the resistin, RBP4, and glucose transporter GLUT4 genes was also determined both in the liver and the abdominal adipose tissue (AAT). Plasma glycated hemoglobin HbA1c, RBP4, and resistin concentrations were significantly lower in OZRs following the WB diet (-20%, -22%, and -27%, respectively, compared to C diet, P<.05). Following WB consumption, resistin expression was significantly downregulated in the liver of both OZRs and LZRs (-28% and -61%, respectively, P<.05), while RBP4 expression was significantly downregulated in the AAT of both OZRs and LZRs (-87% and -43%, respectively, P<.05). All other markers were not significantly affected following WB consumption. In conclusion, WB consumption normalizes some markers related to glucose metabolism in the OZR model of metabolic syndrome, but has no effect on fasting blood glucose or insulin concentrations.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Vendrame S,Zhao A,Merrow T,Klimis-Zacas Ddoi
10.1089/jmf.2014.0065subject
Has Abstractpub_date
2015-06-01 00:00:00pages
619-24issue
6eissn
1096-620Xissn
1557-7600journal_volume
18pub_type
杂志文章abstract：:The fruits, leaves, and roots of Cudrania tricuspidata have been reported to contain large amounts of vitamin B, vitamin C, and flavonoids. They exhibit various physiological activities such as antitumor and anti-inflammatory effects. However, the hepatoprotective effects of C. tricuspidata extracts against oxidative ...
journal_title：Journal of medicinal food
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journal_title：Journal of medicinal food
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journal_title：Journal of medicinal food
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pub_type： 杂志文章
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journal_title：Journal of medicinal food
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journal_title：Journal of medicinal food
pub_type： 杂志文章
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journal_title：Journal of medicinal food
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journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2011.0144
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journal_title：Journal of medicinal food
pub_type： 杂志文章
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journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2008.0080
更新日期：2008-12-01 00:00:00
abstract：:Panax ginseng (P. ginseng C.A. Meyer, Araliaceae) is used as a therapeutic agent for various diseases. P. ginseng saponins, known as ginsenosides, are the main bioactive compounds responsible for its pharmacological activities. In this work, we have developed a new method of P. ginseng root processing termed solid-sta...
journal_title：Journal of medicinal food
pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1089/jmf.2008.0286
更新日期：2009-12-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2009.0036
更新日期：2009-10-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2015.3443
更新日期：2015-12-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2011.2033
更新日期：2012-08-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Journal of medicinal food
pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
abstract：:Polyphenols and particularly flavonoids are well known in vitro antioxidants. Their consumption in foods has been shown to decrease the risk of heart disease in epidemiological studies. Because flavonoids are consumed with vitamin C in the diet, the combination may prove to be more beneficial than either alone. The co...
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pub_type： 杂志文章
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