Abstract：
:Ilex latifolia Thunb. (Aquifoliaceae), a Chinese bitter tea called "kudingcha," has been widely consumed as a health beverage and found to possess antioxidant, antidiabetic, antihypertensive, anti-inflammatory, and anti-ischemic activities. The aim of the present study was to investigate the neuroprotective effects of an ethanol extract of I. latifolia against amyloid β protein (Aβ)-induced memory impairment in mice and neurotoxicity in cultured rat cortical neurons. Memory impairment in mice was induced by intracerebroventricular injection of 15 nmol Aβ (25-35) and measured by the passive avoidance test and Morris water maze test. Chronic administration of I. latifolia (25-100 mg/kg, p.o.) significantly prevented Aβ (25-35)-induced memory loss. I. latifolia also prevented the decrease of glutathione concentrations, increased lipid peroxidation, expression of phosphorylated tau (p-tau), and changes in apoptosis-associated proteins in the memory-impaired mouse brain. Exposure of cultured cortical neurons to 10 μM Aβ (25-35) for 36 h induced neuronal apoptotic death. The neuronal cell death, elevation of intracellular Ca(2+) concentration, generation of reactive oxygen species, and expression of proapoptotic proteins caused by Aβ (25-35) in the cultured neurons were inhibited by treatment with I. latifolia (1-50 μg/mL). These results suggest that I. latifolia may have a possible therapeutic role in managing cognitive impairment associated with Alzheimer's disease. The underlying mechanism might involve the antiapoptotic effects mediated by antioxidant activity and inhibition of p-tau formation.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Kim JY,Lee HK,Jang JY,Yoo JK,Seong YHdoi
10.1089/jmf.2015.3443subject
Has Abstractpub_date
2015-12-01 00:00:00pages
1317-26issue
12eissn
1096-620Xissn
1557-7600journal_volume
18pub_type
杂志文章abstract：:In the traditional system of medicine, the roots and rhizomes of Glycyrrhiza glabra have been employed clinically for centuries for their anti-inflammatory, anti-ulcer, expectorant, antimicrobial, and anxiolytic activities. The present study was undertaken to investigate the effects of G. glabra, popularly known as li...
journal_title：Journal of medicinal food
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journal_title：Journal of medicinal food
pub_type： 杂志文章,评审
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journal_title：Journal of medicinal food
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journal_title：Journal of medicinal food
pub_type： 杂志文章
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更新日期：2009-10-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2010-10-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2010-12-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2014.3248
更新日期：2015-04-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2014.3396
更新日期：2015-10-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2011.0144
更新日期：2012-04-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章,随机对照试验
doi：10.1089/jmf.2010.1096
更新日期：2011-03-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
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更新日期：2018-11-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
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journal_title：Journal of medicinal food
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journal_title：Journal of medicinal food
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journal_title：Journal of medicinal food
pub_type： 杂志文章
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journal_title：Journal of medicinal food
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abstract：:With an increasing understanding of the health benefit of lycopene, how to preserve lycopene during food processing and storage has caused much attention. Lycopene belongs to the carotenoid family and mostly exists in nature as the all-trans form. Heat, light, oxygen, and different food matrices are factors that have ...
journal_title：Journal of medicinal food
pub_type： 杂志文章,评审
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更新日期：2005-01-01 00:00:00
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journal_title：Journal of medicinal food
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journal_title：Journal of medicinal food
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更新日期：2013-08-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
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journal_title：Journal of medicinal food
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