Abstract：
:Extracts obtained from the seeds of Nigella sativa are used as a spice or remedy for the treatment of various inflammatory diseases. The purpose of this study was to examine the analgesic and anti-inflammatory effects of its polyphenols. N. sativa seed polyphenols were prepared, and analgesic and anti-inflammatory effects were studied in mice and rats using the acetic acid-induced writhing, formalin, light tail flick, carrageenan-induced paw edema, and croton oil-induced ear edema tests. In the acetic acid-induced writhing test, oral administration of N. sativa polyphenols (NSP) decreased the number of abdominal constrictions. Both oral and intraperitoneal administration of NSP significantly suppressed in a dose-dependent manner the nociceptive response in the early and late phases of the formalin test, and the effect on the late phase was more pronounced. Pretreatment with naloxone failed to reverse the analgesic activity of NSP in this test. NSP did not produce a significant analgesia in the light tail flick test in mice. Oral administration of NSP did not produce a significant reduction in carrageenan-induced paw edema. However, when injected intraperitoneally, NSP inhibited paw edema in a dosedependent manner. NSP when applied topically failed to reduce croton oil-induced ear edema. These results suggest that NSP have analgesic and anti-inflammatory effects. The lack of analgesic effect of NSP in the light tail flick test and also the failure of naloxone to reverse the analgesia in the formalin test reveal that mechanisms other than stimulation of opioid receptors are involved.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Ghannadi A,Hajhashemi V,Jafarabadi Hdoi
10.1089/jmf.2005.8.488subject
Has Abstractpub_date
2005-01-01 00:00:00pages
488-93issue
4eissn
1096-620Xissn
1557-7600journal_volume
8pub_type
杂志文章abstract：:The purpose of this study was to investigate the effects of a proprietary blend of soybean peptides, taurine, Pueraria isoflavone, and ginseng saponin complex (STPG capsule) on exercise performance in humans. Fourteen male volunteers were randomly assigned to two crossover treatments in which they consumed either four...
journal_title：Journal of medicinal food
pub_type： 杂志文章,随机对照试验
doi：10.1089/jmf.2010.1096
更新日期：2011-03-01 00:00:00
abstract：:Contrasting data partially support a certain antihypertensive efficacy of lactotripeptides derived from enzymatic treatment of casein hydrolysate. We carried out a randomized, double-blind, crossover clinical study to investigate the antihypertensive efficacy of a short-term treatment with lactotripeptides in Mediterr...
journal_title：Journal of medicinal food
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1089/jmf.2009.0253
更新日期：2010-12-01 00:00:00
abstract：:Momordica charantia is used to treat various diseases, including inflammatory conditions. Previous reports indicated that the extract of this plant inhibits activation of nuclear transcription factor-κB (NF-κB) but activates peroxisome proliferator-activated receptor (PPAR). Additionally, cucurbitane-type triterpene g...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2011.1766
更新日期：2012-04-01 00:00:00
abstract：:Cassia tora fiber supplement consisting of 2 g of soluble fiber extracted from Cassia semen (C. tora L.), 200 mg of alpha-tocopherol, 500 mg of ascorbic acid, and 300 mg of maltodextrin was formulated in a pack, and given to 15 type II diabetic subjects (seven men and eight women 57.1 +/- 2.9 years old) with instructi...
journal_title：Journal of medicinal food
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1089/jmf.2005.8.311
更新日期：2005-10-01 00:00:00
abstract：:Telfairia occidentalis (Cucurbitaceae) is a leafy vegetable used in soup and folk medicine in southern Nigeria. Ethnobotanical survey revealed that preparations of the plant are used in the treatment of central nervous system-related disorders including convulsion. This study was conducted to investigate the effect of...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2012.0211
更新日期：2013-09-01 00:00:00
abstract：:The DNA topoisomerase inhibitor beta-lapachone is a quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) in South America. It has been reported to possess a wide range of pharmacological properties, and is a promising cancer chemopreventive agent. In this study, the effects of beta-lapachone on th...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2006.9.161
更新日期：2006-07-01 00:00:00
abstract：:Adipose tissue is a key organ with substantial senescent cell accumulation under both obesity and aging conditions. Chia seed is an ancient seed and is the richest plant source of α-linolenic acid. We aimed to determine how cellular senescence markers will be altered in adipose tissue of senescence-accelerated mouse-p...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2017.4129
更新日期：2018-08-01 00:00:00
abstract：:Advanced glycation endproducts and oxidative stress contribute to the pathogenesis of diabetic complications. The total phenolic content (TPC), antioxidant, and antiglycation properties of crude ethanolic extracts of 10 common culinary herbs and spices from Mauritius were investigated in vitro. Fluorescence at 370 nm/...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2012.0113
更新日期：2012-12-01 00:00:00
abstract：:The relative dialysability of magnesium in a number of different inorganic and organic magnesium-containing compounds from ten commercially available products was investigated using an in vitro method. Reference values were provided by tests carried out in parallel using comparable quantities of pure magnesium compoun...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.1999.2.65
更新日期：1999-01-01 00:00:00
abstract：:Post-traumatic stress disorder (PTSD) is a stress-associated mental disorder characterized by an imbalance of neurotransmitters in response to traumatic events or fear. Genistein (GEN), a natural isoflavone, has been shown to exhibit neuroprotective effects. Here, we used the Morris water maze (MWM) and object recogni...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2019.4519
更新日期：2020-05-01 00:00:00
abstract：:This study was designed to evaluate the effect of dietary conjugated linoleic acid (CLA) on endurance exercise and availability of metabolic substrates in mice. Four-week-old male BALB/c mice were randomized to a control group (normal diet) and a CLA group (normal diet + 1% CLA). Each animal group received its respect...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2009.1358
更新日期：2010-10-01 00:00:00
abstract：:Antimicrobial activities of 10-100% (wt/vol) concentrations of new honey, stored honey, heated honey, ultraviolet-exposed honey, and heated stored honey were tested against common human pathogens, including Escherichia coli, Entrobacter cloacae, Pseudomonas aeruginosa, Shigella dysenteriae, Klebsiella sp., Haemophilus...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/1096620041224139
更新日期：2004-07-01 00:00:00
abstract：:This study evaluates the effects of green tea polyphenols (GTPs) on bone microarchitecture in high-fat-diet (HFD)-induced obese female rats. Thirty-six 3-month-old female rats were fed either a control diet or a HFD for 4 months. Animals in the control group continued on the control diet for another 4 months. Animals ...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2012.0199
更新日期：2013-05-01 00:00:00
abstract：:Obesity is characterized by an increase in the infiltration of monocytes into the adipose tissue, causing an inflammatory condition associated with, for example, the development of insulin resistance. Thus, anti-inflammatory-based treatments could emerge as a novel and interesting approach. It has been reported that C...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2014.0031
更新日期：2015-05-01 00:00:00
abstract：:In this study, the effects of Humulus japonicus (HJ) aqueous extract on 3T3-L1 preadipocytes and HepG2 cells (in vitro model) as well as on C57BL/6 mice fed on high-fat diet (HFD) (in vivo model) were evaluated. Mice fed on HFD for 12-weeks were taken the HJ water extract (HJW) at various doses, 50, 150, and 250 mg/kg...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2017.4135
更新日期：2018-10-01 00:00:00
abstract：:In this article, we report the cloning of an aspartic protease (AP) from flowers of Arctium minus (Hill) Bernh. (Asteraceae) along with the use of depigmented aqueous flower extracts, as a source of APs, for the hydrolysis of whey proteins. The isolated cDNA encoded a protein product with 509 amino acids called arctiu...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2014.0101
更新日期：2015-08-01 00:00:00
abstract：:Ingestion of bioactive compounds, such as hesperidin and naringin, found in citrus fruits and orange juice, can improve the homeostasis of gut microbiota. A controlled clinical study with temporal series intergroup design with 10 apparently healthy women (28.5 ± 8.4 years, 24.1 ± 3.3 kg/m2) were evaluated after contin...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2018.0080
更新日期：2019-02-01 00:00:00
abstract：:This study evaluated the antioxidant and protective effects of bioactive compounds isolated from pressurized steam-treated Corni Fructus (PSC). We had previously tested the protective effects of the furan fraction containing 5-hydroxymethylfurfural (5-HMF), polyphenol fraction containing gallic acid, and iridoid glyco...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2017.4149
更新日期：2018-11-01 00:00:00
abstract：:Species of Hoodia Sweet ex Decne., family Apocynaceae, a southern African succulent plant, have been recognized for their appetite suppressing properties. Products that support appetite and weight control have been developed in Israel from locally cultivated Hoodia spp. To study consumer acceptance, efficacy of, and t...
journal_title：Journal of medicinal food
pub_type： 杂志文章,随机对照试验
doi：10.1089/jmf.2013.0178
更新日期：2015-02-01 00:00:00
abstract：:Oxidative stress and lipid peroxidation are considered key factors linking obesity with its associated complications. Epigallo catechin-3-gallate (EGCG) and oleoylethanolamide, together with its phospholipid precursor N-oleoyl-phosphatidylethanolamine (NOPE), are nutritional compounds that might improve the oxidative ...
journal_title：Journal of medicinal food
pub_type： 杂志文章,随机对照试验
doi：10.1089/jmf.2019.0145
更新日期：2020-03-01 00:00:00
abstract：:Metabolic diseases, such as glucose intolerance and nonalcoholic fatty-liver disease (NAFLD), are primary risk factors for life-threatening conditions such as diabetes, heart attack, stroke, and hepatic cancer. Extracts from the tropical tree Moringa oleifera show antidiabetic, antioxidant, anti-inflammatory, and anti...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2016.3860
更新日期：2017-05-01 00:00:00
abstract：:The use of synbiotics as health promoters is still poorly defined, and human intervention studies are scarce. This study was designed to evaluate the effects of a commercialized synbiotic product containing Lactobacillus acidophilus La5, Bifidobacterium animalis ssp. lactis Bb-12, Lactobacillus delbrueckii ssp. bulgar...
journal_title：Journal of medicinal food
pub_type： 杂志文章,随机对照试验
doi：10.1089/jmf.2008.0328
更新日期：2011-01-01 00:00:00
abstract：:Ilex latifolia Thunb. (Aquifoliaceae), a Chinese bitter tea called "kudingcha," has been widely consumed as a health beverage and found to possess antioxidant, antidiabetic, antihypertensive, anti-inflammatory, and anti-ischemic activities. The aim of the present study was to investigate the neuroprotective effects of...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2015.3443
更新日期：2015-12-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is an autoimmune and chronic inflammatory disease resulting in joint destruction and disability in the adult population. The etiology of RA is not well understood and presently there is no known cure for this disease. The accumulation and proliferation of fibroblast-like synoviocytes may be i...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2019.0046
更新日期：2019-10-01 00:00:00
abstract：:Ganoderma lucidum has been widely used to treat various diseases, including cancer, diabetes, and neurasthenia in many Asian countries. This randomized, double-blind, placebo-controlled parallel study aimed to investigate the efficacy and safety of a polysaccharide extract of G. lucidum (Ganopoly) in Chinese patients ...
journal_title：Journal of medicinal food
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1089/jmf.2005.8.53
更新日期：2005-04-01 00:00:00
abstract：:The aim of this study was to evaluate the effect of salidroside on lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E₂ (PGE₂) production in RAW 264.7 macrophages and related anti-inflammatory mechanism. PGE₂ production was measured by enzyme-linked immunosorbent assay (ELISA); NO production was tes...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2012.2473
更新日期：2013-11-01 00:00:00
abstract：:Neuropathic pain (NP) is associated with chronic hyperglycemia and emotional disorders such as depression in diabetic patients, complicating the course of treatment. Drugs currently used to treat NP have undesirable side effects, so research on other natural sources has been required. β-caryophyllene (BCP), a natural ...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2018.0157
更新日期：2019-05-01 00:00:00
abstract：:Aquaporin-1 (AQP1) is a water channel that is highly expressed on the apical side of the choroid plexus epithelium (CP) and thought to be one of the major pathways for the high water permeability of this structure. Blockade of AQP1 in the CP reduce the production of cerebrospinal fluid (CSF). Downregulation of AQP1 mi...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2012.0208
更新日期：2013-06-01 00:00:00
abstract：:Twenty soybean cultivars, originating from the United States, Russia, Serbia, and China, were analyzed for their isoflavone composition, total polyphenolic content, and antioxidant activity. Isoflavones were extracted by aqueous methanol (80%) and analyzed by high-performance liquid chromatography/diode array detectio...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2009.0050
更新日期：2010-06-01 00:00:00
abstract：:Diabetes is a chronic degenerative disease with no cure, is found in millions of people worldwide, and can cause life-threatening complications at any age. The plant Cissus sicyoides L. is a runner plant found abundantly in Brazil, especially in the Amazon. Its therapeutic properties are widely used in popular medicin...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2008.0157
更新日期：2009-08-01 00:00:00
