Beta-lapachone, a quinone isolated from Tabebuia avellanedae, induces apoptosis in HepG2 hepatoma cell line through induction of Bax and activation of caspase.

Abstract:

:The DNA topoisomerase inhibitor beta-lapachone is a quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) in South America. It has been reported to possess a wide range of pharmacological properties, and is a promising cancer chemopreventive agent. In this study, the effects of beta-lapachone on the growth of the human hepatoma cell line HepG2 were investigated. The results showed that beta-lapachone inhibits the viability of HepG2 by inducing apoptosis, as evidenced by the formation of apoptotic bodies and DNA fragmentation. Reverse transcription-polymerase chain reaction and immunoblotting results indicated that treatments of cells with beta-lapachone resulted in down-regulation of anti-apoptotic Bcl-2 and Bcl-X(L) and up-regulation of pro-apoptotic Bax expression. beta-Lapachone-induced apoptosis was associated with a proteolytic activation of caspase-3 and -9 and degradation of poly(ADP-ribose) polymerase protein. However, beta-lapachone treatment did not affect the inhibitor of apoptosis proteins family and the Fas/FasL system. Taken together, our study indicated that beta-lapachone may have potential as a chemopreventive agent for liver cancer.

journal_name

J Med Food

authors

Woo HJ,Park KY,Rhu CH,Lee WH,Choi BT,Kim GY,Park YM,Choi YH

doi

10.1089/jmf.2006.9.161

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

161-8

issue

2

eissn

1096-620X

issn

1557-7600

journal_volume

9

pub_type

杂志文章
  • Gamma-Irradiated Chrysin Improves Anticancer Activity in HT-29 Colon Cancer Cells Through Mitochondria-Related Pathway.

    abstract::Irradiation technology can improve the biological activities of natural molecules through a structural modification. This study was conducted to investigate the enhancement of the anticancer effects of chrysin upon exposure to gamma irradiation. Gamma irradiation induces the production of new radiolytic peaks simultan...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2018.4320

    authors: Song HY,Kim HM,Mushtaq S,Kim WS,Kim YJ,Lim ST,Byun EB

    更新日期:2019-07-01 00:00:00

  • Reduced Coenzyme Q10 Decreases Urinary 8-Oxo-7,8-Dihydro-2'-Deoxyguanosine Concentrations in Healthy Young Female Subjects.

    abstract::It remains unclear whether dietary supplementation with coenzyme Q10 (CoQ10) provides beneficial effects for healthy individuals, especially young subjects. This study investigated the effects of dietary supplementation with CoQ10 on oxidative stress in healthy young females. We performed a placebo-controlled trial us...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2014.3302

    authors: Ito K,Watanabe C,Nakamura A,Oikawa-Tada S,Murata M

    更新日期:2015-08-01 00:00:00

  • Effects of Cassia tora fiber supplement on serum lipids in Korean diabetic patients.

    abstract::Cassia tora fiber supplement consisting of 2 g of soluble fiber extracted from Cassia semen (C. tora L.), 200 mg of alpha-tocopherol, 500 mg of ascorbic acid, and 300 mg of maltodextrin was formulated in a pack, and given to 15 type II diabetic subjects (seven men and eight women 57.1 +/- 2.9 years old) with instructi...

    journal_title:Journal of medicinal food

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1089/jmf.2005.8.311

    authors: Cho SH,Kim TH,Lee NH,Son HS,Cho IJ,Ha TY

    更新日期:2005-10-01 00:00:00

  • Effect of supplementation of traditional medicinal plants on blood glucose in non-insulin-dependent diabetics: a pilot study.

    abstract::The effect of supplementation of a powdered mixture of three traditional medicinal plants-bittergourd, jamun seeds, and fenugreek seeds-in raw and cooked form on blood glucose was studied in 60 non-insulin-dependent male diabetics. The patients were divided into two groups of 30 each. The patients of group I were give...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2005.8.545

    authors: Kochhar A,Nagi M

    更新日期:2005-01-01 00:00:00

  • Development of a database for government-funded health/functional food research.

    abstract::The Korean Health/Functional Food Act of 2002 has led to the promotion of research on health/functional foods (HFFs). In order to track government-funded studies on HFFs, a free accessible database (National Research & Development on Functional Food, NaReaD(ff)) has been established by the Korea Food and Drug Administ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,评审

    doi:10.1089/jmf.2009.1036

    authors: Kim JY,Park J,Kwon O

    更新日期:2009-12-01 00:00:00

  • Antioxidant and antimicrobial properties of some lichens and their constituents.

    abstract::The aim of this study is to examine the in vitro antioxidant and antimicrobial activities of the acetone, methanol, and aqueous extracts of the lichens Cladonia furcata (many-forked Cladonia), Hypogymnia physodes (puffed lichen), and Umbilicaria polyphylla (manyleaf navel lichen) and the antimicrobial activity of fuma...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2010.0316

    authors: Kosanić M,Ranković B

    更新日期:2011-12-01 00:00:00

  • Determination of minerals extracted from several commercial teas (Camellia sinensis) to hot water (infusion).

    abstract::Mineral contents of some tea and their infusions drunk in Turkey were established by inductively coupled plasma atomic emission spectrometry. The Al, Ca, K, Mg, Mn, P, and S contents were very high in both infusions and tea (i.e., pieces of the tea plant). The As, Cd, Cr, Li, Pb, and Se contents of infusion and tea we...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2006.9.123

    authors: Gezgin S,Ozcan MM,Atalay E

    更新日期:2006-04-01 00:00:00

  • Genistein Prevents Single Prolonged Stress-Induced Cognitive Impairment in a Post-Traumatic Stress Disorder Rat Model via Activation of the Serotonergic System.

    abstract::Post-traumatic stress disorder (PTSD) is a stress-associated mental disorder characterized by an imbalance of neurotransmitters in response to traumatic events or fear. Genistein (GEN), a natural isoflavone, has been shown to exhibit neuroprotective effects. Here, we used the Morris water maze (MWM) and object recogni...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2019.4519

    authors: Lee B,Choi GM,Shim I,Lee H

    更新日期:2020-05-01 00:00:00

  • Relationship between total phenolic content, antioxidant potential, and antiglycation abilities of common culinary herbs and spices.

    abstract::Advanced glycation endproducts and oxidative stress contribute to the pathogenesis of diabetic complications. The total phenolic content (TPC), antioxidant, and antiglycation properties of crude ethanolic extracts of 10 common culinary herbs and spices from Mauritius were investigated in vitro. Fluorescence at 370 nm/...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.0113

    authors: Ramkissoon JS,Mahomoodally MF,Ahmed N,Subratty AH

    更新日期:2012-12-01 00:00:00

  • Fermented Moringa oleifera Decreases Hepatic Adiposity and Ameliorates Glucose Intolerance in High-Fat Diet-Induced Obese Mice.

    abstract::Metabolic diseases, such as glucose intolerance and nonalcoholic fatty-liver disease (NAFLD), are primary risk factors for life-threatening conditions such as diabetes, heart attack, stroke, and hepatic cancer. Extracts from the tropical tree Moringa oleifera show antidiabetic, antioxidant, anti-inflammatory, and anti...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2016.3860

    authors: Joung H,Kim B,Park H,Lee K,Kim HH,Sim HC,Do HJ,Hyun CK,Do MS

    更新日期:2017-05-01 00:00:00

  • Cuscuta chinensis extract promotes osteoblast differentiation and mineralization in human osteoblast-like MG-63 cells.

    abstract::The aim of the present study was to investigate whether the aqueous extract of To-Sa-Za (TSZ-AE), the seed of Cuscuta chinensis Lam., which is a traditional medicinal herb commonly used in Korea and other oriental countries, could induce osteogenic activity in human osteoblast-like MG-63 cells. TSZ-AE treatment mildly...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2007.0665

    authors: Yang HM,Shin HK,Kang YH,Kim JK

    更新日期:2009-02-01 00:00:00

  • Protective effects against H2O2-induced damage by enzymatic hydrolysates of an edible brown seaweed, sea tangle (Laminaria japonica).

    abstract::Enzymatic hydrolysates of Laminaria japonica were evaluated for antioxidative activities using hydroxyl radical scavenging activity and protective effects against H(2)O(2)-induced DNA and cell damage. In addition, activities of antioxidative enzymes, including catalase, glutathione peroxidase, and glutathione S-transf...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2007.0675

    authors: Park PJ,Kim EK,Lee SJ,Park SY,Kang DS,Jung BM,Kim KS,Je JY,Ahn CB

    更新日期:2009-02-01 00:00:00

  • Lactic Acid Bacterial Starter Culture with Antioxidant and γ-Aminobutyric Acid Biosynthetic Activities Isolated from Flatfish-Sikhae Fermentation.

    abstract::The aim of this study is to select a lactic acid bacterial strain as a starter culture for flatfish-Sikhae fermentation and to evaluate its suitability for application in a food system. Four strains of lactic acid bacteria isolated from commercial flatfish-Sikhae were identified and selected as starter culture candida...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2015.3458

    authors: Won YG,Yu HH,Chang YH,Hwang HJ

    更新日期:2015-12-01 00:00:00

  • Bioactive compounds and antioxidant and antiproliferative activities of Korean white lotus cultivars.

    abstract::In traditional Korean medicine, lotus (Nelumbo nucifera Gaertn) roots have been used as an antidiabetic and an antiproliferative remedy. However, scientific publications on lotus properties are very limited. Therefore, it was decided to investigate the Korean white lotus cultivars in order to find out their bioactivit...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.0018

    authors: Park YS,Towantakavanit K,Kowalska T,Jung ST,Ham KS,Heo BG,Cho JY,Yun JG,Kim HJ,Gorinstein S

    更新日期:2009-10-01 00:00:00

  • Morus alba, a Medicinal Plant for Appetite Suppression and Weight Loss.

    abstract::The prevalence of obesity is expanding rapidly worldwide, making the disease a global burden with limited treatment options. The current obesity drug development trends suggest the possibility of reducing weight and reverse metabolic disturbances of obesity by controlling appetite. In this study, we screened more than...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2017.0142

    authors: Yimam M,Jiao P,Hong M,Brownell L,Lee YC,Kim HJ,Nam JB,Kim MR,Jia Q

    更新日期:2019-07-01 00:00:00

  • Cell cycle arrest and induction of apoptosis by lycopene in LNCaP human prostate cancer cells.

    abstract::Lycopene is one of the major carotenoids and is found almost exclusively in tomatoes and tomato products. Since tomato consumption is associated with decreased risk of prostate cancer, characterizing the effects of lycopene on cell growth or survival, cell cycle progression, and apoptosis in LCNaP human prostate cance...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2004.7.284

    authors: Hwang ES,Bowen PE

    更新日期:2004-10-01 00:00:00

  • Safety of an astaxanthin-rich Haematococcus pluvialis algal extract: a randomized clinical trial.

    abstract::A growing body of scientific literature indicates that astaxanthin is a more powerful antioxidant than other carotenoids and vitamin E and may confer numerous health benefits. The purpose of this investigation was to conduct a human safety study with a Haematococcus pluvialis algal extract with high levels of astaxant...

    journal_title:Journal of medicinal food

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1089/109662003765184741

    authors: Spiller GA,Dewell A

    更新日期:2003-04-01 00:00:00

  • Isoflavones prevent endoplasmic reticulum stress-mediated neuronal degeneration by inhibiting tau hyperphosphorylation in SH-SY5Y cells.

    abstract::Several studies have demonstrated a protective effect of estrogen against the risk of developing neurodegenerative diseases; however, the molecular mechanisms involved have not been fully addressed. Isoflavones have been proposed as potential alternatives to estrogen replacement therapy. Therefore, in the present stud...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2008.1069

    authors: Park YJ,Jang YM,Kwon YH

    更新日期:2009-06-01 00:00:00

  • Astaxanthine secured apoptotic death of PC12 cells induced by beta-amyloid peptide 25-35: its molecular action targets.

    abstract::Astaxanthine (ASTx) is a novel carotenoid nutraceutical occurring in many crustaceans and red yeasts. It has potent antioxidant, photoprotective, hepatodetoxicant, and anti-inflammatory activities. Documented effect of ASTx on treatment of neurodegenerative disease is still lacking. We used the beta-amyloid peptide (A...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.1291

    authors: Chang CH,Chen CY,Chiou JY,Peng RY,Peng CH

    更新日期:2010-06-01 00:00:00

  • A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia.

    abstract::Ganoderma lucidum has been widely used to treat various diseases, including cancer, diabetes, and neurasthenia in many Asian countries. This randomized, double-blind, placebo-controlled parallel study aimed to investigate the efficacy and safety of a polysaccharide extract of G. lucidum (Ganopoly) in Chinese patients ...

    journal_title:Journal of medicinal food

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1089/jmf.2005.8.53

    authors: Tang W,Gao Y,Chen G,Gao H,Dai X,Ye J,Chan E,Huang M,Zhou S

    更新日期:2005-04-01 00:00:00

  • The mediterranean diet in cancer prevention: a review.

    abstract::The Mediterranean dietary pattern has a well-established beneficial role in health promotion. Epidemiologic studies reveal the protective role of adherence to this pattern on overall cancer incidence and mortality. This review examines results from prospective cohort, cross-sectional, and case-control studies assessin...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,评审

    doi:10.1089/jmf.2010.0244

    authors: Kontou N,Psaltopoulou T,Panagiotakos D,Dimopoulos MA,Linos A

    更新日期:2011-10-01 00:00:00

  • Effect of a Western-style diet fortified with increased calcium and vitamin D on mammary gland of C57BL/6 mice.

    abstract::We previously reported hyperproliferation and hyperplasia in C57Bl/6 mouse mammary gland after feeding a Western-style diet (WD); these findings decreased after supplementing WD with increased calcium and vitamin D(3). We now again fortified WD with increased calcium and vitamin D(3) from two sources: (1) a food sourc...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2007.619

    authors: Kurihara N,Fan K,Thaler HT,Yang K,Lipkin M

    更新日期:2008-06-01 00:00:00

  • Effects of Chungkookjang supplementation on obesity and atherosclerotic indices in overweight/obese subjects: a 12-week, randomized, double-blind, placebo-controlled clinical trial.

    abstract::This study was designed to investigate the anti-obesity and anti-atherosclerotic effects of supplementation with Chungkookjang (CKJ), a traditional fermented soybean food, in overweight/obese subjects. The study was a 12-week, randomized, double-blind, placebo-controlled clinical trial followed by a 3-week screening p...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jmf.2010.1199

    authors: Back HI,Kim SR,Yang JA,Kim MG,Chae SW,Cha YS

    更新日期:2011-05-01 00:00:00

  • High temperature- and high pressure-processed garlic improves lipid profiles in rats fed high cholesterol diets.

    abstract::Garlic protects against degenerative diseases such as hyperlipidemia and cardiovascular diseases. However, raw garlic has a strong pungency, which is unpleasant. In this study, we examined the effect of high temperature/high pressure-processed garlic on plasma lipid profiles in rats. Sprague-Dawley rats were fed a nor...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2011.1922

    authors: Sohn CW,Kim H,You BR,Kim MJ,Kim HJ,Lee JY,Sok DE,Kim JH,Lee KJ,Kim MR

    更新日期:2012-05-01 00:00:00

  • Chilean native fruit extracts inhibit inflammation linked to the pathogenic interaction between adipocytes and macrophages.

    abstract::Obesity is characterized by an increase in the infiltration of monocytes into the adipose tissue, causing an inflammatory condition associated with, for example, the development of insulin resistance. Thus, anti-inflammatory-based treatments could emerge as a novel and interesting approach. It has been reported that C...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2014.0031

    authors: Reyes-Farias M,Vasquez K,Ovalle-Marin A,Fuentes F,Parra C,Quitral V,Jimenez P,Garcia-Diaz DF

    更新日期:2015-05-01 00:00:00

  • Korean Red Ginseng Regulates Intestinal Tight Junction and Inflammation in the Colon of a Parkinson's Disease Mouse Model.

    abstract::Recent studies have determined that gastrointestinal function contributes to the control of Parkinson's disease (PD). Gastrointestinal dysfunction results in a leaky intestinal barrier, inducing inflammation in the gut. Korean red ginseng (KRG) is widely used for the treatment of numerous afflictions, including inflam...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2019.4640

    authors: Jeon H,Kim HY,Bae CH,Lee Y,Kim S

    更新日期:2020-12-01 00:00:00

  • Antibacterial Investigation of Thyme Essential Oil and Its Main Constituents in Combination with Tetracycline.

    abstract::The chemical composition and antibacterial activity of Thymus glabrescens Willd. (thyme) essential oil were examined, as well as its association with tetracycline. The antibacterial activities of geraniol and thymol, the main constituents of T. glabrescens oil, were also determined. Gas chromatography and gas chromato...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2014.0132

    authors: Miladinović DL,Ilić BS,Kocić BD,Ćirić VM,Nikolić DM

    更新日期:2015-08-01 00:00:00

  • Myricetin protects against cytokine-induced cell death in RIN-m5f β cells.

    abstract::Cytokine-induced cell death is recognized as a major cause of progressive β-cell loss. Tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and interferon γ (IFN-γ) in combination trigger a series of events that lead to β-cell death. In the past few decades, the use of myricetin as an anti-inflammatory and cytopro...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2011.2033

    authors: Ding Y,Zhang ZF,Dai XQ,Li Y

    更新日期:2012-08-01 00:00:00

  • Effect of accessions of Colocasia esculenta-based diets on the hepatic and renal functional indices of weanling Wistar rats.

    abstract::The liver and kidney functional indices of weanling albino rats (Rattus norvegicus) maintained on different accessions (offspring of a variety planted/collected at a specific location and time but differing in certain morphological characteristics) of cooked Colocasia esculenta (cocoyam)-based diets (UFCe1-UFCe7) for ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.0211

    authors: Lewu MN,Yakubu MT,Adebola PO,Afolayan AJ

    更新日期:2010-10-01 00:00:00

  • Protein supplementation increases postexercise plasma myostatin concentration after 8 weeks of resistance training in young physically active subjects.

    abstract::Myostatin (MSTN) is a negative regulator of muscle growth even if some studies have shown a counterintuitive positive correlation between MSTN and muscle mass (MM). Our aim was to investigate the influence of 2 months of resistance training (RT) and diets with different protein contents on plasma MSTN, interleukin 1 b...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jmf.2014.0004

    authors: Paoli A,Pacelli QF,Neri M,Toniolo L,Cancellara P,Canato M,Moro T,Quadrelli M,Morra A,Faggian D,Plebani M,Bianco A,Reggiani C

    更新日期:2015-01-01 00:00:00