Safety of an astaxanthin-rich Haematococcus pluvialis algal extract: a randomized clinical trial.

Abstract:

:A growing body of scientific literature indicates that astaxanthin is a more powerful antioxidant than other carotenoids and vitamin E and may confer numerous health benefits. The purpose of this investigation was to conduct a human safety study with a Haematococcus pluvialis algal extract with high levels of astaxanthin. Thirty-five healthy adults age 35-69 years were enrolled in a randomized, double-blind, placebo-controlled trial of 8 weeks' duration. All participants took three gelcaps per day, one at each meal. Nineteen participants received gelcaps with an algal extract in safflower oil, containing 2 mg of astaxanthin each (treatment); 16 participants received gelcaps containing safflower oil only (placebo). Blood pressure and blood chemistry tests, including a comprehensive metabolic panel and cell blood count, were conducted at the beginning of the trial and after 4 and 8 weeks of supplementation. No significant differences were detected between the treatment and the placebo groups after 8 weeks of supplementation with the algal extract in the parameters analyzed, except for serum calcium, total protein, and eosinophils (P <.01). Although the differences in these three parameters were statistically significant, they were very small and are of no clinical importance. These results reveal that 6 mg of astaxanthin per day from a H. pluvialis algal extract can be safely consumed by healthy adults.

journal_name

J Med Food

authors

Spiller GA,Dewell A

doi

10.1089/109662003765184741

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

51-6

issue

1

eissn

1096-620X

issn

1557-7600

journal_volume

6

pub_type

临床试验,杂志文章,随机对照试验
  • Pistacia lentiscus resin regulates intestinal damage and inflammation in trinitrobenzene sulfonic acid-induced colitis.

    abstract::Mastic (Pistacia lentiscus) of the Anacardiaceae family has exhibited anti-inflammatory and antioxidant properties in patients with Crohn's disease. This study was based on the hypothesis that mastic inhibits intestinal damage in inflammatory bowel disease, regulating inflammation and oxidative stress in intestinal ep...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2010.0240

    authors: Gioxari A,Kaliora AC,Papalois A,Agrogiannis G,Triantafillidis JK,Andrikopoulos NK

    更新日期:2011-11-01 00:00:00

  • A Novel ACE Inhibitory Peptide Ala-His-Leu-Leu Lowering Blood Pressure in Spontaneously Hypertensive Rats.

    abstract::Ala-His-Leu-Leu (AHLL) was isolated and purified from the loach (Misgurnus anguillicaudatus) hydrolysate in our previous study. The aim of this study was to investigate the antihypertensive effects of angiotensin-I-converting enzyme (ACE) inhibitory peptide AHLL in spontaneously hypertensive rats (SHRs). AHLL showed g...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2015.3483

    authors: Li Y,Zhou J,Zeng X,Yu J

    更新日期:2016-02-01 00:00:00

  • Analysis of responses to kava kava in the feline pulmonary vascular bed.

    abstract::This study was designed to test the hypothesis that kava kava induces a depressor response in the pulmonary vascular bed of the cat and to identify the pathways involved in the mediation or modulation of these effects. In separate experiments, the effects of L-N5-(1-iminoethyl)ornithine hydrochloride (L-NIO), a nitric...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2006.9.62

    authors: Hoover JM,Kaye AD,Ibrahim IN,Fields AM,Richards TA

    更新日期:2006-04-01 00:00:00

  • Determination of mineral contents of Turkish herbal tea (Salvia aucheri var. canescens) at different infusion periods.

    abstract::Inductively coupled plasma atomic emission spectrometry has been used for the determination of contents of major and minor elements in Salvia aucheri var. canescens (sage) and its infusions for different intervals. Twenty-five elements (Al, B, Ba, Bi, Ca, Cd, Co, Cr, Cu, Fe, Ga, Ln, K, Li, Mg, Mn, Na, Ni, P, Pb, S, Sr...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2005.8.110

    authors: Ozcan M

    更新日期:2005-04-01 00:00:00

  • β-Caryophyllene, a Natural Sesquiterpene, Attenuates Neuropathic Pain and Depressive-Like Behavior in Experimental Diabetic Mice.

    abstract::Neuropathic pain (NP) is associated with chronic hyperglycemia and emotional disorders such as depression in diabetic patients, complicating the course of treatment. Drugs currently used to treat NP have undesirable side effects, so research on other natural sources has been required. β-caryophyllene (BCP), a natural ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2018.0157

    authors: Aguilar-Ávila DS,Flores-Soto ME,Tapia-Vázquez C,Pastor-Zarandona OA,López-Roa RI,Viveros-Paredes JM

    更新日期:2019-05-01 00:00:00

  • Bioactive chemicals from carrot (Daucus carota) juice extracts for the treatment of leukemia.

    abstract::Overwhelming evidence indicates that consumption of fruits and vegetables with antioxidant properties correlates with reduced risk for cancers, including leukemia. Carrots contain beneficial agents, such as β-carotene and polyacetylenes, which could be effective in the treatment of leukemia. This study investigated th...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2010.0284

    authors: Zaini R,Clench MR,Le Maitre CL

    更新日期:2011-11-01 00:00:00

  • Red Pepper (Capsicum baccatum) Extracts Present Anti-Inflammatory Effects In Vivo and Inhibit the Production of TNF-α and NO In Vitro.

    abstract::Capsicum baccatum is the most consumed red pepper species in Brazil. Our previous studies demonstrated the anti-inflammatory properties of its crude extract, whose activity is yet to be fully characterized. Herein, we examined the anti-inflammatory in vivo effects of enriched extracts obtained through bioguided fracti...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2015.0101

    authors: Allemand A,Leonardi BF,Zimmer AR,Moreno S,Romão PR,Gosmann G

    更新日期:2016-08-01 00:00:00

  • Development of a database for government-funded health/functional food research.

    abstract::The Korean Health/Functional Food Act of 2002 has led to the promotion of research on health/functional foods (HFFs). In order to track government-funded studies on HFFs, a free accessible database (National Research & Development on Functional Food, NaReaD(ff)) has been established by the Korea Food and Drug Administ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,评审

    doi:10.1089/jmf.2009.1036

    authors: Kim JY,Park J,Kwon O

    更新日期:2009-12-01 00:00:00

  • Nephroprotective activity of Prosthechea michuacana against cisplatin-induced acute renal failure in rats.

    abstract::In Mexican traditional medicine the orchid Prosthechea michuacana is highly valued as a food and in the treatment of various human diseases, including drug-related renal disease. Methanol, hexane, and chloroform extracts of bulbs of P. michuacana were studied in the cisplatin-induced renal injury model in rats. Result...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.0175

    authors: Gutierrez RM,Gomez YG,Ramirez EB

    更新日期:2010-08-01 00:00:00

  • The antioxidant property of chitosan green tea polyphenols complex induces transglutaminase activation in wound healing.

    abstract::The present study examined, for the first time, the in vitro wound healing potential of chitosan green tea polyphenols (CGP) complex based on the activation of transglutaminase (TGM) genes in epidermal morphogenesis. Response surface methodology was applied to determine the optimal processing condition that gave maxim...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.2623

    authors: Qin Y,Guo XW,Li L,Wang HW,Kim W

    更新日期:2013-06-01 00:00:00

  • Protective Effects of Quercetin Against HgCl₂-Induced Nephrotoxicity in Sprague-Dawley Rats.

    abstract::Mercury is a well-known environmental pollutant that can cause nephropathic diseases, including acute kidney injury (AKI). Although quercetin (QC), a natural flavonoid, has been reported to have medicinal properties, its potential protective effects against mercury-induced AKI have not been evaluated. In this study, t...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2014.3242

    authors: Shin YJ,Kim JJ,Kim YJ,Kim WH,Park EY,Kim IY,Shin HS,Kim KS,Lee EK,Chung KH,Lee BM,Kim HS

    更新日期:2015-05-01 00:00:00

  • Gustatory Evaluation of Still and Carbonated Waters: A Preference Rating Study.

    abstract::We studied the sensory preference for six still waters and four carbonated waters, nonflavored, by 11 tasting experts (4 women and 7 men). Five tasters rated the still waters, four tasters rated the carbonated water, and seven tasters rated twice on each of the still waters when evaluated with a dry red wine. All rati...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/109662001753165747

    authors: Fong DY,Halpern GM,Wan V

    更新日期:2001-10-01 00:00:00

  • The Antiproliferative Effect of Moringa oleifera Crude Aqueous Leaf Extract on Human Esophageal Cancer Cells.

    abstract::Esophageal cancer (EC) is commonly diagnosed in South Africa (SA), with high incidences occurring in SA's black population. Moringa oleifera (MO), a multipurpose tree, is used traditionally for its nutritional and medicinal properties. It has been used for the treatment of a variety of ailments, including cancer. We i...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2015.0113

    authors: Tiloke C,Phulukdaree A,Chuturgoon AA

    更新日期:2016-04-01 00:00:00

  • Turnera subulata Anti-Inflammatory Properties in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages.

    abstract::In South America, particularly in the Northeastern regions of Brazil, Turnera subulata leaf extract is used as an alternative traditional medicine approach for several types of chronic diseases, such as diabetes, hypertension, chronic pain, and general inflammation. Despite its widespread use, little is known about th...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2016.0047

    authors: Souza NC,de Oliveira JM,Morrone MDS,Albanus RD,Amarante MDSM,Camillo CDS,Langassner SMZ,Gelain DP,Moreira JCF,Dalmolin RJS,de Bittencourt Pasquali MA

    更新日期:2016-10-01 00:00:00

  • The implication of the mineral ratios of Cucumis myriocarpus Naud. and Pergularia daemia (Forsk.) Chiov. in human diets.

    abstract::Vegetables are considered to be the most affordable and sustainable sources of several micronutrients that are essential for physical and mental development, immune system functioning, and various metabolic processes in humans. However, their effectiveness as dietary sources of minerals is influenced by mineral-minera...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2006.252

    authors: Flyman MV,Afolayan AJ

    更新日期:2007-09-01 00:00:00

  • Safety and antioxidant effects of a modest soy protein intervention in hemodialysis patients.

    abstract::Antioxidant/anti-inflammatory effects of isoflavone-containing soy protein could partly explain why hemodialysis patients in Japan tend to outlive U.S. hemodialysis patients. However, a safety concern is that dialysis patients do not clear isoflavones well. A low-dose intervention with high isoflavone soy protein (25 ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jmf.2006.9.368

    authors: Siefker K,DiSilvestro RA

    更新日期:2006-10-01 00:00:00

  • Leafy vegetable mix supplementation improves lipid profiles and antioxidant status in C57BL/6J mice fed a high fat and high cholesterol diet.

    abstract::Daily consumption of an antioxidant-rich leafy vegetable mix (LVM) was assessed for beneficial effects on plasma lipid profiles, tissue lipid peroxidation, and oxidative DNA damage in C57BL/6J mice fed a high fat and high cholesterol diet (20% fat and 1% cholesterol, wt/wt) for 4 weeks. The LVM contained beet leaf, an...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2008.1125

    authors: Kim MY,Cheong SH,Kim MH,Son C,Yook HS,Sok DE,Kim JH,Cho Y,Chun H,Kim MR

    更新日期:2009-08-01 00:00:00

  • Phytochemical, antibacterial, antiproliferative, and antioxidant potentials and DNA damage-protecting activity of Acacia salicina extracts.

    abstract::The extract enriched in total oligomer flavonoids (TOF), and the aqueous, methanol, and ethyl acetate extracts of Acacia salicina were investigated for their polyphenolic compound content, antioxidative activity in the nitro blue tetrazolium/riboflavin assay system, antibacterial activity against Gram-positive and Gra...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2008.0120

    authors: Chatti IB,Limem I,Boubaker J,Skandrani I,Kilani S,Bhouri W,Ben Sghaier M,Nefatti A,Ben Mansour H,Ghedira K,Chekir-Ghedira L

    更新日期:2009-06-01 00:00:00

  • Dietary ungerminated and germinated soybean supplementation improves bone mineralization and strength in growing male rats.

    abstract::It has been thought that soybean products rich in phytoestrogenic isoflavones are effective in promoting bone metabolism in ovariectomized rats. However, it is not clear if such an effect can be changed by germination of soybean and can be observed in growing males. The present study was undertaken to determine the ef...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.1092

    authors: Hong H,Kim WJ,Yoo SH,Abanto OD,Kim TJ,Kim YJ,Jung BM,Yun SS,Hwang SG

    更新日期:2010-06-01 00:00:00

  • High environmental stress yields greater tocotrienol content while changing vitamin e profiles of wild emmer wheat seeds.

    abstract::Vitamin E is an essential human nutrient that was first isolated from wheat. Emmer wheat, the cereal of Old World agriculture and a precursor to durum wheat, grows wild in the Fertile Crescent. Evolution Canyon, Israel, provides a microsite that models effects of contrasting environments. The north-facing and south-fa...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2014.0017

    authors: Watts EJ,Shen Y,Lansky EP,Nevo E,Bobe G,Traber MG

    更新日期:2015-02-01 00:00:00

  • Bioabsorption and in vivo antioxidant properties of grape extract biovin((r)): a human intervention study.

    abstract::ABSTRACT Recent epidemiological studies have indicated that intake of grapes and other food products such as red wine derived from grapes may lower incidence of cancer and coronary heart diseases. Grapes and grape extracts, in addition to the traditional nutrients such as sugars and vitamins, are also rich sources of ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2000.3.15

    authors: Rao AV,Shen H,Agarwal A,Yatcilla MT,Agarwal S

    更新日期:2000-04-01 00:00:00

  • Health benefits of kimchi (Korean fermented vegetables) as a probiotic food.

    abstract::Kimchi is a traditional Korean food manufactured by fermenting vegetables with probiotic lactic acid bacteria (LAB). Many bacteria are involved in the fermentation of kimchi, but LAB become dominant while the putrefactive bacteria are suppressed during salting of baechu cabbage and the fermentation. The addition of ot...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,评审

    doi:10.1089/jmf.2013.3083

    authors: Park KY,Jeong JK,Lee YE,Daily JW 3rd

    更新日期:2014-01-01 00:00:00

  • Liquid chromatography: mass spectrometry of isoflavones.

    abstract::High-performance liquid chromatography (HPLC) or capillary electrophoresis (CE) is particularly suited to the separation and analysis of a wide range of biological compounds. When investigating such compounds in complex matrices (e.g., blood, tissue, urine, foods), specificity of the detection method becomes an import...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.1999.2.111

    authors: Barnes S,Wang CC,Smith-Johnson M,Kirk M

    更新日期:1999-01-01 00:00:00

  • Rice hull extracts inhibit proliferation of MCF-7 cells with G₁ cell cycle arrest in parallel with their antioxidant activity.

    abstract::Rice (Oryza sativa L.) has been a major dietary staple worldwide for centuries. Growing interest in the beneficial effects of antioxidants has inspired investigation of rice hulls as an attractive source of chemopreventive compounds for breast cancer intervention. We prepared methanol extracts from rice hulls of three...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2014.3181

    authors: Chung NJ,Choi KC,Lee SA,Baek JA,Lee JC

    更新日期:2015-03-01 00:00:00

  • Protective effects against H2O2-induced damage by enzymatic hydrolysates of an edible brown seaweed, sea tangle (Laminaria japonica).

    abstract::Enzymatic hydrolysates of Laminaria japonica were evaluated for antioxidative activities using hydroxyl radical scavenging activity and protective effects against H(2)O(2)-induced DNA and cell damage. In addition, activities of antioxidative enzymes, including catalase, glutathione peroxidase, and glutathione S-transf...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2007.0675

    authors: Park PJ,Kim EK,Lee SJ,Park SY,Kang DS,Jung BM,Kim KS,Je JY,Ahn CB

    更新日期:2009-02-01 00:00:00

  • The Effects of Curcuma longa L., Purple Sweet Potato, and Mixtures of the Two on Immunomodulation in C57BL/6J Mice Infected with LP-BM5 Murine Leukemia Retrovirus.

    abstract::The immune response is stimulated to protect the body from external antigens and is controlled by several types of immune cells. In the present study, the immunomodulatory effects of Curcuma longa L., purple sweet potato, and mixtures of the two (CPM) were investigated in C57BL/6 mice infected with LP-BM5 murine leuke...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2017.4093

    authors: Park SJ,Lee D,Lee M,Kwon HO,Kim H,Park J,Jeon W,Cha M,Jun S,Park K,Lee J

    更新日期:2018-07-01 00:00:00

  • Antibacterial Investigation of Thyme Essential Oil and Its Main Constituents in Combination with Tetracycline.

    abstract::The chemical composition and antibacterial activity of Thymus glabrescens Willd. (thyme) essential oil were examined, as well as its association with tetracycline. The antibacterial activities of geraniol and thymol, the main constituents of T. glabrescens oil, were also determined. Gas chromatography and gas chromato...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2014.0132

    authors: Miladinović DL,Ilić BS,Kocić BD,Ćirić VM,Nikolić DM

    更新日期:2015-08-01 00:00:00

  • Crude ethanolic extracts of Garcinia kola seeds Heckel (Guttiferae) prolong the lag phase of Helicobacter pylori: inhibitory and bactericidal potential.

    abstract::Problems associated with current treatment regimens have generated a considerable interest in alternative approaches for the eradication of Helicobacter pylori infections using phytochemical compounds. In an attempt to identify potential sources of such compounds, the antimicrobial activity of five solvent extracts of...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2010.0127

    authors: Njume C,Afolayan AJ,Clarke AM,Ndip RN

    更新日期:2011-07-01 00:00:00

  • Memory-strengthening activity of Glycyrrhiza glabra in exteroceptive and interoceptive behavioral models.

    abstract::In the traditional system of medicine, the roots and rhizomes of Glycyrrhiza glabra have been employed clinically for centuries for their anti-inflammatory, anti-ulcer, expectorant, antimicrobial, and anxiolytic activities. The present study was undertaken to investigate the effects of G. glabra, popularly known as li...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2004.7.462

    authors: Parle M,Dhingra D,Kulkarni SK

    更新日期:2004-01-01 00:00:00

  • A single-dose resveratrol treatment in a mouse model of amyotrophic lateral sclerosis.

    abstract::The underlying causes of denervation of the neuromuscular junction and eventual motor neuron death in amyotrophic lateral sclerosis (ALS) have not been resolved. The superoxide dismutase 1 (SOD1)(G93A) mutant mouse is a frequently used animal model of ALS. We hypothesized that resveratrol (RSV), a polyphenolic molecul...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.0243

    authors: Markert CD,Kim E,Gifondorwa DJ,Childers MK,Milligan CE

    更新日期:2010-10-01 00:00:00