Abstract:
:The Korean Health/Functional Food Act of 2002 has led to the promotion of research on health/functional foods (HFFs). In order to track government-funded studies on HFFs, a free accessible database (National Research & Development on Functional Food, NaReaD(ff)) has been established by the Korea Food and Drug Administration. About 200 project reports funded by government agencies from 1993 through 2007 were retrieved, using existing government-wide online databases created by the Korea Institute Science and Technology, Evaluation and Planning and the Korea Institute of Science and Technology Information. In 2008, the database was released with information regarding individual projects and technological achievements for individual ingredients with a vision for HFF development. Overall, government-funded HFF research has primarily involved botanicals including herbs and food plants. The immune system, oxidant stress alleviation, and the cardiovascular system are the three leading health systems being investigated. With regard to the types of studies performed, the majority were in vitro studies and animal studies with limited numbers of human intervention studies. Government funds have been fragmented for many different ingredients, and this represents a major gap in HFF development. This database is most valuable for evaluating trends in government-funded HFF research. It is also useful to identify research overlaps and gaps and to help research scientists within academia and industry identify potential sources of government funding.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Kim JY,Park J,Kwon Odoi
10.1089/jmf.2009.1036subject
Has Abstractpub_date
2009-12-01 00:00:00pages
1185-9issue
6eissn
1096-620Xissn
1557-7600journal_volume
12pub_type
杂志文章,评审abstract::Ultraviolet (UV) light is a physical carcinogen, and UV irradiation from sunlight has negative effects on human skin. UVB-induced inflammation is linked to excessive induction of various inflammatory cytokines/chemokines in many types of cells, including keratinocytes. The purpose of this study was to investigate the ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2009.1239
更新日期:2010-06-01 00:00:00
abstract::Aerial parts of Medicago sativa L. have been used as food and its consumption has been associated with health benefits, one among the most important being menopausal symptoms control. This work was aimed to explore possible pharmacological effects of two new alfalfa-derived products that have recently emerged as daily...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2016.0024
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abstract::Tropaeolum majus L., popularly known as nasturtium, is a species widely used in the form of infusions and salads. In the last years, the antihypertensive, diuretic, and calcium and potassium sparing activities of T. majus preparations were shown. Moreover, no preclinical 90-day oral toxicity studies were conducted. Th...
journal_title:Journal of medicinal food
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doi:10.1089/jmf.2017.0128
更新日期:2018-08-01 00:00:00
abstract::The anticancer effects of chitosan-added kimchi were investigated by using an in vitro cellular system with HT-29 human colon carcinoma cells. Two different kinds of chitosan-soluble chitosan with a 90% degree of deacetylation and 3 cps viscosity and nonsoluble chitosan with a 95% degree of deacetylation and 22 cps vi...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2009.1213
更新日期:2010-02-01 00:00:00
abstract::Rheumatoid arthritis (RA) is an autoimmune and chronic inflammatory disease resulting in joint destruction and disability in the adult population. The etiology of RA is not well understood and presently there is no known cure for this disease. The accumulation and proliferation of fibroblast-like synoviocytes may be i...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2019.0046
更新日期:2019-10-01 00:00:00
abstract::Dietary patterns high in fat influence local and systemic oxidative stress through adipose tissue (AT) accrual and increased reactive oxygen species generation. Lycopene, a carotenoid with antioxidant functionality, may mitigate excess oxidative stress, yet the lipophilic nature of this compound may limit its function...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2020.0064
更新日期:2020-07-15 00:00:00
abstract::AndoSan™ is an extract of Agaricus blazei Murill (AbM; 82.4%), Hericium erinaceum (14.7%), and Grifola frondosa (2.9%). The main ingredient of AndoSan, AbM, is rich in different forms of β-glucans. Since these exhibit potent antitumor activity and have immunomodulatory effects, the stimulatory effect of AndoSan on the...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2014.0018
更新日期:2015-04-01 00:00:00
abstract::Diabetes is a chronic degenerative disease with no cure, is found in millions of people worldwide, and can cause life-threatening complications at any age. The plant Cissus sicyoides L. is a runner plant found abundantly in Brazil, especially in the Amazon. Its therapeutic properties are widely used in popular medicin...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2008.0157
更新日期:2009-08-01 00:00:00
abstract::The omega-3 (n-3) polyunsaturated fatty acids have a wide range of beneficial effects in several human health conditions. Animal and in vitro studies have indicated that omega-3 fatty acids affect blood lipid profiles, cardiovascular health, membrane lipid composition, eicosanoid biosynthesis, cell signaling cascades,...
journal_title:Journal of medicinal food
pub_type: 杂志文章,评审
doi:10.1089/jmf.2004.7.387
更新日期:2004-01-01 00:00:00
abstract::Antioxidant/anti-inflammatory effects of isoflavone-containing soy protein could partly explain why hemodialysis patients in Japan tend to outlive U.S. hemodialysis patients. However, a safety concern is that dialysis patients do not clear isoflavones well. A low-dose intervention with high isoflavone soy protein (25 ...
journal_title:Journal of medicinal food
pub_type: 杂志文章,随机对照试验
doi:10.1089/jmf.2006.9.368
更新日期:2006-10-01 00:00:00
abstract::Tagatose, a low-calorie, full-bulk natural sugar, has just attained GRAS (Generally Recognized As Safe) status under U.S. Food and Drug Administration (FDA) regulations, thereby permitting its use as a sweetener in foods and beverages. This paper presents all current aspects of tagatose with respect to demonstrated fo...
journal_title:Journal of medicinal food
pub_type: 杂志文章,评审
doi:10.1089/109662002753723197
更新日期:2002-04-01 00:00:00
abstract::This is the first report about the modifying antibiotic activity of Eugenia uniflora L. and Eugenia jambolanum L. In this study the ethanol extract of E. uniflora and E. jambolanum was tested for their antimicrobial activity against strains of Escherichia coli. The growth of the two strains of E. coli bacteria tested ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2009.0158
更新日期:2010-08-01 00:00:00
abstract::The Asteraceae family is widely known for its therapeutic, aromatic, and nutritional properties. Chaptalia nutans (C. nutans), a member of the family, is widely used in folk medicine in southern Brazil. In this study, we aim to assess compounds present in root extracts of C. nutans, and evaluate their antioxidant capa...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2019.0309
更新日期:2020-06-16 00:00:00
abstract::The oral cytotoxicity, antimicrobial and anti-demineralizing effects of a tincture from Bauhinia forficata Link tincture (BFLT) were evaluated in vitro and ex vivo. Susceptibility tests (minimum inhibitory and microbicidal concentrations-MIC and time-kill assay-MMC) were performed against planktonic oral microorganism...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2019.0277
更新日期:2020-09-01 00:00:00
abstract::Mastic (Pistacia lentiscus) of the Anacardiaceae family has exhibited anti-inflammatory and antioxidant properties in patients with Crohn's disease. This study was based on the hypothesis that mastic inhibits intestinal damage in inflammatory bowel disease, regulating inflammation and oxidative stress in intestinal ep...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2010.0240
更新日期:2011-11-01 00:00:00
abstract::Since ancient times, oak wood polyphenols are consumed concomitantly with beverages that are stored and aged in oak wood barrels. Among these polyphenols are roburins, which belong to the class of ellagitannins and only occur in oak. To date, water-extracted standardized French Quercus robur wood extract, commercially...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2020.0165
更新日期:2021-01-28 00:00:00
abstract::Propolis was included in the Argentine Food Code as a functional food. The chemical parameters and antioxidant properties of propolis samples from the same colonies of Apis mellifera in San Juan (Cuyo region, Western Argentine) were compared every month for 1 year using two collection methods. Chemical parameters were...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2008.0286
更新日期:2009-12-01 00:00:00
abstract::Although hydrogen peroxide (H₂O₂) is one of the major antibacterial factors in most honeys, it does not accumulate in medical-grade manuka honey. The goal of this study was to investigate the effect of artificially added methylglyoxal (MGO) on H₂O₂ accumulation in natural non-manuka honeys. H₂O₂ concentrations in the ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2012.0201
更新日期:2014-02-01 00:00:00
abstract::Obesity is generally associated with low-grade chronic inflammation that involves the recruitment of macrophages and other inflammation factors to the adipocytes of obese individuals. Tumor necrosis factor-alpha (TNF-α), a cytokine associated with systemic inflammation, is elevated in conditions of obesity. TNF-α is a...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2017.3941
更新日期:2018-03-01 00:00:00
abstract::The Mediterranean dietary pattern has a well-established beneficial role in health promotion. Epidemiologic studies reveal the protective role of adherence to this pattern on overall cancer incidence and mortality. This review examines results from prospective cohort, cross-sectional, and case-control studies assessin...
journal_title:Journal of medicinal food
pub_type: 杂志文章,评审
doi:10.1089/jmf.2010.0244
更新日期:2011-10-01 00:00:00
abstract::Colon cancer is the second most common cancer among men and women worldwide. We investigated the effect of red chilli (Capsicum annum L.), cumin (Cuminum cyminum L.), and black pepper (Piper nigrum L.) on colon cancer induced in rats by a colon-specific carcinogen, 1,2-dimethylhydrazine (DMH). Colon cancer was induced...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2006.9.237
更新日期:2006-07-01 00:00:00
abstract::Capsicum baccatum is the most consumed red pepper species in Brazil. Our previous studies demonstrated the anti-inflammatory properties of its crude extract, whose activity is yet to be fully characterized. Herein, we examined the anti-inflammatory in vivo effects of enriched extracts obtained through bioguided fracti...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2015.0101
更新日期:2016-08-01 00:00:00
abstract::Bilberry (European blueberry) has been reported to have many biological effects, including anticancer activity. In this study, we investigated the antiproliferative effects of bilberry extract in relation to its ability to induce apoptosis and affect microtubule assembly and organization in MCF7 human breast cancer ce...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2009.0053
更新日期:2010-04-01 00:00:00
abstract::The fruits, leaves, and roots of Cudrania tricuspidata have been reported to contain large amounts of vitamin B, vitamin C, and flavonoids. They exhibit various physiological activities such as antitumor and anti-inflammatory effects. However, the hepatoprotective effects of C. tricuspidata extracts against oxidative ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2018.4322
更新日期:2019-06-01 00:00:00
abstract::The ethyl acetate, methanol, and water extracts of 16 Ballota species (Family Lamiaceae)-Ballota acetabulosa, Ballota antalyanse, Ballota cristata, Ballota glandulosissima, Ballota inaequidens, Ballota larendana, Ballota latibracteolata, Ballota macrodonta, Ballota nigra ssp. anatolica, B. nigra ssp. foetida, B. nigra...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2009.0237
更新日期:2010-12-01 00:00:00
abstract::Abnormal expression of pro-inflammatory mediators such as cell adhesion molecules and cytokines has been implicated in various inflammatory skin diseases, including atopic dermatitis. In this study, we investigated the anti-inflammatory activity of Aronia melanocarpa concentrate (AC) and its action mechanisms using in...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2015.3624
更新日期:2016-07-01 00:00:00
abstract::The effects of the turmeric ethyl acetate fraction (TEF) from the methanolic extract from Curcuma longa L. on lipid metabolism and underlying mechanisms of lipolysis were investigated in 3T3-L1 adipocytes. The intracellular lipid droplets were stained with Oil red O dye and quantified. Compared to the control, lipid a...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2009.1276
更新日期:2010-04-01 00:00:00
abstract::Oxidative stress and lipid peroxidation are considered key factors linking obesity with its associated complications. Epigallo catechin-3-gallate (EGCG) and oleoylethanolamide, together with its phospholipid precursor N-oleoyl-phosphatidylethanolamine (NOPE), are nutritional compounds that might improve the oxidative ...
journal_title:Journal of medicinal food
pub_type: 杂志文章,随机对照试验
doi:10.1089/jmf.2019.0145
更新日期:2020-03-01 00:00:00
abstract::The use of synbiotics as health promoters is still poorly defined, and human intervention studies are scarce. This study was designed to evaluate the effects of a commercialized synbiotic product containing Lactobacillus acidophilus La5, Bifidobacterium animalis ssp. lactis Bb-12, Lactobacillus delbrueckii ssp. bulgar...
journal_title:Journal of medicinal food
pub_type: 杂志文章,随机对照试验
doi:10.1089/jmf.2008.0328
更新日期:2011-01-01 00:00:00
abstract::We have provided a protocol for establishing an atopic dermatitis (AD) in vitro model, and evaluated the effects of Costaria costata (CC) extracts on AD in an in vitro model using keratinocytes and splenocytes from AD-induced mice and mast cells. HaCaT cells were each treated with 200 μg/mL of CC water extract (CCW), ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2016.3691
更新日期:2016-10-01 00:00:00