Abstract:
:In Mexican traditional medicine the orchid Prosthechea michuacana is highly valued as a food and in the treatment of various human diseases, including drug-related renal disease. Methanol, hexane, and chloroform extracts of bulbs of P. michuacana were studied in the cisplatin-induced renal injury model in rats. Results showed that treatment with cisplatin induced significant elevations in concentrations of blood urea and serum creatinine and in lipid peroxidation. Treatments with methanolic extract (200, 400 and 500 mg/kg) increased levels of biochemical markers of renal injury like reduced glutathione, glutathione S-transferase, and superoxide dismutase and inhibited the increases in blood urea and serum creatinine concentrations and lipid peroxidation induced by cisplatin. Hexane and chloroform extracts did not show any effect. The results obtained in the present study indicate that this orchid can be a potential source of natural nephroprotective activity.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Gutierrez RM,Gomez YG,Ramirez EBdoi
10.1089/jmf.2009.0175subject
Has Abstractpub_date
2010-08-01 00:00:00pages
911-6issue
4eissn
1096-620Xissn
1557-7600journal_volume
13pub_type
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