Nephroprotective activity of Prosthechea michuacana against cisplatin-induced acute renal failure in rats.

Abstract:

:In Mexican traditional medicine the orchid Prosthechea michuacana is highly valued as a food and in the treatment of various human diseases, including drug-related renal disease. Methanol, hexane, and chloroform extracts of bulbs of P. michuacana were studied in the cisplatin-induced renal injury model in rats. Results showed that treatment with cisplatin induced significant elevations in concentrations of blood urea and serum creatinine and in lipid peroxidation. Treatments with methanolic extract (200, 400 and 500 mg/kg) increased levels of biochemical markers of renal injury like reduced glutathione, glutathione S-transferase, and superoxide dismutase and inhibited the increases in blood urea and serum creatinine concentrations and lipid peroxidation induced by cisplatin. Hexane and chloroform extracts did not show any effect. The results obtained in the present study indicate that this orchid can be a potential source of natural nephroprotective activity.

journal_name

J Med Food

authors

Gutierrez RM,Gomez YG,Ramirez EB

doi

10.1089/jmf.2009.0175

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

911-6

issue

4

eissn

1096-620X

issn

1557-7600

journal_volume

13

pub_type

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