Protective effect of collagen derivates on the ulcerative lesions caused by oral administration of ethanol.

Abstract:

:The protective effect of beef and pig collagen hydrolysates and their fractions were tested as anti-ulcerogenic agents in rats (weighing 250-350 g) against ulcerative lesions caused by ethanol. Beef and pig collagen hydrolysates were fractionated by ultrafiltration into different molecular weight fractions. The protocol employed a negative and a positive control and a single dose of the experimental samples given by intragastric intubation. The beef collagen did not present a dose-response correlation in the ethanol model, whereas pig collagen showed a logarithmic dose-response relationship. Beef collagen hydrolysate decreased the ulcerative lesion index of 55% versus a 61% decrease for pig collagen hydrolysate at the same dosage (750 mg/kg of body weight). No significant differences were found (P > .05) between the hydrolysates and their fractions.

journal_name

J Med Food

authors

Castro GA,Sgarbieri VC,Carvalho JE,Tinti SV,Possenti A

doi

10.1089/jmf.2006.262

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

154-8

issue

1

eissn

1096-620X

issn

1557-7600

journal_volume

10

pub_type

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