Abstract：
:Red ginseng (Panax ginseng C.A. Meyer) is the most widely recognized medicinal herb due to its remedial effects in various disorders, such as cancers, diabetes, and heart problems. In this study, we investigated the anticancer effect of fermented red ginseng extract (f-RGE; provided by Jeonju Biomaterials Institute, Jeonju, South Korea) in a parallel comparison with the effect of nonfermented red ginseng extract (nf-RGE; control) on several cancer cell lines--MCF-7 breast cancer cells, HepG2 hepatocellular carcinoma cells, and reprogrammed MCF-7 cells (mimicking cancer stem cells). Cells were cultured at various concentrations of RGE (from 0.5 up to 5 mg/mL) and their viabilities and proliferative properties were examined. Our data demonstrate the following: (1) nf-RGE inhibited cell viability at ≥1 mg/mL for MCF-7 cells and ≥2 mg/mL for HepG2 cells, (2) in the presence of a carcinogenic agent, 12-O-tetradecanoylphorbol-13-acetate (TPA), nf-RGE treatment in combination with paclitaxel synergistically decreased MCF-7 as well as HepG2 cell viability, (3) f-RGE (which contained a greater level of Rg3 content) more effectively decreased the viability of MCF-7 and HepG2 cells compared to nf-RGE, and (4) f-RGE appeared more potent for inhibiting cancerous differentiation of reprogrammed MCF-7 cells in a synergistic fashion with paclitaxel, especially in the presence of TPA, compared to nf-RGE. These findings suggest that f-RGE treatment may be more effective for decreasing cancer cell survival by inducing apoptotic cell death and also presumably for preventing cancer stem cell differentiation compared to nf-RGE.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Oh J,Jeon SB,Lee Y,Lee H,Kim J,Kwon BR,Yu KY,Cha JD,Hwang SM,Choi KM,Jeong YSdoi
10.1089/jmf.2014.3248subject
Has Abstractpub_date
2015-04-01 00:00:00pages
421-8issue
4eissn
1096-620Xissn
1557-7600journal_volume
18pub_type
杂志文章abstract：:Aqueous extracts of Gynura procumbens (Lour.) Merr. were orally administered to spontaneously hypertensive (SHR) rats for 4 weeks, and antihypertensive effects were determined. Oral administration of 500 mg/kg of G. procumbens (Lour.) Merr. extract (GPE) resulted in significantly lower blood pressure in SHR rats compa...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2006.9.587
更新日期：2006-01-01 00:00:00
abstract：:Polyphenol-rich foods, such as fruits and vegetables, are protective against cardiovascular diseases, but the mechanisms of the beneficial effects are still unknown. The goal of this research was to clarify actions of procyanidin trimer (C1) in rat aortic endothelial cells (RAECs). Procyanidin C1 at concentrations up ...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2012.2297
更新日期：2012-11-01 00:00:00
abstract：:This study was designed to investigate the effect of heating, storage, and ultraviolet exposure on antimicrobial activity of garlic juice and its bacteriocidal activity against common human pathogens. Antimicrobial activity of fresh garlic juice was tested against Escherichia coli, Staphylococcus aureus, Streptococcus...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2005.067
更新日期：2007-03-01 00:00:00
abstract：:The anti-ulcer potentials of aqueous (AE) and methanol (ME) extracts of whole unripe Carica papaya fruit were evaluated using ethanol- and indomethacin-induced gastric ulcer models in rats. The effect of the extracts on small intestinal propulsion was also investigated. The extracts significantly reduced the ulcer ind...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2008.0197
更新日期：2009-12-01 00:00:00
abstract：:The antioxidant effect of the ethanolic root extract of Hemidesmus indicus, an indigenous Ayurvedic medicinal plant used in soft drinks in India, was studied in rats with ethanol-induced hepatotoxicity. Administering 20% ethanol (5 g/kg of body weight/day) for 60 days to male Wistar rats resulted in significantly decr...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2006.110
更新日期：2007-12-01 00:00:00
abstract：:Tagatose, a low-calorie, full-bulk natural sugar, has just attained GRAS (Generally Recognized As Safe) status under U.S. Food and Drug Administration (FDA) regulations, thereby permitting its use as a sweetener in foods and beverages. This paper presents all current aspects of tagatose with respect to demonstrated fo...
journal_title：Journal of medicinal food
pub_type： 杂志文章,评审
doi：10.1089/109662002753723197
更新日期：2002-04-01 00:00:00
abstract：:Excessive sugar consumption is associated with many chronic inflammatory diseases in adults. The effects of excessive sugar consumption in children have not been determined. In this study, we hypothesized that sinonasal symptoms and proinflammatory cytokine levels would be related and could be altered through reductio...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2017.0126
更新日期：2018-06-01 00:00:00
abstract：:A growing body of scientific literature indicates that astaxanthin is a more powerful antioxidant than other carotenoids and vitamin E and may confer numerous health benefits. The purpose of this investigation was to conduct a human safety study with a Haematococcus pluvialis algal extract with high levels of astaxant...
journal_title：Journal of medicinal food
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1089/109662003765184741
更新日期：2003-04-01 00:00:00
abstract：:In traditional Korean medicine, lotus (Nelumbo nucifera Gaertn) roots have been used as an antidiabetic and an antiproliferative remedy. However, scientific publications on lotus properties are very limited. Therefore, it was decided to investigate the Korean white lotus cultivars in order to find out their bioactivit...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2009.0018
更新日期：2009-10-01 00:00:00
abstract：:With an increasing understanding of the health benefit of lycopene, how to preserve lycopene during food processing and storage has caused much attention. Lycopene belongs to the carotenoid family and mostly exists in nature as the all-trans form. Heat, light, oxygen, and different food matrices are factors that have ...
journal_title：Journal of medicinal food
pub_type： 杂志文章,评审
doi：10.1089/jmf.2005.8.413
更新日期：2005-01-01 00:00:00
abstract：:The aim of this study was to evaluate the effect of salidroside on lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E₂ (PGE₂) production in RAW 264.7 macrophages and related anti-inflammatory mechanism. PGE₂ production was measured by enzyme-linked immunosorbent assay (ELISA); NO production was tes...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2012.2473
更新日期：2013-11-01 00:00:00
abstract：:Garlic has been used medicinally throughout human history. Allicin is considered the most therapeutic constituent of garlic. This study tested the antimicrobial activity of garlic allicin on oral pathogens associated with dental caries and periodontitis. Allicin was found effective against all the tested bacteria. The...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2010.0165
更新日期：2011-11-01 00:00:00
abstract：:This study was designed to test the hypothesis that kava kava induces a depressor response in the pulmonary vascular bed of the cat and to identify the pathways involved in the mediation or modulation of these effects. In separate experiments, the effects of L-N5-(1-iminoethyl)ornithine hydrochloride (L-NIO), a nitric...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2006.9.62
更新日期：2006-04-01 00:00:00
abstract：:The aim of the present study was to investigate the antihyperglycemic and protective potential of crocin, a pharmacologically active constituent of Crocus sativus L., in streptozotocin-induced diabetic rats. Rats were administered crocin intraperitoneally at doses of 15, 30, and 60 mg/kg of body weight for 6 weeks. Th...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2012.2407
更新日期：2013-03-01 00:00:00
abstract：:Glucomannan-enriched squid surimi improves cholesterolemia and liver antioxidant status. The effect of squid surimi enriched with glucomannan or glucomannan plus spirulina on liver and heart structures and cell damage markers was tested in fa/fa rats fed highly saturated-hyper-energetic diets. Animals were fed 70% AIN...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2016.0157
更新日期：2017-06-01 00:00:00
abstract：:In Mexico about 4,000 plant species have some medicinal use. The aim of this work was to evaluate the antimicrobial activity of six Mexican medicinal plants against fungi and Gram-positive and Gram-negative bacteria. Methanolic extracts were prepared from the Mexican medicinal plants Amphypteringium adstrigens, Castel...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2008.0205
更新日期：2009-12-01 00:00:00
abstract：:Twenty soybean cultivars, originating from the United States, Russia, Serbia, and China, were analyzed for their isoflavone composition, total polyphenolic content, and antioxidant activity. Isoflavones were extracted by aqueous methanol (80%) and analyzed by high-performance liquid chromatography/diode array detectio...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2009.0050
更新日期：2010-06-01 00:00:00
abstract：:Overwhelming evidence indicates that consumption of fruits and vegetables with antioxidant properties correlates with reduced risk for cancers, including leukemia. Carrots contain beneficial agents, such as β-carotene and polyacetylenes, which could be effective in the treatment of leukemia. This study investigated th...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2010.0284
更新日期：2011-11-01 00:00:00
abstract：:Eugenol (4-allyl-2-methoxyphenol), a major phenolic component from clove oil (Eugenia caryophyllata), has several biological activities. To estimate the capacity of eugenol to act as an antioxidant, the following were studied: 1,1-diphenyl-2-picryl-hydrazyl-, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid)-, and...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2010.0197
更新日期：2011-09-01 00:00:00
abstract：:Vitamin E is an essential human nutrient that was first isolated from wheat. Emmer wheat, the cereal of Old World agriculture and a precursor to durum wheat, grows wild in the Fertile Crescent. Evolution Canyon, Israel, provides a microsite that models effects of contrasting environments. The north-facing and south-fa...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2014.0017
更新日期：2015-02-01 00:00:00
abstract：:Tamoxifen is effective in breast cancer therapy in postmenopausal women; however, it causes adverse effects that alter the glycolytic pathway and induce hyperglycemia. Quercetin, a flavonoid with antioxidant potential, inhibits butyrylcholinesterase (BuChE), which is positively associated with hyperglycemia. Therefore...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2016.0078
更新日期：2017-03-01 00:00:00
abstract：:Red ginger (Zingiber officinale var. Rubra) has been prescribed as an analgesic for arthritis pain in Indonesian traditional medicine. The surface color of the rhizome is purple because of the anthocyanidins in its peel. We prepared 40% ethanolic extract from dried red ginger (red ginger extract [RGE]) and evaluated i...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2009.1084
更新日期：2010-02-01 00:00:00
abstract：:Several studies have demonstrated a protective effect of estrogen against the risk of developing neurodegenerative diseases; however, the molecular mechanisms involved have not been fully addressed. Isoflavones have been proposed as potential alternatives to estrogen replacement therapy. Therefore, in the present stud...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2008.1069
更新日期：2009-06-01 00:00:00
abstract：:The quantitative distribution of flavan-3-ols was determined using high-performance liquid chromatography in several grape seed extracts (GSEs). In all GSEs, polymers of four or more carbon units were the group of procyanidins present in the highest concentration, the real quantity ranging between 60% and 99.5%. In a ...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/109662001300341770
更新日期：2001-07-01 00:00:00
abstract：:Mercury is a well-known environmental pollutant that can cause nephropathic diseases, including acute kidney injury (AKI). Although quercetin (QC), a natural flavonoid, has been reported to have medicinal properties, its potential protective effects against mercury-induced AKI have not been evaluated. In this study, t...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2014.3242
更新日期：2015-05-01 00:00:00
abstract：:In this study, we investigated the antioxidant and protective effect of Lindera glauca stem (LGS) extracts against oxidative stress. We compared antioxidant properties of water extract (LGSW) with ethanol extract (LGSE) by determining the contents responsible for antioxidant activities such as polyphenols and flavonoi...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2018.4289
更新日期：2019-05-01 00:00:00
abstract：:The anticancer effects of chitosan-added kimchi were investigated by using an in vitro cellular system with HT-29 human colon carcinoma cells. Two different kinds of chitosan-soluble chitosan with a 90% degree of deacetylation and 3 cps viscosity and nonsoluble chitosan with a 95% degree of deacetylation and 22 cps vi...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2009.1213
更新日期：2010-02-01 00:00:00
abstract：:The protective effect of beef and pig collagen hydrolysates and their fractions were tested as anti-ulcerogenic agents in rats (weighing 250-350 g) against ulcerative lesions caused by ethanol. Beef and pig collagen hydrolysates were fractionated by ultrafiltration into different molecular weight fractions. The protoc...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2006.262
更新日期：2007-03-01 00:00:00
abstract：:Pomegranate seed oil was investigated for possible skin cancer chemopreventive efficacy in mice. In the main experiment, two groups consisting each of 30, 4-5-week-old, female CD(1) mice were used. Both groups had skin cancer initiated with an initial topical exposure of 7,12-dimethylbenzanthracene and with biweekly p...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/10966200360716553
更新日期：2003-10-01 00:00:00
abstract：:Despite defenses by polymorphonuclear neutrophils in the host against invading agents, overproduction of oxidant species by phagocytes can lead to damage in the surrounding tissues. Several benzophenones have been shown to possess anti-inflammatory properties. The effect of the natural benzophenone 7-epiclusianone iso...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2011.0043
更新日期：2012-02-01 00:00:00
