Abstract：
:Polyphenol-rich foods, such as fruits and vegetables, are protective against cardiovascular diseases, but the mechanisms of the beneficial effects are still unknown. The goal of this research was to clarify actions of procyanidin trimer (C1) in rat aortic endothelial cells (RAECs). Procyanidin C1 at concentrations up to 50 μM was not cytotoxic to the RAECs. The addition of procyanidin C1 to RAECs exerted a time-dependent hyperpolarization measured using a membrane potential-dependent fluorescent probe, bis-(1,3-dibutylbarbituric acid) trimethine oxonol, whereas the hyperpolarization was significantly inhibited by the nonspecific K(+) channel inhibitor tetraethylammonium chloride (TEA). Moreover, procyanidin C1 elevated intracellular Ca(2+) influx, which was totally abolished in the presence of Ca(2+)-free solution with EGTA. Procyanidin C1 caused a significant increase in nitric oxide (NO) production. The effect was significantly inhibited by an NO synthase inhibitor, N(G)-monomethyl-l-arginine, or TEA. In conclusion, we demonstrated for the first time that procyanidin C1 plays a potent role in promoting Ca(2+)-mediated signals such as the hyperpolarization via multiple K(+) channel activations and the NO release in RAECs, suggesting that procyanidin C1 may represent novel and effective therapy for the treatment of cardiovascular diseases.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Byun MWdoi
10.1089/jmf.2012.2297subject
Has Abstractpub_date
2012-11-01 00:00:00pages
1032-7issue
11eissn
1096-620Xissn
1557-7600journal_volume
15pub_type
杂志文章abstract：:The aim of this study was to evaluate the effects of ethanol extracts of Vaccinium corymbosum (VCE) on exercise-induced fatigue in mice. Mice were randomly divided into three groups; nonexercise control group (CON), exercise control group (Ex-CON), and exercise and VCE supplementation group (Ex-VCE). Compared with Ex-...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2020.4753
更新日期：2020-11-01 00:00:00
abstract：:Isoliquiritigenin (ISL), a flavonoid chalcone that is present in licorice, shallot, and bean sprouts, is known to have antitumorigenic activities. The present study examined whether ISL alters prostate cancer cell cycle progression. DU145 human and MatLyLu (MLL) rat prostate cancer cells were cultured with various con...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2008.0039
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abstract：:In Mexican traditional medicine the orchid Prosthechea michuacana is highly valued as a food and in the treatment of various human diseases, including drug-related renal disease. Methanol, hexane, and chloroform extracts of bulbs of P. michuacana were studied in the cisplatin-induced renal injury model in rats. Result...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2009.0175
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abstract：:Worldwide prevalence of noncommunicable chronic degenerative diseases is among the main causes of death worldwide. The consumption of some foods such as nuts and seeds may be beneficial in preventing these diseases. Dipteryx alata Vogel (DA), known popularly as Baru, belongs to the family Fabaceae and is a native frui...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2017.0052
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abstract：:Contrasting data partially support a certain antihypertensive efficacy of lactotripeptides derived from enzymatic treatment of casein hydrolysate. We carried out a randomized, double-blind, crossover clinical study to investigate the antihypertensive efficacy of a short-term treatment with lactotripeptides in Mediterr...
journal_title：Journal of medicinal food
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2010-12-01 00:00:00
abstract：:Essential oil preparation of the terpenic type was introduced for the first time in the 1930s for the management of urolithiasis. Although essential oil preparations are registered in 50 countries, including some developed countries such as the United Kingdom, Italy, and Japan, for use in urolithiasis, no literature h...
journal_title：Journal of medicinal food
pub_type： 杂志文章,评审
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更新日期：2010-04-01 00:00:00
abstract：:Inflammation and the presence of pro-inflammatory cytokines are associated with numerous chronic diseases such as type-2 diabetes mellitus, cardiovascular disease, Alzheimer's disease, and cancer. An overwhelming amount of data indicates that curcumin, a polyphenol obtained from the Indian spice turmeric, Curcuma long...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2014.0053
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abstract：:Studies have shown that polyphenols reduce the risk of inflammation-related diseases and upregulates energy expenditure in adipose tissue. Here, we investigated the mechanism of the anti-inflammatory and antiobesity effects of almond skin polyphenol extract (ASP) in differentiated 3T3-L1 adipocytes. The antioxidant ef...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2016.3806
更新日期：2017-02-01 00:00:00
abstract：:The present study was carried out to assess the influence of sesame oil on blood glucose, lipid peroxidation, and status of antioxidants in normal and streptozotocin (STZ) diabetic rats. Diabetes was induced in adult female albino Wistar rats weighing 180-200 g by administration of STZ (40 mg/kg of body weight) intrap...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2005.8.377
更新日期：2005-10-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1089/109662003765184741
更新日期：2003-04-01 00:00:00
abstract：:One of the critical features of Alzheimer's disease is cognitive dysfunction, which is, in part, due to decreases in acetylcholine (ACh). The ethanol extract of Perilla frutescens was selected for isolating the acetylcholinesterase (AChE) inhibitor based on preliminary screening. In vivo behavioral tests were performe...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2015.3540
更新日期：2016-03-01 00:00:00
abstract：:The present study evaluated the protective effect of Centella asiatica (gotu kola) leaf extract (CAE) against indomethacin (IND)-induced gastric mucosal injury in rats. Gastric mucosal injury was induced by the oral administration of IND to the rats after a 24 h fast. CAE (50 or 250 mg/kg) or lansoprazole (a reference...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2015.3464
更新日期：2016-01-01 00:00:00
abstract：:We examined the effects of Rhizoma Dioscoreae Tokoronis extracts (RDTEs) on plasma lipids, body weight, and lipogenic enzymes. Mice were administered a standard chow diet, a 60% high-fat diet, or a high-fat diet with RDTE. Mice that were fed a high-fat diet containing RDTE were found to have lower increases in body an...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2008.1010
更新日期：2009-04-01 00:00:00
abstract：:Bilberry (European blueberry) has been reported to have many biological effects, including anticancer activity. In this study, we investigated the antiproliferative effects of bilberry extract in relation to its ability to induce apoptosis and affect microtubule assembly and organization in MCF7 human breast cancer ce...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2009.0053
更新日期：2010-04-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章,评审
doi：10.1089/jmf.2004.7.387
更新日期：2004-01-01 00:00:00
abstract：:Depression is highly prevalent in diabetics and is associated with poor glucose regulation and increased risk of diabetic complications. Identification and effective treatment of comorbid depression are increasingly being considered essential components of clinical care of diabetics. In the present study, the antidepr...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/109662003772519976
更新日期：2003-01-01 00:00:00
abstract：:This is the first report about the modifying antibiotic activity of Eugenia uniflora L. and Eugenia jambolanum L. In this study the ethanol extract of E. uniflora and E. jambolanum was tested for their antimicrobial activity against strains of Escherichia coli. The growth of the two strains of E. coli bacteria tested ...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2009.0158
更新日期：2010-08-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2017.4155
更新日期：2018-10-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章,评审
doi：10.1089/jmf.2007.0091
更新日期：2008-12-01 00:00:00
abstract：:Telfairia occidentalis (Cucurbitaceae) is a leafy vegetable used in soup and folk medicine in southern Nigeria. Ethnobotanical survey revealed that preparations of the plant are used in the treatment of central nervous system-related disorders including convulsion. This study was conducted to investigate the effect of...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2012.0211
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journal_title：Journal of medicinal food
pub_type： 杂志文章
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更新日期：2009-10-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
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更新日期：2018-11-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2016.0024
更新日期：2016-10-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
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更新日期：2004-10-01 00:00:00
abstract：:Despite defenses by polymorphonuclear neutrophils in the host against invading agents, overproduction of oxidant species by phagocytes can lead to damage in the surrounding tissues. Several benzophenones have been shown to possess anti-inflammatory properties. The effect of the natural benzophenone 7-epiclusianone iso...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2011.0043
更新日期：2012-02-01 00:00:00
abstract：:Sweet dream oral liquid (SDOL), a traditional Chinese herbal compound contains 17 traditional Chinese medicines. It has various pharmacological effects, such as improving brain dysfunction and increasing sleeping quality. This study investigated the neuroprotective effect and the underlying mechanisms of SDOL-impaired...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2015.3530
更新日期：2016-05-01 00:00:00
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journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2005.8.488
更新日期：2005-01-01 00:00:00
abstract：:Although diagnostic criteria for metabolic syndrome (MtS) vary among various health professionals and organizations, blood glucose dysregulation and insulin resistance are common to all definitions. Red ginseng is beneficial for glucose regulation and insulin sensitivity but the mechanism is not yet elucidated. Ginsen...
journal_title：Journal of medicinal food
pub_type： 杂志文章,随机对照试验
doi：10.1089/jmf.2012.2583
更新日期：2013-05-01 00:00:00
abstract：:We have provided a protocol for establishing an atopic dermatitis (AD) in vitro model, and evaluated the effects of Costaria costata (CC) extracts on AD in an in vitro model using keratinocytes and splenocytes from AD-induced mice and mast cells. HaCaT cells were each treated with 200 μg/mL of CC water extract (CCW), ...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2016.3691
更新日期：2016-10-01 00:00:00
abstract：:Polyphenols, including green tea catechins, are secondary plant compounds often discussed in the context of health-promoting potential. Evidence for such effects is mainly derived from epidemiological and cell culture studies. The aim of the present study was to investigate antidiabetic, antiadipogenic, and anti-infla...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2012.0205
更新日期：2013-04-01 00:00:00
