Ethanolic Extract of Vaccinium corymbosum Alleviates Muscle Fatigue in Mice.

Abstract:

:The aim of this study was to evaluate the effects of ethanol extracts of Vaccinium corymbosum (VCE) on exercise-induced fatigue in mice. Mice were randomly divided into three groups; nonexercise control group (CON), exercise control group (Ex-CON), and exercise and VCE supplementation group (Ex-VCE). Compared with Ex-CON, Ex-VCE showed increased endurance exercise capacity on day 21. In Ex-VCE mice, the accumulation of lactate was inhibited and the consumption of fatty acids was enhanced, indicating the delay of muscle fatigue. In addition, VCE supplementation elevated mRNA expression levels of mitochondrial biogenesis-associated genes such as peroxisome proliferator-activated receptor-1γ coactivator 1α (PGC-1α), nuclear respiratory factor (NRF), and mitochondrial transcription factor A (Tfam) and fatty acid β-oxidation-associated genes such as carnitine palmitoyltransferase-1 (CPT-1), β-hydroxyacyl coenzyme A dehydrogenase (β-HAD), and peroxisome proliferator-activated receptor-δ (PPAR-δ). These results suggest that VCE can potentially prevent muscle fatigue by enhancing mitochondrial biogenesis and fatty acid β-oxidation.

journal_name

J Med Food

authors

Kim S,Park J,Shin J,You Y,Kim OK,Lee J,Chung JW,Shim S,Kim K,Jun W

doi

10.1089/jmf.2020.4753

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

1225-1229

issue

11

eissn

1096-620X

issn

1557-7600

journal_volume

23

pub_type

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