Cell cycle arrest and induction of apoptosis by lycopene in LNCaP human prostate cancer cells.


:Lycopene is one of the major carotenoids and is found almost exclusively in tomatoes and tomato products. Since tomato consumption is associated with decreased risk of prostate cancer, characterizing the effects of lycopene on cell growth or survival, cell cycle progression, and apoptosis in LCNaP human prostate cancer cells might elucidate the mechanisms of actions of lycopene. To discover the possible anti-cancer mechanism of lycopene, water-soluble lycopene was used, and cell cycle arrest and apoptosis were measured. Placebo formulation at each lycopene dose at 0.1, 1, and 5 microM was used as a control. After 6, 24, and 48 hours of incubation, cells were harvested and measured for cell viability. Lycopene at 1 microM inhibited cell growth by 31%, compared with its placebo formulation after a 48-hour incubation. Lycopene at 5 microM increased the number of cells in the G(2)/M phase of the cell cycle from 13% to 28% and decreased S-phase cells from 45% to 29%, while no shifts in cell cycle were detected in placebo-treated groups. Apoptosis was observed at the 5 microM lycopene formulation at the late stages during the 24- and 48-hour treatments. Lycopene, therefore, deserves further study as a potential chemopreventive/chemotherapeutic agent.


J Med Food


Hwang ES,Bowen PE




Has Abstract


2004-10-01 00:00:00












  • Effect of a Western-style diet fortified with increased calcium and vitamin D on mammary gland of C57BL/6 mice.

    abstract::We previously reported hyperproliferation and hyperplasia in C57Bl/6 mouse mammary gland after feeding a Western-style diet (WD); these findings decreased after supplementing WD with increased calcium and vitamin D(3). We now again fortified WD with increased calcium and vitamin D(3) from two sources: (1) a food sourc...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Kurihara N,Fan K,Thaler HT,Yang K,Lipkin M

    更新日期:2008-06-01 00:00:00

  • Glycoproteins and Polysaccharides are the Main Class of Active Constituents Required for Lymphocyte Stimulation and Antigen-Specific Immune Response Induction by Traditional Medicinal Herbal Plants.

    abstract::Traditional herbal remedies stimulate and modulate the immune system, and it is thought that their glycoproteins and polysaccharides are responsible for this activity. We prepared crude water, protein, and polysaccharide extracts from Atractylodes macrocephala Koidz, Helianthus annuus L., Scutellaria barbata D. Don, a...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Son YO,Kook SH,Lee JC

    更新日期:2017-10-01 00:00:00

  • Effects of solid-state fermented rice on lipid metabolism and antioxidant status in high-cholesterol-fed rats.

    abstract::We investigated the effect of solid-state fermented rice cultured with Basidiomycota (sangwhang) and Monascus ruber on lipid metabolism and antioxidant activity. Forty 4-week-old male Sprague-Dawley rats were fed high cholesterol diets in which carbohydrate sources in the treatment groups consisted of non-fermented ri...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Jang YJ,Kim MH,Nam SH,Kang MY

    更新日期:2007-12-01 00:00:00

  • 90-Day Oral Toxicity Assessment of Tropaeolum majus L. in Rodents and Lagomorphs.

    abstract::Tropaeolum majus L., popularly known as nasturtium, is a species widely used in the form of infusions and salads. In the last years, the antihypertensive, diuretic, and calcium and potassium sparing activities of T. majus preparations were shown. Moreover, no preclinical 90-day oral toxicity studies were conducted. Th...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Araújo VO,Andreotti CEL,Reis MP,de Lima DA,Pauli KB,Nunes BC,Gomes C,Germano RM,Cardozo Junior EL,Gasparotto Junior A,Lourenço ELB

    更新日期:2018-08-01 00:00:00

  • Liquid chromatography: mass spectrometry of isoflavones.

    abstract::High-performance liquid chromatography (HPLC) or capillary electrophoresis (CE) is particularly suited to the separation and analysis of a wide range of biological compounds. When investigating such compounds in complex matrices (e.g., blood, tissue, urine, foods), specificity of the detection method becomes an import...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Barnes S,Wang CC,Smith-Johnson M,Kirk M

    更新日期:1999-01-01 00:00:00

  • Bioactive compounds and antioxidant and antiproliferative activities of Korean white lotus cultivars.

    abstract::In traditional Korean medicine, lotus (Nelumbo nucifera Gaertn) roots have been used as an antidiabetic and an antiproliferative remedy. However, scientific publications on lotus properties are very limited. Therefore, it was decided to investigate the Korean white lotus cultivars in order to find out their bioactivit...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Park YS,Towantakavanit K,Kowalska T,Jung ST,Ham KS,Heo BG,Cho JY,Yun JG,Kim HJ,Gorinstein S

    更新日期:2009-10-01 00:00:00

  • Inhibition of acetylcholinesterase activity and Fe2+-induced lipid peroxidation in rat brain in vitro by some citrus fruit juices.

    abstract::This study sought to characterize the effects of some citrus fruit juices (shaddock [Citrus maxima], grapefruit [Citrus paradisii], lemon [Citrus limoni], orange [Citrus sinensis], and tangerine [Citrus reticulata]) on acetylcholinesterase activity in vitro. The total phenolic content, radical scavenging abilities, an...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Ademosun AO,Oboh G

    更新日期:2012-05-01 00:00:00

  • Determination of mineral contents of Turkish herbal tea (Salvia aucheri var. canescens) at different infusion periods.

    abstract::Inductively coupled plasma atomic emission spectrometry has been used for the determination of contents of major and minor elements in Salvia aucheri var. canescens (sage) and its infusions for different intervals. Twenty-five elements (Al, B, Ba, Bi, Ca, Cd, Co, Cr, Cu, Fe, Ga, Ln, K, Li, Mg, Mn, Na, Ni, P, Pb, S, Sr...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Ozcan M

    更新日期:2005-04-01 00:00:00

  • Antioxidant and antimicrobial activity of Cissus quadrangularis L.

    abstract::Extracts of Cissus quadrangularis L. were tested for antioxidant activity by beta-carotene linoleic acid model and also by 1,1-diphenyl-2-picrylhydrazyl model. The ethyl acetate fraction of both fresh and dry stem extracts at a concentration of 100 ppm showed 64.8% antioxidant activity in the beta-carotene linoleic ac...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Chidambara Murthy KN,Vanitha A,Mahadeva Swamy M,Ravishankar GA

    更新日期:2003-07-01 00:00:00

  • Chia Seed Supplementation Reduces Senescence Markers in Epididymal Adipose Tissue of High-Fat Diet-Fed SAMP8 Mice.

    abstract::Adipose tissue is a key organ with substantial senescent cell accumulation under both obesity and aging conditions. Chia seed is an ancient seed and is the richest plant source of α-linolenic acid. We aimed to determine how cellular senescence markers will be altered in adipose tissue of senescence-accelerated mouse-p...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Rui Y,Yang S,Chen LH,Qin LQ,Wan Z

    更新日期:2018-08-01 00:00:00

  • Isoflavone composition, total polyphenolic content, and antioxidant activity in soybeans of different origin.

    abstract::Twenty soybean cultivars, originating from the United States, Russia, Serbia, and China, were analyzed for their isoflavone composition, total polyphenolic content, and antioxidant activity. Isoflavones were extracted by aqueous methanol (80%) and analyzed by high-performance liquid chromatography/diode array detectio...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Tepavcević V,Atanacković M,Miladinović J,Malencić D,Popović J,Cvejić J

    更新日期:2010-06-01 00:00:00

  • Inhibitory effects of salidroside on nitric oxide and prostaglandin E₂ production in lipopolysaccharide-stimulated RAW 264.7 macrophages.

    abstract::The aim of this study was to evaluate the effect of salidroside on lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E₂ (PGE₂) production in RAW 264.7 macrophages and related anti-inflammatory mechanism. PGE₂ production was measured by enzyme-linked immunosorbent assay (ELISA); NO production was tes...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Song B,Huang G,Xiong Y,Liu J,Xu L,Wang Z,Li G,Lu J,Guan S

    更新日期:2013-11-01 00:00:00

  • Cardioprotective Effects of a Phlorotannin Extract Against Doxorubicin-Induced Cardiotoxicity in a Rat Model.

    abstract::Long-term therapy with doxorubicin (DOX) is associated with high incidence of cumulative and irreversible dilated cardiomyopathy. The goal of this study was to evaluate the cardioprotective effects and safety of a phlorotannin extract from a brown algae Ecklonia cava (Seapolynol™, SPN) against DOX-induced cardiotoxici...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Ahn HS,Lee DH,Kim TJ,Shin HC,Jeon HK

    更新日期:2017-10-01 00:00:00

  • The Effects of Curcuma longa L., Purple Sweet Potato, and Mixtures of the Two on Immunomodulation in C57BL/6J Mice Infected with LP-BM5 Murine Leukemia Retrovirus.

    abstract::The immune response is stimulated to protect the body from external antigens and is controlled by several types of immune cells. In the present study, the immunomodulatory effects of Curcuma longa L., purple sweet potato, and mixtures of the two (CPM) were investigated in C57BL/6 mice infected with LP-BM5 murine leuke...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Park SJ,Lee D,Lee M,Kwon HO,Kim H,Park J,Jeon W,Cha M,Jun S,Park K,Lee J

    更新日期:2018-07-01 00:00:00

  • Tagatose, the new GRAS sweetener and health product.

    abstract::Tagatose, a low-calorie, full-bulk natural sugar, has just attained GRAS (Generally Recognized As Safe) status under U.S. Food and Drug Administration (FDA) regulations, thereby permitting its use as a sweetener in foods and beverages. This paper presents all current aspects of tagatose with respect to demonstrated fo...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,评审


    authors: Levin GV

    更新日期:2002-04-01 00:00:00

  • Review of Clinical Effects and Presumed Mechanism of Action of the French Oak Wood Extract Robuvit.

    abstract::Since ancient times, oak wood polyphenols are consumed concomitantly with beverages that are stored and aged in oak wood barrels. Among these polyphenols are roburins, which belong to the class of ellagitannins and only occur in oak. To date, water-extracted standardized French Quercus robur wood extract, commercially...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Weichmann F,Avaltroni F,Burki C

    更新日期:2021-01-28 00:00:00

  • Antibacterial, antiadherence, antiprotease, and anti-inflammatory activities of various tea extracts: potential benefits for periodontal diseases.

    abstract::Porphyromonas gingivalis is a key etiologic agent of chronic periodontitis. This Gram-negative anaerobic bacterium produces several virulence factors and can induce a host inflammatory response that contributes to periodontal disease. In the present study, we investigated green tea, white tea, oolong tea, and black te...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Zhao L,La VD,Grenier D

    更新日期:2013-05-01 00:00:00

  • Phloretin inhibits phorbol ester-induced tumor promotion and expression of cyclooxygenase-2 in mouse skin: extracellular signal-regulated kinase and nuclear factor-κB as potential targets.

    abstract::The present study investigated the effect of phloretin [2',4',6'-trihydroxy-3-(4-hydroxyphenyl)-propiophenone] on 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression and tumor promotion in mouse skin and explored the underlying molecular mechanisms. Topical application of phloretin s...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Shin JW,Kundu JK,Surh YJ

    更新日期:2012-03-01 00:00:00

  • Phytochemical, antibacterial, antiproliferative, and antioxidant potentials and DNA damage-protecting activity of Acacia salicina extracts.

    abstract::The extract enriched in total oligomer flavonoids (TOF), and the aqueous, methanol, and ethyl acetate extracts of Acacia salicina were investigated for their polyphenolic compound content, antioxidative activity in the nitro blue tetrazolium/riboflavin assay system, antibacterial activity against Gram-positive and Gra...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Chatti IB,Limem I,Boubaker J,Skandrani I,Kilani S,Bhouri W,Ben Sghaier M,Nefatti A,Ben Mansour H,Ghedira K,Chekir-Ghedira L

    更新日期:2009-06-01 00:00:00

  • Perilla frutescens Extract Ameliorates Acetylcholinesterase and Trimethyltin Chloride-Induced Neurotoxicity.

    abstract::One of the critical features of Alzheimer's disease is cognitive dysfunction, which is, in part, due to decreases in acetylcholine (ACh). The ethanol extract of Perilla frutescens was selected for isolating the acetylcholinesterase (AChE) inhibitor based on preliminary screening. In vivo behavioral tests were performe...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Choi SJ,Oh SS,Kim CR,Kwon YK,Suh SH,Kim JK,Park GG,Son SY,Shin DH

    更新日期:2016-03-01 00:00:00

  • 4-methylcoumarin derivatives inhibit human neutrophil oxidative metabolism and elastase activity.

    abstract::Increased neutrophil activation significantly contributes to the tissue damage in inflammatory illnesses; this phenomenon has motivated the search for new compounds to modulate their effector functions. Coumarins are natural products that are widely consumed in the human diet. We have evaluated the antioxidant and imm...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Kabeya LM,Fuzissaki CN,Andrade MF,Azzolini AE,Taleb-Contini SH,Vermelho RB,Lopes JL,Lucisano-Valim YM

    更新日期:2013-08-01 00:00:00

  • 7-epiclusianone, the natural prenylated benzophenone, inhibits superoxide anions in the neutrophil respiratory burst.

    abstract::Despite defenses by polymorphonuclear neutrophils in the host against invading agents, overproduction of oxidant species by phagocytes can lead to damage in the surrounding tissues. Several benzophenones have been shown to possess anti-inflammatory properties. The effect of the natural benzophenone 7-epiclusianone iso...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Santa-Cecília FV,Santos GB,Fuzissaki CN,Derogis PB,Freitas LA,Gontijo VS,Stringheta PC,Nagem TJ,Brigagão MR,Santos MH

    更新日期:2012-02-01 00:00:00

  • Fermented Moringa oleifera Decreases Hepatic Adiposity and Ameliorates Glucose Intolerance in High-Fat Diet-Induced Obese Mice.

    abstract::Metabolic diseases, such as glucose intolerance and nonalcoholic fatty-liver disease (NAFLD), are primary risk factors for life-threatening conditions such as diabetes, heart attack, stroke, and hepatic cancer. Extracts from the tropical tree Moringa oleifera show antidiabetic, antioxidant, anti-inflammatory, and anti...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Joung H,Kim B,Park H,Lee K,Kim HH,Sim HC,Do HJ,Hyun CK,Do MS

    更新日期:2017-05-01 00:00:00

  • Effects of heating, storage, and ultraviolet exposure on antimicrobial activity of garlic juice.

    abstract::This study was designed to investigate the effect of heating, storage, and ultraviolet exposure on antimicrobial activity of garlic juice and its bacteriocidal activity against common human pathogens. Antimicrobial activity of fresh garlic juice was tested against Escherichia coli, Staphylococcus aureus, Streptococcus...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Al-Waili NS,Saloom KY,Akmal M,Al-Waili TN,Al-Waili AN,Al-Waili H,Ali A,Al-Sahlani K

    更新日期:2007-03-01 00:00:00

  • Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice.

    abstract::Pomegranate seed oil was investigated for possible skin cancer chemopreventive efficacy in mice. In the main experiment, two groups consisting each of 30, 4-5-week-old, female CD(1) mice were used. Both groups had skin cancer initiated with an initial topical exposure of 7,12-dimethylbenzanthracene and with biweekly p...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Hora JJ,Maydew ER,Lansky EP,Dwivedi C

    更新日期:2003-10-01 00:00:00

  • In vitro antimicrobial properties of coconut oil on Candida species in Ibadan, Nigeria.

    abstract::The emergence of antimicrobial resistance, coupled with the availability of fewer antifungal agents with fungicidal actions, prompted this present study to characterize Candida species in our environment and determine the effectiveness of virgin coconut oil as an antifungal agent on these species. In 2004, 52 recent i...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Ogbolu DO,Oni AA,Daini OA,Oloko AP

    更新日期:2007-06-01 00:00:00

  • Methylglyoxal may affect hydrogen peroxide accumulation in manuka honey through the inhibition of glucose oxidase.

    abstract::Although hydrogen peroxide (H₂O₂) is one of the major antibacterial factors in most honeys, it does not accumulate in medical-grade manuka honey. The goal of this study was to investigate the effect of artificially added methylglyoxal (MGO) on H₂O₂ accumulation in natural non-manuka honeys. H₂O₂ concentrations in the ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Majtan J,Bohova J,Prochazka E,Klaudiny J

    更新日期:2014-02-01 00:00:00

  • The mediterranean diet in cancer prevention: a review.

    abstract::The Mediterranean dietary pattern has a well-established beneficial role in health promotion. Epidemiologic studies reveal the protective role of adherence to this pattern on overall cancer incidence and mortality. This review examines results from prospective cohort, cross-sectional, and case-control studies assessin...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,评审


    authors: Kontou N,Psaltopoulou T,Panagiotakos D,Dimopoulos MA,Linos A

    更新日期:2011-10-01 00:00:00

  • Red Pepper (Capsicum baccatum) Extracts Present Anti-Inflammatory Effects In Vivo and Inhibit the Production of TNF-α and NO In Vitro.

    abstract::Capsicum baccatum is the most consumed red pepper species in Brazil. Our previous studies demonstrated the anti-inflammatory properties of its crude extract, whose activity is yet to be fully characterized. Herein, we examined the anti-inflammatory in vivo effects of enriched extracts obtained through bioguided fracti...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Allemand A,Leonardi BF,Zimmer AR,Moreno S,Romão PR,Gosmann G

    更新日期:2016-08-01 00:00:00

  • Antioxidant effect of Hemidesmus indicus on ethanol-induced hepatotoxicity in rats.

    abstract::The antioxidant effect of the ethanolic root extract of Hemidesmus indicus, an indigenous Ayurvedic medicinal plant used in soft drinks in India, was studied in rats with ethanol-induced hepatotoxicity. Administering 20% ethanol (5 g/kg of body weight/day) for 60 days to male Wistar rats resulted in significantly decr...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章


    authors: Saravanan N,Nalini N

    更新日期:2007-12-01 00:00:00