Abstract：
:The n-3 polyunsaturated fatty acids (PUFAs) are known to reduce risk for coronary heart disease partly by altering blood lipids. The purpose of this study was to determine the effect of low doses of n-3 PUFAs on the lipid profile and their tolerability in mildly hypertriglyceridemic subjects. Subjects with a serum triacylglycerol (TG) level between 100 and 300 mg/dL were placed on a corn oil placebo (seven capsules per day; single-blind) for 4 weeks and then randomized to continue seven capsules per day of placebo (n = 49) or one of the following doses of n-3 PUFAs for 20 weeks: 0.5 g (n = 51), 1 g (n = 23), or 2 g (n = 12). During the treatment period, 48-50% of the 1-g and 2-g dose groups reported noticing burping (P < .05), and only about half as many in the 0.5-g group noticed burping. Interestingly, 2% of those assigned to the placebo did report a fishy burping during the study, but this dropped back to nearly 0% by week 20. There was no significant effect for any dosage group on fasting and postprandial serum TG, chylomicron TG, very-low-density lipoprotein-cholesterol, or high-density lipoprotein-cholesterol concentration. However, 1-g and 2-g n-3 PUFA treatments significantly increased total cholesterol and low-density lipoprotein-cholesterol concentration. In addition, all doses of n-3 PUFA treatments significantly increased plasma phospholipid n-3 PUFAs. We conclude that doses of n-3 PUFAs of 0.5-2 g/day in healthy volunteers with above average TG levels did not have beneficial effects on their lipid profiles.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Park Y,Harris WSdoi
10.1089/jmf.2008.1250subject
Has Abstractpub_date
2009-08-01 00:00:00pages
803-8issue
4eissn
1096-620Xissn
1557-7600journal_volume
12pub_type
杂志文章,随机对照试验abstract：:Hyacinth bean, Dolichos lablab or Lablab purpureus, has been used for centuries in India and China as an edible pod and animal forage, as well as to treat diarrhea and other gastrointestinal disease in traditional Korean medicine. Recently, we have demonstrated that D. lablab extract (DLL-Ex) prevented free fatty acid...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2017.4036
更新日期：2017-12-01 00:00:00
abstract：:Allium cepa (Family Liliaceae) is a reputed Indian medicinal herb that is prescribed as an effective remedy for several ailments in the Ayurvedic system of medicine. The aim of this study was to evaluate its efficacy against various events responsible for Type I allergic reactions. A herbal fraction (ALC-02) from A. c...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2007.0642
更新日期：2009-04-01 00:00:00
abstract：:This study was designed to investigate the effect of heating, storage, and ultraviolet exposure on antimicrobial activity of garlic juice and its bacteriocidal activity against common human pathogens. Antimicrobial activity of fresh garlic juice was tested against Escherichia coli, Staphylococcus aureus, Streptococcus...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2005.067
更新日期：2007-03-01 00:00:00
abstract：:Glyceollins, which are derived from daidzein in soybean in response to various stimuli or stresses, have been reported to activate antioxidant/detoxifying enzymes in a nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-dependent manner, in addition to exerting anti-inflammatory effects in murine macrophages. As the Nr...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2017.3960
更新日期：2017-11-01 00:00:00
abstract：:Esophageal cancer (EC) is commonly diagnosed in South Africa (SA), with high incidences occurring in SA's black population. Moringa oleifera (MO), a multipurpose tree, is used traditionally for its nutritional and medicinal properties. It has been used for the treatment of a variety of ailments, including cancer. We i...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2015.0113
更新日期：2016-04-01 00:00:00
abstract：:We previously reported hyperproliferation and hyperplasia in C57Bl/6 mouse mammary gland after feeding a Western-style diet (WD); these findings decreased after supplementing WD with increased calcium and vitamin D(3). We now again fortified WD with increased calcium and vitamin D(3) from two sources: (1) a food sourc...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2007.619
更新日期：2008-06-01 00:00:00
abstract：:Obesity is generally associated with low-grade chronic inflammation that involves the recruitment of macrophages and other inflammation factors to the adipocytes of obese individuals. Tumor necrosis factor-alpha (TNF-α), a cytokine associated with systemic inflammation, is elevated in conditions of obesity. TNF-α is a...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2017.3941
更新日期：2018-03-01 00:00:00
abstract：:Vegetables are considered to be the most affordable and sustainable sources of several micronutrients that are essential for physical and mental development, immune system functioning, and various metabolic processes in humans. However, their effectiveness as dietary sources of minerals is influenced by mineral-minera...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2006.252
更新日期：2007-09-01 00:00:00
abstract：:Many studies have focused on the effect of fresh fruits on the risk of developing cancer and other diseases involved with reactive species and free radicals. The intake of frozen fruits has spread widely in the last years, but, until now, their biological activity is not completely known. In this study, 23 samples of ...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2007.598
更新日期：2008-03-01 00:00:00
abstract：:Panax ginseng (P. ginseng C.A. Meyer, Araliaceae) is used as a therapeutic agent for various diseases. P. ginseng saponins, known as ginsenosides, are the main bioactive compounds responsible for its pharmacological activities. In this work, we have developed a new method of P. ginseng root processing termed solid-sta...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2017.4035
更新日期：2018-04-01 00:00:00
abstract：:Oxidative stress triggered by hyperglycemia is thought to be a major factor in the development of liver disease during diabetes mellitus (DM). The aim of this study was to determine the antioxidant capacity of aqueous extracts of selenium-enriched Auricularia auricular (AESA) and further investigate the hepatic protec...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2019.4416
更新日期：2020-02-01 00:00:00
abstract：:Fermentation has shown to be an effective technique in bioactive peptides release. That is why in this study antihypertensive, antithrombotic, and antioxidant activity was evaluated during amaranth proteins fermentation with Lactobacillus casei Shirota and Streptococcus thermophilus 54102 in mono and combined culture....
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2019.0039
更新日期：2019-10-01 00:00:00
abstract：:The protective effect of beef and pig collagen hydrolysates and their fractions were tested as anti-ulcerogenic agents in rats (weighing 250-350 g) against ulcerative lesions caused by ethanol. Beef and pig collagen hydrolysates were fractionated by ultrafiltration into different molecular weight fractions. The protoc...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2006.262
更新日期：2007-03-01 00:00:00
abstract：:Safety of intravenous (i.v.) or intrapulmonary administration of different concentrations of honey and their effects on blood sugar, renal and liver function tests, bone marrow function, lipid profile, and carbon tetrachloride (CCl(4))-induced liver damage were studied. Healthy sheep of either sex, 6-8 months old, wer...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/10966200360716652
更新日期：2003-10-01 00:00:00
abstract：:Cardiovascular disease (CVD) is the leading cause of death in the world and is the primary cause of mortality among Americans. One of the many reasons for the pathogenesis of CVD is attributed to eating diets high in saturated fat and refined carbohydrates and low in fruits and vegetables. Epidemiological evidence has...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2013.0034
更新日期：2014-05-01 00:00:00
abstract：:We investigated age-related changes in intestinal intraepithelial lymphocyte (IEL) subsets in mice by flow cytometric analysis and their functional preservation as affected by feeding Spirulina, a cyanobacterium that is known to possess various therapeutic effects, including immune modulation activity. The number of c...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2008.1260
更新日期：2009-10-01 00:00:00
abstract：:Glucomannan-enriched squid surimi improves cholesterolemia and liver antioxidant status. The effect of squid surimi enriched with glucomannan or glucomannan plus spirulina on liver and heart structures and cell damage markers was tested in fa/fa rats fed highly saturated-hyper-energetic diets. Animals were fed 70% AIN...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2016.0157
更新日期：2017-06-01 00:00:00
abstract：:Vernonia amygdalina Del. (Family Compositae) is used in Nigerian folk medicine as a tonic and remedy against constipation, fever, high blood pressure, and many infectious diseases. We have evaluated the hepatoprotective and antioxidant effects of an aqueous extract of V. amygdalina leaves against acetaminophen-induced...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2006.9.524
更新日期：2006-01-01 00:00:00
abstract：:The oral cytotoxicity, antimicrobial and anti-demineralizing effects of a tincture from Bauhinia forficata Link tincture (BFLT) were evaluated in vitro and ex vivo. Susceptibility tests (minimum inhibitory and microbicidal concentrations-MIC and time-kill assay-MMC) were performed against planktonic oral microorganism...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2019.0277
更新日期：2020-09-01 00:00:00
abstract：:This study aimed to assess the effects of a yacon-based product (YBP) on constipation in adults, including the elderly. Forty-eight individuals were recruited and divided into equal intervention groups named the test and control groups. The YBP (test) and the control (maltodextrin) were dissolved in commercial orange ...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2014.0115
更新日期：2015-09-01 00:00:00
abstract：:Neuropathic pain (NP) is associated with chronic hyperglycemia and emotional disorders such as depression in diabetic patients, complicating the course of treatment. Drugs currently used to treat NP have undesirable side effects, so research on other natural sources has been required. β-caryophyllene (BCP), a natural ...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2018.0157
更新日期：2019-05-01 00:00:00
abstract：:High glucose levels can change podocyte gene expression and subsequently induce podocyte damage through altered glucose metabolism. l-Carnitine is known to play a beneficial role in diabetes; however, there are no studies on the effects of l-carnitine on podocyte alteration under high glucose conditions. This study in...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2010.1079
更新日期：2010-12-01 00:00:00
abstract：:Eugenol (4-allyl-2-methoxyphenol), a major phenolic component from clove oil (Eugenia caryophyllata), has several biological activities. To estimate the capacity of eugenol to act as an antioxidant, the following were studied: 1,1-diphenyl-2-picryl-hydrazyl-, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid)-, and...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2010.0197
更新日期：2011-09-01 00:00:00
abstract：:Soy products are mainly composed of proteins, phytochemicals such as isoflavones, soy lipids, and carbohydrates. It is unclear whether an individual component alone or a combined effect of multiple bioactive compounds contributes to the beneficial properties of soy. We investigated the effect of dietary genistein (the...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2006.9.459
更新日期：2006-01-01 00:00:00
abstract：:This study researched the effects of Lactobacillus plantarum PMO 08 alone and combined with chia seeds on metabolic syndrome and parameters related to microbiota modulation and intestinal barrier integrity in obese mice fed high-fat diets (HFDs; 45% kcal fat). Male C57BL/6J mice were acclimated for a period of 2 weeks...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2018.4349
更新日期：2019-12-01 00:00:00
abstract：:Capsicum baccatum is the most consumed red pepper species in Brazil. Our previous studies demonstrated the anti-inflammatory properties of its crude extract, whose activity is yet to be fully characterized. Herein, we examined the anti-inflammatory in vivo effects of enriched extracts obtained through bioguided fracti...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2015.0101
更新日期：2016-08-01 00:00:00
abstract：:Several studies have demonstrated a protective effect of estrogen against the risk of developing neurodegenerative diseases; however, the molecular mechanisms involved have not been fully addressed. Isoflavones have been proposed as potential alternatives to estrogen replacement therapy. Therefore, in the present stud...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2008.1069
更新日期：2009-06-01 00:00:00
abstract：:Obesity is characterized by an increase in the infiltration of monocytes into the adipose tissue, causing an inflammatory condition associated with, for example, the development of insulin resistance. Thus, anti-inflammatory-based treatments could emerge as a novel and interesting approach. It has been reported that C...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2014.0031
更新日期：2015-05-01 00:00:00
abstract：:The underlying causes of denervation of the neuromuscular junction and eventual motor neuron death in amyotrophic lateral sclerosis (ALS) have not been resolved. The superoxide dismutase 1 (SOD1)(G93A) mutant mouse is a frequently used animal model of ALS. We hypothesized that resveratrol (RSV), a polyphenolic molecul...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2009.0243
更新日期：2010-10-01 00:00:00
abstract：:The transport behavior and absorption mechanism of Ala-His-Leu-Leu (AHLL) intestinal absorption in Caco-2 cell monolayers were clarified systemically. The safe absorptive concentration of AHLL was 200 μg/mL, which was determined by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay. The permeat...
journal_title：Journal of medicinal food
pub_type： 杂志文章
doi：10.1089/jmf.2016.3842
更新日期：2017-03-01 00:00:00
