Dolichos lablab Protects Against Nonalcoholic Fatty Liver Disease in Mice Fed High-Fat Diets.

Abstract:

:Hyacinth bean, Dolichos lablab or Lablab purpureus, has been used for centuries in India and China as an edible pod and animal forage, as well as to treat diarrhea and other gastrointestinal disease in traditional Korean medicine. Recently, we have demonstrated that D. lablab extract (DLL-Ex) prevented free fatty acid-induced lipid accumulation in an in vitro cellular nonalcoholic fatty liver disease (NAFLD) model. In this study, we, thus, aimed at clarifying the hepatoprotective effects of DLL-Ex in a high-fat diet-induced in vivo animal NAFLD model, as well as at elucidating underlying mechanisms of identified effects. Sixty, 6-week-old, male C57BL/6J mice were randomly divided into six groups: a control group fed a low-fat diet, four high-fat diet (HFD) groups, three receiving daily oral supplementation of DLL-Ex (25, 50, and 100 mg/kg/day), and one HFD group receiving daily oral supplementation of MILK (100 mg/kg/day). Effects of DLL-Ex supplementation were evaluated by histopathological and histochemical assessments. DLL-Ex supplementation inhibited HFD-induced increases in body weight and body fat mass and ameliorated increases in body weight, manifested as decreased liver function tests, lower serum triglycerides and cholesterol levels, and increased serum adiponectin levels. The expression of hepatic genes involved in lipid droplet accumulation and in fatty acid uptake was also decreased. We provide evidence of a protective effect of DLL-Ex against HFD-induced fatty liver disease in an animal model.

journal_name

J Med Food

authors

Im AR,Kim YH,Kim YH,Yang WK,Kim SH,Song KH

doi

10.1089/jmf.2017.4036

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

1222-1232

issue

12

eissn

1096-620X

issn

1557-7600

journal_volume

20

pub_type

杂志文章
  • The Effects of Costaria costata Extracts on Atopic Dermatitis in an In Vitro Model.

    abstract::We have provided a protocol for establishing an atopic dermatitis (AD) in vitro model, and evaluated the effects of Costaria costata (CC) extracts on AD in an in vitro model using keratinocytes and splenocytes from AD-induced mice and mast cells. HaCaT cells were each treated with 200 μg/mL of CC water extract (CCW), ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2016.3691

    authors: Kim OK,Nam DE,Lee M,Kwon HO,Park J,You Y,Kim SI,Lee J,Jun W

    更新日期:2016-10-01 00:00:00

  • Aronia melanocarpa Concentrate Ameliorates Pro-Inflammatory Responses in HaCaT Keratinocytes and 12-O-Tetradecanoylphorbol-13-Acetate-Induced Ear Edema in Mice.

    abstract::Abnormal expression of pro-inflammatory mediators such as cell adhesion molecules and cytokines has been implicated in various inflammatory skin diseases, including atopic dermatitis. In this study, we investigated the anti-inflammatory activity of Aronia melanocarpa concentrate (AC) and its action mechanisms using in...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2015.3624

    authors: Goh AR,Youn GS,Yoo KY,Won MH,Han SZ,Lim SS,Lee KW,Choi SY,Park J

    更新日期:2016-07-01 00:00:00

  • Dietary conjugated linoleic acid increases endurance capacity of mice during treadmill exercise.

    abstract::This study was designed to evaluate the effect of dietary conjugated linoleic acid (CLA) on endurance exercise and availability of metabolic substrates in mice. Four-week-old male BALB/c mice were randomized to a control group (normal diet) and a CLA group (normal diet + 1% CLA). Each animal group received its respect...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.1358

    authors: Kim JH,Park HG,Pan JH,Kim SH,Yoon HG,Bae GS,Lee H,Eom SH,Kim YJ

    更新日期:2010-10-01 00:00:00

  • Adlay Bran Oil Suppresses Hepatic Gluconeogenesis and Attenuates Hyperlipidemia in Type 2 Diabetes Rats.

    abstract::This study aimed to examine the antidiabetic effects of various concentrations of adlay bran oil (ABO) in high fat diet and streptozotocin-induced diabetic rats. Dietary supplementation with 10% ABO for 4 weeks effectively decreased the blood triacylglycerol, glucose, and total cholesterol levels in diabetic rats, alt...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2018.4237

    authors: Tseng YH,Chang CW,Chiang W,Hsieh SC

    更新日期:2019-01-01 00:00:00

  • Cuscuta chinensis extract promotes osteoblast differentiation and mineralization in human osteoblast-like MG-63 cells.

    abstract::The aim of the present study was to investigate whether the aqueous extract of To-Sa-Za (TSZ-AE), the seed of Cuscuta chinensis Lam., which is a traditional medicinal herb commonly used in Korea and other oriental countries, could induce osteogenic activity in human osteoblast-like MG-63 cells. TSZ-AE treatment mildly...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2007.0665

    authors: Yang HM,Shin HK,Kang YH,Kim JK

    更新日期:2009-02-01 00:00:00

  • Anti-ulcerogenic effect of a whey protein isolate and collagen hydrolysates against ethanol ulcerative lesions on oral administration to rats.

    abstract::The effect of the administration of a whey protein isolate (WPI) and collagen hydrolysates on ethanol-induced ulcerative lesions was studied in rats. WPI and bovine or porcine collagen hydrolysate (BCH and PCH, respectively) were given to rats by gavage. In acute experiments, (single-dose) physiological saline (10 mL/...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2008.0277

    authors: Castro GA,Carvalho JE,Tinti SV,Possenti A,Sgarbieri VC

    更新日期:2010-02-01 00:00:00

  • Myricetin protects against cytokine-induced cell death in RIN-m5f β cells.

    abstract::Cytokine-induced cell death is recognized as a major cause of progressive β-cell loss. Tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and interferon γ (IFN-γ) in combination trigger a series of events that lead to β-cell death. In the past few decades, the use of myricetin as an anti-inflammatory and cytopro...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2011.2033

    authors: Ding Y,Zhang ZF,Dai XQ,Li Y

    更新日期:2012-08-01 00:00:00

  • Radical quenching activity, ferric-reducing antioxidant power, and ferrous ion-chelating capacity of 16 Ballota species and their total phenol and flavonoid contents.

    abstract::The ethyl acetate, methanol, and water extracts of 16 Ballota species (Family Lamiaceae)-Ballota acetabulosa, Ballota antalyanse, Ballota cristata, Ballota glandulosissima, Ballota inaequidens, Ballota larendana, Ballota latibracteolata, Ballota macrodonta, Ballota nigra ssp. anatolica, B. nigra ssp. foetida, B. nigra...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.0237

    authors: Erdogan-Orhan I,Sever-Yılmaz B,Altun ML,Saltan G

    更新日期:2010-12-01 00:00:00

  • Anticonvulsant activity of ethanol leaf extract of Spathodea campanulata P. Beauv (Bignoniaceae).

    abstract::The anticonvulsant properties of ethanol leaf extract of Spathodea campanulata, a plant used in traditional medicine to treat convulsion and epilepsy, were studied in mice using pentylenetetrazole-, picrotoxin-, and electroshock-induced models in mice. Other central nervous system effects and anticonvulsant-related ac...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.0144

    authors: Ilodigwe EE,Akah PA,Nworu CS

    更新日期:2010-08-01 00:00:00

  • The natural flavonoid apigenin suppresses Th1- and Th2-related chemokine production by human monocyte THP-1 cells through mitogen-activated protein kinase pathways.

    abstract::Dietary flavonoids have various biological functions, and there is increasing evidence that reduced prevalence and severity of allergic reactions are associated with the intake of flavonoids. Among natural flavonoids, apigenin is a potent anti-inflammatory agent. However, the mechanisms of apigenin's effect remain unc...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.1229

    authors: Huang CH,Kuo PL,Hsu YL,Chang TT,Tseng HI,Chu YT,Kuo CH,Chen HN,Hung CH

    更新日期:2010-04-01 00:00:00

  • Lactic Acid Bacterial Starter Culture with Antioxidant and γ-Aminobutyric Acid Biosynthetic Activities Isolated from Flatfish-Sikhae Fermentation.

    abstract::The aim of this study is to select a lactic acid bacterial strain as a starter culture for flatfish-Sikhae fermentation and to evaluate its suitability for application in a food system. Four strains of lactic acid bacteria isolated from commercial flatfish-Sikhae were identified and selected as starter culture candida...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2015.3458

    authors: Won YG,Yu HH,Chang YH,Hwang HJ

    更新日期:2015-12-01 00:00:00

  • Effect of genistein with carnitine administration on lipid parameters and obesity in C57Bl/6J mice fed a high-fat diet.

    abstract::Soy products are mainly composed of proteins, phytochemicals such as isoflavones, soy lipids, and carbohydrates. It is unclear whether an individual component alone or a combined effect of multiple bioactive compounds contributes to the beneficial properties of soy. We investigated the effect of dietary genistein (the...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2006.9.459

    authors: Yang JY,Lee SJ,Park HW,Cha YS

    更新日期:2006-01-01 00:00:00

  • Perilla frutescens Extract Ameliorates Acetylcholinesterase and Trimethyltin Chloride-Induced Neurotoxicity.

    abstract::One of the critical features of Alzheimer's disease is cognitive dysfunction, which is, in part, due to decreases in acetylcholine (ACh). The ethanol extract of Perilla frutescens was selected for isolating the acetylcholinesterase (AChE) inhibitor based on preliminary screening. In vivo behavioral tests were performe...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2015.3540

    authors: Choi SJ,Oh SS,Kim CR,Kwon YK,Suh SH,Kim JK,Park GG,Son SY,Shin DH

    更新日期:2016-03-01 00:00:00

  • Schisandra chinensis prevents alcohol-induced fatty liver disease in rats.

    abstract::Schisandra chinensis (SC), a traditional herbal medicine, has been prescribed for patients suffering from various liver diseases, including hepatic cancer, hypercholesterolemia, and CCl₄-induced liver injury. We investigated whether SC extract has a protective effect on alcohol-induced fatty liver and studied its unde...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2013.2849

    authors: Park HJ,Lee SJ,Song Y,Jang SH,Ko YG,Kang SN,Chung BY,Kim HD,Kim GS,Cho JH

    更新日期:2014-01-01 00:00:00

  • Antidepressant activity of quercetin, a bioflavonoid, in streptozotocin-induced diabetic mice.

    abstract::Depression is highly prevalent in diabetics and is associated with poor glucose regulation and increased risk of diabetic complications. Identification and effective treatment of comorbid depression are increasingly being considered essential components of clinical care of diabetics. In the present study, the antidepr...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/109662003772519976

    authors: Anjaneyulu M,Chopra K,Kaur I

    更新日期:2003-01-01 00:00:00

  • Antioxidant effect of Hemidesmus indicus on ethanol-induced hepatotoxicity in rats.

    abstract::The antioxidant effect of the ethanolic root extract of Hemidesmus indicus, an indigenous Ayurvedic medicinal plant used in soft drinks in India, was studied in rats with ethanol-induced hepatotoxicity. Administering 20% ethanol (5 g/kg of body weight/day) for 60 days to male Wistar rats resulted in significantly decr...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2006.110

    authors: Saravanan N,Nalini N

    更新日期:2007-12-01 00:00:00

  • A meta-analysis of clinical improvements of general well-being by a standardized Lycium barbarum.

    abstract::Four randomized, blind, placebo-controlled clinical trials were pooled to study the general effects of oral consumption of Lycium barbarum at 120 mL/day, as a standardized juice, GoChi(®) (FreeLife International, Phoenix, AZ, USA). A questionnaire consisting of symptoms graded 0-5 was given to the participants. For ea...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,meta分析

    doi:10.1089/jmf.2012.0013

    authors: Paul Hsu CH,Nance DM,Amagase H

    更新日期:2012-11-01 00:00:00

  • Beneficial effects of resveratrol on atherosclerosis.

    abstract::Atherosclerosis, a progressive disease characterized by the accumulation of lipids and fibrous elements in the arteries, is a most important contributor to cardiovascular diseases. Resveratrol is a naturally occurring phytopolyphenol compound and shows the ability to reduce the risk of cardiovascular diseases. In this...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,评审

    doi:10.1089/jmf.2007.0091

    authors: Fan E,Zhang L,Jiang S,Bai Y

    更新日期:2008-12-01 00:00:00

  • Lindera glauca (Siebold et Zucc.) Blume Stem Extracts Protect Against tert-Butyl Hydroperoxide-Induced Oxidative Stress.

    abstract::In this study, we investigated the antioxidant and protective effect of Lindera glauca stem (LGS) extracts against oxidative stress. We compared antioxidant properties of water extract (LGSW) with ethanol extract (LGSE) by determining the contents responsible for antioxidant activities such as polyphenols and flavonoi...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2018.4289

    authors: Kim YS,Kim EK,Dong X,Park JS,Shin WB,Kim SJ,Go EA,Park PJ,Lim BO

    更新日期:2019-05-01 00:00:00

  • Fermented Rice Germ Extract Alleviates Morphological and Functional Damage to Murine Gastrocnemius Muscle by Inactivation of AMP-Activated Protein Kinase.

    abstract::Sarcopenia, loss of muscle mass and function, is mainly observed in elderly people. In this study, we investigated whether fermented rice germ extract (FRGE) has some effects on the mouse gastrocnemius muscle by using behavioral and morphological analyses, Western blotting, and a murine model of immobilization-induced...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2016.3906

    authors: Tanaka M,Yoshino Y,Takeda S,Toda K,Shimoda H,Tsuruma K,Shimazawa M,Hara H

    更新日期:2017-10-01 00:00:00

  • Quantification of saponins in extractive solution of mate leaves (Ilex paraguariensis A. St. Hil.).

    abstract::Mate (Ilex paraguariensis A. St. Hil.) is a raw material used to prepare popular beverages in South America, whose healthy effects have been pointed out. The leaves and stems of mate contain a complex assemblage of saponins, mainly ursolic acid and oleanolic acid glycosides, and their quantification presents difficult...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.0046

    authors: Coelho GC,Gnoatto SB,Bassani VL,Schenkel EP

    更新日期:2010-04-01 00:00:00

  • The mediterranean diet in cancer prevention: a review.

    abstract::The Mediterranean dietary pattern has a well-established beneficial role in health promotion. Epidemiologic studies reveal the protective role of adherence to this pattern on overall cancer incidence and mortality. This review examines results from prospective cohort, cross-sectional, and case-control studies assessin...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,评审

    doi:10.1089/jmf.2010.0244

    authors: Kontou N,Psaltopoulou T,Panagiotakos D,Dimopoulos MA,Linos A

    更新日期:2011-10-01 00:00:00

  • Effects of Lactobacillus plantarum PMO 08 Alone and Combined with Chia Seeds on Metabolic Syndrome and Parameters Related to Gut Health in High-Fat Diet-Induced Obese Mice.

    abstract::This study researched the effects of Lactobacillus plantarum PMO 08 alone and combined with chia seeds on metabolic syndrome and parameters related to microbiota modulation and intestinal barrier integrity in obese mice fed high-fat diets (HFDs; 45% kcal fat). Male C57BL/6J mice were acclimated for a period of 2 weeks...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2018.4349

    authors: Oh YJ,Kim HJ,Kim TS,Yeo IH,Ji GE

    更新日期:2019-12-01 00:00:00

  • The polar high molecular weight fraction of the Agaricus blazei Murill extract, AndoSan™, reduces the activity of the tumor-associated protease, legumain, in RAW 264.7 cells.

    abstract::AndoSan™ is an extract of Agaricus blazei Murill (AbM; 82.4%), Hericium erinaceum (14.7%), and Grifola frondosa (2.9%). The main ingredient of AndoSan, AbM, is rich in different forms of β-glucans. Since these exhibit potent antitumor activity and have immunomodulatory effects, the stimulatory effect of AndoSan on the...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2014.0018

    authors: Berven L,Karppinen P,Hetland G,Samuelsen AB

    更新日期:2015-04-01 00:00:00

  • The grapevine-shoot extract Vineatrol30 inhibits the chemically induced malignant transformation of BALB/c-3T3 cells.

    abstract::Vineatrol®30 (developed and produced jointly by Breko GmbH [Bremen, Germany] and Actichem [Montauban, France]) is a grapevine-shoot extract that contains resveratrol as well as considerable amounts of resveratrol oligomers. In the present study it is shown that Vineatrol30 at a noncytotoxic concentration of 2.3 μg/mL ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2010.0022

    authors: Müller C,Ullmann K,Steinberg P

    更新日期:2011-01-01 00:00:00

  • Bioguided Fractionation, and Antioxidant, Antiproliferative, and Anti-Inflammatory Activity of Annona cacans Warm.

    abstract::This study evaluated to determine the phenolic and flavonoids contents, and antioxidant, anti-inflammatory, and antiproliferative activity of the hydromethanolic extracts of the leaves, pulp, and seeds of Annona cacans. The isolation and structural identification of the constituent acetogenin, phenolic acid, and flavo...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2018.0198

    authors: Volobuff CRF,Pederiva MMC,Benites RSR,Lima CJ,Argandoña EJS,Cardoso CAL,Pereira ZV,Ruiz ALTG,Foglio MA,de Carvalho JE,Formagio ASN

    更新日期:2019-10-01 00:00:00

  • Impact of Selenium Supplementation in Neutropenia and Immunoglobulin Production in Childhood Cancer Patients.

    abstract::Essential to human health, selenium (Se) has enzymatic functions of fundamental importance to human biology due to its effects on DNA damage repair, its antioxidant properties, and cancer prevention. The best studied relationships between Se and the immune system is its role in the functions of neutrophils and of lymp...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jmf.2015.0145

    authors: Rocha KC,Vieira ML,Beltrame RL,Cartum J,Alves SI,Azzalis LA,Junqueira VB,Pereira EC,Fonseca FL

    更新日期:2016-06-01 00:00:00

  • High temperature- and high pressure-processed garlic improves lipid profiles in rats fed high cholesterol diets.

    abstract::Garlic protects against degenerative diseases such as hyperlipidemia and cardiovascular diseases. However, raw garlic has a strong pungency, which is unpleasant. In this study, we examined the effect of high temperature/high pressure-processed garlic on plasma lipid profiles in rats. Sprague-Dawley rats were fed a nor...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2011.1922

    authors: Sohn CW,Kim H,You BR,Kim MJ,Kim HJ,Lee JY,Sok DE,Kim JH,Lee KJ,Kim MR

    更新日期:2012-05-01 00:00:00

  • Induction of cell cycle arrest in prostate cancer cells by the dietary compound isoliquiritigenin.

    abstract::Isoliquiritigenin (ISL), a flavonoid chalcone that is present in licorice, shallot, and bean sprouts, is known to have antitumorigenic activities. The present study examined whether ISL alters prostate cancer cell cycle progression. DU145 human and MatLyLu (MLL) rat prostate cancer cells were cultured with various con...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2008.0039

    authors: Lee YM,Lim DY,Choi HJ,Jung JI,Chung WY,Park JH

    更新日期:2009-02-01 00:00:00

  • Effect of Daily Consumption of Orange Juice on the Levels of Blood Glucose, Lipids, and Gut Microbiota Metabolites: Controlled Clinical Trials.

    abstract::Ingestion of bioactive compounds, such as hesperidin and naringin, found in citrus fruits and orange juice, can improve the homeostasis of gut microbiota. A controlled clinical study with temporal series intergroup design with 10 apparently healthy women (28.5 ± 8.4 years, 24.1 ± 3.3 kg/m2) were evaluated after contin...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2018.0080

    authors: Lima ACD,Cecatti C,Fidélix MP,Adorno MAT,Sakamoto IK,Cesar TB,Sivieri K

    更新日期:2019-02-01 00:00:00