Anti-ulcerogenic effect of a whey protein isolate and collagen hydrolysates against ethanol ulcerative lesions on oral administration to rats.

Abstract:

:The effect of the administration of a whey protein isolate (WPI) and collagen hydrolysates on ethanol-induced ulcerative lesions was studied in rats. WPI and bovine or porcine collagen hydrolysate (BCH and PCH, respectively) were given to rats by gavage. In acute experiments, (single-dose) physiological saline (10 mL/kg of body weight) was used as the negative control, and carbenoxolone (200 mg/kg of body weight) was used as a positive control. Ethanol (1 mL per 250-g rat) was also given by gavage. These treatments reduced the ulcerative lesion index (ULI) in a range of 40-77%, depending on the dosage. Some mixtures of WPI with either PCH or BCH provided results that suggested synergisms between WPI and the collagen hydrolysates. For example, WPI/BCH (in the proportion of 375:375 mg/kg of body weight) decreased ULI by 64%. The mechanism for mucosal protection involved a decrease in plasma gastrin (approximately 40%), a significant increase (50-267%) in mucus production, and a reduction in ULI (percentage) when intragastric administrations were performed after in vivo alkylation by N-ethylmaleimide. Results suggest that gastrin, sulfhydryl substances, and some mechanisms related to mucus production are all involved in gastric ulcer protection against ethanol. The collagen hydrolysates (both PCH and BCH) presented a stronger effect on mucus production; on the other hand, the effect of WPI was also dependent on sulfhydryl compounds, resulting in a more protective effect when the two proteins were administered together.

journal_name

J Med Food

authors

Castro GA,Carvalho JE,Tinti SV,Possenti A,Sgarbieri VC

doi

10.1089/jmf.2008.0277

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

83-90

issue

1

eissn

1096-620X

issn

1557-7600

journal_volume

13

pub_type

杂志文章
  • Pistacia lentiscus resin regulates intestinal damage and inflammation in trinitrobenzene sulfonic acid-induced colitis.

    abstract::Mastic (Pistacia lentiscus) of the Anacardiaceae family has exhibited anti-inflammatory and antioxidant properties in patients with Crohn's disease. This study was based on the hypothesis that mastic inhibits intestinal damage in inflammatory bowel disease, regulating inflammation and oxidative stress in intestinal ep...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2010.0240

    authors: Gioxari A,Kaliora AC,Papalois A,Agrogiannis G,Triantafillidis JK,Andrikopoulos NK

    更新日期:2011-11-01 00:00:00

  • Liquid chromatography: mass spectrometry of isoflavones.

    abstract::High-performance liquid chromatography (HPLC) or capillary electrophoresis (CE) is particularly suited to the separation and analysis of a wide range of biological compounds. When investigating such compounds in complex matrices (e.g., blood, tissue, urine, foods), specificity of the detection method becomes an import...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.1999.2.111

    authors: Barnes S,Wang CC,Smith-Johnson M,Kirk M

    更新日期:1999-01-01 00:00:00

  • Garlic powder ameliorates cisplatin-induced nephrotoxicity and oxidative stress.

    abstract::cis-Diamminedichloroplatinum (II) (cisplatin) is an effective chemotherapeutic agent successfully used in the treatment of a wide range of tumors. Nevertheless, nephrotoxicity has restricted its clinical use. The use of more than a few antioxidants has shown that reactive oxygen species are involved in cisplatin-induc...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2008.0033

    authors: Razo-Rodríguez AC,Chirino YI,Sánchez-González DJ,Martínez-Martínez CM,Cruz C,Pedraza-Chaverri J

    更新日期:2008-09-01 00:00:00

  • Lipolysis-Stimulating Peptide from Soybean Protects Against High Fat Diet-Induced Apoptosis in Skeletal Muscles.

    abstract::Obesity is generally associated with low-grade chronic inflammation that involves the recruitment of macrophages and other inflammation factors to the adipocytes of obese individuals. Tumor necrosis factor-alpha (TNF-α), a cytokine associated with systemic inflammation, is elevated in conditions of obesity. TNF-α is a...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2017.3941

    authors: Marthandam Asokan S,Hung TH,Chiang WD,Lin WT

    更新日期:2018-03-01 00:00:00

  • Influence of sesame oil on blood glucose, lipid peroxidation, and antioxidant status in streptozotocin diabetic rats.

    abstract::The present study was carried out to assess the influence of sesame oil on blood glucose, lipid peroxidation, and status of antioxidants in normal and streptozotocin (STZ) diabetic rats. Diabetes was induced in adult female albino Wistar rats weighing 180-200 g by administration of STZ (40 mg/kg of body weight) intrap...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2005.8.377

    authors: Ramesh B,Saravanan R,Pugalendi KV

    更新日期:2005-10-01 00:00:00

  • Myricetin protects against cytokine-induced cell death in RIN-m5f β cells.

    abstract::Cytokine-induced cell death is recognized as a major cause of progressive β-cell loss. Tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and interferon γ (IFN-γ) in combination trigger a series of events that lead to β-cell death. In the past few decades, the use of myricetin as an anti-inflammatory and cytopro...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2011.2033

    authors: Ding Y,Zhang ZF,Dai XQ,Li Y

    更新日期:2012-08-01 00:00:00

  • Effects of Stevia rebaudiana (Bertoni) extract and N-nitro-L-arginine on renal function and ultrastructure of kidney cells in experimental type 2 Diabetes.

    abstract::Diabetes is the leading cause of chronic renal failure. Our purpose was to determine the effects of N-nitro-l-arginine (l-NNA) and an extract of Stevia rebaudiana (Bertoni) (SrB) leaves on renal function in streptozotocin-nicotinamide (STZ-NA)-induced diabetic rats. Rats were divided into seven groups. Three of these ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2010.0280

    authors: Ozbayer C,Kurt H,Kalender S,Ozden H,Gunes HV,Basaran A,Cakmak EA,Civi K,Kalender Y,Degirmenci I

    更新日期:2011-10-01 00:00:00

  • Hemodynamic effects of lactotripeptides from casein hydrolysate in Mediterranean normotensive subjects and patients with high-normal blood pressure: a randomized, double-blind, crossover clinical trial.

    abstract::Contrasting data partially support a certain antihypertensive efficacy of lactotripeptides derived from enzymatic treatment of casein hydrolysate. We carried out a randomized, double-blind, crossover clinical study to investigate the antihypertensive efficacy of a short-term treatment with lactotripeptides in Mediterr...

    journal_title:Journal of medicinal food

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1089/jmf.2009.0253

    authors: Cicero AF,Rosticci M,Veronesi M,Bacchelli S,Strocchi E,Melegari C,Grandi E,Borghi C

    更新日期:2010-12-01 00:00:00

  • Antioxidant effect of Hemidesmus indicus on ethanol-induced hepatotoxicity in rats.

    abstract::The antioxidant effect of the ethanolic root extract of Hemidesmus indicus, an indigenous Ayurvedic medicinal plant used in soft drinks in India, was studied in rats with ethanol-induced hepatotoxicity. Administering 20% ethanol (5 g/kg of body weight/day) for 60 days to male Wistar rats resulted in significantly decr...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2006.110

    authors: Saravanan N,Nalini N

    更新日期:2007-12-01 00:00:00

  • Increase of bioavailability of coenzyme Q(10) and vitamin E.

    abstract::Commercial coenzyme Q(10) (CoQ(10)) and alpha-tocopherol (vitamin E) formulations often show poor intestinal absorption. Delivery of CoQ(10) and vitamin E was enhanced when used with a new formulation, NanoSolve (Lipoid GmbH, Ludwigshafen, Germany), as shown by an open, comparative monocenter, crossover study of 24 vo...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jmf.2006.254

    authors: Wajda R,Zirkel J,Schaffer T

    更新日期:2007-12-01 00:00:00

  • Rice hull extracts inhibit proliferation of MCF-7 cells with G₁ cell cycle arrest in parallel with their antioxidant activity.

    abstract::Rice (Oryza sativa L.) has been a major dietary staple worldwide for centuries. Growing interest in the beneficial effects of antioxidants has inspired investigation of rice hulls as an attractive source of chemopreventive compounds for breast cancer intervention. We prepared methanol extracts from rice hulls of three...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2014.3181

    authors: Chung NJ,Choi KC,Lee SA,Baek JA,Lee JC

    更新日期:2015-03-01 00:00:00

  • Yacon-Based Product in the Modulation of Intestinal Constipation.

    abstract::This study aimed to assess the effects of a yacon-based product (YBP) on constipation in adults, including the elderly. Forty-eight individuals were recruited and divided into equal intervention groups named the test and control groups. The YBP (test) and the control (maltodextrin) were dissolved in commercial orange ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2014.0115

    authors: de Souza Lima Sant'Anna M,Rodrigues VC,Araújo TF,de Oliveira TT,do Carmo Gouveia Peluzio M,de Luces Fortes Ferreira CL

    更新日期:2015-09-01 00:00:00

  • Inhibitory effects of salidroside on nitric oxide and prostaglandin E₂ production in lipopolysaccharide-stimulated RAW 264.7 macrophages.

    abstract::The aim of this study was to evaluate the effect of salidroside on lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E₂ (PGE₂) production in RAW 264.7 macrophages and related anti-inflammatory mechanism. PGE₂ production was measured by enzyme-linked immunosorbent assay (ELISA); NO production was tes...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2012.2473

    authors: Song B,Huang G,Xiong Y,Liu J,Xu L,Wang Z,Li G,Lu J,Guan S

    更新日期:2013-11-01 00:00:00

  • Phytochemical investigation and proximate analysis on the leaves of Cnidoscolus aconitifolius.

    abstract::The study was designed to carry out the phytochemical screening and the proximate analysis of Cnidoscolus aconitifolius leaves. The results obtained showed the presence of tannins, saponin, alkaloids, and flavonoids with the absence of glycosides. The proximate analysis and mineral composition of C. aconitifolius leav...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2008.0321

    authors: Oyagbemi AA,Odetola AA,Azeez OI

    更新日期:2011-03-01 00:00:00

  • A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia.

    abstract::Ganoderma lucidum has been widely used to treat various diseases, including cancer, diabetes, and neurasthenia in many Asian countries. This randomized, double-blind, placebo-controlled parallel study aimed to investigate the efficacy and safety of a polysaccharide extract of G. lucidum (Ganopoly) in Chinese patients ...

    journal_title:Journal of medicinal food

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1089/jmf.2005.8.53

    authors: Tang W,Gao Y,Chen G,Gao H,Dai X,Ye J,Chan E,Huang M,Zhou S

    更新日期:2005-04-01 00:00:00

  • Health benefits of kimchi (Korean fermented vegetables) as a probiotic food.

    abstract::Kimchi is a traditional Korean food manufactured by fermenting vegetables with probiotic lactic acid bacteria (LAB). Many bacteria are involved in the fermentation of kimchi, but LAB become dominant while the putrefactive bacteria are suppressed during salting of baechu cabbage and the fermentation. The addition of ot...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,评审

    doi:10.1089/jmf.2013.3083

    authors: Park KY,Jeong JK,Lee YE,Daily JW 3rd

    更新日期:2014-01-01 00:00:00

  • Turnera subulata Anti-Inflammatory Properties in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages.

    abstract::In South America, particularly in the Northeastern regions of Brazil, Turnera subulata leaf extract is used as an alternative traditional medicine approach for several types of chronic diseases, such as diabetes, hypertension, chronic pain, and general inflammation. Despite its widespread use, little is known about th...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2016.0047

    authors: Souza NC,de Oliveira JM,Morrone MDS,Albanus RD,Amarante MDSM,Camillo CDS,Langassner SMZ,Gelain DP,Moreira JCF,Dalmolin RJS,de Bittencourt Pasquali MA

    更新日期:2016-10-01 00:00:00

  • Red Pepper (Capsicum baccatum) Extracts Present Anti-Inflammatory Effects In Vivo and Inhibit the Production of TNF-α and NO In Vitro.

    abstract::Capsicum baccatum is the most consumed red pepper species in Brazil. Our previous studies demonstrated the anti-inflammatory properties of its crude extract, whose activity is yet to be fully characterized. Herein, we examined the anti-inflammatory in vivo effects of enriched extracts obtained through bioguided fracti...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2015.0101

    authors: Allemand A,Leonardi BF,Zimmer AR,Moreno S,Romão PR,Gosmann G

    更新日期:2016-08-01 00:00:00

  • The grapevine-shoot extract Vineatrol30 inhibits the chemically induced malignant transformation of BALB/c-3T3 cells.

    abstract::Vineatrol®30 (developed and produced jointly by Breko GmbH [Bremen, Germany] and Actichem [Montauban, France]) is a grapevine-shoot extract that contains resveratrol as well as considerable amounts of resveratrol oligomers. In the present study it is shown that Vineatrol30 at a noncytotoxic concentration of 2.3 μg/mL ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2010.0022

    authors: Müller C,Ullmann K,Steinberg P

    更新日期:2011-01-01 00:00:00

  • Effect of a Western-style diet fortified with increased calcium and vitamin D on mammary gland of C57BL/6 mice.

    abstract::We previously reported hyperproliferation and hyperplasia in C57Bl/6 mouse mammary gland after feeding a Western-style diet (WD); these findings decreased after supplementing WD with increased calcium and vitamin D(3). We now again fortified WD with increased calcium and vitamin D(3) from two sources: (1) a food sourc...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2007.619

    authors: Kurihara N,Fan K,Thaler HT,Yang K,Lipkin M

    更新日期:2008-06-01 00:00:00

  • Ethanolic Extract of Vaccinium corymbosum Alleviates Muscle Fatigue in Mice.

    abstract::The aim of this study was to evaluate the effects of ethanol extracts of Vaccinium corymbosum (VCE) on exercise-induced fatigue in mice. Mice were randomly divided into three groups; nonexercise control group (CON), exercise control group (Ex-CON), and exercise and VCE supplementation group (Ex-VCE). Compared with Ex-...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2020.4753

    authors: Kim S,Park J,Shin J,You Y,Kim OK,Lee J,Chung JW,Shim S,Kim K,Jun W

    更新日期:2020-11-01 00:00:00

  • Antioxidant activity of eugenol: a structure-activity relationship study.

    abstract::Eugenol (4-allyl-2-methoxyphenol), a major phenolic component from clove oil (Eugenia caryophyllata), has several biological activities. To estimate the capacity of eugenol to act as an antioxidant, the following were studied: 1,1-diphenyl-2-picryl-hydrazyl-, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid)-, and...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2010.0197

    authors: Gülçin İ

    更新日期:2011-09-01 00:00:00

  • Anticonvulsant activity of ethanol leaf extract of Spathodea campanulata P. Beauv (Bignoniaceae).

    abstract::The anticonvulsant properties of ethanol leaf extract of Spathodea campanulata, a plant used in traditional medicine to treat convulsion and epilepsy, were studied in mice using pentylenetetrazole-, picrotoxin-, and electroshock-induced models in mice. Other central nervous system effects and anticonvulsant-related ac...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2009.0144

    authors: Ilodigwe EE,Akah PA,Nworu CS

    更新日期:2010-08-01 00:00:00

  • The Antiproliferative Effect of Moringa oleifera Crude Aqueous Leaf Extract on Human Esophageal Cancer Cells.

    abstract::Esophageal cancer (EC) is commonly diagnosed in South Africa (SA), with high incidences occurring in SA's black population. Moringa oleifera (MO), a multipurpose tree, is used traditionally for its nutritional and medicinal properties. It has been used for the treatment of a variety of ailments, including cancer. We i...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2015.0113

    authors: Tiloke C,Phulukdaree A,Chuturgoon AA

    更新日期:2016-04-01 00:00:00

  • A Randomized Double-Blind Placebo-Control Study to Assess the Efficacy and Safety of OLNP-05 Versus Placebo for the Treatment of Subjects with Premature Ejaculation.

    abstract::Premature ejaculation (PE) is one of the foremost sex-related health problems among men. The global occurrence ranges from 20% to 30%, according to various studies. PE has a great impact on the men's quality of life, with deleterious effects such as embarrassment, frustration, and feeling of incompetence. Considering ...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2019.4661

    authors: Panda SK,Nirvanashetty S,Parachur VA,Mohanty N

    更新日期:2020-09-01 00:00:00

  • Effects of heating, storage, and ultraviolet exposure on antimicrobial activity of garlic juice.

    abstract::This study was designed to investigate the effect of heating, storage, and ultraviolet exposure on antimicrobial activity of garlic juice and its bacteriocidal activity against common human pathogens. Antimicrobial activity of fresh garlic juice was tested against Escherichia coli, Staphylococcus aureus, Streptococcus...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2005.067

    authors: Al-Waili NS,Saloom KY,Akmal M,Al-Waili TN,Al-Waili AN,Al-Waili H,Ali A,Al-Sahlani K

    更新日期:2007-03-01 00:00:00

  • Reduced Coenzyme Q10 Decreases Urinary 8-Oxo-7,8-Dihydro-2'-Deoxyguanosine Concentrations in Healthy Young Female Subjects.

    abstract::It remains unclear whether dietary supplementation with coenzyme Q10 (CoQ10) provides beneficial effects for healthy individuals, especially young subjects. This study investigated the effects of dietary supplementation with CoQ10 on oxidative stress in healthy young females. We performed a placebo-controlled trial us...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2014.3302

    authors: Ito K,Watanabe C,Nakamura A,Oikawa-Tada S,Murata M

    更新日期:2015-08-01 00:00:00

  • Leafy vegetable mix supplementation improves lipid profiles and antioxidant status in C57BL/6J mice fed a high fat and high cholesterol diet.

    abstract::Daily consumption of an antioxidant-rich leafy vegetable mix (LVM) was assessed for beneficial effects on plasma lipid profiles, tissue lipid peroxidation, and oxidative DNA damage in C57BL/6J mice fed a high fat and high cholesterol diet (20% fat and 1% cholesterol, wt/wt) for 4 weeks. The LVM contained beet leaf, an...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2008.1125

    authors: Kim MY,Cheong SH,Kim MH,Son C,Yook HS,Sok DE,Kim JH,Cho Y,Chun H,Kim MR

    更新日期:2009-08-01 00:00:00

  • The effects of powdered fertilized eggs on depression.

    abstract::This 12-week, double-blind, placebo-controlled study investigated the effects of fertilized egg powder (Young Tissue Extract; YT®) intake on outcome measures for depression. Fifty-five patients with depression were randomly assigned to receive YTE, YTE plus Melissa officinalis, or placebo for 12 weeks. At baseline, th...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jmf.2010.0146

    authors: Solberg E

    更新日期:2011-07-01 00:00:00

  • Analysis of responses to kava kava in the feline pulmonary vascular bed.

    abstract::This study was designed to test the hypothesis that kava kava induces a depressor response in the pulmonary vascular bed of the cat and to identify the pathways involved in the mediation or modulation of these effects. In separate experiments, the effects of L-N5-(1-iminoethyl)ornithine hydrochloride (L-NIO), a nitric...

    journal_title:Journal of medicinal food

    pub_type: 杂志文章

    doi:10.1089/jmf.2006.9.62

    authors: Hoover JM,Kaye AD,Ibrahim IN,Fields AM,Richards TA

    更新日期:2006-04-01 00:00:00