Ameliorating effects of L-carnitine on diabetic podocyte injury.

Abstract:

:High glucose levels can change podocyte gene expression and subsequently induce podocyte damage through altered glucose metabolism. l-Carnitine is known to play a beneficial role in diabetes; however, there are no studies on the effects of l-carnitine on podocyte alteration under high glucose conditions. This study investigated whether l-carnitine can attenuate diabetic podocyte injury through the prevention of loss of slit diaphragm proteins. The l-carnitine treatment group showed increased glucose uptakes compared to the control group, suggesting that glucose utilization in the podocytes was increased by l-carnitine. l-Carnitine treatment also prevented decreased mRNA expressions of nephrin and podocin in the high glucose-stimulated podocytes. However, mRNA expressions of CD2AP and α-actinin-4 were not significantly changed by the high glucose conditions. When these data are taken together, l-carnitine can increase glucose uptake in podocytes under high glucose conditions, and its mechanism may be at least partly related to the up-regulation of nephrin and podocin. Our results help clarify the beneficial effects of l-carnitine in diabetic nephropathy.

journal_name

J Med Food

authors

Fan JP,Kim D,Kawachi H,Ha TS,Han GD

doi

10.1089/jmf.2010.1079

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

1324-30

issue

6

eissn

1096-620X

issn

1557-7600

journal_volume

13

pub_type

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