Abstract:
:High glucose levels can change podocyte gene expression and subsequently induce podocyte damage through altered glucose metabolism. l-Carnitine is known to play a beneficial role in diabetes; however, there are no studies on the effects of l-carnitine on podocyte alteration under high glucose conditions. This study investigated whether l-carnitine can attenuate diabetic podocyte injury through the prevention of loss of slit diaphragm proteins. The l-carnitine treatment group showed increased glucose uptakes compared to the control group, suggesting that glucose utilization in the podocytes was increased by l-carnitine. l-Carnitine treatment also prevented decreased mRNA expressions of nephrin and podocin in the high glucose-stimulated podocytes. However, mRNA expressions of CD2AP and α-actinin-4 were not significantly changed by the high glucose conditions. When these data are taken together, l-carnitine can increase glucose uptake in podocytes under high glucose conditions, and its mechanism may be at least partly related to the up-regulation of nephrin and podocin. Our results help clarify the beneficial effects of l-carnitine in diabetic nephropathy.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Fan JP,Kim D,Kawachi H,Ha TS,Han GDdoi
10.1089/jmf.2010.1079subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1324-30issue
6eissn
1096-620Xissn
1557-7600journal_volume
13pub_type
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journal_title:Journal of medicinal food
pub_type: 杂志文章
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