Abstract:
:We investigated age-related changes in intestinal intraepithelial lymphocyte (IEL) subsets in mice by flow cytometric analysis and their functional preservation as affected by feeding Spirulina, a cyanobacterium that is known to possess various therapeutic effects, including immune modulation activity. The number of cells possessing the leukocyte-common antigen CD45(+) cells in mice (43 weeks old) of the aged group, used as a representative marker for IELs, was significantly lower than that of adult mice (5 weeks old). Either the proportion or the number of CD45(+)CD8(+) cells of the aged mice was significantly lower than that of adult mice, corresponding to previous reports. Proportions and numbers of CD4(+)CD8(+) cells in aged mice, on the other hand, were higher than those in adult mice. Increased or decreased levels of the cell surface antigens observed in the aged mice tended to be restored in aged mice fed Spirulina (aged-SP group), which ingested a hot water extract of Spirulina (SpHW). In fact, the proportions of CD45(+)CD8(+) cells and CD45(+)TCRgammadelta(+) cells in the aged-SP group significantly increased in comparison to the control aged group, which ingested ordinary chow and water ad libitum. These results suggest that ingestion of SpHW in the aged-SP group may contribute to the functional preservation of the intestinal epithelium as a first line of mucosal barrier against infectious agents through retaining the number of certain IELs. Changes in the number of other IEL subsets and blood cells are also discussed.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Hayashi O,Katayanagi Y,Ishii K,Kato Tdoi
10.1089/jmf.2008.1260subject
Has Abstractpub_date
2009-10-01 00:00:00pages
982-9issue
5eissn
1096-620Xissn
1557-7600journal_volume
12pub_type
杂志文章abstract::Bone is maintained by an intricate balance between bone formation and bone resorption. The presence of inflammation can contribute to an imbalance in bone homeostasis by enhancing differentiation and activity of osteoclasts, the cells that participate in the breakdown of bone. Polyphenols such as flavonoids found in p...
journal_title:Journal of medicinal food
pub_type: 杂志文章
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journal_title:Journal of medicinal food
pub_type: 杂志文章,评审
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2010-12-01 00:00:00
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journal_title:Journal of medicinal food
pub_type: 杂志文章
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journal_title:Journal of medicinal food
pub_type: 杂志文章
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journal_title:Journal of medicinal food
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更新日期:2017-10-01 00:00:00
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journal_title:Journal of medicinal food
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abstract::Honey has been used as a medicine throughout the ages and has recently been reintroduced to modern medical practice. Much of the research to date has addressed honey's antibacterial properties and its effects on wound healing. Laboratory studies and clinical trials have shown that honey is an effective broad-spectrum ...
journal_title:Journal of medicinal food
pub_type: 杂志文章,评审
doi:10.1089/jmf.2010.0161
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abstract::Ala-His-Leu-Leu (AHLL) was isolated and purified from the loach (Misgurnus anguillicaudatus) hydrolysate in our previous study. The aim of this study was to investigate the antihypertensive effects of angiotensin-I-converting enzyme (ACE) inhibitory peptide AHLL in spontaneously hypertensive rats (SHRs). AHLL showed g...
journal_title:Journal of medicinal food
pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
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journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2018.4391
更新日期:2019-08-01 00:00:00
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journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2016.0024
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journal_title:Journal of medicinal food
pub_type: 杂志文章,评审
doi:10.1089/jmf.2009.1036
更新日期:2009-12-01 00:00:00
abstract::Glucomannan-enriched squid surimi improves cholesterolemia and liver antioxidant status. The effect of squid surimi enriched with glucomannan or glucomannan plus spirulina on liver and heart structures and cell damage markers was tested in fa/fa rats fed highly saturated-hyper-energetic diets. Animals were fed 70% AIN...
journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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journal_title:Journal of medicinal food
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doi:10.1089/jmf.2013.2849
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journal_title:Journal of medicinal food
pub_type: 杂志文章,随机对照试验
doi:10.1089/jmf.2008.1250
更新日期:2009-08-01 00:00:00
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journal_title:Journal of medicinal food
pub_type: 杂志文章
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journal_title:Journal of medicinal food
pub_type: 杂志文章
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journal_title:Journal of medicinal food
pub_type: 杂志文章
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journal_title:Journal of medicinal food
pub_type: 杂志文章,评审
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更新日期:2007-03-01 00:00:00
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journal_title:Journal of medicinal food
pub_type: 杂志文章,随机对照试验
doi:10.1089/jmf.2017.0115
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journal_title:Journal of medicinal food
pub_type: 杂志文章
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abstract::The Terminalia genus includes plants that are used in a variety of food, nutritional products, and traditional medicines. Aqueous bark extract of Terminalia paniculata (TPW) was screened for its antioxidant and analgesic potential. The major polyphenols were identified by high-performance liquid chromatography. In vit...
journal_title:Journal of medicinal food
pub_type: 杂志文章
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abstract::This study was designed to investigate the effect of heating, storage, and ultraviolet exposure on antimicrobial activity of garlic juice and its bacteriocidal activity against common human pathogens. Antimicrobial activity of fresh garlic juice was tested against Escherichia coli, Staphylococcus aureus, Streptococcus...
journal_title:Journal of medicinal food
pub_type: 杂志文章
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