Abstract:
:Supplements containing pharmacological concentrations of biotin are commercially available over the counter. Classical toxicity studies have considered biotin administration as harmless; however, recent investigations have shown that biotin supplementation modifies tissue morphology without changes in toxicity markers, raising concerns about the consequences of morphological changes on tissues' functions and the safety of pharmacological concentrations of the vitamin. Testes are very sensitive to toxicants, and testicular histology is a reliable method to study its function. In this work, we investigated the effects of dietary biotin supplementation on testis morphology and spermatogenesis function using an experimental model, in which we have not observed unfavorable effects on other tissue functions or toxicity markers. Male BALB/cAnNHsd mice were fed a control or a biotin-supplemented diet (1.76 or 97.7 mg biotin/kg diet) for 8 weeks. Compared to the control group, the biotin-supplemented mice presented remarkable testis morphology changes, including increased spermatogonia layers; the cellular mechanism involved is related to increased proliferation. Sperm count and serum testosterone levels were not affected, but spermatozoa motility and morphology were significantly impaired in the biotin-supplemented mice. These results caution against the use of supplements with high concentrations of biotin and indicate that biotin's pharmacological effects on morphology need to be considered in toxicological studies.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Pastén-Hidalgo K,Riverón-Negrete L,Sicilia-Argumedo G,Canul-Medina G,Salazar-Anzures T,Tapia-Rodríguez M,Hernández-González EO,Roa-Espitia AL,Cedillo-Peláez C,Fernandez-Mejia Cdoi
10.1089/jmf.2019.0137subject
Has Abstractpub_date
2020-05-01 00:00:00pages
535-544issue
5eissn
1096-620Xissn
1557-7600journal_volume
23pub_type
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